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Current IssueEditorial BoardOnline First ArticlesArchive

Research Article

volume 53 issue 10 (october 2019) : 1316-1320,   Doi: 10.18805/ijar.v0iOF.9115

Increased total antioxidant capacity in renal tissue of female BWF1 mice infected with Plasmodium chabaudi

M
Mostafa A. Abdel-Maksoud
F
Fathy A. Abdel-Ghaffar
A
Azza El-Amir
G
Gamal Badr
S
Saleh Al-Quraishy
1<div style="text-align:justify">Zoology Department, College of Science,&nbsp;King Saud University, Riyadh 11451, Saudi Arabia.</div>
Cite article:- Abdel-Maksoud A. Mostafa, Abdel-Ghaffar A. Fathy, El-Amir Azza, Badr Gamal, Al-Quraishy Saleh (2017). Increased total antioxidant capacity in renal tissue of female BWF1 mice infected with Plasmodium chabaudi. Indian Journal of Animal Research. 53(10): 1316-1320. doi: 10.18805/ijar.v0iOF.9115.

ABSTRACT

We have investigated the effect of malaria infection on the urine biochemistry and the renal and hepatic levels of total antioxidant capacity (TAC) in female BWF1 lupus mice. A total of 30 female BWF1 lupus mice were divided into three groups as follows: group (I) control group; group (II) lupus mice infected with live Plasmodium. chabaudi; group (III) lupus mice infected with irradiated P. chabaudi. Mice were killed at day 14 post-infection and plasma samples were collected. live P. chabaudi infection was associated with decreased level of glucose in urine (glucosuria), increased urinary level of both ketones (ketonuria) and blood (hematuria). Additionally, live P. chabaudi infection was associated with increased level of TAC in the renal tissue with decreased level of TAC in the hepatic tissue of infected mice. In conclusion, P. chabaudi infection has a direct effect on the urine biochemistry and the renal and hepatic levels of TAC in BWF1 mice.

REFERENCES

  1. Abdel-Maksoud, M.A., Abdel-Ghaffar, F.A., El-Amir, A., Badr, G., Al-Quraishy, S., (2016). Altered renal immune complexes deposition in female BWF1 lupus mice following Plasmodium chabaudi infection. Saudi J. of Biol. Sci. Article in press.
  2. Al-Quraishy, S., Abdel-Maksoud, M.A., El-Amir, A., Abdel-Ghaffar, F.A., Badr, G., (2013). Malarial infection of female BWF1 lupus mice alters the redox state in kidney and liver tissues and confers protection against lupus nephritis. Oxid. Med. Cell. Longev. Doi:10.1155/2013/156562. 
  3. Bartoloni,A., Zammarchi,L.,(2012).Clinical aspects of uncomplicated and severe malaria. Mediterr. J. Hematol. Infect. Dis. 4(1):e2012026. doi:10.4084/MJHID.2012.026. 
  4. Bekhof, J., Kollen, B.J., Kok, J.H., Van Straaten, H.L., (2015). Glucosuria as an early marker of late-onset sepsis in preterms: a prospective cohort study. BMC Pediatr. 17:15-125. 
  5. Clatworthy, L., Willcocks, B., Urban, J., Langhorne, T.N., Williams, N., Peshu, N.A., Watkins, R.A., Floto, K.G., Smith., (2007). Systemic lupus erythematosus-associated defects in the inhibitory receptor Fc gamma RIIb reduces susceptibility to malaria. Proc. Natl. Acad. Sci. USA. 104: 7169–7174.
  6. Gaál, K., Tarr, T., Lõrincz, H., Borbás, V., Seres, I., Harangi, M., Fülöp, P., Paragh, G., (2016). High-density lipopoprotein antioxidant capacity, subpopulation distribution and paraoxonase-1 activity in patients with systemic lupus erythematosus. Lipids Health Dis. 22:15-60.
  7. Ghiselli, A., Serafini, M., Natella, F., Scaccini, C., (2000). Total antioxidant capacity as a tool to assess redox status: critical view and experimental data. Free Rad. Biol. Med. 29:1106–1114.
  8. GouS,J., Yuan,J., Wang,C., Zhao,M.H., Chen,M.,(2013).Alternative complement pathway activation products in urine and kidneys of patients with ANCA-associated GN. Clin. J. Am. Soc. Nephrol. 8:1884-91. 
  9. Greenwood, E.M., Herrick., A. Voller., (1970). Suppression of autoimmune disease in NZB and (NZW×NZB) F1 hybrid mice by infection with malaria. Nature. 226: 266-267.
  10. Greenwood, T., Corrah., (2001). Systemic lupus erythematosus in African immigrants. Lancet. 358: 1182.
  11. Hentati, M.N., Sato, B., Payelle-Brogardm, S., Avrameas, T., Ternynck., (1994). Beneficial effect of polyclonal immunoglobulins from malaria-infected BALB/c mice on the lupus-like syndrome of (NZB x NZW) F1 mice. Eur. J. Immunol. 24:8-15.
  12. Kurien, B.T., Hensley, K., Bachmann, M., Scofield, R.H., (2006). Oxidatively modified autoantigens in autoimmune diseases. Free Rad. Biol. Med 41:549–556.
  13. Kusano, C., Ferrari, B., (2008). Total Antioxidant Capacity: a biomarker in biomedical and nutritional studies. J. of Cell and Molecular Biology 7: 1-15.
  14. Lozovoy, M.A., Simão, A.N., Panis, C., Rotter, M.A., Reiche, E.M., Morimoto, H.K., Lavado, E., Cecchini, R., Dichi, I., (2011). Oxidative stress is associated with liver damage, inflammatory status, and corticosteroid therapy in patients with systemic lupus erythematosus. Lupus. 20:1250-9. 
  15. Minaur, S., Sawyers., J. Parker., J. Darmawan., (2004). Rheumatic disease in an Australian aboriginal community in North Queensland, Australia. J. Rheumatol. 31: 965–972.
  16. Monova, D., Monov, S., Todorov, T., (2011). Clinical and Morphologic Differences between Class IV-S and Class IV-G Lupus Nephritis. ISRN Immunology., DOI: 10.5402/2011/502578.
  17. Reyes-Thomas, J., Blanco, I., Putterman, C., (2011). Urinary biomarkers in lupus nephritis. Clin. Rev. Allergy Immunol. 40:138-50. 
  18. Sies, H., (2007). Total antioxidant capacity: appraisal of a concept. J. Nutr. 137:1493-1495.
  19. Smith, E.M., Beresford, M.W., (2016). Urinary biomarkers in childhood lupus nephritis. Clin. Immunol. doi: 10.1016/ j.cim.2016.06.010. 
  20. Tobón Castaño, A., del Mar Cortina, A., Felipe Miranda, A., Blair Trujillo, S., (2010). Dark urine and jaundice as warning signs in Plasmodium falciparum malaria in Colombia. Rev Cubana Med. Trop. 62:28-35. 
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Indian Journal of Animal Research
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    Research Article

