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Current IssueEditorial BoardOnline First ArticlesArchive

Research Article

volume 49 issue 5 (october 2015) : 400-406,   Doi: 10.18805/ijare.v49i5.5801

Antihyperglycemic activity of Ophiocordyceps sinensis: A Review

K
Kanjana Sirisidthi
P
Piya Kosai
W
Wannee Jiraungkoorskul
1Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok-10400, Thailand.
Cite article:- Sirisidthi Kanjana, Kosai Piya, Jiraungkoorskul Wannee (2025). Antihyperglycemic activity of Ophiocordyceps sinensis: A Review. Indian Journal of Agricultural Research. 49(5): 400-406. doi: 10.18805/ijare.v49i5.5801.

ABSTRACT

Diabetes mellitus, one of the non-communicable diseases, is still the seriously problem due to leading the causes of death in the developed countries. Therefore it is important to identify novel nutraceuticals or drugs for curing or preventing diabetes because the existing synthetic drugs have several limitations. Traditional medicinal plants and medicinal mushrooms are used in the treatment of diabetes mellitus more than century, but only a few of these have proofed their safe and efficacy. Aim of this review article is focused Ophiocordyceps sinensis one of the edible and medicinal mushrooms used for therapeutic effects and antioxidant activities. It contains several kinds of polysaccharides, proteins, nitrogen compounds, fatty acids, phenolic acids, and isoflavones. Many researches have evaluated that these phytochemical substances have the major impact on diabetes mellitus. This review focuses on the antihyperglycemic activity of this mushroom and clears that it has the potential to be considered as a candidate for preparing the new treatment of diabetes mellitus.

REFERENCES

  1. Ashton, C.M., J. Septimus., N.J. Petersen., J. Souchek., T.J. Menke., T.C. Collins. and N.P. Wray. 2003. Healthcare use by veterans for diabetes mellitus in the veterans affairs medical care system. Am. J. Manag. Care 9: 145–150.
  2. Balon, T.W., A.P. Jasman. and J.S. Zhu. 2002. A fermentation product of Cordyceps sinensis increases whole-body insulin sensitivity in rats. J. Altern. Complement. Med. 8: 315–323.
  3. Bok, J.W., L. Lermer., J. Chilton., H.G. Klingeman. and G.H.N. Towers. 1999. Antitumor sterols from the mycelia of Cordyceps sinensis. Phytochem. 51: 891-898.
  4. Chen, J., W. Zhang., T. Lu., J. Li., Y. Zheng. and L. Kong. 2006. Morphological and genetic characterization of a cultivated Cordyceps sinensis fungus and its polysaccharide component possessing antioxidant property in H22 tumor- bearing mice. Life Sci. 78: 2742–2748.
  5. Chen, S.D., S.Y. Lin., Y.S. Lai. and Y.H. Cheng. 2008. Effect of Cordyceps sinensis adlay fermentative products on antioxidant activities and macrophage functions. Taiwan J. Agric. Chem. Food Sci. 46: 223–233.
  6. Dong, C.H. and Y.J. Yao. 2007. In vitro evaluation of antioxidant activities of aqueous extracts from natural and cultured mycelia of Cordyceps sinensis. Food Sci. Technol. 41: 669–677.
  7. El Ashry, F.E.Z., M.F. Mahmoud., N.N. El Maraghy. and A.F. Ahmed. 2012. Effect of Cordyceps sinensis and taurine either alone or in combination on streptozotocin induced diabetes. Food Chem. Toxicol. 50: 1159-1165.
  8. Gong, Z., M. Wang. and J. Zhang. 1990. Molecular structure and immuno-activity of the polysaccharides from Cordyceps sinensis. Shengwu Huaxue Zazhi. 6: 486–492.
  9. Guo, J.Y., C.C. Han. and Y.M. Liu. 2010. A contemporary treatment approach to both diabetes and depression by Cordyceps sinensis, rich in vanadium. Evid. Based Complement Alternat. Med. 7: 387–389. 
  10. Guo, J., C. Li., J. Wang., Y. Liu. and J. Zhang. 2011. Vanadium-enriched Cordyceps sinensis, a contemporary treatment approach to both diabetes and depression in rats. Evid. Based Complement Alternat. Med. Article ID 450316, 6 pages. 
  11. Holliday, J. and M. Cleaver. 2008. Medicinal value of the caterpillar fungi species of the genus Cordyceps (Fr.) Link (Ascomycetes): a review. Int. J. Med. Mushrooms 10: 219–234.
  12. Huang, Z.J., H. Ji., P. Li., L. Xie. and X.C. Zhao. 2002. Hypoglycemic effect and mechanism of polysaccharides from cultured mycelium of Cordyceps sinensis. J. Chin. Pharm. Univ. 33: 51–54.
  13. Huang, L.F., F.Q. Guo., Y.Z. Liang. and B.M. Chen. 2004. Determination of adenosine and cordycepin in Cordyceps sinensis and C. militarris with HPLC-ESI-MS. Zhongguo Zhong Yao Za Zhi 29: 762–764.
  14. Hui, M.Y., B.S. Wang., C.H. Shiow. and P.D. Duh. 2006. Comparison of protective effects between cultured Cordyceps militaris and natural Cordyceps sinensis against oxidative damage. J. Agric. Food Chem. 54: 3132–3138.
  15. Jia, J.M., H.H. Tao. and B.M. Feng. 2009. Cordyceamides A and B from the culture liquid of Cordyceps sinensis (Berk.) Sacc. Chem. Pharm. Bull. 57: 99-101.
  16. Jonsson, B. 2002. Revealing the cost of type II diabetes in Europe. Diabetologia 45: S5–S12.
  17. Kai, Z., G. Sheng., L. Yongjian., Z. Boya., L. Yu. and J. Zhe. 2014. Preventive effects of Cordyceps sinensis against contrast induced nephropathy in type 2 diabetics with renal insufficiency undergoing coronary angiography. J. Am. College Cardiol. 64: C138.
  18. Kan, W.C., H.Y. Wang., C.C. Chien., S.L. Li., Y.C. Chen., L.H. Chang., et al. 2012. Effects of extract from solid-state fermented Cordyceps sinensison type 2 diabetes mellitus. Evid. Based Complement Alternat. Med. Article ID 743107, 10 pages. 
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    Research Article

