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Current IssueEditorial BoardOnline First ArticlesArchive

Research Article

volume 54 issue 8 (august 2020) : 953-956,   Doi: 10.18805/ijar.B-831

Influence of obesity on the tolerance of abdominal hypertension in rats-some mechanical aspects

V
V.I. Turiyski
I
I.V. Dimitrov
R
R.G. Ardasheva
P
P.G. Vassilev
1Department of Chemistry and Biochemistry, Faculty of Pharmacy, Medical University of Plovdiv, 15A Vassil Aprilov blvd., Plovdiv 4000, Bulgaria.
Cite article:- Turiyski V.I., Dimitrov I.V., Ardasheva R.G., Vassilev P.G. (2018). Influence of obesity on the tolerance of abdominal hypertension in rats-some mechanical aspects. Indian Journal of Animal Research. 54(8): 953-956. doi: 10.18805/ijar.B-831.

ABSTRACT

The present study investigates the relations between obesity and survival during intra-abdominal hypertension (IAH) in diet induced obesity Wistar rats. The animals from model group were fed with high-fat diet for 45 days. Intra-abdominal pressure in both groups (control and model) was elevated by manual system for air insufflations. The pressure was of value (25mmHg) corresponding to the typical values observed in abdominal compartment syndrome. Quantification of the serum levels of serum amyloid A was carried out after deflation. The results interpretation was made in correlation with clinical observations in patients with proved cardiovascular diseases caused by obesity, as well as with patients to whom surgery had caused an increased intra-abdominal pressure. Experimental observations have shown increased survival in diet induced obesity rats with IAH compared to control rats with IAH. Increased resistance to IAH is due to changes in the structure and in the mechanical characteristics of the abdominal wall, following obesity.

REFERENCES

  1. Andreollo, N., Santos, E., Araujo M. and Lopes L. (2012). Rat’s age versus human’s age: what is the relationship. Arq Bras Cir Dig, 25(1): 49-51.
  2. Benoist, S., Panis, Y., Alves, A. and Valleur, P. (2000). Impact of obesity on surgical outcomes after colorectal resection. The American Journal of surgery, 179: 275-81.
  3. Bokey, E.L., Chapius, P.H. and Fung, C., et al. (1995). Postoperative morbidity and mortality following resection of the colon and rectum for cancer. Dis Colon Rectum, 38: 480-87.
  4. Boustany, C., Bharadwaj, K., Daugherty, A., Brown, D., Randall, D. and Cassis, L. (2004). Activation of the systemic and adipose renin-angiotensin system in rats with diet-induced obesity and hypertension. Am J Physiol Integr Comp Physiol, 287: 943-49.
  5. Chalkias, A. and Xanthos, T. (2012). Intra-abdominal hypertension: a potent silent killer of cardiac arrest survivors. The American Journal of Emergency Medicine, 30(3): 502-504.
  6. Cheatham, M., White, M. and Sagraves, S. et al. (2000). Abdominal perfusion pressure: a superior parameter in the assessment of intra-abdominal hypertension. J Trauma, 49(4):621-6.
  7. Choban, P.S., Flankbaum, L. (1997). The impact of obesity on surgical outcomes: a revew. J Am Coll Surg, 185:593-603.
  8. Chun-yin Geng, Min Zhang*, Cheng-yun Li, Ying-hai Jin, Chang-guo Yan and Yi Jin (2016). Effectiveness of medium-chain fatty acids on feed intake and weight gain in animal: Depending on balance. Indian J. Anim. Res., 50 (6): 885-892. 
  9. Deenichin, G., Kristev, A., Molov, V. and Turiiski, V. (2010). Effect of elevated intra-abdominal pressure on the contractile activity and reactivity of smooth muscle tissue from rat gastrointestinal tract to galantamine and drotaverine (No-Spa). Folia Medica, 52(3): 31-36.
  10. Dimitrov, I., Kamenov, V., Argirova, M. and Angelova, P. (2015). Changed serum amyloid-A concentration in blood serum, liver and adipose tissue in obesity. Med Post, 6: 8-11.
  11. Drenick, E., J. (1981). Risk of obesity and surgical indications. Int J Obes, 5: 387-98.
  12. Dumont, L., Mattys, M., Mardirisoff, C., Picard, V., Alle, J. L. and Massaut, J. (1997). Hemodynamic changes during laparoscopic gastroplasty in morbidly obese patients. Obesity Surgery. 7: 326-31.
  13. Ferrannini, E., (1995). Physiological and metabolic consequences of obesity. Metabolism, 44: 15-17.
  14. Guojun Zhang, Xia Wang, Huanhuan Feng, Aiping Sun, Shuming Sun, Lili Yu, Xiangfeng Song and Hui Wang (2017). Immune profiles of T lymphocyte subsets in adipose tissue of obese mouse induced by high-fat diet. Indian J. Anim. Res. 51 (5): 868-874
  15. Rezende-Neto, J., Moore, E., Masuno, T., Moore, P., Johnson, J., Sheppard, F., Cunha-Melo, J. and Silliman, C., (2003). The abdominal compartment syndrome as a second insult during systemic neutrophil priming provokes multiple organ injury. Shock, 20(4): 303-8.
  16. Schachtrupp, A., Jansen, M., Bertram, P., Kuhlen, R. and Schumpelick, V. (2006). Abdominal compartment syndrome: significance, diagnosis and treatment. Anaesthesist, 55(6): 660-7.
  17. Schein, M., Wittmann, D. and Aprahamian, C. et al. (1995). The abdominal compartment syndrome: the physiological and clinical consequences of elevated intra-abdominal pressure. J Am CollSurg, 180: 745-53.
  18. Sengupta, P. (2011). A scientific review of age determination for a laboratory rat: how old is it in comparison with human age. Biomedicine International, 2(2): 81-89. 
  19. Sood, D.R., Deka, S.C., Rajat Sood and Alka Sharma (2014). Intestinal absorption of nutrients using rats fed different diets. Asian J. Dairy & Food Res, 33(4): 311-314.
  20. Uhlar, C.M. and Whitehead, A.S. (1999). Serum amyloid A, the major vertebrate acute phase reactant. European Journal of Biochemistry, 265: 501–23. 
  21. Woods, S., Seeley, R., Rushing, P., D’alessio, D. and Tso, P. (2003). A controlled high-fat diet induces an obese syndrome in rats. The Journal of Nutrition, 133(4): 1081-87.
  22. Xing, L., Culberson, E., Wen, Y., Robson, M. and Franz, M. (2011). Impaired laparotomy wound healing in obese rats. Obessurg, 21: 1937-46.
  23. Deenichin, G., Dimov, R., Deenichina, I. (2013). Intra-abdominal hypertension and abdominal compartment syndrome in surgery. Lac Book. Plovdiv.
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Indian Journal of Animal Research
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    Research Article

