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Current IssueEditorial BoardOnline First ArticlesArchive

Research Article

volume 52 issue 12 (december 2018) : 1778-1781,   Doi: 10.18805/ijar.B-932

Comparison of serum procalcitonin, haptoglobin and C-reactive protein levels in goats with Corynebacterium pseudotuberculosis

G
G. Akgul
M
M.B. Akgul
D
D. Ozenand S. Kahya Demýrbýlek
1Department of Internal Medicine, Faculty of Veterinary Medicine, Siirt University, Siirt, Turkey.
Cite article:- Akgul G., Akgul M.B., Demýrbýlek Kahya S. Ozenand D. (2018). Comparison of serum procalcitonin, haptoglobin and C-reactive protein levels in goats with Corynebacterium pseudotuberculosis. Indian Journal of Animal Research. 52(12): 1778-1781. doi: 10.18805/ijar.B-932.

ABSTRACT

This study was conducted to investigate the response of acute phase proteins, mainly Haptoglobin, C-reactive protein, Procalcitonin and the negative acute phase response, especially albumin in goats suffering from C. pseudotuberculosis. A total of 19 Turkish hair goats between the ages of 1.5 and 2 years in a special dairy farm was selected for the study, consisting of 9 healthy animals and 10 with C. pseudotuberculosis. There was a statistically significant difference in serum haptoglobin, C-reactive protein, procalcitonin and albumin levels in goats with C. pseudotuberculosis, compared to the control group (p<0.05). The results showed that Haptoglobin, C-reactive protein and Procalcitonin produce a higher, and Alb a lower, response in goats with C. pseudotuberculosis compared to the control. The presented study suggests that C. pseudotuberculosis can influence the level of acute phase proteins in goats. These results indicate that monitoring a number of acute phase proteins can increase the diagnostic information available for this disease.

REFERENCES

  1. Alonso, M.C., Simon, O., Girones, J.L., Muzquiz, C., Ortega, J. (1993). Garcia The effect of experimental infection with Corynebacterium pseudotuberculosis on reproduction in adult ewes. Res Vet Sc., 52:267-272.
  2. Alsemgeest, S.P.M., Kalsbeek, H.C., Wensing, T., Koeman, J.P., Van Ederen, A.M., Gruys, E. (1994). Concentrations of serum amyloid-    a (SAA) and haptoglobin (Hp) as parameters of inflammatory diseases in cattle. Vet Quart, 16: 21-23.
  3. Ambalavanan, N., Carlo, W.A., D’Angio, C.T., McDonald, S.A., Das. A., Schendel, D., Thorsen, P., Higgins, R.D.( 2009). Cytokines associated with bronchopulmonary dysplasia or death in extremely low birth weight infants. Pediatrics 123: 1132-1141.
  4. Ceciliani, F., Ceron, J.J, Eckersall, P.D, Sauerwein, H. (2012). Acute phase proteins in ruminants. J. Proteomic., 75: 4207-4231.
  5. Cray, C., Zaias, J., N.H. Altman N.H. (2009). Acute phase response in animals: A review Comp. Med., 59: 517-526.
  6. Dorella, F.A., Pacheco, L.G.C., Oliveira, S.C., Miyoshi, A., Azevedo, V. (2006). Corynebacterium pseudotuberculosis: microbiology, biochemical properties, pathogenesis and molecular studies of virulence. Vet Res, 37:201-218.
  7. Elsammak, M., Hanna, H., Ghazal, A., Edeen, F.B., aKandil, M. (2006). Diagnostic value of serum procalcitonin and C-reactive protein in Egyptian children with streptococcal tonsillopharyngitis. Pediatr Infect Dis J, 25:174-6. 
  8. Fontaine, M.C., Baird, G., Connor, K.M., Rudge, K., Sales, J., Donachie, W. (2006). Vaccination confers significant protection of sheep against infection with a virulent United Kingdom strain of Corynebacterium pseudotuberculosis. Vaccines, 24: 5986–96.
  9. Fontaine, M.C. and Baird, G.J. (2008). Caseous lymphadenitis. Small Rumin Res, 76: 42-8.
  10. Gruys, E., Obwolo, M.J., Toussaint, M.J.M. (1994). Diagnostic significance of major acute phase proteins in veterinary clinical chemistry. A rev Vet Bull, 64: 1009-18.
  11. Gruys, E., Toussaint, M.J.M., Niewold, T.A., Koopmans, S.J. (2005). Acute phase reaction and acute phase proteins. J Zhejiang Univ-SC, 11: 045-1056.
  12. He, Z.X., Sun, Z.H., Yang, W.Z., Beauchemin, K.A., Tang, S.X., Zhou, C.S., Han, X.F., Wang, M., Kang, J.H., Tan, Z.L.(2014): Effects of maternal protein or energy restriction during late gestation on immune status and responses to lipopolysaccharide challenge in postnatal young goats. J Anim Sci 92: 4856-4864.
  13. Joo, K., Park, W., Lim, M.J., Kwon, S.R., Yoon, J. (2011). Serum procalcitonin for differentiating bacterial infection from disease flares in patients with autoimmune diseases. J Korean Med. Sci, 26:1147-51.
  14. Kheir, I.M., Ahmed M.M.M. (2008). Effects of water and feed restriction on some physiological and haematological parameters and blood constituents of sudanese desert goats fed high and low quality forages under semi-arid conditions. Indýan J Aným Res 42: 39-43.
  15. Khera, A., McGuire, D.K, Murphy, S.A., Stanek, H.G., Vongpatanasin, W., Wians, F.H., Grundy, S.M., Lomes, J.A. (2005). Race and gender differences in C-reactive protein levels. J Am Coll Cardiol., 46: 464-469.
  16. Ozkanlar, Y., Aktas,M., Kaynar,O., Ozkanlar, S.,E. Kireccl, E. (2012). Bovine respiratory disease in naturally infected calves: clinical signs, blood gases and cytokine response. Revue Med. Vet, 163: 123-130.
  17. Pepys, M.B. (1981). C-reactive protein fifty years on. Lancet. 1:653-657
  18. Petersen, H.H., Nielsen, J.P., Heegard, P.M.H. (2004). Application of acute phase protein measurements in veterinary clinical chemistry. Vet Res, 35:163-187.
  19. Reingardiene, D. (2004). Procalcitonin as a marker of the systemic inflammatory response to infection. Medicina. 40: 696-701. 
  20. Sãez-Llorens, X., Lagrutta, F. (1993). The acute phase host reaction during bacterial infection and its clinical impact in children. Pediatr Infect Dis J, 12: 83-87.
  21. Sevgisunar, N.S., Þahinduran, Þ. (2014). Hayvanlarda akut faz proteinleri, kullaným amaçlarý ve klinik önemi. MAEU Sag Bil Derg., 2: 50-72.
  22. Schuetz, P., Werner, A., Beat, M. (2011). Procalcitonin for diagnosis of infection and guide to antibiotic decisions: past, present and future. BMC Medicine, 9: 107. 
  23. Valli, V.E., Parry, B.W. (1993). Caseous lymphadenitis. Pathology of Domestic Animals. In: Jubb K.V.F, Kennedy P.C., Palmer N. 
  24. (ed.). Academic Press, San Diego, USA, PP: 238-240.
  25. When-Chuan, L., Huo-Cheng, H., Ying-Ling, W. (2003). Serum C reactive protein in dairy herds. Can J Vet Res, 67:102-107.
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Indian Journal of Animal Research
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    Research Article