    volume 49 issue 5 (october 2015) : 400-406,   Doi: 10.18805/ijare.v49i5.5801

    Antihyperglycemic activity of Ophiocordyceps sinensis: A Review

    K
    Kanjana Sirisidthi
    P
    Piya Kosai
    W
    Wannee Jiraungkoorskul
    1Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok-10400, Thailand.
    Cite article:- Sirisidthi Kanjana, Kosai Piya, Jiraungkoorskul Wannee (2025). Antihyperglycemic activity of Ophiocordyceps sinensis: A Review. Indian Journal of Agricultural Research. 49(5): 400-406. doi: 10.18805/ijare.v49i5.5801.

    ABSTRACT

    Diabetes mellitus, one of the non-communicable diseases, is still the seriously problem due to leading the causes of death in the developed countries. Therefore it is important to identify novel nutraceuticals or drugs for curing or preventing diabetes because the existing synthetic drugs have several limitations. Traditional medicinal plants and medicinal mushrooms are used in the treatment of diabetes mellitus more than century, but only a few of these have proofed their safe and efficacy. Aim of this review article is focused Ophiocordyceps sinensis one of the edible and medicinal mushrooms used for therapeutic effects and antioxidant activities. It contains several kinds of polysaccharides, proteins, nitrogen compounds, fatty acids, phenolic acids, and isoflavones. Many researches have evaluated that these phytochemical substances have the major impact on diabetes mellitus. This review focuses on the antihyperglycemic activity of this mushroom and clears that it has the potential to be considered as a candidate for preparing the new treatment of diabetes mellitus.

