Banner
Current IssueEditorial BoardOnline First ArticlesArchive
Current IssueEditorial BoardOnline First ArticlesArchive

Reviewer Article

volume 53 issue 10 (october 2019) : 1265-1268,   Doi: 10.18805/ijar.B-992

Pathology and molecular genetics of intersexual goats: A review

S
Shu-Zhu Cheng
G
Guang-Xin E
R
Ri-Su Na
Y
Yong-Fu Huang
1<div style="text-align: justify;">College of Animal Science and Technology, Chongqing Key Laboratory of Forage and Herbivore, Chongqing Engineering Research Centre for Herbivores Resource Protection and Utilization, Southwest University, Chongqing, 400 716, China.</div>
Cite article:- Cheng Shu-Zhu, E Guang-Xin, Na Ri-Su, Huang Yong-Fu (2018). Pathology and molecular genetics of intersexual goats: A review. Indian Journal of Animal Research. 53(10): 1265-1268. doi: 10.18805/ijar.B-992.

ABSTRACT

Intersex traits are serious reproductive disorders in goats, and the intersexual goat can influence development of goat husbandry. In goats, the PIS (polled intersex syndrome) mutation is responsible for both the absence of horns and sex reversal, exclusively affecting XX individuals. PIS is caused by a large deletion of goat chromosome 1q43 that affects the transcription of the genes PISRT1 and FOXL2. Here, we aim to contribute to the discussion on the pathology and molecular genetics of goats’ intersex based on the characteristics of morphology.

