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Research Article

volume 53 issue 8 (august 2019) : 1029-1032,   Doi: 10.18805/ijar.B-966

Comparative hypolipidemic efficacy of homeopathic mother tincture Allium Sativa Q, Curcuma Longa Q and statin in normal and cholesterol fed rabbits

K
Khalid Mahmood Anjum
F
Fayyaz Rasool
E
Ehsan Mehmood Bhatti
S
Samina Liaquat
M
Muhammad Zubair Yousaf
S
Shafaq Zahid
N
Noor Khan
M
Muhammad Yameen
1Department of Wildlife and Ecology, University of Veterinary and Animal Sciences, Lahore-Pakistan.
Cite article:- Anjum Mahmood Khalid, Rasool Fayyaz, Bhatti Mehmood Ehsan, Liaquat Samina, Yousaf Zubair Muhammad, Zahid Shafaq, Khan Noor, Yameen Muhammad (2019). Comparative hypolipidemic efficacy of homeopathic mother tincture Allium Sativa Q, Curcuma Longa Q and statin in normal and cholesterol fed rabbits. Indian Journal of Animal Research. 53(8): 1029-1032. doi: 10.18805/ijar.B-966.

ABSTRACT

Although, lipid lowering drugs regulate the blood serum lipids, they have several reported side effects. Therefore, a substance that is less toxic and yet effective would be beneficial. Here, we compared the antihypercholesterolemic effects of combinations of homeopathic mother tincture (HMT) Allium sativa Q (garlic) and Curcuma longa Q (turmeric), with standard lipid lowering drug statin. For experimentation, a total of 20 rabbits were recruited and divided into four groups with five rabbits (n = 5). Normal saline (NS) group served as control; second group served as high fat diet (HFD) group, third group received Allium sativa Q (garlic) and Curcuma longa Q (turmeric) and HFD (T & G group) while the fourth group received statin and HFD (statin group). At the end of the 8th week, blood was collected to analyze the comparative efficacy of Allium sativa Q, Curcuma longa Q and statin on total cholesterol (TC), low density lipoproteins (LDL), high density lipoproteins (HDL) and triglyceride (TG). Various parameters measured (mg/dl) in HFD rabbits were, TC (291.76±2.2), LDL (244.20±8.3) and triglycerides (243.79±4.3) increased significantly and HDL (32.19±3.3) was reduced to an alarming level as compared to the NS group after eight weeks. TC, LDL and triglycerides level reduced significantly in T& G group while the HDL level increased significantly as compared to HFD. In statin group, TC (148.37±1.2), LDL (76.32 ±3.4) and TG (104.33 ±8.9) decreased while HDL increased (p<0.05) as compared to the HFD after eight weeks. It was therefore concluded that that homeopathic medicine Allium sativa Q and Curcuma longa Q is equally good like statin and can safely be used to regulate the circulating serum lipid profile.                   