    volume 52 issue 12 (december 2018) : 1778-1781,   Doi: 10.18805/ijar.B-932

    Comparison of serum procalcitonin, haptoglobin and C-reactive protein levels in goats with Corynebacterium pseudotuberculosis

    G
    G. Akgul
    M
    M.B. Akgul
    D
    D. Ozenand S. Kahya Demýrbýlek
    1Department of Internal Medicine, Faculty of Veterinary Medicine, Siirt University, Siirt, Turkey.
    Cite article:- Akgul G., Akgul M.B., Demýrbýlek Kahya S. Ozenand D. (2018). Comparison of serum procalcitonin, haptoglobin and C-reactive protein levels in goats with Corynebacterium pseudotuberculosis. Indian Journal of Animal Research. 52(12): 1778-1781. doi: 10.18805/ijar.B-932.

    ABSTRACT

    This study was conducted to investigate the response of acute phase proteins, mainly Haptoglobin, C-reactive protein, Procalcitonin and the negative acute phase response, especially albumin in goats suffering from C. pseudotuberculosis. A total of 19 Turkish hair goats between the ages of 1.5 and 2 years in a special dairy farm was selected for the study, consisting of 9 healthy animals and 10 with C. pseudotuberculosis. There was a statistically significant difference in serum haptoglobin, C-reactive protein, procalcitonin and albumin levels in goats with C. pseudotuberculosis, compared to the control group (p<0.05). The results showed that Haptoglobin, C-reactive protein and Procalcitonin produce a higher, and Alb a lower, response in goats with C. pseudotuberculosis compared to the control. The presented study suggests that C. pseudotuberculosis can influence the level of acute phase proteins in goats. These results indicate that monitoring a number of acute phase proteins can increase the diagnostic information available for this disease.