REFERENCES

  1. Arango N A, Lovell-Badge R, Behringer R R. (1999). Targeted mutagenesis of the endogenous mouse Mis gene promoter: in vivo definition of genetic pathways of vertebrate sexual development. Cell. 99:409–419.
  2. Boulanger L, Kocer A, Daniel N, Pannetier M, Chesne P, Heyman Y, Renault L, Mandon-Pepin B, Chavatte-Palmer P. Vignon X et al. (2008) Attempt to rescue sex-reversal by transgenic expression of the PISRT1 gene in XX PIS-/- goats. Sexual Development, 2: 142–151.
  3. Boulanger L, Pannetier M, Gall L, Allais-Bonnet A, Elzaiat M, LBourhis D, Daniel N, Richard C, Cotinot C, Norbert, Ghyselinck, Pailhoux E. (2014) FOXL2 is a female sex-determining gene in the goat. Current Biology, 24 (4) : 404.
  4. Buscara L, Montazer-Torbati F, Chadi S, Auguste A, Laubier J, Amandine Chassot A, Renault L, Passet B, Costa J, Pannetier M,Vilotte M, Chaboissier M C, Vilotte J L, Pailhoux E, Provost F L. (2009) Goat RSPO1 over-expression rescues sex-reversal in Rspo1 -knockout XX mice but does not perturb testis differentiation in XY or sex-reversed XX mice. Transgenic Research, 18 (4) : 649-654.
  5. Cao Bukai, Huang Yonghong. (2000) The study of intergoat sex. Chinese herbivores science, 2 (1) : 40-42.
  6. Chen Yang, Yang Yongmei, Chen Juan, Jiang Huaizhi. (2010) Research on the characteristics of intersex goats and it’s related research progress. Journal of China animal husbandry and veterinarian, 37 (6) : 125-129.
  7. E. Pailhoux, E. P. Cribiu, S. Chaffaux, R. Darre, M. Fellous, C. Cotinot. (1994) Molecular analysis of 60,XX pseudohermaphrodite polled goats for the presence of SRY and ZFY genes. J Reprod Fertil, 100 (2) : 491-496.
  8. GuangXin E, YongFu Huang, YongJu Zhao, RiSu Na, ZhongQuan Zhao,YaWang Sun, LiPeng Chen, and XiaoYu Qiu. (2015) Comparative analysis the variability of a complete mitochondrial genome of polledness intersexual goat (PIS- -) from China. Indian Journal of Animal Research, 2015.
  9. Hamerton J L, Dickson J M, Pollard C E, et al. (1969) Genetic intersexuality in goats. J Reprod Fertil, 7(Sup pl) : 25-51.
  10. Hou Ce, Su Xiaoping, Wang Qitian, Cui Kuiqing, Shi Deshun, Liu Qingyou. (2017) PIS regional sequence polymorphism analysis of guanzhong goat. China Animal Husbandry and Veterinarian, 44 (12) : 3554 -3562.
  11. Karras S, Modransky P, Welker B. (1992) Surgical correction of urethral dilatation in an intersex goats. ReprodFertil, 201(10) : 1584-6.
  12. Kijas J W, Ortiz J S, Mcculloch M, James A, Brice B, Swain B, Klopp G T, (2013) International Goat Genome Consortium. Genetic diversity and investigation of polledness in divergent goat populations. Animal Genetics, 44 (3) : 325-335.
  13. Kocer A, Pinheiro I, Pannetier M, Renault L, Parma P, Radi O, Kim KA,Camerino G, Pailhoux E (2008) R-spondin1 and FOXL2 act into two distinct cellular types during goat ovarian differentiation. BMC Dev Biol 8:36. doi:10.1186/1471-213X-8-36.
  14. Luo Mingfeng. (1989) The genetic rule of goat horn type and its relationship with sexual deformity. Shanxi, Northwest Agricultural University.
  15. Pailhoux E, Vigier B, Chaûaux S, Servel N, Taourit S, Furet JP, Fellous M, Grosclaude F, Cribiu EP, Cotinot C et al. (2001) A 11.7-kb deletion triggers intersexuality and polledness in goats. Nature Genetics, 29: 453–458.
