<div>The aim of this study was to investigate the effect of isoflurane (ISO) and sevoflurane (SEVO) anesthesia on coagulation parameters in dogs. A total of 12 dogs were used in the study in two groups as ISO(n = 6) and SEVO(n = 6), which were brought to the clinic for ovariohysterectomy. Premedication was performed by the intravenous administration of 0.3 mg/kg midazolam, followed by 5 mg/kg intravenous bolus propofol infusion. This was followed by 1.5% ISO administration in the ISO group and 2% sevoflurane administration in the SEVO group for anesthesia maintenance. Before anesthesia, prothrombin time (PT), active partial thromboplastin time (APTT), thrombin time (TT), and fibrinogen (FIB) level were measured at the 0th minute before anesthesia, at the 15th and 30th minutes during anesthesia, and at the 0th minute and the 1st hour after anesthesia. It was observed that the changes in TT, PT, APTT, and FIB level with time were not significant in the ISO and SEVO groups. It was determined that the changes in TT between the measurements in groups at the 30th minute during anesthesia and 0th minute after anesthesia were statistically significant (P&lt;0.05).</div>


<div>Effect of isoflurane and sevoflurane anesthesia on coagulation parameters in dogs</div>


<div>The study was aimed to compare the efficacy and safety of isoflurane and sevoflurane as maintenance agent in a balanced anaesthetic combination for buffaloes undergoing diaphragmatic herniorrhaphy. Twelve clinical cases of diaphragmatic hernia in female buffaloes were randomly selected and assigned to two groups (PS and PI) of six animals each. After premedication with glycopyrrolate, xylazine and butorphanol, induction was done with propofol. For maintenance, either sevoflurane (PS) or isoflurane (PI) was used with oxygen through a partial rebreathing system. Clinical, physiological, behavioral, haematological and biochemical parameters were recorded at different intervals. No significant differences were observed in maintenance scores, degree of muscle relaxation as well as haematological and blood biochemical parameters between the groups. The heart and respiratory rates were observed to be less depressed in PS than in PI. The recovery and standing with ataxia in PS was significantly earlier than the PI. Both isoflurane and sevoflurane were found to be safe and effective maintenance anaesthetic agents for buffaloes undergoing diaphragmatic herniorrhaphy; however, the sevoflurane was assessed to be slightly better as maintenance agent because of faster recovery and lesser cardiovascular depression than isoflurane.</div>


<div>Evaluation of sevoflurane and isoflurane as maintenance agent in buffaloes after glycopyrrolate-xylazine-butorphanol-propofol anaesthesia&nbsp;</div>
