<div>Background: Injury or inflammation to the animal body resulted in the initiation of the acute-phase response (APR). Many plasma proteins increase in concentration in response to inflammatory stimuli, but C- reactive protein is considered as the most suitable markers due to their rapid and substantial increase in concentration and short half-lives. The CRP response varied according to the degree of surgical trauma on 3-standardized levels indicating CRP as an inflammatory activity indicator and monitoring markers. The aim of this study was to assess CRP concentrations in female dogs undergoing laparoscopic and open elective ovariectomy.&nbsp; 
 
Methods: The studies were conducted on twenty clinically healthy, adult, female dogs under elective spaying. Twenty healthy bitches were randomly assigned into four groups (A, B, C and D) consisting of five animals in each group. The studies were conducted in two phases (I and II). In phase I ovariectomy had been performed in animals of groups A and B with laparoscopy whereas, in phase II ovariectomy in animals of groups C and D were done by open laparotomy. &nbsp; 
 
Result: The pre-treatment CRP values did not show any significant change whereas post treatment values of group B were significantly lower as compared to groups D and C.&nbsp;On day 4th, group D values were significantly higher than groups C, B and A. Group C values were also significantly higher than group B. The highest value in group D might be due to more surgical manipulations and post-operative infection at surgical site in the animals under this group.&nbsp;</div>

C-reactive Protein as a Quantitative Biomarker in Female Dogs Undergoing Laparoscopic and Open Elective Ovariectomy