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Current IssueEditorial BoardOnline First ArticlesArchive

Research Article

volume 54 issue 11 (november 2020) : 1343-1346,   Doi: 10.18805/ijar.B-894

Detection of genetic polymorphism of ANGPTL4 and POMC gene and correlation with growth traits in Guanling cattle

L
L.X. Xu
J
J. Liu
G
G.Z. He
L
L. Zhang
W
W.Z. Zhou
1Institute of Husbandry and Veterinary, Guizhou Province, Guiyang 550 005, China.
Cite article:- Xu L.X., Liu J., He G.Z., Zhang L., Zhou W.Z. (2018). Detection of genetic polymorphism of ANGPTL4 and POMC gene and correlation with growth traits in Guanling cattle. Indian Journal of Animal Research. 54(11): 1343-1346. doi: 10.18805/ijar.B-894.

ABSTRACT

In this study, the polymorphism of ANGPTL4 and POMCgene in 92 individuals of Guanling cattle was detected using DNA sequencing technology, and the correlation between polymorphic loci and growth traits of Guanling cattle was analyzed. Three mutation sites including 387 C > T, 418 C > T and 449 A > T were detected in ANGPTL4 gene. Five mutation sites including 138 C > T, 430 C > T, 644 C > T, 668C > T, and 693A >G were detected in POMC gene. The results showed that three polymorphic mutation sites of ANGPTL4 gene in the Hardy - Weinberg disequilibrium (HWE) (P < 0.05), POMC gene in 430 C > T mutation the mutation in HWE equilibrium (P > 0.05), multi peptide information content of ANGPTL4, POMC gene polymorphisms (PIC) showed moderate polymorphism. The correlation analysis results showed that the ANGPTL4 gene 418 C > T mutation genotypes and Guanling yellow body height, body length, chest circumference, abdominal circumference showed significant differences (P < 0.01), 449 A>T mutation genotypes and Guanling yellow body height showed a significant difference (P < 0.05) and chest circumference, abdominal circumference showed significant differences (P < 0.01). POMC gene 644 C > T and 668C > T mutation loci and body length of Guanling yellow cattle showed significant difference (P < 0.05).

REFERENCES

  1. Aronsson, L., Huang, Y., Parini, P., Marion, K.A., Hakansson, J., Gustafsson, J.A., Pettersson, S., Arulamurugesan, V., Rafter, J.(2010). Decreased fat storage by Lactobacillus paracasei is associated with increased levels of angiopoietin-like 4 protein (ANGPTL4). PLOS One, 5(9): e13087.
  2. Buchanan, F.C., Thue, T.D., Yu, P., Winkelman-Sim, D.C.(2005).Single nucleotide polymorphisms in the corticotrophin-releasing hormone and pro-opiomelancortin genes are association with growth and carcass yield in beef cattle [J]. Anim Genet, 36(2):127-131.
  3. Kaddatz, K., Adhikary, T., Finkernagel, F.(2010).Transcriptional profiling indentifies functional interactions of TGF beta and PPAP beta / delta signaling : synergistic induction of ANGPTL4 transcription. J Biol Chem, 258(38): 29469-29479.
  4. Koster, A., Chao, Y.B., Mosior, M., Ford, A., Patricia, A., Whitt, G.D., John, E.H., Deshan, L., Qiu, Y.B., et al (2005).Transgenic angiopoietin-like (angptl)4 overexpression and targeted of ANGPTL4 and ANGPTL3: regulation of triglyceride metabolism Endocrinology, 146(11):4943-4950.
  5. Lichtenstein, L., Berbee, J.F., VanDijk, S.J. (2007).ANGPTL4 upregulates cholesterol synthesis in liver via inhibition of LPL and HL-    dependent hepatic cholesterol uptake. Arterioscler Thromb Vasc Biol, 27(11):2420-2427.
  6. Ma, S.H., Li, Y.N., He, H.Y., Wang, H.D., Yang, L., Dong, C.S. (2015). POMC Expression and localization in sheep skin with different coat color. Scientia Agricultura Sinica, 48(9):1818-1824.
  7. Nakanishi, S., Inoue, A., Kita, T., Lnoue, A., Nakamura, M., Annie, C.Y., Stanley, N.C., Numa, S.A. (1979). Nucleotide sequence of cloned cDNA for bovine corticotrophin-beta-lipotropin precursor. Nature, 278(5703): 423-427.
  8. National Livestock and Poultry Genetic Resources Committee. (2011). Chinese livestock and poultry genetic resources (The cattle breed records). China Agricultural Publishing House.
  9. Thue, T.D. and Buchanan, F.C. (2003). Linkage mapping of POMC to bovine chromosome 11. Anim Genet, 24(2):146-160. 
  10. Zhu H, Li J, Qin W, et al. (2008).Cloning of a novel gene, ANGPTL4 and the functiona study in angiogenesis . Natl Med J China, 82(2): 94-99.
  11. Zhang, C.L., Wang, Y.H., Chen, H., Lei, C.H., Fang, X.T., Wang, J.Q., Ma, G.B., Niu, H., Xiao, J.(2009) The polymorphism of bovine POMC gene and its association with the growth traits of Nanyang cattle. Hereditas(Beijing), 31(12):1221-1225
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Indian Journal of Animal Research
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    Research Article

    volume 54 issue 11 (november 2020) : 1343-1346,   Doi: 10.18805/ijar.B-894

    Detection of genetic polymorphism of ANGPTL4 and POMC gene and correlation with growth traits in Guanling cattle