    REFERENCES

    1. Alonso, M.C., Simon, O., Girones, J.L., Muzquiz, C., Ortega, J. (1993). Garcia The effect of experimental infection with Corynebacterium pseudotuberculosis on reproduction in adult ewes. Res Vet Sc., 52:267-272.
    2. Alsemgeest, S.P.M., Kalsbeek, H.C., Wensing, T., Koeman, J.P., Van Ederen, A.M., Gruys, E. (1994). Concentrations of serum amyloid-    a (SAA) and haptoglobin (Hp) as parameters of inflammatory diseases in cattle. Vet Quart, 16: 21-23.
    3. Ambalavanan, N., Carlo, W.A., D’Angio, C.T., McDonald, S.A., Das. A., Schendel, D., Thorsen, P., Higgins, R.D.( 2009). Cytokines associated with bronchopulmonary dysplasia or death in extremely low birth weight infants. Pediatrics 123: 1132-1141.
    4. Ceciliani, F., Ceron, J.J, Eckersall, P.D, Sauerwein, H. (2012). Acute phase proteins in ruminants. J. Proteomic., 75: 4207-4231.
    5. Cray, C., Zaias, J., N.H. Altman N.H. (2009). Acute phase response in animals: A review Comp. Med., 59: 517-526.
    6. Dorella, F.A., Pacheco, L.G.C., Oliveira, S.C., Miyoshi, A., Azevedo, V. (2006). Corynebacterium pseudotuberculosis: microbiology, biochemical properties, pathogenesis and molecular studies of virulence. Vet Res, 37:201-218.
    7. Elsammak, M., Hanna, H., Ghazal, A., Edeen, F.B., aKandil, M. (2006). Diagnostic value of serum procalcitonin and C-reactive protein in Egyptian children with streptococcal tonsillopharyngitis. Pediatr Infect Dis J, 25:174-6. 
    8. Fontaine, M.C., Baird, G., Connor, K.M., Rudge, K., Sales, J., Donachie, W. (2006). Vaccination confers significant protection of sheep against infection with a virulent United Kingdom strain of Corynebacterium pseudotuberculosis. Vaccines, 24: 5986–96.
    9. Fontaine, M.C. and Baird, G.J. (2008). Caseous lymphadenitis. Small Rumin Res, 76: 42-8.
    10. Gruys, E., Obwolo, M.J., Toussaint, M.J.M. (1994). Diagnostic significance of major acute phase proteins in veterinary clinical chemistry. A rev Vet Bull, 64: 1009-18.
    11. Gruys, E., Toussaint, M.J.M., Niewold, T.A., Koopmans, S.J. (2005). Acute phase reaction and acute phase proteins. J Zhejiang Univ-SC, 11: 045-1056.
    12. He, Z.X., Sun, Z.H., Yang, W.Z., Beauchemin, K.A., Tang, S.X., Zhou, C.S., Han, X.F., Wang, M., Kang, J.H., Tan, Z.L.(2014): Effects of maternal protein or energy restriction during late gestation on immune status and responses to lipopolysaccharide challenge in postnatal young goats. J Anim Sci 92: 4856-4864.
    13. Joo, K., Park, W., Lim, M.J., Kwon, S.R., Yoon, J. (2011). Serum procalcitonin for differentiating bacterial infection from disease flares in patients with autoimmune diseases. J Korean Med. Sci, 26:1147-51.
    14. Kheir, I.M., Ahmed M.M.M. (2008). Effects of water and feed restriction on some physiological and haematological parameters and blood constituents of sudanese desert goats fed high and low quality forages under semi-arid conditions. Indýan J Aným Res 42: 39-43.
    15. Khera, A., McGuire, D.K, Murphy, S.A., Stanek, H.G., Vongpatanasin, W., Wians, F.H., Grundy, S.M., Lomes, J.A. (2005). Race and gender differences in C-reactive protein levels. J Am Coll Cardiol., 46: 464-469.
    16. Ozkanlar, Y., Aktas,M., Kaynar,O., Ozkanlar, S.,E. Kireccl, E. (2012). Bovine respiratory disease in naturally infected calves: clinical signs, blood gases and cytokine response. Revue Med. Vet, 163: 123-130.
    17. Pepys, M.B. (1981). C-reactive protein fifty years on. Lancet. 1:653-657
    18. Petersen, H.H., Nielsen, J.P., Heegard, P.M.H. (2004). Application of acute phase protein measurements in veterinary clinical chemistry. Vet Res, 35:163-187.
    19. Reingardiene, D. (2004). Procalcitonin as a marker of the systemic inflammatory response to infection. Medicina. 40: 696-701. 
    20. Sãez-Llorens, X., Lagrutta, F. (1993). The acute phase host reaction during bacterial infection and its clinical impact in children. Pediatr Infect Dis J, 12: 83-87.
    21. Sevgisunar, N.S., Þahinduran, Þ. (2014). Hayvanlarda akut faz proteinleri, kullaným amaçlarý ve klinik önemi. MAEU Sag Bil Derg., 2: 50-72.
    22. Schuetz, P., Werner, A., Beat, M. (2011). Procalcitonin for diagnosis of infection and guide to antibiotic decisions: past, present and future. BMC Medicine, 9: 107. 
    23. Valli, V.E., Parry, B.W. (1993). Caseous lymphadenitis. Pathology of Domestic Animals. In: Jubb K.V.F, Kennedy P.C., Palmer N. 
    24. (ed.). Academic Press, San Diego, USA, PP: 238-240.
    25. When-Chuan, L., Huo-Cheng, H., Ying-Ling, W. (2003). Serum C reactive protein in dairy herds. Can J Vet Res, 67:102-107.
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