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Current IssueEditorial BoardOnline First ArticlesArchive

Research Article

volume 53 issue 5 (may 2019) : 583-586,   Doi: 10.18805/ijar.B-991

Aerobic exercise regulating expression of ERá and ERâ in prostate to prevent benign prostatic hyperplasia of obesity mice

X
Xiangyun Liu
J
Jiulin Xiang
K
Kai Li
R
Ru Wang
Q
Qin Yang
1Key Laboratory of Exercise and Health Sciences of Ministry of Education at the Shanghai University of Sport, 188 Hengren Road, Shanghai, 200 438, China.
Cite article:- Liu Xiangyun, Xiang Jiulin, Li Kai, Wang Ru, Yang Qin (2019). Aerobic exercise regulating expression of ERá and ERâ in prostate to prevent benign prostatic hyperplasia of obesity mice. Indian Journal of Animal Research. 53(5): 583-586. doi: 10.18805/ijar.B-991.

ABSTRACT

High-fat-diet (HFD) induced BPH mice model used to examine how aerobics exercise prevents the development of BPH and try to find the mechanism. Materials and Methods: C57BL/6J mice were randomized into three groups for a 6-week intervention: Control group (Co, n = 8) and Diet group (Di, n = 8) fed standard diet, and Exercise and diet group fed standard diet meanwhile run on a treadmill at 12m/min, 30 min/day, 6 days/week (Ex+Di, n = 8). Body weight (BW), fat, prostate weight (PW), prostate index (PI), Estradio(E2), Testosterona (T)  and estrogen receptor(ER) were detected. Results: The Di had a higher BW, fat, PW and PI, compared to Co and Ex+Di. BW and PI in Ex+Di significantly lower compared to Di, thus running prevented increase in BW and PI. Although, E2 and T in Di and Ex+Di haven’t seen anything statistically significant, compared with Co. However, ERá in Ex+Di (0.039±0.012 ng/ml) was significant reduced (P<0.05) compared with Di (0.046±0.011 ng/ml); Compared with Di (0.032±0.009 ng/ml), ERâ in Ex+Di (0.039±0.011 ng/ml) was significant reduced (P<0.05). Conclusion: Obesity is an important risk factor for the development of BPH. It may also provide scientific evidence to promote weight loss and aerobic exercise beneficial adjuvant therapies for BPH.