    volume 53 issue 10 (october 2019) : 1316-1320,   Doi: 10.18805/ijar.v0iOF.9115

    Increased total antioxidant capacity in renal tissue of female BWF1 mice infected with Plasmodium chabaudi

    M
    Mostafa A. Abdel-Maksoud
    F
    Fathy A. Abdel-Ghaffar
    A
    Azza El-Amir
    G
    Gamal Badr
    S
    Saleh Al-Quraishy
    1<div style="text-align:justify">Zoology Department, College of Science,&nbsp;King Saud University, Riyadh 11451, Saudi Arabia.</div>
    Cite article:- Abdel-Maksoud A. Mostafa, Abdel-Ghaffar A. Fathy, El-Amir Azza, Badr Gamal, Al-Quraishy Saleh (2017). Increased total antioxidant capacity in renal tissue of female BWF1 mice infected with Plasmodium chabaudi. Indian Journal of Animal Research. 53(10): 1316-1320. doi: 10.18805/ijar.v0iOF.9115.

    ABSTRACT

    We have investigated the effect of malaria infection on the urine biochemistry and the renal and hepatic levels of total antioxidant capacity (TAC) in female BWF1 lupus mice. A total of 30 female BWF1 lupus mice were divided into three groups as follows: group (I) control group; group (II) lupus mice infected with live Plasmodium. chabaudi; group (III) lupus mice infected with irradiated P. chabaudi. Mice were killed at day 14 post-infection and plasma samples were collected. live P. chabaudi infection was associated with decreased level of glucose in urine (glucosuria), increased urinary level of both ketones (ketonuria) and blood (hematuria). Additionally, live P. chabaudi infection was associated with increased level of TAC in the renal tissue with decreased level of TAC in the hepatic tissue of infected mice. In conclusion, P. chabaudi infection has a direct effect on the urine biochemistry and the renal and hepatic levels of TAC in BWF1 mice.