  16. Pailhoux E, Vigier B, Vaiman D, Servel N, Chaffaux S, Edmondp C,Corinne C. (2002) Ontogenesis of Female-to-Male Sex-Reversal in XX Polled Goats. Developmental Dynamics, 224 (1) : 39.
  17. Pannetier M, Renault L, Jolivet G, Cotinot C, Pailhoux E. (2005) Ovarian-specific expression of a new gene regulated by the goat PIS region and transcribed by a FOXL2 bidirectional promoter. Genomics, 85 (6) : 715-726.
  18. Pannetier M, Tilly G, Kocer A, Hudrisier M, Renault L, Chesnais N, Costa J, Provost F L, Vaiman D, Vilotte J L, Pailhoux E. (2006) Goat SRY induces testis development in XX transgenic mice. Febs Letters, 580 (15) : 3715-3720.
  19. Pannetier M, Elzaiat M, Thépot D, et al. (2012) Telling the story of XX sex reversal in the goat : High lighting the sex-crossroad in domestic mammals. Sexual Development, 6(1-3):33-45.
  20. Schibler L, Cribuep, Oustryvaiman, Furetjp. (2000) Vaiman D. Fine mapping suggests that the goat Polled Intersex Syndrome and the human Blepharophimosis Ptosis Epicanthus Syndrome map to a 100-kb homologous region. Genome Research, 10(3) : 311-318.
  21. Shi Hengbo, Luojun, Wang Wei, Xu Huifen, Zhu Jiangjiang, Lijun. (2013) Genetic identification and AFLP fingerprint analysis of the intersex individuals of the goat. Journal of Northwest Agricultural Science and Technology University, 41 (4):1-6.
  22. Shi Qishun, Peng Mengde, Li Jufen, Jiang Wuming, Xie Xinming, He Changqing. (1988) Study of intersex goats. Journal of Zhengzhou Pastoral Science, 14(3):72-78.
  23. Song Chenfeng, Luo Yonghua, Zhang Dianxin, Jiao Li, Wang Guiming, Liu Xiujuan. (2015) Anatomical Observation of Reproductive Organs in Intersex Goats. Heilongjiang Animal Science and Veterinary Medicine, 16 : 81-81.
  24. Szatkowska I, Zaborski D,Proskura W S,Tabor S. (2015) Polledness intersex syndrome in goats – molecular and histological aspects. Turkish Journal of Veterinary and Animal Sciences, 38 (6) :612-617.
  25. Vaiman D, Koutita O, Ous try A, et al.(1996) Genetic m apping of the autosomal region involved in XX sex-reversal and horn development in goats. Mammalian Genome, 7: 133-137.
  26. Vaiman D, Schibler L, Oustry-Vaiman A, Pailhoux E, Goldammer T, Stevanovic M, Furet JP, Schwerin M, Cotinot C, Fellous M et al (1999). High-resolution human/goat comparative map of the goat polled/intersex syndrome (PIS): the human homologue is contained in a human YAC from HSA3q23. Genomics, 56: 31–39.
  27. Vallenzascac,Gallia. (1990) Cytogenetical and histopathologic study of two cases of polled goats. Andrologia, 22(3) : 289-290.
  28. Wang Yongqiang, Zhang Xiuyu. (1993) Study on cytogenetics of intersex livestock. Journal of zhengzhou pastoral science, 13(3) : 20-23.
  29. Yokota S, Matsuu A, Morita T, Tsuka T, Hishinuma M, Minami S, Hikasai Y. (2011) Polled Intersex Syndrome with urethral atresia in a goat. Journal of Veterinary Medical Science, 73 (10) : 1355-1357.
  30. Zhang Jingjing. (2010) Study on the variation of FOXL2 gene and PIS in the non-interhorned milk goats. Agricultural University of Hebei, Heibei.
  31. Zhang Yu. (2014) Study on the genes of PISRT1, FOXL2 and PIS in intersex milk goats. Heibei, Agricultural University of Hebei, Hebei. 
Published In
Indian Journal of Animal Research
Article Metrics
Metrics Icon
0
Views
0
Citations
Reviewed By
Share Article
Download Article
In this Article
    Contact us
    Follow us