REFERENCES

  1. Alcaraz, A., P. Hammerer, A. Tubaro, F. Schröder and R. Castro (2009). “Is there evidence of a relationship between benign prostatic hyperplasia and prostate cancer? Findings of a literature review.” Eur. Urol. 55(4): 864-873.
  2. Brown, C. T. and M. Emberton (2009). “Self-management for men with lower urinary tract symptoms.” Curr Urol Rep 10(4): 261-266.
  3. Corona, G., L. Vignozzi and G. Rastrelli (2014). “Benign prostatic hyperplasia: a new metabolic disease of the aging male and its correlation with sexual dysfunctions.” 2014: 329456.
  4. Freisling, H., M. Arnold, I. Soerjomataram, M. O’Doherty, J. Ordóñez-Mena, C. Bamia, E. Kampman, M. Leitzmann, I. Romieu, F. Kee, K. Tsilidis, A. Tjønneland, A. Trichopoulou, P. Boffetta, V. Benetou, H. Bueno-de-Mesquita, J. Huerta, H. Brenner, T. Wilsgaard and M. Jenab (2017). “Comparison of general obesity and measures of body fat distribution in older adults in relation to cancer risk: meta-analysis of individual participant data of seven prospective cohorts in Europe.” Br. J. Cancer 116(11): 1486-1497.
  5. Gabal, S. M., F. M. Habib, D. O. Helmy and M. F. Ibrahim (2007). “Expression of estrogen receptor-B ( ER-B ) in bengin and malignant prostatic epithelial cells and its correlation with the clinico-pathological features.” J Egypt Natl Canc Inst. 19(4): 239-248.
  6. Hu, W. Y., G. B. Shi, D. P. Hu, J. L. Nelles and G. S. Prins (2012). “Actions of estrogens and endocrine disrupting chemicals on human prostate stem/progenitor cells and prostate cancer risk.” Mol Cell Endocrinol. 354(1-2): 63-73.
  7. Jarred, R. A., S. J. McPherson, J. J. Bianco, J. F. Couse, K. S. Korach and G. P. Risbridger (2002). “Prostate phenotypes in estrogen-    modulated transgenic mice.” Trends Endocrinol Metab. 13(4): 163-168.
  8. Jitnarin, N., V. Kosulwat, N. Rojroongwasinkul, A. Boonpraderm, C. K. Haddock and W. S. Poston (2011). “Prevalence of overweight and obesity in Thai population: results of the National Thai Food Consumption Survey.” Eat Weight Disord. 16(4): e242-249.
  9. Jung, S., E. N. Lee, S. R. Lee, M. S. Kim and M. S. Lee (2012). “Tai chi for lower urinary tract symptoms and quality of life in elderly patients with benign prostate hypertrophy: a randomized controlled trial.” Evid Based Complement Alternat Med. 2012: 624692.
  10. Kristal, A. R., K. B. Arnold, J. M. Schenk, M. L. Neuhouser, N. Weiss, P. Goodman, C. M. Antvelink, D. F. Penson and I. M. Thompson (2007). “Race/ethnicity, obesity, health related behaviors and the risk of symptomatic benign prostatic hyperplasia: results from the prostate cancer prevention trial.” J Urol. 177(4): 1395-1400; quiz 1591.
  11. Lee, H. W., S. A. Kim, J. W. Nam, M. K. Kim, B. Y. Choi and H. S. Moon (2014). “The study about physical activity for subjects with prevention of benign prostate hyperplasia.” Int Neurourol J. 18(3): 155-162. 
  12. Mohamud, W. N., K. I. Musa, A. S. Khir, A. A. Ismail, I. S. Ismail, K. A. Kadir, N. A. Kamaruddin, N. A. Yaacob, N. Mustafa, O. Ali, S. H. Isa and W. M. Bebakar (2011). “Prevalence of overweight and obesity among adult Malaysians: an update.” Asia Pac J Clin Nutr. 20(1): 35-41.
  13. Parikesit, D., C. Mochtar, R. Umbas and A. Hamid (2016). “The impact of obesity towards prostate diseases.” Prostate Int. 4(1): 1-6.
  14. Poon, K. S. and K. T. McVary (2009). “Dietary patterns, supplement use, and the risk of benign prostatic hyperplasia.” Curr Urol Rep. 10(4): 279-286.
  15. Rhodes, L., V. D. Ding, R. K. Kemp, M. S. Khan, A. M. Nakhla, B. Pikounis, W. Rosner, H. M. Saunders and W. P. Feeney (2000). “Estradiol causes a dose-dependent stimulation of prostate growth in castrated beagle dogs.” Prostate. 44(1): 8-18.
  16. Schefer, V. and M. I. Talan (1996). “Oxygen consumption in adult and AGED C57BL/6J mice during acute treadmill exercise of different intensity.” Exp Gerontol. 31(3): 387-392.
  17. Sugiyama, N., R. P. Barros, M. Warner and J. A. Gustafsson (2010). “ERbeta: recent understanding of estrogen signaling.” Trends Endocrinol Metab. 21(9): 545-552.
  18. Wang, H. H., C. J. Hsieh, K. J. Lin, S. H. Chu, C. K. Chuang, H. W. Chen, M. L. Hsieh, T. M. Wang, Y. Chen, K. L. Liu, H. C. Huang, Y. C. Hsu and Y. J. Chiang (2011). “Waist circumference is an independent risk factor for prostatic hyperplasia in Taiwanese males.” Asian J Surg. 34(4): 163-167.
  19. Wang, S., Q. Mao, Y. Lin, J. Wu, X. Wang, X. Zheng and L. Xie (2012). “Body mass index and risk of BPH: a meta-analysis.” Prostate Cancer Prostatic Dis. 15(3): 265-272.
  20. Winter, M. L. and J. G. Liehr (1996). “Possible mechanism of induction of benign prostatic hyperplasia by estradiol and dihydrotestosterone    in dogs.” Toxicol Appl Pharmacol. 136(2): 211-219.
  21. Xiang-Yun, L., X. Ying-Wen, X. Chen-Jing, W. Jiu-Jiu, P. Qi, G. Bo and S. Zu-Yue (2010). “Possible mechanism of benign prostatic hyperplasia induced by androgen-estrogen ratios in castrated rats.” Indian J Pharmacol. 42(5): 312-317. 
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    Research Article

    volume 53 issue 5 (may 2019) : 583-586,   Doi: 10.18805/ijar.B-991

    Aerobic exercise regulating expression of ERá and ERâ in prostate to prevent benign prostatic hyperplasia of obesity mice

