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Current IssueEditorial BoardOnline First ArticlesArchive

Research Article

volume 52 issue 6 (june 2018) : 893-897,   Doi: 10.18805/ijar.B-778

Preparation and pharmacokinetics of cefquinome sulfate liposomes in goats

H
Haigang Wu
J
Jinni Liu
G
Gugangke Xu
Z
Zhaowei Ye
J
Jicheng Liu
B
Benchi Yi
1Laboratory of Veterinary Pharmacology and Toxicology, College of Animal Science and Veterinary Medicine, Xinyang Agriculture and Forestry University, Xinyang 464 000, PR China.
Cite article:- Wu Haigang, Liu Jinni, Xu Gugangke, Ye Zhaowei, Liu Jicheng, Yi Benchi (2018). Preparation and pharmacokinetics of cefquinome sulfate liposomes in goats. Indian Journal of Animal Research. 52(6): 893-897. doi: 10.18805/ijar.B-778.

ABSTRACT

We evaluated the pharmacokinetics of cefquinome sulfate (CEF) liposomes in eight healthy goats following intramuscular administration at 4 mg/kg. The average particle diameter of CEF liposomes prepared by the ethanol injection method was 335nm with a CEF entrapment efficiency of 69.56%. The elimination half-life (t1/2b) of CEF liposomes was 33.04h compared with 16.21 h for CEF injected without carrier (p<0.05). The area under the concentration curve (AUC) for CEF liposomes was approximately three-times greater than for CEF alone (P<0.05). The time-point of maximum plasma concentration of the drug (Tp) and the maximum plasma concentration (Cmax) were 4.38 h and 1.99 ìg/mL for CEF liposomes, compared with 1.86 h and 3.55 ìg/mL for CEF without carrier, respectively. 

REFERENCES

  1. Aarestrup F M, Skov R L.(2010).Evaluation of ceftiofur and cefquinome for phenotypic detection of methicillin resistance in Staphylococcus aureus using disk diffusion testing and MIC-determination,Veterinary Microbiology, doi:org/10.1016/    j.vetmic.2009.07.005 
  2. Cagnardi P, Gallo M, Zonca A, Locatelli C, Moroni P, Carli S.(2009) Pharmacokinetics of cefquinome in lactating cows after intramammary administration in healthy and infected animals. J Vet Pharmacol Ther 32:145-146.
  3. Cao J Y. Veterinary Pharmacokinetics [M]. Beijing: China Agriculture Press. 2005, 03.
  4. Chen XL,Jiang CM,Zhu LX.(2012). Pharmacokinetic of cefquinome in Cattle after single-dose intramuscular injection,Jiangsu Agricultural Sciences, 5:69-71,doi: 10.3969/j.issn.1002-1302.
  5. Chin N X, Gu JW, Fang W, Neu HC.(1992). In vitro activity of cefquinome, a new cephalosporin, compared with other cephalosporin antibiotics.Diagn Microbiol Infect Dis. May-Jun;15: 331-337.
  6. Dinakaran V, Dumka VK, Ranjan B, Balaje R, Sidhu PK.(2013).Pharmacokinetics following intravenous administration and pharmacodynamics of cefquinome in buffalo calves. Tropical Animal Health and Production,45:1509-1512. doi: 10.1007/s11250-013-0390-7 PMID: 23456794
  7. Ehinger AM ,Schmidt H,Kietzmann M.(2005).Tissue distribution of cefquinome after intramammary and “systemic” administration in the isolated perfused bovine udder. Veterinary Journal, doi:10.1016/j.tvjl.2005.02.029.
  8. Fan M H, Xu S Y, Xia S Q.(2008).Preparation of salidroside nano liposomes by ethanol injection method and in vitro release study,Eur Food Res Technol, doi:10.1007/s00217.007.0706.9
  9. Heinritzi K, Hagn. J. (1999). Studies on the efficacy and safety of the new cephalosporin cefquinome in sows with puerperal septicaemia and toxaemia syndrome.Tierarztliche -Praxis-Ausgabe- Grosstiere/Nutztiere,27:114-121.
  10. Liu M R,Zhao D S,Liu B S,.(2013). Developments in Cefqinome, Chinese Animal husbandry and Veterinary Medicine, 40(4):216-    220
  11. Lu GF,Yang HF,Li YJ,Jiang CM.ÿ2007    ÿ.Pharmacokiietics of cefquiiome sulfate suspension in pigs,Joumal of Yangzhou University (Agricultural and Life Science Edition),28(4):18-21
  12. Mengxiao Gu, Nan Zhang, Longfei Zhang.(2015).Response of a clinical Escherichia coli strain to repeated cefquinome exposure in a piglet tissue-cage model,BMC Veterinary Research , 11:169
  13. Michael Limbert.(1991).Antibacterial Activities In Vitro and vivo and pharmacokinetics Of Cefquinome(HR lllv), a New Broad Spectrum Cephalosporin. Antimicrobial Agents andChemotherapy, 35:14-19.
  14. Murphy SP, Erwin ME, Jones RN. (1994). Cefquinome(HR 111v). In vitro evaluation of a broad-spectrum cephalosporin indicated for infections in animals.Diagn Microbiol Infect Dis. Sep; 20:49—55. 
  15. Sheng Z J, Xu W P, Xu T P, etal.ÿ2015    ÿ.New Developments in Liposomal Drug Delivery Systems. China Pharmaceuticals ,24(23):6-8
  16. Thomas G,Martin B,Voss A,Boettner P,Porramier W,Loehlein.(2002). A comparative field study of the efficacy of cefqinome and amoxycllin against acute meningitis of weaned piglets. The Pig Journal, 3: 50.
  17. Wang J, Shan Q, Ding H, Liang C, Zeng Z.(2014).Pharmacodynamics of cefquinome in a neutropenic mouse thigh model of Staphylococcus aureus infection. Antimicrob Agents Chemother,58: 3008-3012. doi: 10.1128/AAC.01666-13 PMID:24614373
  18. Xu D W,Liu T X.(2015).Preparation and quality evaluation of naringenin liposomes by ethanol injection method,Central South Pharmacy, 13(12):1266-1269 
  19. Yang D. (2009).New Developments in Liposomal. Herald of Medicine. 28(3): 336-338.
  20. Yang P B, Zhang H.(2013). New Progress of The Research of Liposome, ZhejiangUniversity TraditionalChinese Medicine DOI:10.16466/    J.issn1005-5509.
  21. Zhao DH, Zhou YF, Yu Y, Shi W, Yang X, Xiao X.(2014). Integration of pharmacokinetic and pharmacodynamic indices of valnemulin in broiler chickens after a single intravenous and intramuscular administration, Vet J 201:109-115. doi: 10.1016/    j.tvj1.2014.05.010 PMID: 24906499
  22. Zheng Z Z(2009).Quality control and Antibacterial activities of Cefquinome sulfate suspension in vitro.Chinese Journal of Veterinary Drug, 43(9):11-15
  23. Zhou YF, Zhao DH, Yu Y, Yang X, Shi W, Peng YB.(2015). Pharmacokinetics, bioavailability and PK/PD relationship of cefquinome for Escherichia coli in Beagle dogs. J Vet Pharmacol Ther,38: 543-548. doi: 10.1111/jvp.12225 PMID: 25776615 
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Indian Journal of Animal Research
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    Research Article