    REFERENCES

    1. Ashton, C.M., J. Septimus., N.J. Petersen., J. Souchek., T.J. Menke., T.C. Collins. and N.P. Wray. 2003. Healthcare use by veterans for diabetes mellitus in the veterans affairs medical care system. Am. J. Manag. Care 9: 145–150.
    2. Balon, T.W., A.P. Jasman. and J.S. Zhu. 2002. A fermentation product of Cordyceps sinensis increases whole-body insulin sensitivity in rats. J. Altern. Complement. Med. 8: 315–323.
    3. Bok, J.W., L. Lermer., J. Chilton., H.G. Klingeman. and G.H.N. Towers. 1999. Antitumor sterols from the mycelia of Cordyceps sinensis. Phytochem. 51: 891-898.
    4. Chen, J., W. Zhang., T. Lu., J. Li., Y. Zheng. and L. Kong. 2006. Morphological and genetic characterization of a cultivated Cordyceps sinensis fungus and its polysaccharide component possessing antioxidant property in H22 tumor- bearing mice. Life Sci. 78: 2742–2748.
    5. Chen, S.D., S.Y. Lin., Y.S. Lai. and Y.H. Cheng. 2008. Effect of Cordyceps sinensis adlay fermentative products on antioxidant activities and macrophage functions. Taiwan J. Agric. Chem. Food Sci. 46: 223–233.
    6. Dong, C.H. and Y.J. Yao. 2007. In vitro evaluation of antioxidant activities of aqueous extracts from natural and cultured mycelia of Cordyceps sinensis. Food Sci. Technol. 41: 669–677.
    7. El Ashry, F.E.Z., M.F. Mahmoud., N.N. El Maraghy. and A.F. Ahmed. 2012. Effect of Cordyceps sinensis and taurine either alone or in combination on streptozotocin induced diabetes. Food Chem. Toxicol. 50: 1159-1165.
    8. Gong, Z., M. Wang. and J. Zhang. 1990. Molecular structure and immuno-activity of the polysaccharides from Cordyceps sinensis. Shengwu Huaxue Zazhi. 6: 486–492.
    9. Guo, J.Y., C.C. Han. and Y.M. Liu. 2010. A contemporary treatment approach to both diabetes and depression by Cordyceps sinensis, rich in vanadium. Evid. Based Complement Alternat. Med. 7: 387–389. 
    10. Guo, J., C. Li., J. Wang., Y. Liu. and J. Zhang. 2011. Vanadium-enriched Cordyceps sinensis, a contemporary treatment approach to both diabetes and depression in rats. Evid. Based Complement Alternat. Med. Article ID 450316, 6 pages. 
    11. Holliday, J. and M. Cleaver. 2008. Medicinal value of the caterpillar fungi species of the genus Cordyceps (Fr.) Link (Ascomycetes): a review. Int. J. Med. Mushrooms 10: 219–234.
    12. Huang, Z.J., H. Ji., P. Li., L. Xie. and X.C. Zhao. 2002. Hypoglycemic effect and mechanism of polysaccharides from cultured mycelium of Cordyceps sinensis. J. Chin. Pharm. Univ. 33: 51–54.
    13. Huang, L.F., F.Q. Guo., Y.Z. Liang. and B.M. Chen. 2004. Determination of adenosine and cordycepin in Cordyceps sinensis and C. militarris with HPLC-ESI-MS. Zhongguo Zhong Yao Za Zhi 29: 762–764.
    14. Hui, M.Y., B.S. Wang., C.H. Shiow. and P.D. Duh. 2006. Comparison of protective effects between cultured Cordyceps militaris and natural Cordyceps sinensis against oxidative damage. J. Agric. Food Chem. 54: 3132–3138.
    15. Jia, J.M., H.H. Tao. and B.M. Feng. 2009. Cordyceamides A and B from the culture liquid of Cordyceps sinensis (Berk.) Sacc. Chem. Pharm. Bull. 57: 99-101.
    16. Jonsson, B. 2002. Revealing the cost of type II diabetes in Europe. Diabetologia 45: S5–S12.
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