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Research Article

volume 52 issue 10 (october 2018) : 1488-1493,   Doi: 10.18805/ijar.B-934

The effect of nizatidine on ovarian ischaemia/reperfusion injury in rats

I
Ilhan Bahri Delibas
I
Ibrahim Karaca
O
Omer Erkan Yapca
M
Metin Ingec
S
Serkan Kumbasar
F
Ferda Keskin Cimen
R
Resit Coskun
A
Aziz Inan Celik
M
Murat Cankaya
D
Durdu Altuner
1Department of Gynecology and Obstetrics, Faculty of Medicine, Gaziosmanpasa University, Tokat, 60030, Turkey.
Cite article:- Delibas Bahri Ilhan, Karaca Ibrahim, Yapca Erkan Omer, Ingec Metin, Kumbasar Serkan, Cimen Keskin Ferda, Coskun Resit, Celik Inan Aziz, Cankaya Murat, Altuner Durdu (2018). The effect of nizatidine on ovarian ischaemia/reperfusion injury in rats. Indian Journal of Animal Research. 52(10): 1488-1493. doi: 10.18805/ijar.B-934.

ABSTRACT

An ischaemia/reperfusion (I/R) injury in an organ can also cause damage to other organs. In this study, the effects of nizatidine were investigated on ovarian I/R injury and subsequent heart damage in rats. Rats were divided into groups; ovarian I/R (IRG), nizatidine 25 mg/kg+ ovarian I/R (NIR), and control (CG) groups. The NIR and IRG groups were given 2 hours of ischaemia followed by 2 hours of reperfusion by applying, and subsequently releasing, a vascular clip to the right ovarian artery. While oxidant levels in the IRG group were higher than NIR and CG groups, antioxidant levels were lower. Necrosis, congested blood vessels, haemorrhage, leukocyte infiltration and oedema were observed in the ovarian and heart tissues of the IRG group. These findings were reduced in the NIR group. Nizatidine suppressed oxidative stress in ovarian and heart tissues and may be useful in prevention of I/R–induced ovarian and cardiac injury.