    volume 52 issue 6 (june 2018) : 893-897,   Doi: 10.18805/ijar.B-778

    Preparation and pharmacokinetics of cefquinome sulfate liposomes in goats

    H
    Haigang Wu
    J
    Jinni Liu
    G
    Gugangke Xu
    Z
    Zhaowei Ye
    J
    Jicheng Liu
    B
    Benchi Yi
    1Laboratory of Veterinary Pharmacology and Toxicology, College of Animal Science and Veterinary Medicine, Xinyang Agriculture and Forestry University, Xinyang 464 000, PR China.
    Cite article:- Wu Haigang, Liu Jinni, Xu Gugangke, Ye Zhaowei, Liu Jicheng, Yi Benchi (2018). Preparation and pharmacokinetics of cefquinome sulfate liposomes in goats. Indian Journal of Animal Research. 52(6): 893-897. doi: 10.18805/ijar.B-778.

    ABSTRACT

    We evaluated the pharmacokinetics of cefquinome sulfate (CEF) liposomes in eight healthy goats following intramuscular administration at 4 mg/kg. The average particle diameter of CEF liposomes prepared by the ethanol injection method was 335nm with a CEF entrapment efficiency of 69.56%. The elimination half-life (t1/2b) of CEF liposomes was 33.04h compared with 16.21 h for CEF injected without carrier (p<0.05). The area under the concentration curve (AUC) for CEF liposomes was approximately three-times greater than for CEF alone (P<0.05). The time-point of maximum plasma concentration of the drug (Tp) and the maximum plasma concentration (Cmax) were 4.38 h and 1.99 ìg/mL for CEF liposomes, compared with 1.86 h and 3.55 ìg/mL for CEF without carrier, respectively. 