    L
    L.X. Xu
    J
    J. Liu
    G
    G.Z. He
    L
    L. Zhang
    W
    W.Z. Zhou
    1Institute of Husbandry and Veterinary, Guizhou Province, Guiyang 550 005, China.
    Cite article:- Xu L.X., Liu J., He G.Z., Zhang L., Zhou W.Z. (2018). Detection of genetic polymorphism of ANGPTL4 and POMC gene and correlation with growth traits in Guanling cattle. Indian Journal of Animal Research. 54(11): 1343-1346. doi: 10.18805/ijar.B-894.

    ABSTRACT

    In this study, the polymorphism of ANGPTL4 and POMCgene in 92 individuals of Guanling cattle was detected using DNA sequencing technology, and the correlation between polymorphic loci and growth traits of Guanling cattle was analyzed. Three mutation sites including 387 C > T, 418 C > T and 449 A > T were detected in ANGPTL4 gene. Five mutation sites including 138 C > T, 430 C > T, 644 C > T, 668C > T, and 693A >G were detected in POMC gene. The results showed that three polymorphic mutation sites of ANGPTL4 gene in the Hardy - Weinberg disequilibrium (HWE) (P < 0.05), POMC gene in 430 C > T mutation the mutation in HWE equilibrium (P > 0.05), multi peptide information content of ANGPTL4, POMC gene polymorphisms (PIC) showed moderate polymorphism. The correlation analysis results showed that the ANGPTL4 gene 418 C > T mutation genotypes and Guanling yellow body height, body length, chest circumference, abdominal circumference showed significant differences (P < 0.01), 449 A>T mutation genotypes and Guanling yellow body height showed a significant difference (P < 0.05) and chest circumference, abdominal circumference showed significant differences (P < 0.01). POMC gene 644 C > T and 668C > T mutation loci and body length of Guanling yellow cattle showed significant difference (P < 0.05).

    REFERENCES

    1. Aronsson, L., Huang, Y., Parini, P., Marion, K.A., Hakansson, J., Gustafsson, J.A., Pettersson, S., Arulamurugesan, V., Rafter, J.(2010). Decreased fat storage by Lactobacillus paracasei is associated with increased levels of angiopoietin-like 4 protein (ANGPTL4). PLOS One, 5(9): e13087.
    2. Buchanan, F.C., Thue, T.D., Yu, P., Winkelman-Sim, D.C.(2005).Single nucleotide polymorphisms in the corticotrophin-releasing hormone and pro-opiomelancortin genes are association with growth and carcass yield in beef cattle [J]. Anim Genet, 36(2):127-131.
    3. Kaddatz, K., Adhikary, T., Finkernagel, F.(2010).Transcriptional profiling indentifies functional interactions of TGF beta and PPAP beta / delta signaling : synergistic induction of ANGPTL4 transcription. J Biol Chem, 258(38): 29469-29479.
    4. Koster, A., Chao, Y.B., Mosior, M., Ford, A., Patricia, A., Whitt, G.D., John, E.H., Deshan, L., Qiu, Y.B., et al (2005).Transgenic angiopoietin-like (angptl)4 overexpression and targeted of ANGPTL4 and ANGPTL3: regulation of triglyceride metabolism Endocrinology, 146(11):4943-4950.
    5. Lichtenstein, L., Berbee, J.F., VanDijk, S.J. (2007).ANGPTL4 upregulates cholesterol synthesis in liver via inhibition of LPL and HL-    dependent hepatic cholesterol uptake. Arterioscler Thromb Vasc Biol, 27(11):2420-2427.
    6. Ma, S.H., Li, Y.N., He, H.Y., Wang, H.D., Yang, L., Dong, C.S. (2015). POMC Expression and localization in sheep skin with different coat color. Scientia Agricultura Sinica, 48(9):1818-1824.
    7. Nakanishi, S., Inoue, A., Kita, T., Lnoue, A., Nakamura, M., Annie, C.Y., Stanley, N.C., Numa, S.A. (1979). Nucleotide sequence of cloned cDNA for bovine corticotrophin-beta-lipotropin precursor. Nature, 278(5703): 423-427.
    8. National Livestock and Poultry Genetic Resources Committee. (2011). Chinese livestock and poultry genetic resources (The cattle breed records). China Agricultural Publishing House.
    9. Thue, T.D. and Buchanan, F.C. (2003). Linkage mapping of POMC to bovine chromosome 11. Anim Genet, 24(2):146-160. 
    10. Zhu H, Li J, Qin W, et al. (2008).Cloning of a novel gene, ANGPTL4 and the functiona study in angiogenesis . Natl Med J China, 82(2): 94-99.
    11. Zhang, C.L., Wang, Y.H., Chen, H., Lei, C.H., Fang, X.T., Wang, J.Q., Ma, G.B., Niu, H., Xiao, J.(2009) The polymorphism of bovine POMC gene and its association with the growth traits of Nanyang cattle. Hereditas(Beijing), 31(12):1221-1225
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