REFERENCES

  1. Ayaz, N. O., Ramadan, K. S., Farid, H. E. A. and Alnahdi, H. S. (2017). Protective role and antioxidant activity of arabic gum against trichloroacetate-induced toxicity in liver of male rats. Indian J. Anim. Res., 51: 303-309.
  2. Bradley, P. P., Priebat, D. A., Christensen, R. D. and Rothstein, G. (1982)). Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J. Invest. Dermatol., 78: 206-209.
  3. Cadirci, E., Oral, A., Odabasoglu, F., Kilic, C., Coskun, K., Halici, Z., Suleyman, H., Keles, O. N.and Unal, B. (2010). Atorvastatin reduces tissue damage in rat ovaries subjected to torsion and detorsion: biochemical and histopathologic evaluation. Naunyn Schmiedebergs Arch. Pharmacol., 381: 455-466.
  4. Carden, D. L. and Granger, D. N. (2000). Pathophysiology of ischaemia–reperfusion injury. J. Pathol., 190: 255-266.
  5. Cetin, N., Suleyman, H., Sener, E., Demirci, E., Gundogdu, C. and Akcay, F. (2014). The prevention of ischemia/reperfusion induced oxidative damage by venous blood in rabbit kidneys monitored with biochemical, histopatological and immunohistochemical analysis. J. Physiol. Pharmacol., 65: 383-392..
  6. Demiryilmaz, I., Sener, E., Cetin, N., Altuner, D., Akcay, F.and Suleyman H. (2013). A comparative investigation of biochemical and histopathological effects of thiamine and thiamine pyrophosphate on ischemia–reperfusion induced oxidative damage in rat ovarian tissue. Arch. Pharm. Res., 36: 1133-1139.
  7. Dikensoy, E., Gocmen, A. and Sari, I. (2007). A conservative approach to unilateral ovarian torsion in a rat model. Saudi. Med. J., 28: 1204-1207.
  8. Fang, Y.-Z., Yang, S. and Wu, G. (2002). Free radicals, antioxidants, and nutrition. Nutrition., 18: 872-879.
  9. Howell, J. G., Zibari, G. B., Brown, M. F., Burney, D. L., Sawaya, D. E., Olinde, J. G., Granger, D. N. and McDonald, J. C. (2000). Both ischemic and pharmacological preconditioning decrease hepatic leukocyte/endothelial cell interactions 1. Transplantation., 69: 300.
  10. Huchon, C. and Fauconnier, A. (2010)). Adnexal torsion: a literature review. Eur. J. Obstet. Gynecol. Reprod. Biol., 150: 8-12.
  11. Ingec, M., Calik, M., Gundogdu, C., Kurt, A., Yilmaz, M., Isaoglu, U., Salman, S., Akcay, F. and Suleyman, H. (2012)). Biological and histopathological investigations of moclobemide on injured ovarian tissue following induction of ischemia-reperfusion in rats. Int. J. Fertil. Steril., 6: 19-26.
  12. Kisaoglu, A., Borekci, B., Yapca, O. E., Bilen, H. and Suleyman, H. (2013). Tissue damage and oxidant/antioxidant balance. Eurasian J. Med., 45: 47-49.
  13. Kumbasar, S., Cetin, N., Yapca, O. E., Sener, E., Isaoglu, U., Salman, S., Aksoy, A. N., Gul, M. A. and Suleyman, H. (2014). Exogenous ATP administration prevents ischemia/reperfusion-induced oxidative stress and tissue injury by modulation of hypoxanthine metabolic pathway in rat ovary. Ciência. Rural., 44: 1257-1263.
  14. Kunak, C. S., Kukula, O., Mutlu, E., Genç, F. , Güleç Peker, G., Kuyrukluyýldýz, U., Binici, O., Altuner, D. and Alp, H. H. (2015). The effect of etoricoxib on hepatic ischemia-reperfusion injury in rats. Oxid. Med. Cell. Longev.,2015:1-8.
  15. Kurt, A., Isaoglu, U., Yilmaz, M., Calik, M., Polat, B., Hakan, H., Ingec, M. and Suleyman, H. (2011). Biochemical and histological investigation of famotidine effect on postischemic reperfusion injury in the rat ovary. J. Pediatr. Surg., 46: 1817-1823.
