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Current IssueEditorial BoardOnline First ArticlesArchive

Short Communication

volume 53 issue 6 (june 2019) : 832-836,   Doi: 10.18805/ijar.B-911

Treatment of Bovine papillomavirus-induced teat warts in a cow by using Podophyllin magistral formula and autologous vaccine applications together
 

M
M. Kale
H
H.S. Saltik
S
S. Hasircioglu
Y
Y. Yildirim
S
S. Yavru
N
N. Mamak
K
K. Atli
1Department of Virology, Faculty of Veterinary Medicine, Mehmet Akif Ersoy University, Burdur, Turkey.
Cite article:- Kale M., Saltik H.S., Hasircioglu S., Yildirim Y., Yavru S., Mamak N., Atli K. (2018). Treatment of Bovine papillomavirus-induced teat warts in a cow by using Podophyllin magistral formula and autologous vaccine applications together. Indian Journal of Animal Research. 53(6): 832-836. doi: 10.18805/ijar.B-911.

ABSTRACT

In this study, a 32-month-old Holstein cow that had a calving and common Bovine papillomavirus (BPV)-induced wart on its teats was treated. For this purpose, BPV antigen presence in blood serum sample from the animal was studied by ELISA and was revealed as positive. Magistral drug containing podophyllin active substance was applied topically on teat warts of the animal. Applications were performed for all teat warts once in three days during 27 days. Eight hours after applying the drug, teats were washed with sterile water. Warts on teat were proved to have regressed and dried out on the day 27th. The same animal was given papilloma autologous vaccine prepared from warts coming off from the teat on the day 28th. As a result of the vaccination, teats showed full recovery from warts. Finally, it is recommended that using podophyllin formulations topical and autologous vaccine applications together in treating teat warts caused by BPV. 