REFERENCES

  1. Afkhami-Ardekani, M., Kamali-Ardekani, A. and Shojaoddiny-Ardekani, A. (2006). Effects of garlic on serum lipids and blood glucose of type 2 diabetic patients. Int. J. Diab. Dev. Ctries. 26: 86-88.
  2. Al-Sultan, S. and Gameel, A. (2004). Histopathological changes in the livers of broiler chicken supplemented with turmeric (Curcuma longa). Int. J. Poultry Sci. 3: 333-336.
  3. Anjum, K., Sayyed, U., Ullah, A., Mughal, M., Yaqub, A., Rashid, M. and Yousaf, M. (2014). Antihypercholesterolemic and anti-    atherogenic activity of Terminalia chebula fruit in normal and cholesterol fed rabbits. J. Anim. Plant Sci. 24: 1618-1622.
  4. Ashraf, M.Z., Hussain, M. and Fahim, M. (2005). Antiatherosclerotic effects of dietary supplementations of garlic and turmeric: Restoration of endothelial function in rats. Life Sci. 77: 837-857.
  5. Banerjee Sanjay, K. and Maulik Subir, K. (2002). Effect of garlic on cardiovascular disorders: a review. Nut. J. 1: 1-4.
  6. Braun, L. and Cohen, M. (2010). Herbs and Natural Supplements: An Evidence-based Guide Third Edition. J. Aust. Coll. Nut. Env. Med. 29: 13-17.
  7. Brunton, L., Lazo, J. and Parker, K.G. (2005). Gilman’s The Pharmacological Basis of Therapeutics. 11th. New York: Mc Graw-Hill.
  8. Bundy, R., Walker, A.F., Middleton, R.W. and Booth, J. (2004). Turmeric extract may improve irritable bowel syndrome symptomology in otherwise healthy adults: a pilot study. J. Alte. Comp. Med. 10: 1015-1018.
  9. Colpo, A. (2005). LDL Cholesterol:” Bad” Cholesterol or Bad Science? J. Am. Phys. Surg. 10: 83.
  10. Donato, A.J., Eskurza, I., Silver, A.E., Levy, A.S., Pierce, G.L., Gates, P.E. and Seals, D.R. (2007). Direct evidence of endothelial oxidative stress with aging in humans. Circulation Res. 100: 1659-1666.
  11. Itokawa, H., Shi, Q., Akiyama, T., Morris-Natschke, S.L. and Lee, K.-H. (2008). Recent advances in the investigation of curcuminoids. Chinese Med. 3: 11-16.
  12. Kumar, A. and Singh, V. (2010). Atherogenic dyslipidemia and diabetes mellitus: what’s new in the management arena? Vas. Heal. Risk Manag. 6: 665-669.
  13. Levine, G.N., Keaney Jr, J.F. and Vita, J.A. (1995). Cholesterol reduction in cardiovascular disease—clinical benefits and possible mechanisms. New Eng. J. Med. 332: 512-521.
  14. Liu, L. and Yeh, Y.-Y. (2002). S-alk (en) yl cysteines of garlic inhibit cholesterol synthesis by deactivating HMG-CoA reductase in cultured rat hepatocytes. J. Nut. 132: 1129-1134.
  15. Pari, L. and Umamaheswari, J. (2000). Antihyperglycaemic activity of Musa sapientum flowers: effect on lipid peroxidation in alloxan diabetic rats. Phytother. Res. 14:136-138.
  16. Podrez, E.A. (2013). Bad versus good cholesterol in the bone marrow. Nature Med. 19: 541-543.
  17. Pollex, R.L., Joy, T.R. and Hegele, R.A. (2008). Emerging antidyslipidemic drugs. Exp. Opi. Emerg. Drug. 13: 363-381.
  18. Santoshkumar, J. and Manjunath, S. (2013). A study of anti-hyperlipidemia, hypolipedimic and anti-atherogenic activity of fruit of Emblica officinalis (amla) in high fat fed albino rats. Int. J. Med. Res.Heal. Sci. 2: 70-77.
  19. Stevinson, C., Pittler, M.H. and Ernst, E. (2000). Garlic for treating hypercholesterolemiaA Meta-Analysis of randomized clinical trials. Annals Inter. Med. 133: 420-429.
  20. Sukandar, E.Y., Sigit, J.I. and Deviana, R. (2013). Antihyperlipidemic and antidiabetic effect of combination of garlic and turmeric extract in rats. J. Med. Plant. 1: 5-10.
  21. Sukandar, E.Y., Sudjana, P., Sigit, J.I., Leliqia, N.P.E. and Lestari, F. (2013). Safety of garlic (Allium Sativum) and turmeric (Curcuma domestica) extract in comparison with simvastatin on improving lipid profile in dyslipidemia patients. J. Med. Sci. 13: 10-13.
  22. Thompson Coon, J. and Ernst, E. (2002). Herbal medicinal products for non-ulcer dyspepsia. Ali. Pharm. Ther. 16: 1689-1699.
  23. Zahid, S., Anjum, K. M., Mughal, M. S., Yaqub, A. and Yameen, M. (2018). Evaluation of antioxidant and anti-hyperlipidemic activity of Emblica officinalis (Indian gooseberry) fruit in high fat fed rabbits. J. Anim. Plant Sci. 28: 1007-1013. 
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Indian Journal of Animal Research
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    Research Article

    volume 53 issue 8 (august 2019) : 1029-1032,   Doi: 10.18805/ijar.B-966

    Comparative hypolipidemic efficacy of homeopathic mother tincture Allium Sativa Q, Curcuma Longa Q and statin in normal and cholesterol fed rabbits

