Oxidant-antioxidant status in bovine ephemeral fever

DOI: 10.18805/ijar.B-806    | Article Id: B-806 | Page : 408-411
Citation :- Oxidant-antioxidant status in bovine ephemeral fever.Indian Journal Of Animal Research.2019.(53):408-411
Güzin Camkerten, Ilker Camkerten, Hikmet Ün, Burcu Menekse Balkan, Hüdai Ipek, Abdullah Taskýn and Tekin Sahin oguzalperen@hotmail.com
Address : Aksaray University, Aksaray Technical Sciences Vocational School, Aksaray-Turkey.
Submitted Date : 1-08-2017
Accepted Date : 10-03-2018


Bovine ephemeral fever is an economically important viral disease of cattle and water buffalo. In this study, it was aimed to investigate oxidant-antioxidant status in cattle with ephemeral fever disease. A total of 32 Holsteins aged between 12 - 18 months kept under same care and feeding conditions were used. Activities of GPx, CAT and SOD and the levels of TAC, TOS, CP, SH and MDA were measured. Levels of CP and TAC were significantly (p<0,05) higher in IG compared to HG. Levels of SH and CP were significantly (p<0,05) lower and CAT activity were significantly (p<0,05) higher in RG compared with IG. Levels of SH and activity of GPx and were significantly (p<0,05) lower and CAT levels were significantly (p<0,05) higher in RG compared with HG. The results or this experiment suggest a possible relationship between oxidant/antioxidant balance in favor of antioxidants in ephemeral fever in cattle.


Antioxidant Bovine ephemeral fever Oxidative stress Oxidant.


  1. Aebi, H.E. (1983). Catalase In: Methods of Enzymatic Analysis. (H.U.Bermeyer (Hrsy))Verlag Chemie; Weinheim, Bd. III, pp 273-286.
  2. Akkus, I. (1995). Free Radicals and Phsyopatologic Effects. Mimoza Press, Konya
  3. Ay, M., Gürbilek, M., Vatansev, H. (1998). Akut faz proteinleri. Genel Týp Dergisi 8(3): 125-132.
  4. Cemek, M., Caksen, H., Bayiroglu, F., Cemek, F., Dede, S. (2006). Oxidative stress and enzymic-non-enzymic antioxidant responses in children with acute pneumonia. Cell Biochem Funct, 24: 269-273.
  5. Çelikezen, F.Ç., Ertekin, A. (2003). Investigation of the levels of lipid peroxidation (MDA), antioxidant substances (glutathione,    ceruloplasmin) and antioxidant vitamins (B-carotene and retinol) in the experimental pulmoner fibrosis in rats. YYÜ Vet Fak Derg, 2: 17-20.
  6. Dündar, Y., Aslan, R. (2000). Oxidants and Antioxidants in Medicine. Afyon Kocatepe Üniversitesi Press, Ankara.
  7. Ellman, G.L. (1959). Tissue sulfhydryl groups. Arch Biochem Biophys, 82: 70–77.
  8. Erbay, A., Erbay, A.R., Baykam, N., Eren, S., Dokuzouz, B. (2003). Oxidative stress in measles. Turkish J Infect, 17: 381–383.
  9. Erel, O. (2004). A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem, 37: 112–119.
  10. Erel, O. (2005). A new automated colorimetric method for measuring total oxidant status. Clin Biochem, 38: 1103–1111.
  11. Ghisellia, A., Serafinia, M., Natellaa, F., Scaccinia, C. (2000). Total antioxidant capacity as a tool to assess redox status: critical view and experimental data. Free Radical Biology and Medicine, 29 (11): 1106–1114.
  12. Hu, M.L., Louie, S., Cross, C.E., Motchnik, P., Halliwell, B. (1993). Antioxidant protection against hydrochlorous acid in human plasma. J Lab Clin Med, 121: 257–262.
  13. Iþýk, A., Koca, S.S., Ustundag, B., Selek, S. (2007). Decreased total antioxidant response and increased oxidative stress in behcet’s diseases. Tohoku J Exp Med, 212: 133-141.
  14. Ivanov, A.V., Bartosch, B., Isaguliants, M.G. (2017). Oxidative Stress in Infection and Consequent Disease. Oxidative Medicine and Cellular Longevit. doi:10.1155/2017/3496043.
  15. Kahraman, A., Çakar, H., Vurmaz, A., Gürsoy, F., Koçak, S., Serteser, M. (2003). Effect of heavy exercise on oxidative stress. Medical J Kocatepe, 2: 33-38.
  16. Kosecik, M., Erel, O., Sevinc, E., Selek, S. (2005). Increased oxidative stress in children exposed to passive smoking. Int J Cardiol, 100: 61–64.
  17. Lobanova, E.M. and Tahanovich, A.D. (2006). Hydrogen peroxide metabolism in alveolar macrophages after exposure to hypoxia and heat. Physiol. Res, 55: 569-575.
  18. Manat, T.D., Chaudhary, S.S., Singh, V.K., Patel, S.B. and Tyagi. K.K. (2017). Oxidative stress profile during postpartum period in `    Surti goats. Indian J. Anim. Res., 51 (5): 837-840.
  19. McKeown, M.J., Hall, N.D., Corvalan, J.R. (1984). Defective monocyte accessory function due to surface sulphydryl (SH) oxidation in rheumatoid arthritis. Clin Exp Immunol, 56: 607–613.
  20. Nandi, S., Negi, B.S. (1999). Bovine ephemeral fever: a review. Comparative Immunology Microbiol Infect Dis, 22: 81-91.
  21. Nath R., Prasad R.L. and Sarma S. (2014). Oxidative stress biomarkers in cross-bred cows affected with foot and mouth disease. Indian J. Anim. Res., 48 (6): 628-632.
  22. Paglie D.E., Valantine, W.N. (1967). Studies on qualitative and quantative characterization of erythrocyte glutathion peroxidase. J Lab Clin Met, 70: 158-169.
  23. Peterhans, E. (1997). Oxidants and antioxidants in viral diseases: disease mechanisms and metabolic regulation. J Nutr, 127: 962-965.
  24. Sangha, G.K. and Kalra. S. (2016). Evaluation of oxidative stress in rats (Rattus rattus) inhabiting Bathinda region of Punjab, India. Indian J. Anim. Res., 50 (2): 168-174.
  25. Skotnicka, E., Baranowska-Bosiacka, I., Dudziñska, W., Susk, M. (2010). Purine turnover metabolites and selected antioxidants in blood of goats during the periparturient period. Acta Vet Brno, 79: 571-579.
  26. Sun, Y., Oberley, L.W., Li. Y., (1988). A simple for clinical assay of superoxide dismutase. Clin Chem, 34: 497-500.
  27. Tietz, W.N. (1987). Measurement of plasma hemoglobin. Fundamental of Clinical Chemistry Saunders Company pp 805-806.
  28. Uren, M.F. (1989). Bovine ephemeral fever. Aust Vet J, 66: 233-236.
  29. Walker, P.J. (2005). Bovine ephemeral fever in Australia and the world. Curr Top Microbiol Immunol, 292: 57-80
  30. Winterbourn, C.C., Hawkins, R.E., Brain, M., Carrel, W. (1975). The estimation of red cell superoxide dismutase activity. J Lab Clin Me, 55: 337–341.
  31. Yoshika, T., Kawada, K., Shimada, T. (1979). Lipid peroxidation in maternal and cord blood protective mechanism against active-    oxygen toxicity in blood. Am J Obstet Gynecol, 135: 372-376. 

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