REFERENCES

  1. Atasever, A., Cam, Y., and Atalay, O. (2005). Bir sýðýr sürüsünde deri papillomatosis olgularý. Ankara Univ Vet Fak Derg, 52: 197-200.
  2. Avki, S., Turutoglu, H., Simsek, A., and Unsal A. (2004). Clinical and immunological effects of Newcastle disease virus (NDV) vaccine on bovine papillomatosis. Vet Immunol Immunopathol, 98: 9-16.
  3. Campo, M.S. (2002). Animal models of papillomavirus pathogenesis. Virus Res, 89: 249-61.
  4. Campo, M.S. (2006). Papillomavirus research: from natural history to vaccines and beyond. Caister Academic Press, Norfolk, England. pp. 373-83.
  5. Cihan, M., Özaydýn, Ý., Özba, B., and Baran, V. (2004). Clinical effects of levamisole in bovine papillomatosis. Indian Vet J, 81: 321-23.
  6. Cimtay, Ý., Biricik, H.S., Keskin, O., and Baba, Z.F. (2003). Sýðýr Papillomatozisinin saðaltýmýnda farklý aþýlama yöntemlerinin etkinliði üzerine karþýlaþtýrmalý araþtýrmalar. Turk J Vet Anim Sci, 27: 929-33.
  7. Dagalp, S.B., Dogan, F., Farzaný, T.A., Salar, S. and Bastan, A. (2017). The genetic diversity of bovine papillomaviruses (BPV) from different papillomatosis cases in dairy cows in Turkey. Arch Virol, 162: 1507-18.
  8. De Villiers, E.M., Fauquet, C., Broker, T.R., Bernard, H.U., and zur Hausen, H. (2004). Classification of papillomaviruses. Virology, 324: 17-27. 
  9. Durusoy, C. and Gozel Ulusoy, B. (2007). Dermatolojide bitkisel tedavi-Fitoterapi. Turk J Dermatol, 1: 47-50.
  10. Gross, G. and Von Krogh, G. (1997). Therapy of anogenital HPV-induced lesions. Clin Dermatol, 15: 457-70.
  11. Howley, P.M. and Lowy, D.R. (2007). Fields’ virology (5th Edn.). Wolters Kluwer Health and Lippincott Williams & Wilkins, Philadelphia, USA. pp. 2299-354.
  12. Hunt, E. (1984). Fibropapillomatosis and papillomatosis. Vet Clin North Am Large Anim Pract, 6: 163-67.
  13. Jarrett, W.F.H. (1985). Advances in Viral Oncology, (5th Edn.). Raven Press, New York, USA. pp. 83-102.
  14. Kahrs, R.F. (2001). Viral Diseases of Cattle, (2nd Edn.), Iowa State University Press, Ames, Iowa, USA. pp. 141-49.
  15. Kale, M. (2016). Sýðýrlarda siðillerden sorumlu olan virus: BPV. Ayrýntý Derg, 4: 17-21.
  16. Kýrmýzýgul, A.H., Gökçe, E., Sözmen, M., Yýldýrým, Y., Beytut E. (2010). Ývermektin’in sýðýr deri papillomatozisinde tedavi etkinliði. Kafkas Univ Vet Fak Derg, 16: 627-31.
  17. Knowles, G., O’Neil, B.W., and Campo, M.S. (1996). Phenotypic characterization of lymphocytes infiltrating regressing papillomas. J Virology, 70: 8451-58.
  18. Kutlubay, Z., Uzunçakmak, T.K., Engin, B., and Serdaroglu S. (2011). Ýmmunosupresif tedavi alan ve tedaviye dirençli kondilomata aküminata olgusunda kombinasyon tedavisi. Dermatoz, 2: 339-42.
  19. Lesnik, F., Bires, J., Suli, J., Korim, P., Posivak, J., Mattova, J., Svrcek, S., Sevcikova, Z., et al. (1999). Autovaccination and metabolic profiles at Bovine Papillomatosis. Slovensky Vet, 24: 290-94.
  20. Lindholm, I,. Murphy, J., O’Neil, B.W., Campo, M.S., and Jarrett, W.F. (1984). Papillomas of the teats and udder of cattle and their causal viruses. Vet Rec, 115: 574-77.
