<div>Background: Alternative materials for antibiotics used in white leg shrimp farming were extensively investigated. The promising effects of plant based extracts in controlling aquaculture diseases has been reported elsewhere. This study was conducted to examine the effect of Solanum procumbens Lour. extract on survival, growth performance, innate immunity and protection against acute hepatopancreas necrosis disease caused by Vibrio parahaemolyticus (VpAHPND) in white leg shrimp. 
 
Methods: From March 2021 to September 2021, four difference diets were examined including the supplementation of&nbsp; S. procumbens L. extract at 0.0%, 0.5%, 1.0% and 1.5%. After 30 days of culture, the experimental shrimp was examined for survival rate, growth responses,&nbsp; innate immune parameters&nbsp;and mortality as challenged with VpAHPND. 
 
Result: The results indicated shrimp fed diets with and without S. procumbens L. extract supplementation showed no significant differences in survival and growth performances. However, the innate immune parameters were likely increased in shrimp fed diets at 1.0% and 1.5% extract supplementation and shrimp fed diets at 1.0% and 1.5% extract supplementation reduced the accumulate mortality of VpAHPND challenged shrimp by 47.6%. S. procumbens L. could be a potential material for enhancing innate immunity of white leg shrimp and can protect shrimp from AHPND infection.</div>

Effect of Solanum procumbens Lour. Extract on Survival, Growth Performances, Immune Responses and against Vibrio parahaemolyticus causing Acute Hepatopancreas Necrosis Disease in White Leg Shrimp (Litopenaeus vannamei)