<div>Background: Joint health is very vital in canines. Immediate attention and diagnosis will help to prevent suffering in canines. This study was designed to evaluate the in vivo efficacy of the poly-herbal formulation Mobility Plus&reg; for arthritis, inflammation and analgesic activities in canines. 
 
Methods: A total of 18 client-owned dogs with a history of joint inflammation, hip dysplasia and arthritis were selected (n = 18) and supplemented with one tablet of Mobility Plus&reg; daily until complete recovery. The changes in assessment parameters scores, viz. lameness score, joint mobility score, pain on palpation score, weight-bearing score and the overall clinical condition score were evaluated. The results revealed that lameness, joint mobility, pain and weight-bearing scores significantly (p&lt;0.001) decreased in dogs as early as day 15; hence, the overall clinical condition score also decreased significantly (p&lt;0.001) as early as day 15 after Mobility Plus&reg; supplementation. 
 
Result: Present study revealed that lameness, joint mobility, pain and weight-bearing scores significantly (p and lt; 0.001) decreased in dogs as early as day 15; hence, the overall clinical condition score also decreased significantly (p and lt; 0.001) as early as day 15 after Mobility Plus&reg; supplementation. Supplementation of Mobility Plus&reg; has antiarthritic and anti-inflammatory activities. Mobility Plus&reg; could be recommended for the amelioration of joint inflammation and osteoarthritis conditions in canines.</div>

Evaluation of the Efficacy of Mobility Plus&reg; in the Management of Osteoarthritis and Joint Inflammation in Canines

<div>Background: In this study, mesenchymal stem cell therapy and the findings were discussed in a bilateral chronic osteoarthritis case in a Cane Corso breed dog. 
 
Methods: A patient was brpought to the clinic with the complaint of lameness, malaise, fear, anxiety and reluctance in running, stair climbing and descending movements. In the orthopedic examination, Art. Genu was found to have pain in flexion and extension movements and on radiological examination, joint space was reduced and bilateral chronic osteoarthritis was found. The patient was sedated and mesenchymal stem cells were injected into both knee joints. These procedures were repeated twice with an interval of three weeks. 
 
Result: The joint space of both knees widened and the joint fluid increased after the treatment. In addition, there was a relief in flexion and extension movements on the both knees. The patient&rsquo;s lameness decreased and he did not experience uneasiness when going up and down the stairs and there was a significant improvement. It was determined that mesenchymal stem cell therapy gave a positive response in the current osteoarthritis case. It has been concluded that this method can be applied as an alternative to steroids, NSAID (Nonsteroid anti-inflammatory drugs) and GAG (Glycosaminoglycan) applications in similar cases.</div>

Evaluation of the Efficacy of Mobility Plus® in the Management of Osteoarthritis and Joint Inflammation in Canines

Mesenchymal Stem Cell Therapy in a Case of Bilateral Chronic Osteoarthritis Occurring in Articulatio Genu in a Dog of Cane Corso Breed