    Reviewer Article

    volume 53 issue 10 (october 2019) : 1265-1268,   Doi: 10.18805/ijar.B-992

    Pathology and molecular genetics of intersexual goats: A review

    S
    Shu-Zhu Cheng
    G
    Guang-Xin E
    R
    Ri-Su Na
    Y
    Yong-Fu Huang
    1<div style="text-align: justify;">College of Animal Science and Technology, Chongqing Key Laboratory of Forage and Herbivore, Chongqing Engineering Research Centre for Herbivores Resource Protection and Utilization, Southwest University, Chongqing, 400 716, China.</div>
    Cite article:- Cheng Shu-Zhu, E Guang-Xin, Na Ri-Su, Huang Yong-Fu (2018). Pathology and molecular genetics of intersexual goats: A review. Indian Journal of Animal Research. 53(10): 1265-1268. doi: 10.18805/ijar.B-992.

    ABSTRACT

    Intersex traits are serious reproductive disorders in goats, and the intersexual goat can influence development of goat husbandry. In goats, the PIS (polled intersex syndrome) mutation is responsible for both the absence of horns and sex reversal, exclusively affecting XX individuals. PIS is caused by a large deletion of goat chromosome 1q43 that affects the transcription of the genes PISRT1 and FOXL2. Here, we aim to contribute to the discussion on the pathology and molecular genetics of goats’ intersex based on the characteristics of morphology.