  16. Lavelli, V., Peri, C. and Rizzolo, A. (2000). Antioxidant activity of tomato products as studied by model reactions using xanthine oxidase, myeloperoxidase, and copper-induced lipid peroxidation. J. Agric. Food. Chem., 48: 1442-1448.
  17. Lawrence, R. A. and Burk, R. F. (1976). Glutathione peroxidase activity in selenium-deficient rat liver. Biochem. Biophys. Res. Commun., 71: 952-958.
  18. Liu, J., Sun, D., He, J., Yang, C., Hu, T., Zhang, L., Cao, H., Tong, A.-p., Song, X. and Xie, Y. (2016). Gastroprotective effects of several H 2 RAs on ibuprofen-induced gastric ulcer in rats. Life Sci.,149: 65-71.
  19. Lohiya, A., Kumar, V. and Punia, J. S. (2017). Imidacloprid induced oxidative stress and histopathological changes in liver of rats. Indian J. Anim. Res., 51: 531-536.
  20. Melchiorri, D., Sewerynek, E., Reiter, R. J., Ortiz, G. G., Poeggeler, B. and Nisticò, G. (1997). Suppressive effect of melatonin administration on ethanol induced gastroduodenal injury in rats in vivo. Brit. J. Pharmacol., 121: 264-270.
  21. Neary, P. and Redmond, H. (1999). Ischaemia-reperfusion injury and the systemic inflammatory response syndrome. Ischemia-    Reperfusion Injury. Blackwell Science: London:123-136.
  22. Ohkawa, H., Ohishi, N. and Yagi, K. (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem., 95: 351-358.
  23. Poonai, N., Poonai, C., Lim, R. and Lynch, T. (2013). Pediatric ovarian torsion: case series and review of the literature. Can. J. of Surg., 56: 103..
  24. Rock, J.A., T. J. (2003). Surgery for benign disease of the ovary. Te Linde Operative Gynecology 9th ed. Lippincott Williams & Wilkins;, Philadelphia:. : p.648-698.
  25. Rowe, P. B. and Wyngaarden, J. B. (1966). The mechanism of dietary alterations in rat hepatic xanthine oxidase levels. J. Biol. Chem., 241: 5571-5576.
  26. Salman, S., Kumbasar, S., Gursan, N., Kumtepe, Y., Borekci, B., Polat, B., Alp, H. H., Sener, M. T. and Suleyman H. (2011). Investigation of the relationship of some antihypertensive drugs with oxidant/antioxidant parameters and DNA damage on rat uterus tissue. Int. J. Ferti.l Steril., 5:96-103.
  27. Sedlak, J. and Lindsay, R. H. (1968). Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman’s reagent. Anal. Biochem., 25: 192-205.
  28. Urso, M. L. and Clarkson, P. M. (2003). Oxidative stress, exercise, and antioxidant supplementation. Toxicology., 189: 41-54.
  29. van Zyl, J. M., Kriegler, A. and van Der Walt, B. J. (1993). Anti-oxidant properties of H2-receptor antagonists: Effects on myelo    peroxidase-catalysed reactions and hydroxyl radical generation in a ferrous-hydrogen peroxide system. Biochem. Pharmacol.,    45: 2389-2397.
  30. Yapca, O. E., Borekci, B. and Suleyman, H. (2013). Ischemia-reperfusion damage. Eurasian J. Med., 45: 126.
  31. Yapca, O. E., Turan, M. I., Yilmaz, I., Salman, S., Gulapoglu, M. and Suleyman, H. (2014). Benefits of the antioxidant and anti inflammatory activity of etoricoxib in the prevention of ovarian ischemia/reperfusion injury induced experimentally in rats. J. Obst. Gynaec. Res., 40: 1674-1679. 
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Indian Journal of Animal Research
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    Research Article