    K
    Khalid Mahmood Anjum
    F
    Fayyaz Rasool
    E
    Ehsan Mehmood Bhatti
    S
    Samina Liaquat
    M
    Muhammad Zubair Yousaf
    S
    Shafaq Zahid
    N
    Noor Khan
    M
    Muhammad Yameen
    1Department of Wildlife and Ecology, University of Veterinary and Animal Sciences, Lahore-Pakistan.
    Cite article:- Anjum Mahmood Khalid, Rasool Fayyaz, Bhatti Mehmood Ehsan, Liaquat Samina, Yousaf Zubair Muhammad, Zahid Shafaq, Khan Noor, Yameen Muhammad (2019). Comparative hypolipidemic efficacy of homeopathic mother tincture Allium Sativa Q, Curcuma Longa Q and statin in normal and cholesterol fed rabbits. Indian Journal of Animal Research. 53(8): 1029-1032. doi: 10.18805/ijar.B-966.

    ABSTRACT

    Although, lipid lowering drugs regulate the blood serum lipids, they have several reported side effects. Therefore, a substance that is less toxic and yet effective would be beneficial. Here, we compared the antihypercholesterolemic effects of combinations of homeopathic mother tincture (HMT) Allium sativa Q (garlic) and Curcuma longa Q (turmeric), with standard lipid lowering drug statin. For experimentation, a total of 20 rabbits were recruited and divided into four groups with five rabbits (n = 5). Normal saline (NS) group served as control; second group served as high fat diet (HFD) group, third group received Allium sativa Q (garlic) and Curcuma longa Q (turmeric) and HFD (T & G group) while the fourth group received statin and HFD (statin group). At the end of the 8th week, blood was collected to analyze the comparative efficacy of Allium sativa Q, Curcuma longa Q and statin on total cholesterol (TC), low density lipoproteins (LDL), high density lipoproteins (HDL) and triglyceride (TG). Various parameters measured (mg/dl) in HFD rabbits were, TC (291.76±2.2), LDL (244.20±8.3) and triglycerides (243.79±4.3) increased significantly and HDL (32.19±3.3) was reduced to an alarming level as compared to the NS group after eight weeks. TC, LDL and triglycerides level reduced significantly in T& G group while the HDL level increased significantly as compared to HFD. In statin group, TC (148.37±1.2), LDL (76.32 ±3.4) and TG (104.33 ±8.9) decreased while HDL increased (p<0.05) as compared to the HFD after eight weeks. It was therefore concluded that that homeopathic medicine Allium sativa Q and Curcuma longa Q is equally good like statin and can safely be used to regulate the circulating serum lipid profile.                   