  21. Lunardi, Michele, Amauri Alcindo Alfieri, Rodrigo Alejandro Arellano Otonel, and Alice Fernandes Alfieri (2013). Bovine Papillomaviruses    -Taxonomy and Genetic. Vet Microbiol. 162:207-13.
  22. Marins, R.S.Q.S., Travassos, C.E.P.F., Pereira, S.R.F.G., Pereira, M.A.V.C., Vieira, L.F.P. (2006). Avaliação da eficácia da homeopatia e fitoterapia no tratamento da papilomatose cutânea bovina. R Bras Ci Vet, 13: 10-2.
  23. Murphy, F.A., Gibbs, E.P.J., Horzinek, M.C., Studdert, M.J. (1999). Veterinary Virology, (3rd Edn.). Academic Press, San Diego, USA. pp. 335–42.
  24. Nasir, L., Campo, M.S. (2008). Bovine papillomaviruses: their role in the aetiology of cutaneous tumours of bovids and equids. Vet Dermatol, 19: 243-54.
  25. Nicholls, P.K. and Stanley, M.A. (2000). The immunology of animal papillomaviruses. Vet Immunol Immunopathol. 73: 101-27.
  26. Ocal, H., Yýldýz, A., Apaydýn, A.M., and Kaygusuzoglu E. (2001). Ýnek ve düvelerde meme papillomatozisinin tedavisi ve etiyolojisi üzerine çalýþma. Fýrat Üniv Sag Bil Derg, 15: 23-6.
  27. Ogawa, T., Tomita, Y., Okada, M., Shinozaki, K., Kubonoya, H., Kaiho, I. and Shirasawa, H. (2004). Broad-spectrum detection of papillomaviruses in bovine teat papillomas and healthy teat skin. J Gen Virol, 85: 2191-97.
  28. Oswaldo, P, Alfredo, D.C., Néstor, F.P., and Alberto, M.S. (2011). Efficacy of the Newcastle disease vaccine on the control of bovine papillomatosis. Rev Inv Vet Perú, 22:388-393.
  29. Paksoy, Z., Gulescý, N., Kandemir, F.M., and Dincel G.C. (2015). Effectiveness of levamisole and tarantula cubensis extract in the treatment of teat papillomatosis of cows. Indian J Anim Res, 49: 704-8. 
  30. Pekcan, A.N. (2014). Majistral makaleler, (1. Basým). Ýrdesel Yayýncýlýk, Bahçelievler, Ankara. pp. 260-68.
  31. Rakesh, R., Ghuma, S.P.S., Bhatt, G.R., and Singh, R.S. (2013). Efficacy of autogenous vaccine and auto-hemotherapy in bovine cutaneous papillomatosis. Intas Polivet, 14: 411-14.
  32. Risvanli, A. and Kalkan, C. (2001). Ýneklerde meme papillomatozisi ile mastitis arasýndaki iliþki. Selcuk Univ Vet Bil Derg, 17: 143-47.
  33. Sarýkaya, E. and Iscimen A. (2010). Verruka vulgaris tedavisinde kriyoterapi ile %1 kantaridin, %5 podofilin ve %30 salisilik asit içeren topikal ürün (Canthacur-Ps®)’ün etkinliðinin karþýlaþtýrýlmasý. Dermatoz, 1: 121-24.
  34. Tan, M.T., Yýldýrým, Y., Sözmen, M., Daðalp, S.B., Yýlmaz, V., Kýrmýzýgül, A.H., and Gökçe E. (2012). A histopathological, immunohistochemical and molecular study of cutaneous bovine papillomatosis. Kafkas Univ Vet Fak Derg, 18: 739-44.
  35. Turk, N., Zupancýc, Z., Staresýna, V., Kovac, S., Babýc, T., Kreszýnger, M., Curýc, S., Barbýc, Lj., and Milas Z. (2005). Severe bovine papillomatosis: detection of bovine papillomavirus in tumour tissue and efficacy of treatment using autogenous vaccine and parammunity inducer. Vet Arhiv, 75: 391-97. 
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Indian Journal of Animal Research
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    Short Communication

