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Current IssueEditorial BoardOnline First ArticlesArchive

Short Communication

volume 53 issue 2 (february 2019) : 236-238,   Doi: 10.18805/ijar.B-784

Effects of methionine deficiency on the number of IgA+ B cells and immunoglobulins in ileum of broiler chicken

T
Tao Ruan
L
Lingjun Li
B
Bangyuan Wu
1College of Life Science, China West Normal University, Sichuan, Nanchong-637 009, PR China
Cite article:- Ruan Tao, Li Lingjun, Wu Bangyuan (2018). Effects of methionine deficiency on the number of IgA+ B cells and immunoglobulins in ileum of broiler chicken. Indian Journal of Animal Research. 53(2): 236-238. doi: 10.18805/ijar.B-784.

ABSTRACT

Effects of methionine (Met) deficiency on IgA+ B cells and immunoglobulins (Igs) in the ileum of Cobb broiler were observed by the methods of immunohistochemistry and enzyme-linked immunosorbent assay (ELISA) ranging from 1 to 42 days of age. Results showed a significant decrease of the number of IgA+ B cells and the amount of Igs in Met deficient group in comparison with control group. In conclusion, dietary Met deficiency exerts significant effect on the humoral immune function of the intestinal mucosa. This study would provide new experimental information for future studies in the effects of Met on the intestinal functions of human or other animals.

REFERENCES

  1. Benatar, T., Tkalec, L., Ratcliffe, M.J. (1992). Stochastic rearrangement of immunoglobulin variable-region genes in chicken B-cell development. Proceedings of the National Academy of Sciences, 89: 7615-7619. 
  2. Brosnan, J.T. and Brosnan, M.E. (2006). The sulfur-containing amino acids: an overview. The Journal of Nutrition, 136: 1636S-1640S.    Hirano, T., Yasukawa, K., Harada, H., Taga, T., Watanabe, Y., Matsuda, T., Kashiwamura, S.I., Nakajima, K., et al.(1986). Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature, 324: 73-76.    Horvat, S., Mlinaric-majerski, K., Glavas-obrovac, L., Jakas, A., Veljkovic, J., Marczi, S., Kragol, G et al. (2006). Tumor-cell-targeted methionine-enkephalin analogues containing unnatural amino acids: design, synthesis, and in vitro antitumor activity. Journal of Medicinal Chemistry, 49: 3136-3142. 
  3. Kapoor, K., and Singh, O. (2017). Histoenzymic distribution of phosphatases, dehydrogenases and esterases in ileal peyer’s patches of neonatal buffalo calves. Indian Journal of Animal Research, 51: 670-675.
  4. Khan, N., Sheikh, F. A., Rana, M. S., Kant, K., Kewalramani, N. (2012). Effect of supplementation of protected methionine, lysine and choline on performance of lactating cows - a review. Agricultural Reviews, 33: 322-332.
  5. Li, C., Li, Z., Sletten, E., Arnesano, F., Losacco, M., Natile, G., Liu, Y. (2009). Methionine can favor DNA Platination by trans-    Coordinated Platinum Antitumor Drugs. Angewandte Chemie, 121: 8497-8500. 
  6. Li, G.W., Burkhardt, D., Gross, C., Weissman, J.S. (2014). Quantifying absolute protein synthesis rates reveals principles underlying allocation of cellular resources. Cell, 157: 624-635. 
  7. Liu, J., Cui, H.M., Peng, X., Fang, J., Zuo, Z.C., Deng, J.L., Wang, H.S., Wu, B.Y., Deng, Y.X., Wang, K.P. (2013). Decreased IgA+ B cells population and IgA, IgG, IgM contents of the cecal tonsil induced by dietary high fluorine in broilers. International Journal of Environmental Research & Public Health, 10: 1775-1785.
  8. Mirzaaghatabar, F., Saki, A.A., Zamani, P., Aliarabi, H., Hemati Matin, H.R. (2011). Effect of different levels of diet methionine and metabolisable energy on broiler performance and immune system. Food & Agricultural Immunology, 22: 93-103. 
  9. Oz, H.S., Chen, T.S., Neuman, M. (2008). Methionine deficiency and hepatic injury in a dietary steatohepatitis model. Digestive Diseases and Sciences, 53: 767-776. 
  10. Perdigon, G., Alvarez, S., Rachid, M., Aguero, G., Gobbato, N. (1995). Immune system stimulation by probiotics. Journal of Dairy Science, 78: 1597-1606. 
  11. Perez-carbajal, C., Caldwell, D., Farnell, M., Stringfellow, K., Pohl, S., Casco, G., Pro-martinez, A., Ruiz-feria, C.A. (2010). Immune response of broiler chickens fed different levels of arginine and vitamin E to a coccidiosis vaccine and Eimeria challenge. Poultry Science, 89: 1870-1877. 
  12. Rama, Rao, S.V., Prahara, J.N.K., Panda, A.K., Reddy, M.R. (2003). Interaction between genotype and dietary concentrations of methionine for immune function in commercial broilers. British Poultry Science, 44: 104-112. 
  13. Sanchez-roman, I., Gomez, A., Gomez, J., Suarez, H., Sanchez, C., Naudi, A., Ayala, V., et al. (2011). Forty percent methionine restriction lowers DNA methylation, complex I ROS generation, and oxidative damage to mtDNA and mitochondrial proteins in rat heart. Journal of Bioenergetics and Biomembranes, 43: 699-708. 
  14. Schroeder, H.W. and Cavacini, L. (2010). Structure and function of immunoglobulins. Journal of Allergy and Clinical Immunology, 125: S41-S52. 
  15. Stadtman, E.R., Moskovitz, J., Berlett, B.S. and Levine, R.L. (2002). Cyclic oxidation and reduction of protein methionine residues is an important antioxidant mechanism. Molecular and Cellular Biochemistry, 234: 3-9.
  16. Tesseraud, S., Everaert, N., Ezzine, S.B., Collin, A., Berri, S.M.C. (2011). Manipulating tissue metabolism by amino acids. World’s Poultry Science Journal, 67: 243-252. 
  17. Waterland, R.A. (2006). Assessing the effects of high methionine intake on DNA methylation. The Journal of Nutrition, 136: 1706S-1710S.    Wu, B., Cui, H., Peng, X., Fang, J., Cui, W., Liu, X.D. (2013). Pathology of bursae of Fabricius in methionine-deficient broiler chickens. Nutrients, 5: 877-886. 
  18. Yang, L.J., Huo, Z.C., Hou, J.C., Cheng, P., Sun, S.L. (2004). The comparision of the effect of the solid methionine and liquid methionine on the chicken biological titer. Chinese Journal of Animal Science, 40: 16-18. 
  19. Yen, C.L., Mar, M.H., Craciunescu, C.N., Edwards, L.J., Zeisel, S.H. (2002). Deficiency in methionine, tryptophan, isoleucine, or choline induces apoptosis in cultured cells. The Journal of Nutrition, 132: 1840-1847. 
  20. Yogi, R.K., Das, A., Kullu, S.S., Saini, M., Garg A.K., Sharma, A.K. (2016). Effect of supplementation of lutein and DL-methionine on certain haemato-biochemical parameters and serum concentration of corticosteronein captive Golden pheasants (Chrysolophus pictus). Indian Journal of Animal Research, DOI10.18805/ijar.vOiOF.3800
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Indian Journal of Animal Research
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    Short Communication