    REFERENCES

    1. Aarestrup F M, Skov R L.(2010).Evaluation of ceftiofur and cefquinome for phenotypic detection of methicillin resistance in Staphylococcus aureus using disk diffusion testing and MIC-determination,Veterinary Microbiology, doi:org/10.1016/    j.vetmic.2009.07.005 
    2. Cagnardi P, Gallo M, Zonca A, Locatelli C, Moroni P, Carli S.(2009) Pharmacokinetics of cefquinome in lactating cows after intramammary administration in healthy and infected animals. J Vet Pharmacol Ther 32:145-146.
    3. Cao J Y. Veterinary Pharmacokinetics [M]. Beijing: China Agriculture Press. 2005, 03.
    4. Chen XL,Jiang CM,Zhu LX.(2012). Pharmacokinetic of cefquinome in Cattle after single-dose intramuscular injection,Jiangsu Agricultural Sciences, 5:69-71,doi: 10.3969/j.issn.1002-1302.
    5. Chin N X, Gu JW, Fang W, Neu HC.(1992). In vitro activity of cefquinome, a new cephalosporin, compared with other cephalosporin antibiotics.Diagn Microbiol Infect Dis. May-Jun;15: 331-337.
    6. Dinakaran V, Dumka VK, Ranjan B, Balaje R, Sidhu PK.(2013).Pharmacokinetics following intravenous administration and pharmacodynamics of cefquinome in buffalo calves. Tropical Animal Health and Production,45:1509-1512. doi: 10.1007/s11250-013-0390-7 PMID: 23456794
    7. Ehinger AM ,Schmidt H,Kietzmann M.(2005).Tissue distribution of cefquinome after intramammary and “systemic” administration in the isolated perfused bovine udder. Veterinary Journal, doi:10.1016/j.tvjl.2005.02.029.
    8. Fan M H, Xu S Y, Xia S Q.(2008).Preparation of salidroside nano liposomes by ethanol injection method and in vitro release study,Eur Food Res Technol, doi:10.1007/s00217.007.0706.9
    9. Heinritzi K, Hagn. J. (1999). Studies on the efficacy and safety of the new cephalosporin cefquinome in sows with puerperal septicaemia and toxaemia syndrome.Tierarztliche -Praxis-Ausgabe- Grosstiere/Nutztiere,27:114-121.
    10. Liu M R,Zhao D S,Liu B S,.(2013). Developments in Cefqinome, Chinese Animal husbandry and Veterinary Medicine, 40(4):216-    220
    11. Lu GF,Yang HF,Li YJ,Jiang CM.ÿ2007    ÿ.Pharmacokiietics of cefquiiome sulfate suspension in pigs,Joumal of Yangzhou University (Agricultural and Life Science Edition),28(4):18-21
    12. Mengxiao Gu, Nan Zhang, Longfei Zhang.(2015).Response of a clinical Escherichia coli strain to repeated cefquinome exposure in a piglet tissue-cage model,BMC Veterinary Research , 11:169
    13. Michael Limbert.(1991).Antibacterial Activities In Vitro and vivo and pharmacokinetics Of Cefquinome(HR lllv), a New Broad Spectrum Cephalosporin. Antimicrobial Agents andChemotherapy, 35:14-19.
    14. Murphy SP, Erwin ME, Jones RN. (1994). Cefquinome(HR 111v). In vitro evaluation of a broad-spectrum cephalosporin indicated for infections in animals.Diagn Microbiol Infect Dis. Sep; 20:49—55. 
    15. Sheng Z J, Xu W P, Xu T P, etal.ÿ2015    ÿ.New Developments in Liposomal Drug Delivery Systems. China Pharmaceuticals ,24(23):6-8
    16. Thomas G,Martin B,Voss A,Boettner P,Porramier W,Loehlein.(2002). A comparative field study of the efficacy of cefqinome and amoxycllin against acute meningitis of weaned piglets. The Pig Journal, 3: 50.
    17. Wang J, Shan Q, Ding H, Liang C, Zeng Z.(2014).Pharmacodynamics of cefquinome in a neutropenic mouse thigh model of Staphylococcus aureus infection. Antimicrob Agents Chemother,58: 3008-3012. doi: 10.1128/AAC.01666-13 PMID:24614373
    18. Xu D W,Liu T X.(2015).Preparation and quality evaluation of naringenin liposomes by ethanol injection method,Central South Pharmacy, 13(12):1266-1269 
    19. Yang D. (2009).New Developments in Liposomal. Herald of Medicine. 28(3): 336-338.
    20. Yang P B, Zhang H.(2013). New Progress of The Research of Liposome, ZhejiangUniversity TraditionalChinese Medicine DOI:10.16466/    J.issn1005-5509.
    21. Zhao DH, Zhou YF, Yu Y, Shi W, Yang X, Xiao X.(2014). Integration of pharmacokinetic and pharmacodynamic indices of valnemulin in broiler chickens after a single intravenous and intramuscular administration, Vet J 201:109-115. doi: 10.1016/    j.tvj1.2014.05.010 PMID: 24906499
    22. Zheng Z Z(2009).Quality control and Antibacterial activities of Cefquinome sulfate suspension in vitro.Chinese Journal of Veterinary Drug, 43(9):11-15
    23. Zhou YF, Zhao DH, Yu Y, Yang X, Shi W, Peng YB.(2015). Pharmacokinetics, bioavailability and PK/PD relationship of cefquinome for Escherichia coli in Beagle dogs. J Vet Pharmacol Ther,38: 543-548. doi: 10.1111/jvp.12225 PMID: 25776615 
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