<p style="text-align: justify;">Investigation of functional hepatoprotective components from plants origin is a new model for drug evolution. The study examined the protective effects of Arabic gum (AG) induction on liver serum markers, antioxidant enzymes and lipid peroxidation in liver tissue against trichloroacetate (TCA) induced hepatotoxicity in male albino rats. Also, the chemical constituents and antioxidant assay of aqueous extract of AG was determined. TCA at the dose of 50 mg/kg for 2 months produced hepatotoxicity as examined by the significant increase of serum activities of ALT, AST, ALP and conjugated bilirubin level in the TCA treated animals alone and decrease in total protein and albumin levels. Pretreatment with AG aqueous extract (0.5 g/kg/day) significantly (P&lt; 0.05) lowered the serum enzyme activities and increased in total proteins and albumin level. The antioxidant studies showed that the activities of hepatic SOD, CAT and GPx were decreased in TCA induced animals with significantly elevated in MDA content which is reversed in pretreatment with aqueous extract of AG. Histopathology of the liver sections confirmed that the AG extract ameliorated hepatic damage induced by TCA. In conclusion, the study demonstrated that AG supplementation for 2 months in TCA induced toxicity in rats benefited hepatic antioxidant status and improved liver injury and damage in male albino rats exposed to TCA.&nbsp;</p>


<p>Protective role and antioxidant activity of arabic gum against&nbsp;trichloroacetate-induced toxicity in liver of male rats</p>


<div style="text-align: justify;">The present study aimed to investigate the protective role of Salvia Miltiorrhiza against Trichloroacetic acid (TCA) induced liver and kidney toxicity in rats. Twenty eight adults Wister albino male rats were divided into 4 equal groups. Group 1 served as control, while group 2 received SM extracts at 200 mg/kg body weight; group 3 was treated with 50 mg/kg/day TCA by gavage daily. Group 4 received the extract at 200 mg/kg body weight and 50 mg/kg/day TCA for two months. A significant increase was observed in liver function, kidney function and MDA (malondialdehyde) levels among the TCA administered animals compared to normal control. Daily oral administration of SM normalized most biochemical changes observed among the TCA treated animals. Histopathologically, higher amount of mononuclear cells infiltration, necrotic cells and few fibroblasts were observed in liver and kidney of TCA treated group. The administration of Salvia Miltiorrhiza extract regulates and decreases liver and kidney damage.</div>

Protective role and antioxidant activity of arabic gum against trichloroacetate-induced toxicity in liver of male rats

Effects of Salvia Miltiorrhiza extract on the regulation of antioxidant enzyme activities in liver and kidney of rats exposed to TCA