    REFERENCES

    1. Abdel-Maksoud, M.A., Abdel-Ghaffar, F.A., El-Amir, A., Badr, G., Al-Quraishy, S., (2016). Altered renal immune complexes deposition in female BWF1 lupus mice following Plasmodium chabaudi infection. Saudi J. of Biol. Sci. Article in press.
    2. Al-Quraishy, S., Abdel-Maksoud, M.A., El-Amir, A., Abdel-Ghaffar, F.A., Badr, G., (2013). Malarial infection of female BWF1 lupus mice alters the redox state in kidney and liver tissues and confers protection against lupus nephritis. Oxid. Med. Cell. Longev. Doi:10.1155/2013/156562. 
    3. Bartoloni,A., Zammarchi,L.,(2012).Clinical aspects of uncomplicated and severe malaria. Mediterr. J. Hematol. Infect. Dis. 4(1):e2012026. doi:10.4084/MJHID.2012.026. 
    4. Bekhof, J., Kollen, B.J., Kok, J.H., Van Straaten, H.L., (2015). Glucosuria as an early marker of late-onset sepsis in preterms: a prospective cohort study. BMC Pediatr. 17:15-125. 
    5. Clatworthy, L., Willcocks, B., Urban, J., Langhorne, T.N., Williams, N., Peshu, N.A., Watkins, R.A., Floto, K.G., Smith., (2007). Systemic lupus erythematosus-associated defects in the inhibitory receptor Fc gamma RIIb reduces susceptibility to malaria. Proc. Natl. Acad. Sci. USA. 104: 7169–7174.
    6. Gaál, K., Tarr, T., Lõrincz, H., Borbás, V., Seres, I., Harangi, M., Fülöp, P., Paragh, G., (2016). High-density lipopoprotein antioxidant capacity, subpopulation distribution and paraoxonase-1 activity in patients with systemic lupus erythematosus. Lipids Health Dis. 22:15-60.
    7. Ghiselli, A., Serafini, M., Natella, F., Scaccini, C., (2000). Total antioxidant capacity as a tool to assess redox status: critical view and experimental data. Free Rad. Biol. Med. 29:1106–1114.
    8. GouS,J., Yuan,J., Wang,C., Zhao,M.H., Chen,M.,(2013).Alternative complement pathway activation products in urine and kidneys of patients with ANCA-associated GN. Clin. J. Am. Soc. Nephrol. 8:1884-91. 
    9. Greenwood, E.M., Herrick., A. Voller., (1970). Suppression of autoimmune disease in NZB and (NZW×NZB) F1 hybrid mice by infection with malaria. Nature. 226: 266-267.
    10. Greenwood, T., Corrah., (2001). Systemic lupus erythematosus in African immigrants. Lancet. 358: 1182.
    11. Hentati, M.N., Sato, B., Payelle-Brogardm, S., Avrameas, T., Ternynck., (1994). Beneficial effect of polyclonal immunoglobulins from malaria-infected BALB/c mice on the lupus-like syndrome of (NZB x NZW) F1 mice. Eur. J. Immunol. 24:8-15.
    12. Kurien, B.T., Hensley, K., Bachmann, M., Scofield, R.H., (2006). Oxidatively modified autoantigens in autoimmune diseases. Free Rad. Biol. Med 41:549–556.
    13. Kusano, C., Ferrari, B., (2008). Total Antioxidant Capacity: a biomarker in biomedical and nutritional studies. J. of Cell and Molecular Biology 7: 1-15.
    14. Lozovoy, M.A., Simão, A.N., Panis, C., Rotter, M.A., Reiche, E.M., Morimoto, H.K., Lavado, E., Cecchini, R., Dichi, I., (2011). Oxidative stress is associated with liver damage, inflammatory status, and corticosteroid therapy in patients with systemic lupus erythematosus. Lupus. 20:1250-9. 
    15. Minaur, S., Sawyers., J. Parker., J. Darmawan., (2004). Rheumatic disease in an Australian aboriginal community in North Queensland, Australia. J. Rheumatol. 31: 965–972.
    16. Monova, D., Monov, S., Todorov, T., (2011). Clinical and Morphologic Differences between Class IV-S and Class IV-G Lupus Nephritis. ISRN Immunology., DOI: 10.5402/2011/502578.
    17. Reyes-Thomas, J., Blanco, I., Putterman, C., (2011). Urinary biomarkers in lupus nephritis. Clin. Rev. Allergy Immunol. 40:138-50. 
    18. Sies, H., (2007). Total antioxidant capacity: appraisal of a concept. J. Nutr. 137:1493-1495.
    19. Smith, E.M., Beresford, M.W., (2016). Urinary biomarkers in childhood lupus nephritis. Clin. Immunol. doi: 10.1016/ j.cim.2016.06.010. 
    20. Tobón Castaño, A., del Mar Cortina, A., Felipe Miranda, A., Blair Trujillo, S., (2010). Dark urine and jaundice as warning signs in Plasmodium falciparum malaria in Colombia. Rev Cubana Med. Trop. 62:28-35. 
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