    REFERENCES

    1. Arango N A, Lovell-Badge R, Behringer R R. (1999). Targeted mutagenesis of the endogenous mouse Mis gene promoter: in vivo definition of genetic pathways of vertebrate sexual development. Cell. 99:409–419.
    2. Boulanger L, Kocer A, Daniel N, Pannetier M, Chesne P, Heyman Y, Renault L, Mandon-Pepin B, Chavatte-Palmer P. Vignon X et al. (2008) Attempt to rescue sex-reversal by transgenic expression of the PISRT1 gene in XX PIS-/- goats. Sexual Development, 2: 142–151.
    3. Boulanger L, Pannetier M, Gall L, Allais-Bonnet A, Elzaiat M, LBourhis D, Daniel N, Richard C, Cotinot C, Norbert, Ghyselinck, Pailhoux E. (2014) FOXL2 is a female sex-determining gene in the goat. Current Biology, 24 (4) : 404.
    4. Buscara L, Montazer-Torbati F, Chadi S, Auguste A, Laubier J, Amandine Chassot A, Renault L, Passet B, Costa J, Pannetier M,Vilotte M, Chaboissier M C, Vilotte J L, Pailhoux E, Provost F L. (2009) Goat RSPO1 over-expression rescues sex-reversal in Rspo1 -knockout XX mice but does not perturb testis differentiation in XY or sex-reversed XX mice. Transgenic Research, 18 (4) : 649-654.
    5. Cao Bukai, Huang Yonghong. (2000) The study of intergoat sex. Chinese herbivores science, 2 (1) : 40-42.
    6. Chen Yang, Yang Yongmei, Chen Juan, Jiang Huaizhi. (2010) Research on the characteristics of intersex goats and it’s related research progress. Journal of China animal husbandry and veterinarian, 37 (6) : 125-129.
    7. E. Pailhoux, E. P. Cribiu, S. Chaffaux, R. Darre, M. Fellous, C. Cotinot. (1994) Molecular analysis of 60,XX pseudohermaphrodite polled goats for the presence of SRY and ZFY genes. J Reprod Fertil, 100 (2) : 491-496.
    8. GuangXin E, YongFu Huang, YongJu Zhao, RiSu Na, ZhongQuan Zhao,YaWang Sun, LiPeng Chen, and XiaoYu Qiu. (2015) Comparative analysis the variability of a complete mitochondrial genome of polledness intersexual goat (PIS- -) from China. Indian Journal of Animal Research, 2015.
    9. Hamerton J L, Dickson J M, Pollard C E, et al. (1969) Genetic intersexuality in goats. J Reprod Fertil, 7(Sup pl) : 25-51.
    10. Hou Ce, Su Xiaoping, Wang Qitian, Cui Kuiqing, Shi Deshun, Liu Qingyou. (2017) PIS regional sequence polymorphism analysis of guanzhong goat. China Animal Husbandry and Veterinarian, 44 (12) : 3554 -3562.
    11. Karras S, Modransky P, Welker B. (1992) Surgical correction of urethral dilatation in an intersex goats. ReprodFertil, 201(10) : 1584-6.
    12. Kijas J W, Ortiz J S, Mcculloch M, James A, Brice B, Swain B, Klopp G T, (2013) International Goat Genome Consortium. Genetic diversity and investigation of polledness in divergent goat populations. Animal Genetics, 44 (3) : 325-335.
    13. Kocer A, Pinheiro I, Pannetier M, Renault L, Parma P, Radi O, Kim KA,Camerino G, Pailhoux E (2008) R-spondin1 and FOXL2 act into two distinct cellular types during goat ovarian differentiation. BMC Dev Biol 8:36. doi:10.1186/1471-213X-8-36.
    14. Luo Mingfeng. (1989) The genetic rule of goat horn type and its relationship with sexual deformity. Shanxi, Northwest Agricultural University.
    15. Pailhoux E, Vigier B, Chaûaux S, Servel N, Taourit S, Furet JP, Fellous M, Grosclaude F, Cribiu EP, Cotinot C et al. (2001) A 11.7-kb deletion triggers intersexuality and polledness in goats. Nature Genetics, 29: 453–458.
    16. Pailhoux E, Vigier B, Vaiman D, Servel N, Chaffaux S, Edmondp C,Corinne C. (2002) Ontogenesis of Female-to-Male Sex-Reversal in XX Polled Goats. Developmental Dynamics, 224 (1) : 39.
    17. Pannetier M, Renault L, Jolivet G, Cotinot C, Pailhoux E. (2005) Ovarian-specific expression of a new gene regulated by the goat PIS region and transcribed by a FOXL2 bidirectional promoter. Genomics, 85 (6) : 715-726.
    18. Pannetier M, Tilly G, Kocer A, Hudrisier M, Renault L, Chesnais N, Costa J, Provost F L, Vaiman D, Vilotte J L, Pailhoux E. (2006) Goat SRY induces testis development in XX transgenic mice. Febs Letters, 580 (15) : 3715-3720.
    19. Pannetier M, Elzaiat M, Thépot D, et al. (2012) Telling the story of XX sex reversal in the goat : High lighting the sex-crossroad in domestic mammals. Sexual Development, 6(1-3):33-45.
    20. Schibler L, Cribuep, Oustryvaiman, Furetjp. (2000) Vaiman D. Fine mapping suggests that the goat Polled Intersex Syndrome and the human Blepharophimosis Ptosis Epicanthus Syndrome map to a 100-kb homologous region. Genome Research, 10(3) : 311-318.
    21. Shi Hengbo, Luojun, Wang Wei, Xu Huifen, Zhu Jiangjiang, Lijun. (2013) Genetic identification and AFLP fingerprint analysis of the intersex individuals of the goat. Journal of Northwest Agricultural Science and Technology University, 41 (4):1-6.
    22. Shi Qishun, Peng Mengde, Li Jufen, Jiang Wuming, Xie Xinming, He Changqing. (1988) Study of intersex goats. Journal of Zhengzhou Pastoral Science, 14(3):72-78.
    23. Song Chenfeng, Luo Yonghua, Zhang Dianxin, Jiao Li, Wang Guiming, Liu Xiujuan. (2015) Anatomical Observation of Reproductive Organs in Intersex Goats. Heilongjiang Animal Science and Veterinary Medicine, 16 : 81-81.
    24. Szatkowska I, Zaborski D,Proskura W S,Tabor S. (2015) Polledness intersex syndrome in goats – molecular and histological aspects. Turkish Journal of Veterinary and Animal Sciences, 38 (6) :612-617.
    25. Vaiman D, Koutita O, Ous try A, et al.(1996) Genetic m apping of the autosomal region involved in XX sex-reversal and horn development in goats. Mammalian Genome, 7: 133-137.
    26. Vaiman D, Schibler L, Oustry-Vaiman A, Pailhoux E, Goldammer T, Stevanovic M, Furet JP, Schwerin M, Cotinot C, Fellous M et al (1999). High-resolution human/goat comparative map of the goat polled/intersex syndrome (PIS): the human homologue is contained in a human YAC from HSA3q23. Genomics, 56: 31–39.
    27. Vallenzascac,Gallia. (1990) Cytogenetical and histopathologic study of two cases of polled goats. Andrologia, 22(3) : 289-290.
    28. Wang Yongqiang, Zhang Xiuyu. (1993) Study on cytogenetics of intersex livestock. Journal of zhengzhou pastoral science, 13(3) : 20-23.
    29. Yokota S, Matsuu A, Morita T, Tsuka T, Hishinuma M, Minami S, Hikasai Y. (2011) Polled Intersex Syndrome with urethral atresia in a goat. Journal of Veterinary Medical Science, 73 (10) : 1355-1357.
    30. Zhang Jingjing. (2010) Study on the variation of FOXL2 gene and PIS in the non-interhorned milk goats. Agricultural University of Hebei, Heibei.
    31. Zhang Yu. (2014) Study on the genes of PISRT1, FOXL2 and PIS in intersex milk goats. Heibei, Agricultural University of Hebei, Hebei. 
    In this Article
      Contact us
      Follow us
      Published In
      Indian Journal of Animal Research

      Editorial Board

      View all (0)