    volume 52 issue 10 (october 2018) : 1488-1493,   Doi: 10.18805/ijar.B-934

    The effect of nizatidine on ovarian ischaemia/reperfusion injury in rats

    I
    Ilhan Bahri Delibas
    I
    Ibrahim Karaca
    O
    Omer Erkan Yapca
    M
    Metin Ingec
    S
    Serkan Kumbasar
    F
    Ferda Keskin Cimen
    R
    Resit Coskun
    A
    Aziz Inan Celik
    M
    Murat Cankaya
    D
    Durdu Altuner
    1Department of Gynecology and Obstetrics, Faculty of Medicine, Gaziosmanpasa University, Tokat, 60030, Turkey.
    Cite article:- Delibas Bahri Ilhan, Karaca Ibrahim, Yapca Erkan Omer, Ingec Metin, Kumbasar Serkan, Cimen Keskin Ferda, Coskun Resit, Celik Inan Aziz, Cankaya Murat, Altuner Durdu (2018). The effect of nizatidine on ovarian ischaemia/reperfusion injury in rats. Indian Journal of Animal Research. 52(10): 1488-1493. doi: 10.18805/ijar.B-934.

    ABSTRACT

    An ischaemia/reperfusion (I/R) injury in an organ can also cause damage to other organs. In this study, the effects of nizatidine were investigated on ovarian I/R injury and subsequent heart damage in rats. Rats were divided into groups; ovarian I/R (IRG), nizatidine 25 mg/kg+ ovarian I/R (NIR), and control (CG) groups. The NIR and IRG groups were given 2 hours of ischaemia followed by 2 hours of reperfusion by applying, and subsequently releasing, a vascular clip to the right ovarian artery. While oxidant levels in the IRG group were higher than NIR and CG groups, antioxidant levels were lower. Necrosis, congested blood vessels, haemorrhage, leukocyte infiltration and oedema were observed in the ovarian and heart tissues of the IRG group. These findings were reduced in the NIR group. Nizatidine suppressed oxidative stress in ovarian and heart tissues and may be useful in prevention of I/R–induced ovarian and cardiac injury.