    volume 53 issue 6 (june 2019) : 832-836,   Doi: 10.18805/ijar.B-911

    Treatment of Bovine papillomavirus-induced teat warts in a cow by using Podophyllin magistral formula and autologous vaccine applications together
     

    M
    M. Kale
    H
    H.S. Saltik
    S
    S. Hasircioglu
    Y
    Y. Yildirim
    S
    S. Yavru
    N
    N. Mamak
    K
    K. Atli
    1Department of Virology, Faculty of Veterinary Medicine, Mehmet Akif Ersoy University, Burdur, Turkey.
    Cite article:- Kale M., Saltik H.S., Hasircioglu S., Yildirim Y., Yavru S., Mamak N., Atli K. (2018). Treatment of Bovine papillomavirus-induced teat warts in a cow by using Podophyllin magistral formula and autologous vaccine applications together. Indian Journal of Animal Research. 53(6): 832-836. doi: 10.18805/ijar.B-911.

    ABSTRACT

    In this study, a 32-month-old Holstein cow that had a calving and common Bovine papillomavirus (BPV)-induced wart on its teats was treated. For this purpose, BPV antigen presence in blood serum sample from the animal was studied by ELISA and was revealed as positive. Magistral drug containing podophyllin active substance was applied topically on teat warts of the animal. Applications were performed for all teat warts once in three days during 27 days. Eight hours after applying the drug, teats were washed with sterile water. Warts on teat were proved to have regressed and dried out on the day 27th. The same animal was given papilloma autologous vaccine prepared from warts coming off from the teat on the day 28th. As a result of the vaccination, teats showed full recovery from warts. Finally, it is recommended that using podophyllin formulations topical and autologous vaccine applications together in treating teat warts caused by BPV. 

