Background: Diabetes is a worldwide disease threatens a large number of the human population due to their complication which extended to almost all body organs. Recently querectin were studied to their pharmaceutical activities.&nbsp; 
 
Methods: Therefore this paper studied the effect of querectin on multiple physiological, biochemical and immunological markers for diabetic rats supplemented with querectin 150 m/k orally for 30 days. 
 
Result: The result revealed that lipid profile improved in treated rats in-compared to untreated groups as cholesterol result was 176&plusmn;3.09 mg/dl versus 210&plusmn;5.2 mg/dl in the untreated group, triglyceride 150.3&plusmn;2.85 mg/dl versus 176&plusmn;4.30 mg/dl, high density lipoprotein result was 37.42&plusmn;2.9 mg/dl versus 24.43&plusmn;3.2 mg/dl, low density lipoprotein 109.59&plusmn;6.85 mg/dl versus 151.29&plusmn;5.70 mg/dl and very low density lipoprotein (30.45&plusmn;2.90 versus 35.20&plusmn;3.52) mg/dl in P value &le;0.01. In addition, glucose level was gradually reduced in treated group against non-treated one (200.43&plusmn;1.96, 320&plusmn;2.85) mg/dl. Urea and creatinine level was restored in quarectin treated rats (29.50&plusmn;2.43, 0.96&plusmn;0.06) mg/dl respectively in compared to diabetic untreated rats (37.54&plusmn;3.53, 1.6&plusmn;0.05) mg/dl. Immunological parameters including TNF-&alpha;, IL-1, IL-6 and C-reactive protein (CRP) showed a significant reduction in comparison to untreated rats (2.48&plusmn;0.39, 4.70&plusmn;1.22) for TNF-&alpha;, (4.38&plusmn;1.59, 7.69&plusmn;1.32) for IL-1, (3.24&plusmn;0.12, 5.05&plusmn;1.42)&nbsp; and (4.60&plusmn;0.53, 5.05&plusmn;0.54) for CRP. Similar results was shown in lactate dehydrogenase (157.54&plusmn;3.65, 17.54&plusmn;3.32) for treated and non treated rats respectively, anti-oxidant parameters were measured and te results were catalase significantly restored in treated group (10.30&plusmn;2.76, 13.70&plusmn;2.63), super oxide dismutase (7.13&plusmn;2.67, 9.94&plusmn;2.94) and malondialhdeyde (2.90&plusmn;0.39, 4.89&plusmn;0.48) in a P value &le;0.05.

Assessment of Querectin Influence on Multiple Physiological, Biochemical and Immunological Parameters in Diabetic Rats