    REFERENCES

    1. Ayaz, N. O., Ramadan, K. S., Farid, H. E. A. and Alnahdi, H. S. (2017). Protective role and antioxidant activity of arabic gum against trichloroacetate-induced toxicity in liver of male rats. Indian J. Anim. Res., 51: 303-309.
    2. Bradley, P. P., Priebat, D. A., Christensen, R. D. and Rothstein, G. (1982)). Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J. Invest. Dermatol., 78: 206-209.
    3. Cadirci, E., Oral, A., Odabasoglu, F., Kilic, C., Coskun, K., Halici, Z., Suleyman, H., Keles, O. N.and Unal, B. (2010). Atorvastatin reduces tissue damage in rat ovaries subjected to torsion and detorsion: biochemical and histopathologic evaluation. Naunyn Schmiedebergs Arch. Pharmacol., 381: 455-466.
    4. Carden, D. L. and Granger, D. N. (2000). Pathophysiology of ischaemia–reperfusion injury. J. Pathol., 190: 255-266.
    5. Cetin, N., Suleyman, H., Sener, E., Demirci, E., Gundogdu, C. and Akcay, F. (2014). The prevention of ischemia/reperfusion induced oxidative damage by venous blood in rabbit kidneys monitored with biochemical, histopatological and immunohistochemical analysis. J. Physiol. Pharmacol., 65: 383-392..
    6. Demiryilmaz, I., Sener, E., Cetin, N., Altuner, D., Akcay, F.and Suleyman H. (2013). A comparative investigation of biochemical and histopathological effects of thiamine and thiamine pyrophosphate on ischemia–reperfusion induced oxidative damage in rat ovarian tissue. Arch. Pharm. Res., 36: 1133-1139.
    7. Dikensoy, E., Gocmen, A. and Sari, I. (2007). A conservative approach to unilateral ovarian torsion in a rat model. Saudi. Med. J., 28: 1204-1207.
    8. Fang, Y.-Z., Yang, S. and Wu, G. (2002). Free radicals, antioxidants, and nutrition. Nutrition., 18: 872-879.
    9. Howell, J. G., Zibari, G. B., Brown, M. F., Burney, D. L., Sawaya, D. E., Olinde, J. G., Granger, D. N. and McDonald, J. C. (2000). Both ischemic and pharmacological preconditioning decrease hepatic leukocyte/endothelial cell interactions 1. Transplantation., 69: 300.
    10. Huchon, C. and Fauconnier, A. (2010)). Adnexal torsion: a literature review. Eur. J. Obstet. Gynecol. Reprod. Biol., 150: 8-12.
    11. Ingec, M., Calik, M., Gundogdu, C., Kurt, A., Yilmaz, M., Isaoglu, U., Salman, S., Akcay, F. and Suleyman, H. (2012)). Biological and histopathological investigations of moclobemide on injured ovarian tissue following induction of ischemia-reperfusion in rats. Int. J. Fertil. Steril., 6: 19-26.
    12. Kisaoglu, A., Borekci, B., Yapca, O. E., Bilen, H. and Suleyman, H. (2013). Tissue damage and oxidant/antioxidant balance. Eurasian J. Med., 45: 47-49.
    13. Kumbasar, S., Cetin, N., Yapca, O. E., Sener, E., Isaoglu, U., Salman, S., Aksoy, A. N., Gul, M. A. and Suleyman, H. (2014). Exogenous ATP administration prevents ischemia/reperfusion-induced oxidative stress and tissue injury by modulation of hypoxanthine metabolic pathway in rat ovary. Ciência. Rural., 44: 1257-1263.
    14. Kunak, C. S., Kukula, O., Mutlu, E., Genç, F. , Güleç Peker, G., Kuyrukluyýldýz, U., Binici, O., Altuner, D. and Alp, H. H. (2015). The effect of etoricoxib on hepatic ischemia-reperfusion injury in rats. Oxid. Med. Cell. Longev.,2015:1-8.
    15. Kurt, A., Isaoglu, U., Yilmaz, M., Calik, M., Polat, B., Hakan, H., Ingec, M. and Suleyman, H. (2011). Biochemical and histological investigation of famotidine effect on postischemic reperfusion injury in the rat ovary. J. Pediatr. Surg., 46: 1817-1823.
    16. Lavelli, V., Peri, C. and Rizzolo, A. (2000). Antioxidant activity of tomato products as studied by model reactions using xanthine oxidase, myeloperoxidase, and copper-induced lipid peroxidation. J. Agric. Food. Chem., 48: 1442-1448.
    17. Lawrence, R. A. and Burk, R. F. (1976). Glutathione peroxidase activity in selenium-deficient rat liver. Biochem. Biophys. Res. Commun., 71: 952-958.
    18. Liu, J., Sun, D., He, J., Yang, C., Hu, T., Zhang, L., Cao, H., Tong, A.-p., Song, X. and Xie, Y. (2016). Gastroprotective effects of several H 2 RAs on ibuprofen-induced gastric ulcer in rats. Life Sci.,149: 65-71.
    19. Lohiya, A., Kumar, V. and Punia, J. S. (2017). Imidacloprid induced oxidative stress and histopathological changes in liver of rats. Indian J. Anim. Res., 51: 531-536.
    20. Melchiorri, D., Sewerynek, E., Reiter, R. J., Ortiz, G. G., Poeggeler, B. and Nisticò, G. (1997). Suppressive effect of melatonin administration on ethanol induced gastroduodenal injury in rats in vivo. Brit. J. Pharmacol., 121: 264-270.
    21. Neary, P. and Redmond, H. (1999). Ischaemia-reperfusion injury and the systemic inflammatory response syndrome. Ischemia-    Reperfusion Injury. Blackwell Science: London:123-136.
    22. Ohkawa, H., Ohishi, N. and Yagi, K. (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem., 95: 351-358.
    23. Poonai, N., Poonai, C., Lim, R. and Lynch, T. (2013). Pediatric ovarian torsion: case series and review of the literature. Can. J. of Surg., 56: 103..
    24. Rock, J.A., T. J. (2003). Surgery for benign disease of the ovary. Te Linde Operative Gynecology 9th ed. Lippincott Williams & Wilkins;, Philadelphia:. : p.648-698.
    25. Rowe, P. B. and Wyngaarden, J. B. (1966). The mechanism of dietary alterations in rat hepatic xanthine oxidase levels. J. Biol. Chem., 241: 5571-5576.
    26. Salman, S., Kumbasar, S., Gursan, N., Kumtepe, Y., Borekci, B., Polat, B., Alp, H. H., Sener, M. T. and Suleyman H. (2011). Investigation of the relationship of some antihypertensive drugs with oxidant/antioxidant parameters and DNA damage on rat uterus tissue. Int. J. Ferti.l Steril., 5:96-103.
    27. Sedlak, J. and Lindsay, R. H. (1968). Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman’s reagent. Anal. Biochem., 25: 192-205.
    28. Urso, M. L. and Clarkson, P. M. (2003). Oxidative stress, exercise, and antioxidant supplementation. Toxicology., 189: 41-54.
    29. van Zyl, J. M., Kriegler, A. and van Der Walt, B. J. (1993). Anti-oxidant properties of H2-receptor antagonists: Effects on myelo    peroxidase-catalysed reactions and hydroxyl radical generation in a ferrous-hydrogen peroxide system. Biochem. Pharmacol.,    45: 2389-2397.
    30. Yapca, O. E., Borekci, B. and Suleyman, H. (2013). Ischemia-reperfusion damage. Eurasian J. Med., 45: 126.
    31. Yapca, O. E., Turan, M. I., Yilmaz, I., Salman, S., Gulapoglu, M. and Suleyman, H. (2014). Benefits of the antioxidant and anti inflammatory activity of etoricoxib in the prevention of ovarian ischemia/reperfusion injury induced experimentally in rats. J. Obst. Gynaec. Res., 40: 1674-1679. 
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