Published In
Indian Journal of Animal Research
Article Metrics

0
Views
0
Citations
Reviewed By
In this Article
APC
APC cover the cost of turning a manuscript into a published manuscript through peer-review process, editorial work as well as the cost of hosting, distributing, indexing and promoting the manuscript.
Publish With US
Submit your manuscript through user friendly platform and acquire the maximum impact for your research by publishing with ARCC Journals.
Become a Reviewer/Member
Join our esteemed reviewers panel and become an editorial board member with international experts in the domain of numerous specializations.
Open Access
Filling the gap between research and communication ARCC provide Open Access of all journals which empower research community in all the ways which is accessible to all.
Products and Services
We provide prime quality of services to assist you select right product of your requirement.
Support and Policies
Finest policies are designed to ensure world class support to our authors, members and readers. Our efficient team provides best possible support for you.
Follow us
Research Article
volume 53 issue 6 (june 2019) : 827-831, Doi: 10.18805/ijar.B-924
Comparison of the clinical effects of Prednisolone, Azathioprine and Oligodeoxynucleotide (ODN) applications in experimentally induced endotoxin uveitis in rats
1Namik Kemal University, Faculty of Veterinary Medicine, Department of Surgery, Degirmenaltý Campus, 59030 Suleymanpasa, Tekirdag, Turkey.
Submitted19-02-2018|
Accepted27-05-2018|
First Online 17-07-2018|
Cite article:- Erkal Yaşar Özge Tuba, Kılıç Servet, Hatipoğlu Fatih, Terzi Funda (2018). Comparison of the clinical effects of Prednisolone, Azathioprine and Oligodeoxynucleotide (ODN) applications in experimentally induced endotoxin uveitis in rats. Indian Journal of Animal Research. 53(6): 827-831. doi: 10.18805/ijar.B-924.
ABSTRACT
Clinical effects and pathological changes of synthetic oligodeoxynucleotide (ODN), prednol (PRD) and azathioprine (AZA) was compared on uveitis treatment in rats. A total of 28 Wistar Albino, female, adult rats were divided into Control (C), PRD, AZA and ODN groups. Uveitis was induced by 176 ìg/rat subcutan injection E. coli, LPS and observed in all animals after 48 hours. Then, 0.25 mg/rat/day AZA and 1.25 mg/rat/day of methylprenidolone was administered by gavage in AZA and PRD groups for ten days. In the ODN group, 178 ìg/rat ODN was administered IP totally four times. A numerical weight loss was seen in all groups in the course of the infection period, but dropped dramatically in the PRD group during the treatment period. Average value of right and left eye results showed that immunesuppressive effect of Prednol was higher in terms of IOP values compared to others whereas Shirmer test values were the lowest in the post-treatment period. Finally, Prednol was more effective with its immunesuppressive effect resulting in recovery of photophobia, vascularization and oedema in iris vessels.
KEYWORDS
REFERENCES
- Agarwal, R.K. and Caspi, RR. (2004) Rodent models of experimental autoimmune uveitis. Methods in Molecular Medicine,102:395 419.
- Aibara, M., Lindsey, J.D., Weinreb, R.N. (2002) Reduction of intraocular pressure in mouse eyes treated with latanoprost. Investigative Ophthalmology and Visual Science,43: 146–150.
- Avunduk, M.C., Avunduk, A.M.., Oztekin, E., Baltaci, A.K.., Ozyazgan, Y., Mogolkoc, R. (2004) Etanercept treatment in the endotoxin- induced uveitis of rats. Experimental Eye Research, 79: 357–365.
- Bansal, S., Barathi, V.A., Iwata, D., Agrawal, R. (2015) Experimental autoimmun uveitis and other animal models of uveitis: An update. Indian Journal of Ophthalmology, 63:211-218.
- Behar-Cohen, F.F., Parel J.M., Pouliquen, Y. (1997) Iontophoresis of dexamethasone in the treatment of endotoxin-induced uveitis in rats. Experimental Eye Research, 65:533–45.
- Bucolo, C., Cuzzocrea, S., Mazzon, E., Achille, P., Caputi, A.P.(2003) Effects of Cloricromene, a Coumarin Derivative on endotoxin- induced uveitis in Lewis Rats. Investigative Ophthalmology and Visual Science, 44: 1178-1184.