    REFERENCES

    1. Atasever, A., Cam, Y., and Atalay, O. (2005). Bir sýðýr sürüsünde deri papillomatosis olgularý. Ankara Univ Vet Fak Derg, 52: 197-200.
    2. Avki, S., Turutoglu, H., Simsek, A., and Unsal A. (2004). Clinical and immunological effects of Newcastle disease virus (NDV) vaccine on bovine papillomatosis. Vet Immunol Immunopathol, 98: 9-16.
    3. Campo, M.S. (2002). Animal models of papillomavirus pathogenesis. Virus Res, 89: 249-61.
    4. Campo, M.S. (2006). Papillomavirus research: from natural history to vaccines and beyond. Caister Academic Press, Norfolk, England. pp. 373-83.
    5. Cihan, M., Özaydýn, Ý., Özba, B., and Baran, V. (2004). Clinical effects of levamisole in bovine papillomatosis. Indian Vet J, 81: 321-23.
    6. Cimtay, Ý., Biricik, H.S., Keskin, O., and Baba, Z.F. (2003). Sýðýr Papillomatozisinin saðaltýmýnda farklý aþýlama yöntemlerinin etkinliði üzerine karþýlaþtýrmalý araþtýrmalar. Turk J Vet Anim Sci, 27: 929-33.
    7. Dagalp, S.B., Dogan, F., Farzaný, T.A., Salar, S. and Bastan, A. (2017). The genetic diversity of bovine papillomaviruses (BPV) from different papillomatosis cases in dairy cows in Turkey. Arch Virol, 162: 1507-18.
    8. De Villiers, E.M., Fauquet, C., Broker, T.R., Bernard, H.U., and zur Hausen, H. (2004). Classification of papillomaviruses. Virology, 324: 17-27. 
    9. Durusoy, C. and Gozel Ulusoy, B. (2007). Dermatolojide bitkisel tedavi-Fitoterapi. Turk J Dermatol, 1: 47-50.
    10. Gross, G. and Von Krogh, G. (1997). Therapy of anogenital HPV-induced lesions. Clin Dermatol, 15: 457-70.
    11. Howley, P.M. and Lowy, D.R. (2007). Fields’ virology (5th Edn.). Wolters Kluwer Health and Lippincott Williams & Wilkins, Philadelphia, USA. pp. 2299-354.
    12. Hunt, E. (1984). Fibropapillomatosis and papillomatosis. Vet Clin North Am Large Anim Pract, 6: 163-67.
    13. Jarrett, W.F.H. (1985). Advances in Viral Oncology, (5th Edn.). Raven Press, New York, USA. pp. 83-102.
    14. Kahrs, R.F. (2001). Viral Diseases of Cattle, (2nd Edn.), Iowa State University Press, Ames, Iowa, USA. pp. 141-49.
    15. Kale, M. (2016). Sýðýrlarda siðillerden sorumlu olan virus: BPV. Ayrýntý Derg, 4: 17-21.
    16. Kýrmýzýgul, A.H., Gökçe, E., Sözmen, M., Yýldýrým, Y., Beytut E. (2010). Ývermektin’in sýðýr deri papillomatozisinde tedavi etkinliði. Kafkas Univ Vet Fak Derg, 16: 627-31.
    17. Knowles, G., O’Neil, B.W., and Campo, M.S. (1996). Phenotypic characterization of lymphocytes infiltrating regressing papillomas. J Virology, 70: 8451-58.
    18. Kutlubay, Z., Uzunçakmak, T.K., Engin, B., and Serdaroglu S. (2011). Ýmmunosupresif tedavi alan ve tedaviye dirençli kondilomata aküminata olgusunda kombinasyon tedavisi. Dermatoz, 2: 339-42.
    19. Lesnik, F., Bires, J., Suli, J., Korim, P., Posivak, J., Mattova, J., Svrcek, S., Sevcikova, Z., et al. (1999). Autovaccination and metabolic profiles at Bovine Papillomatosis. Slovensky Vet, 24: 290-94.
    20. Lindholm, I,. Murphy, J., O’Neil, B.W., Campo, M.S., and Jarrett, W.F. (1984). Papillomas of the teats and udder of cattle and their causal viruses. Vet Rec, 115: 574-77.
    21. Lunardi, Michele, Amauri Alcindo Alfieri, Rodrigo Alejandro Arellano Otonel, and Alice Fernandes Alfieri (2013). Bovine Papillomaviruses    -Taxonomy and Genetic. Vet Microbiol. 162:207-13.
    22. Marins, R.S.Q.S., Travassos, C.E.P.F., Pereira, S.R.F.G., Pereira, M.A.V.C., Vieira, L.F.P. (2006). Avaliação da eficácia da homeopatia e fitoterapia no tratamento da papilomatose cutânea bovina. R Bras Ci Vet, 13: 10-2.
    23. Murphy, F.A., Gibbs, E.P.J., Horzinek, M.C., Studdert, M.J. (1999). Veterinary Virology, (3rd Edn.). Academic Press, San Diego, USA. pp. 335–42.
    24. Nasir, L., Campo, M.S. (2008). Bovine papillomaviruses: their role in the aetiology of cutaneous tumours of bovids and equids. Vet Dermatol, 19: 243-54.
    25. Nicholls, P.K. and Stanley, M.A. (2000). The immunology of animal papillomaviruses. Vet Immunol Immunopathol. 73: 101-27.
    26. Ocal, H., Yýldýz, A., Apaydýn, A.M., and Kaygusuzoglu E. (2001). Ýnek ve düvelerde meme papillomatozisinin tedavisi ve etiyolojisi üzerine çalýþma. Fýrat Üniv Sag Bil Derg, 15: 23-6.
    27. Ogawa, T., Tomita, Y., Okada, M., Shinozaki, K., Kubonoya, H., Kaiho, I. and Shirasawa, H. (2004). Broad-spectrum detection of papillomaviruses in bovine teat papillomas and healthy teat skin. J Gen Virol, 85: 2191-97.
    28. Oswaldo, P, Alfredo, D.C., Néstor, F.P., and Alberto, M.S. (2011). Efficacy of the Newcastle disease vaccine on the control of bovine papillomatosis. Rev Inv Vet Perú, 22:388-393.
    29. Paksoy, Z., Gulescý, N., Kandemir, F.M., and Dincel G.C. (2015). Effectiveness of levamisole and tarantula cubensis extract in the treatment of teat papillomatosis of cows. Indian J Anim Res, 49: 704-8. 
    30. Pekcan, A.N. (2014). Majistral makaleler, (1. Basým). Ýrdesel Yayýncýlýk, Bahçelievler, Ankara. pp. 260-68.
    31. Rakesh, R., Ghuma, S.P.S., Bhatt, G.R., and Singh, R.S. (2013). Efficacy of autogenous vaccine and auto-hemotherapy in bovine cutaneous papillomatosis. Intas Polivet, 14: 411-14.
    32. Risvanli, A. and Kalkan, C. (2001). Ýneklerde meme papillomatozisi ile mastitis arasýndaki iliþki. Selcuk Univ Vet Bil Derg, 17: 143-47.
    33. Sarýkaya, E. and Iscimen A. (2010). Verruka vulgaris tedavisinde kriyoterapi ile %1 kantaridin, %5 podofilin ve %30 salisilik asit içeren topikal ürün (Canthacur-Ps®)’ün etkinliðinin karþýlaþtýrýlmasý. Dermatoz, 1: 121-24.
    34. Tan, M.T., Yýldýrým, Y., Sözmen, M., Daðalp, S.B., Yýlmaz, V., Kýrmýzýgül, A.H., and Gökçe E. (2012). A histopathological, immunohistochemical and molecular study of cutaneous bovine papillomatosis. Kafkas Univ Vet Fak Derg, 18: 739-44.
    35. Turk, N., Zupancýc, Z., Staresýna, V., Kovac, S., Babýc, T., Kreszýnger, M., Curýc, S., Barbýc, Lj., and Milas Z. (2005). Severe bovine papillomatosis: detection of bovine papillomavirus in tumour tissue and efficacy of treatment using autogenous vaccine and parammunity inducer. Vet Arhiv, 75: 391-97. 
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