    volume 54 issue 8 (august 2020) : 953-956,   Doi: 10.18805/ijar.B-831

    Influence of obesity on the tolerance of abdominal hypertension in rats-some mechanical aspects

    V
    V.I. Turiyski
    I
    I.V. Dimitrov
    R
    R.G. Ardasheva
    P
    P.G. Vassilev
    1Department of Chemistry and Biochemistry, Faculty of Pharmacy, Medical University of Plovdiv, 15A Vassil Aprilov blvd., Plovdiv 4000, Bulgaria.
    Cite article:- Turiyski V.I., Dimitrov I.V., Ardasheva R.G., Vassilev P.G. (2018). Influence of obesity on the tolerance of abdominal hypertension in rats-some mechanical aspects. Indian Journal of Animal Research. 54(8): 953-956. doi: 10.18805/ijar.B-831.

    ABSTRACT

    The present study investigates the relations between obesity and survival during intra-abdominal hypertension (IAH) in diet induced obesity Wistar rats. The animals from model group were fed with high-fat diet for 45 days. Intra-abdominal pressure in both groups (control and model) was elevated by manual system for air insufflations. The pressure was of value (25mmHg) corresponding to the typical values observed in abdominal compartment syndrome. Quantification of the serum levels of serum amyloid A was carried out after deflation. The results interpretation was made in correlation with clinical observations in patients with proved cardiovascular diseases caused by obesity, as well as with patients to whom surgery had caused an increased intra-abdominal pressure. Experimental observations have shown increased survival in diet induced obesity rats with IAH compared to control rats with IAH. Increased resistance to IAH is due to changes in the structure and in the mechanical characteristics of the abdominal wall, following obesity.