    X
    Xiangyun Liu
    J
    Jiulin Xiang
    K
    Kai Li
    R
    Ru Wang
    Q
    Qin Yang
    1Key Laboratory of Exercise and Health Sciences of Ministry of Education at the Shanghai University of Sport, 188 Hengren Road, Shanghai, 200 438, China.
    Cite article:- Liu Xiangyun, Xiang Jiulin, Li Kai, Wang Ru, Yang Qin (2019). Aerobic exercise regulating expression of ER&aacute; and ER&acirc; in prostate to prevent benign prostatic hyperplasia of obesity mice. Indian Journal of Animal Research. 53(5): 583-586. doi: 10.18805/ijar.B-991.

    ABSTRACT

    High-fat-diet (HFD) induced BPH mice model used to examine how aerobics exercise prevents the development of BPH and try to find the mechanism. Materials and Methods: C57BL/6J mice were randomized into three groups for a 6-week intervention: Control group (Co, n = 8) and Diet group (Di, n = 8) fed standard diet, and Exercise and diet group fed standard diet meanwhile run on a treadmill at 12m/min, 30 min/day, 6 days/week (Ex+Di, n = 8). Body weight (BW), fat, prostate weight (PW), prostate index (PI), Estradio(E2), Testosterona (T)  and estrogen receptor(ER) were detected. Results: The Di had a higher BW, fat, PW and PI, compared to Co and Ex+Di. BW and PI in Ex+Di significantly lower compared to Di, thus running prevented increase in BW and PI. Although, E2 and T in Di and Ex+Di haven’t seen anything statistically significant, compared with Co. However, ERá in Ex+Di (0.039±0.012 ng/ml) was significant reduced (P<0.05) compared with Di (0.046±0.011 ng/ml); Compared with Di (0.032±0.009 ng/ml), ERâ in Ex+Di (0.039±0.011 ng/ml) was significant reduced (P<0.05). Conclusion: Obesity is an important risk factor for the development of BPH. It may also provide scientific evidence to promote weight loss and aerobic exercise beneficial adjuvant therapies for BPH.