    volume 53 issue 2 (february 2019) : 236-238,   Doi: 10.18805/ijar.B-784

    Effects of methionine deficiency on the number of IgA+ B cells and immunoglobulins in ileum of broiler chicken

    T
    Tao Ruan
    L
    Lingjun Li
    B
    Bangyuan Wu
    1College of Life Science, China West Normal University, Sichuan, Nanchong-637 009, PR China
    Cite article:- Ruan Tao, Li Lingjun, Wu Bangyuan (2018). Effects of methionine deficiency on the number of IgA+ B cells and immunoglobulins in ileum of broiler chicken. Indian Journal of Animal Research. 53(2): 236-238. doi: 10.18805/ijar.B-784.

    ABSTRACT

    Effects of methionine (Met) deficiency on IgA+ B cells and immunoglobulins (Igs) in the ileum of Cobb broiler were observed by the methods of immunohistochemistry and enzyme-linked immunosorbent assay (ELISA) ranging from 1 to 42 days of age. Results showed a significant decrease of the number of IgA+ B cells and the amount of Igs in Met deficient group in comparison with control group. In conclusion, dietary Met deficiency exerts significant effect on the humoral immune function of the intestinal mucosa. This study would provide new experimental information for future studies in the effects of Met on the intestinal functions of human or other animals.