    REFERENCES

    1. Andreollo, N., Santos, E., Araujo M. and Lopes L. (2012). Rat’s age versus human’s age: what is the relationship. Arq Bras Cir Dig, 25(1): 49-51.
    2. Benoist, S., Panis, Y., Alves, A. and Valleur, P. (2000). Impact of obesity on surgical outcomes after colorectal resection. The American Journal of surgery, 179: 275-81.
    3. Bokey, E.L., Chapius, P.H. and Fung, C., et al. (1995). Postoperative morbidity and mortality following resection of the colon and rectum for cancer. Dis Colon Rectum, 38: 480-87.
    4. Boustany, C., Bharadwaj, K., Daugherty, A., Brown, D., Randall, D. and Cassis, L. (2004). Activation of the systemic and adipose renin-angiotensin system in rats with diet-induced obesity and hypertension. Am J Physiol Integr Comp Physiol, 287: 943-49.
    5. Chalkias, A. and Xanthos, T. (2012). Intra-abdominal hypertension: a potent silent killer of cardiac arrest survivors. The American Journal of Emergency Medicine, 30(3): 502-504.
    6. Cheatham, M., White, M. and Sagraves, S. et al. (2000). Abdominal perfusion pressure: a superior parameter in the assessment of intra-abdominal hypertension. J Trauma, 49(4):621-6.
    7. Choban, P.S., Flankbaum, L. (1997). The impact of obesity on surgical outcomes: a revew. J Am Coll Surg, 185:593-603.
    8. Chun-yin Geng, Min Zhang*, Cheng-yun Li, Ying-hai Jin, Chang-guo Yan and Yi Jin (2016). Effectiveness of medium-chain fatty acids on feed intake and weight gain in animal: Depending on balance. Indian J. Anim. Res., 50 (6): 885-892. 
    9. Deenichin, G., Kristev, A., Molov, V. and Turiiski, V. (2010). Effect of elevated intra-abdominal pressure on the contractile activity and reactivity of smooth muscle tissue from rat gastrointestinal tract to galantamine and drotaverine (No-Spa). Folia Medica, 52(3): 31-36.
    10. Dimitrov, I., Kamenov, V., Argirova, M. and Angelova, P. (2015). Changed serum amyloid-A concentration in blood serum, liver and adipose tissue in obesity. Med Post, 6: 8-11.
    11. Drenick, E., J. (1981). Risk of obesity and surgical indications. Int J Obes, 5: 387-98.
    12. Dumont, L., Mattys, M., Mardirisoff, C., Picard, V., Alle, J. L. and Massaut, J. (1997). Hemodynamic changes during laparoscopic gastroplasty in morbidly obese patients. Obesity Surgery. 7: 326-31.
    13. Ferrannini, E., (1995). Physiological and metabolic consequences of obesity. Metabolism, 44: 15-17.
    14. Guojun Zhang, Xia Wang, Huanhuan Feng, Aiping Sun, Shuming Sun, Lili Yu, Xiangfeng Song and Hui Wang (2017). Immune profiles of T lymphocyte subsets in adipose tissue of obese mouse induced by high-fat diet. Indian J. Anim. Res. 51 (5): 868-874
    15. Rezende-Neto, J., Moore, E., Masuno, T., Moore, P., Johnson, J., Sheppard, F., Cunha-Melo, J. and Silliman, C., (2003). The abdominal compartment syndrome as a second insult during systemic neutrophil priming provokes multiple organ injury. Shock, 20(4): 303-8.
    16. Schachtrupp, A., Jansen, M., Bertram, P., Kuhlen, R. and Schumpelick, V. (2006). Abdominal compartment syndrome: significance, diagnosis and treatment. Anaesthesist, 55(6): 660-7.
    17. Schein, M., Wittmann, D. and Aprahamian, C. et al. (1995). The abdominal compartment syndrome: the physiological and clinical consequences of elevated intra-abdominal pressure. J Am CollSurg, 180: 745-53.
    18. Sengupta, P. (2011). A scientific review of age determination for a laboratory rat: how old is it in comparison with human age. Biomedicine International, 2(2): 81-89. 
    19. Sood, D.R., Deka, S.C., Rajat Sood and Alka Sharma (2014). Intestinal absorption of nutrients using rats fed different diets. Asian J. Dairy & Food Res, 33(4): 311-314.
    20. Uhlar, C.M. and Whitehead, A.S. (1999). Serum amyloid A, the major vertebrate acute phase reactant. European Journal of Biochemistry, 265: 501–23. 
    21. Woods, S., Seeley, R., Rushing, P., D’alessio, D. and Tso, P. (2003). A controlled high-fat diet induces an obese syndrome in rats. The Journal of Nutrition, 133(4): 1081-87.
    22. Xing, L., Culberson, E., Wen, Y., Robson, M. and Franz, M. (2011). Impaired laparotomy wound healing in obese rats. Obessurg, 21: 1937-46.
    23. Deenichin, G., Dimov, R., Deenichina, I. (2013). Intra-abdominal hypertension and abdominal compartment syndrome in surgery. Lac Book. Plovdiv.
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