<div style="text-align:justify">Background: A study was conducted to evaluate the antioxidant and immunological profile of methanolic extract of Adhatoda vasica leaves (AVE) in naturally infected sheep with gastrointestinal nematodes and compared with commonly used anthelmintic albendazole in sheep.&nbsp; 
 
Methods: Fifty four sheep found positive for gastrointestinal nematodes were divided into 3 equal groups, GI (infected-untreated: control), GII (infected- AVE treated) and GIII (infected- albendazole treated). Blood samples were drawn on 5th and 14th day after treatment for analysis of oxidative stress markers such as TBARS, TAC, SOD and catalase and immunological parameters such as total immunoglobulin, IgG and IL-10. 
 
Result: Helminthiasis in sheep cause a considerable oxidative stress. The anthelmintic activity of Adhatoda vasica surpassed the conventional synthetic drug albendazole in sheep in terms of oxidative and immunological changes in blood.</div>

Effect of Adhatoda vasica (Acanthaceae) on Antioxidant and Immunological Profile in Sheep

Background: Diabetes mellitus, a chronic metabolic disease with multiple secondary effects, is on the rise. Treatment of type II diabetes mellitus with phytochemicals is gaining importance to avoid secondary complications used in the treatment. Justicia adhatoda is said to be an evergreen perennial shrub with a multitude of uses, especially as a stimulant of the respiratory tract.&nbsp; 
 
Methods: Vasicine, a major alkaloid extracted from the leaves of the adhatoda was used in the current study to identify its antidiabetic activity through the Computer Aided Drug Design technique. The molecular docking technique was performed between vasicine and five different receptors Protein Tyrosine Phosphate 1B (PTP 1B), Glucose Transporter (GLUT2), Glucagon Like Peptide 1 (GLP-1) and Peroxisome Proliferator Activated Receptors (PPAR Ɣ) which are usually targeted by anti-diabetic drugs. The Libdock score for the interaction between the receptors and vasicine is indicative of the antidiabetic activity of the vasicine in various pathways.&nbsp; 
 
Result: PTP 1B presented the highest LibDock score of 101.46 indicating the antidiabetic property of vasicine.&nbsp;

Effect of Adhatoda vasica (Acanthaceae) on Antioxidant and Immunological Profile in Sheep

An in silico Evaluation of Anti-diabetic Potential of Vasicine, A Quinazoline Alkaloid of Justicia adhatoda Linnaeus