- Caspi, R.R.(2006) Animal models of autoimmune and immune-mediated uveitis. Drug Discovery Today: Disease Models, 3: 3-9.
- Cousins, S.W., Guss, R.B., Howes, E.L. Jr,, Rosenbaum, J.T., (1984) Endotoxin-induced uveitis in the rat: observations on altered vascular permeability, clinical findings, and histology. Experimental Eye Research, 39: 665-676.
- Fujimoto, C., Klinman, D.M., Shi, G., Yin, H., Vistica, B.P., Lovaas, J.D., Wawrousek, E.F., et al., (2009) A suppressive oligodeoxynucleotide inhibits ocular inflammation. Clinical and Experimental Immunology,156: 528-534.
- Griffiths, M.J.D., Curzen, N.P., Mitchell, J.A., Evans, T.W. (1997) In vivo treatment with endotoxin increases rat pulmonary vascular contractility despite NOS induction. American Journal of Respiratory and Clinical Care Medicine, 156: 654-658.
- Kalariya, N.M., Shoeb, M., Reddy, A.B., Zhang, M., van Kuijk, F.J., Ramana, K.V. (2010) Prevention of endotoxin-induced uveitis in rats by plant sterol guggulsterone. Investigative Ophthalmology and Visual Science, 51: 5105-5113.
- Luna, L. (1968) Manual of Histologic Staining Methods of the Armed Forces Institute of Pathology. New York, NY: McGraw-Hill, 114-115, DOI:10.1016/S0031-3025(16)39410-7.
- Mermoud, A., Baerveldt, G., Minckler, D.S., Lee, M.B., Rao, N.A. (1994) Intraocular pressure in Lewis rats. Investigative Ophthalmology and Visual Science, 35:2455-60.
- Pacheco, P.A., Taylor, S.R., Cuchacovich, M.T., Diaz, G.V. (2008) Azathioprine in the management of autoimmune uveitis. Ocular Immunology and Inflammation, 16: 161-165.
- Tian, Q., Bi, H., Cui, Y., Wu, J., Xie, X., Guo, J., Guo, D., Qian, J., (2015) Influence of yanyankang powder on Th1/Th2 in rats with experimental autoimmune uveitis, Chinese Journal of Integrative Medicine,22: 214-218.
- Tsuji, F., Sawa, K., Kato, M., Mibu, H., Shirasawa, E. (1997) The effect of betamethasone derivatives on endotoxin-induced uveitis in rats. Experimental Eye Research,64: 31–6.
- Yadav, U.C.S., Subramanyam, S., Ramana, V.K. (2009) Preventation of endotoxin-ýnduced uveitis in rats by benfotiamine, a lipophilic analogue of vitamin B1. Investigative Ophthalmology and Visual Science, 50: 2276-2282.
- Yagci, C.F., Aslan, O., Gursel, M., Tincer, G., Ozdamar, Y., Karatepe, K., Akcali, C.K. (2010) Mammalian Telomeric DNA suppresses endotoxin-induced uveitis. Journal of Biological Chemistry, 285: 28806-28811.
- Zagon, I.S., Campbell, A.M., Sassani, J.W., Mclaughlin, J.P. (2012) Spontaneous episodic decreased tear secration in rats is related to opioidergic signaling pathways. Investigative Ophthalmology and Visual Science, 53: 3234–3240.
Disclaimer :
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Copyright :
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
In this Article
APC
APC cover the cost of turning a manuscript into a published manuscript through peer-review process, editorial work as well as the cost of hosting, distributing, indexing and promoting the manuscript.
Publish With US
Submit your manuscript through user friendly platform and acquire the maximum impact for your research by publishing with ARCC Journals.
Become a Reviewer/Member
Join our esteemed reviewers panel and become an editorial board member with international experts in the domain of numerous specializations.
Open Access
Filling the gap between research and communication ARCC provide Open Access of all journals which empower research community in all the ways which is accessible to all.
Products and Services
We provide prime quality of services to assist you select right product of your requirement.
Support and Policies
Finest policies are designed to ensure world class support to our authors, members and readers. Our efficient team provides best possible support for you.
Follow us
Published In
Indian Journal of Animal Research