    REFERENCES

    1. Afkhami-Ardekani, M., Kamali-Ardekani, A. and Shojaoddiny-Ardekani, A. (2006). Effects of garlic on serum lipids and blood glucose of type 2 diabetic patients. Int. J. Diab. Dev. Ctries. 26: 86-88.
    2. Al-Sultan, S. and Gameel, A. (2004). Histopathological changes in the livers of broiler chicken supplemented with turmeric (Curcuma longa). Int. J. Poultry Sci. 3: 333-336.
    3. Anjum, K., Sayyed, U., Ullah, A., Mughal, M., Yaqub, A., Rashid, M. and Yousaf, M. (2014). Antihypercholesterolemic and anti-    atherogenic activity of Terminalia chebula fruit in normal and cholesterol fed rabbits. J. Anim. Plant Sci. 24: 1618-1622.
    4. Ashraf, M.Z., Hussain, M. and Fahim, M. (2005). Antiatherosclerotic effects of dietary supplementations of garlic and turmeric: Restoration of endothelial function in rats. Life Sci. 77: 837-857.
    5. Banerjee Sanjay, K. and Maulik Subir, K. (2002). Effect of garlic on cardiovascular disorders: a review. Nut. J. 1: 1-4.
    6. Braun, L. and Cohen, M. (2010). Herbs and Natural Supplements: An Evidence-based Guide Third Edition. J. Aust. Coll. Nut. Env. Med. 29: 13-17.
    7. Brunton, L., Lazo, J. and Parker, K.G. (2005). Gilman’s The Pharmacological Basis of Therapeutics. 11th. New York: Mc Graw-Hill.
    8. Bundy, R., Walker, A.F., Middleton, R.W. and Booth, J. (2004). Turmeric extract may improve irritable bowel syndrome symptomology in otherwise healthy adults: a pilot study. J. Alte. Comp. Med. 10: 1015-1018.
    9. Colpo, A. (2005). LDL Cholesterol:” Bad” Cholesterol or Bad Science? J. Am. Phys. Surg. 10: 83.
    10. Donato, A.J., Eskurza, I., Silver, A.E., Levy, A.S., Pierce, G.L., Gates, P.E. and Seals, D.R. (2007). Direct evidence of endothelial oxidative stress with aging in humans. Circulation Res. 100: 1659-1666.
    11. Itokawa, H., Shi, Q., Akiyama, T., Morris-Natschke, S.L. and Lee, K.-H. (2008). Recent advances in the investigation of curcuminoids. Chinese Med. 3: 11-16.
    12. Kumar, A. and Singh, V. (2010). Atherogenic dyslipidemia and diabetes mellitus: what’s new in the management arena? Vas. Heal. Risk Manag. 6: 665-669.
    13. Levine, G.N., Keaney Jr, J.F. and Vita, J.A. (1995). Cholesterol reduction in cardiovascular disease—clinical benefits and possible mechanisms. New Eng. J. Med. 332: 512-521.
    14. Liu, L. and Yeh, Y.-Y. (2002). S-alk (en) yl cysteines of garlic inhibit cholesterol synthesis by deactivating HMG-CoA reductase in cultured rat hepatocytes. J. Nut. 132: 1129-1134.
    15. Pari, L. and Umamaheswari, J. (2000). Antihyperglycaemic activity of Musa sapientum flowers: effect on lipid peroxidation in alloxan diabetic rats. Phytother. Res. 14:136-138.
    16. Podrez, E.A. (2013). Bad versus good cholesterol in the bone marrow. Nature Med. 19: 541-543.
    17. Pollex, R.L., Joy, T.R. and Hegele, R.A. (2008). Emerging antidyslipidemic drugs. Exp. Opi. Emerg. Drug. 13: 363-381.
    18. Santoshkumar, J. and Manjunath, S. (2013). A study of anti-hyperlipidemia, hypolipedimic and anti-atherogenic activity of fruit of Emblica officinalis (amla) in high fat fed albino rats. Int. J. Med. Res.Heal. Sci. 2: 70-77.
    19. Stevinson, C., Pittler, M.H. and Ernst, E. (2000). Garlic for treating hypercholesterolemiaA Meta-Analysis of randomized clinical trials. Annals Inter. Med. 133: 420-429.
    20. Sukandar, E.Y., Sigit, J.I. and Deviana, R. (2013). Antihyperlipidemic and antidiabetic effect of combination of garlic and turmeric extract in rats. J. Med. Plant. 1: 5-10.
    21. Sukandar, E.Y., Sudjana, P., Sigit, J.I., Leliqia, N.P.E. and Lestari, F. (2013). Safety of garlic (Allium Sativum) and turmeric (Curcuma domestica) extract in comparison with simvastatin on improving lipid profile in dyslipidemia patients. J. Med. Sci. 13: 10-13.
    22. Thompson Coon, J. and Ernst, E. (2002). Herbal medicinal products for non-ulcer dyspepsia. Ali. Pharm. Ther. 16: 1689-1699.
    23. Zahid, S., Anjum, K. M., Mughal, M. S., Yaqub, A. and Yameen, M. (2018). Evaluation of antioxidant and anti-hyperlipidemic activity of Emblica officinalis (Indian gooseberry) fruit in high fat fed rabbits. J. Anim. Plant Sci. 28: 1007-1013. 
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