    REFERENCES

    1. Alcaraz, A., P. Hammerer, A. Tubaro, F. Schröder and R. Castro (2009). “Is there evidence of a relationship between benign prostatic hyperplasia and prostate cancer? Findings of a literature review.” Eur. Urol. 55(4): 864-873.
    2. Brown, C. T. and M. Emberton (2009). “Self-management for men with lower urinary tract symptoms.” Curr Urol Rep 10(4): 261-266.
    3. Corona, G., L. Vignozzi and G. Rastrelli (2014). “Benign prostatic hyperplasia: a new metabolic disease of the aging male and its correlation with sexual dysfunctions.” 2014: 329456.
    4. Freisling, H., M. Arnold, I. Soerjomataram, M. O’Doherty, J. Ordóñez-Mena, C. Bamia, E. Kampman, M. Leitzmann, I. Romieu, F. Kee, K. Tsilidis, A. Tjønneland, A. Trichopoulou, P. Boffetta, V. Benetou, H. Bueno-de-Mesquita, J. Huerta, H. Brenner, T. Wilsgaard and M. Jenab (2017). “Comparison of general obesity and measures of body fat distribution in older adults in relation to cancer risk: meta-analysis of individual participant data of seven prospective cohorts in Europe.” Br. J. Cancer 116(11): 1486-1497.
    5. Gabal, S. M., F. M. Habib, D. O. Helmy and M. F. Ibrahim (2007). “Expression of estrogen receptor-B ( ER-B ) in bengin and malignant prostatic epithelial cells and its correlation with the clinico-pathological features.” J Egypt Natl Canc Inst. 19(4): 239-248.
    6. Hu, W. Y., G. B. Shi, D. P. Hu, J. L. Nelles and G. S. Prins (2012). “Actions of estrogens and endocrine disrupting chemicals on human prostate stem/progenitor cells and prostate cancer risk.” Mol Cell Endocrinol. 354(1-2): 63-73.
    7. Jarred, R. A., S. J. McPherson, J. J. Bianco, J. F. Couse, K. S. Korach and G. P. Risbridger (2002). “Prostate phenotypes in estrogen-    modulated transgenic mice.” Trends Endocrinol Metab. 13(4): 163-168.
    8. Jitnarin, N., V. Kosulwat, N. Rojroongwasinkul, A. Boonpraderm, C. K. Haddock and W. S. Poston (2011). “Prevalence of overweight and obesity in Thai population: results of the National Thai Food Consumption Survey.” Eat Weight Disord. 16(4): e242-249.
    9. Jung, S., E. N. Lee, S. R. Lee, M. S. Kim and M. S. Lee (2012). “Tai chi for lower urinary tract symptoms and quality of life in elderly patients with benign prostate hypertrophy: a randomized controlled trial.” Evid Based Complement Alternat Med. 2012: 624692.
    10. Kristal, A. R., K. B. Arnold, J. M. Schenk, M. L. Neuhouser, N. Weiss, P. Goodman, C. M. Antvelink, D. F. Penson and I. M. Thompson (2007). “Race/ethnicity, obesity, health related behaviors and the risk of symptomatic benign prostatic hyperplasia: results from the prostate cancer prevention trial.” J Urol. 177(4): 1395-1400; quiz 1591.
    11. Lee, H. W., S. A. Kim, J. W. Nam, M. K. Kim, B. Y. Choi and H. S. Moon (2014). “The study about physical activity for subjects with prevention of benign prostate hyperplasia.” Int Neurourol J. 18(3): 155-162. 
    12. Mohamud, W. N., K. I. Musa, A. S. Khir, A. A. Ismail, I. S. Ismail, K. A. Kadir, N. A. Kamaruddin, N. A. Yaacob, N. Mustafa, O. Ali, S. H. Isa and W. M. Bebakar (2011). “Prevalence of overweight and obesity among adult Malaysians: an update.” Asia Pac J Clin Nutr. 20(1): 35-41.
    13. Parikesit, D., C. Mochtar, R. Umbas and A. Hamid (2016). “The impact of obesity towards prostate diseases.” Prostate Int. 4(1): 1-6.
    14. Poon, K. S. and K. T. McVary (2009). “Dietary patterns, supplement use, and the risk of benign prostatic hyperplasia.” Curr Urol Rep. 10(4): 279-286.
    15. Rhodes, L., V. D. Ding, R. K. Kemp, M. S. Khan, A. M. Nakhla, B. Pikounis, W. Rosner, H. M. Saunders and W. P. Feeney (2000). “Estradiol causes a dose-dependent stimulation of prostate growth in castrated beagle dogs.” Prostate. 44(1): 8-18.
    16. Schefer, V. and M. I. Talan (1996). “Oxygen consumption in adult and AGED C57BL/6J mice during acute treadmill exercise of different intensity.” Exp Gerontol. 31(3): 387-392.
    17. Sugiyama, N., R. P. Barros, M. Warner and J. A. Gustafsson (2010). “ERbeta: recent understanding of estrogen signaling.” Trends Endocrinol Metab. 21(9): 545-552.
    18. Wang, H. H., C. J. Hsieh, K. J. Lin, S. H. Chu, C. K. Chuang, H. W. Chen, M. L. Hsieh, T. M. Wang, Y. Chen, K. L. Liu, H. C. Huang, Y. C. Hsu and Y. J. Chiang (2011). “Waist circumference is an independent risk factor for prostatic hyperplasia in Taiwanese males.” Asian J Surg. 34(4): 163-167.
    19. Wang, S., Q. Mao, Y. Lin, J. Wu, X. Wang, X. Zheng and L. Xie (2012). “Body mass index and risk of BPH: a meta-analysis.” Prostate Cancer Prostatic Dis. 15(3): 265-272.
    20. Winter, M. L. and J. G. Liehr (1996). “Possible mechanism of induction of benign prostatic hyperplasia by estradiol and dihydrotestosterone    in dogs.” Toxicol Appl Pharmacol. 136(2): 211-219.
    21. Xiang-Yun, L., X. Ying-Wen, X. Chen-Jing, W. Jiu-Jiu, P. Qi, G. Bo and S. Zu-Yue (2010). “Possible mechanism of benign prostatic hyperplasia induced by androgen-estrogen ratios in castrated rats.” Indian J Pharmacol. 42(5): 312-317. 
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