    REFERENCES

    1. Benatar, T., Tkalec, L., Ratcliffe, M.J. (1992). Stochastic rearrangement of immunoglobulin variable-region genes in chicken B-cell development. Proceedings of the National Academy of Sciences, 89: 7615-7619. 
    2. Brosnan, J.T. and Brosnan, M.E. (2006). The sulfur-containing amino acids: an overview. The Journal of Nutrition, 136: 1636S-1640S.    Hirano, T., Yasukawa, K., Harada, H., Taga, T., Watanabe, Y., Matsuda, T., Kashiwamura, S.I., Nakajima, K., et al.(1986). Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature, 324: 73-76.    Horvat, S., Mlinaric-majerski, K., Glavas-obrovac, L., Jakas, A., Veljkovic, J., Marczi, S., Kragol, G et al. (2006). Tumor-cell-targeted methionine-enkephalin analogues containing unnatural amino acids: design, synthesis, and in vitro antitumor activity. Journal of Medicinal Chemistry, 49: 3136-3142. 
    3. Kapoor, K., and Singh, O. (2017). Histoenzymic distribution of phosphatases, dehydrogenases and esterases in ileal peyer’s patches of neonatal buffalo calves. Indian Journal of Animal Research, 51: 670-675.
    4. Khan, N., Sheikh, F. A., Rana, M. S., Kant, K., Kewalramani, N. (2012). Effect of supplementation of protected methionine, lysine and choline on performance of lactating cows - a review. Agricultural Reviews, 33: 322-332.
    5. Li, C., Li, Z., Sletten, E., Arnesano, F., Losacco, M., Natile, G., Liu, Y. (2009). Methionine can favor DNA Platination by trans-    Coordinated Platinum Antitumor Drugs. Angewandte Chemie, 121: 8497-8500. 
    6. Li, G.W., Burkhardt, D., Gross, C., Weissman, J.S. (2014). Quantifying absolute protein synthesis rates reveals principles underlying allocation of cellular resources. Cell, 157: 624-635. 
    7. Liu, J., Cui, H.M., Peng, X., Fang, J., Zuo, Z.C., Deng, J.L., Wang, H.S., Wu, B.Y., Deng, Y.X., Wang, K.P. (2013). Decreased IgA+ B cells population and IgA, IgG, IgM contents of the cecal tonsil induced by dietary high fluorine in broilers. International Journal of Environmental Research & Public Health, 10: 1775-1785.
    8. Mirzaaghatabar, F., Saki, A.A., Zamani, P., Aliarabi, H., Hemati Matin, H.R. (2011). Effect of different levels of diet methionine and metabolisable energy on broiler performance and immune system. Food & Agricultural Immunology, 22: 93-103. 
    9. Oz, H.S., Chen, T.S., Neuman, M. (2008). Methionine deficiency and hepatic injury in a dietary steatohepatitis model. Digestive Diseases and Sciences, 53: 767-776. 
    10. Perdigon, G., Alvarez, S., Rachid, M., Aguero, G., Gobbato, N. (1995). Immune system stimulation by probiotics. Journal of Dairy Science, 78: 1597-1606. 
    11. Perez-carbajal, C., Caldwell, D., Farnell, M., Stringfellow, K., Pohl, S., Casco, G., Pro-martinez, A., Ruiz-feria, C.A. (2010). Immune response of broiler chickens fed different levels of arginine and vitamin E to a coccidiosis vaccine and Eimeria challenge. Poultry Science, 89: 1870-1877. 
    12. Rama, Rao, S.V., Prahara, J.N.K., Panda, A.K., Reddy, M.R. (2003). Interaction between genotype and dietary concentrations of methionine for immune function in commercial broilers. British Poultry Science, 44: 104-112. 
    13. Sanchez-roman, I., Gomez, A., Gomez, J., Suarez, H., Sanchez, C., Naudi, A., Ayala, V., et al. (2011). Forty percent methionine restriction lowers DNA methylation, complex I ROS generation, and oxidative damage to mtDNA and mitochondrial proteins in rat heart. Journal of Bioenergetics and Biomembranes, 43: 699-708. 
    14. Schroeder, H.W. and Cavacini, L. (2010). Structure and function of immunoglobulins. Journal of Allergy and Clinical Immunology, 125: S41-S52. 
    15. Stadtman, E.R., Moskovitz, J., Berlett, B.S. and Levine, R.L. (2002). Cyclic oxidation and reduction of protein methionine residues is an important antioxidant mechanism. Molecular and Cellular Biochemistry, 234: 3-9.
    16. Tesseraud, S., Everaert, N., Ezzine, S.B., Collin, A., Berri, S.M.C. (2011). Manipulating tissue metabolism by amino acids. World’s Poultry Science Journal, 67: 243-252. 
    17. Waterland, R.A. (2006). Assessing the effects of high methionine intake on DNA methylation. The Journal of Nutrition, 136: 1706S-1710S.    Wu, B., Cui, H., Peng, X., Fang, J., Cui, W., Liu, X.D. (2013). Pathology of bursae of Fabricius in methionine-deficient broiler chickens. Nutrients, 5: 877-886. 
    18. Yang, L.J., Huo, Z.C., Hou, J.C., Cheng, P., Sun, S.L. (2004). The comparision of the effect of the solid methionine and liquid methionine on the chicken biological titer. Chinese Journal of Animal Science, 40: 16-18. 
    19. Yen, C.L., Mar, M.H., Craciunescu, C.N., Edwards, L.J., Zeisel, S.H. (2002). Deficiency in methionine, tryptophan, isoleucine, or choline induces apoptosis in cultured cells. The Journal of Nutrition, 132: 1840-1847. 
    20. Yogi, R.K., Das, A., Kullu, S.S., Saini, M., Garg A.K., Sharma, A.K. (2016). Effect of supplementation of lutein and DL-methionine on certain haemato-biochemical parameters and serum concentration of corticosteronein captive Golden pheasants (Chrysolophus pictus). Indian Journal of Animal Research, DOI10.18805/ijar.vOiOF.3800
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