Preparation and pharmacokinetics of cefquinome sulfate liposomes in goats

DOI: 10.18805/ijar.B-778    | Article Id: B-778 | Page : 893-897
Citation :- Preparation and pharmacokinetics of cefquinome sulfate liposomes in goats.Indian Journal Of Animal Research.2018.(52):893-897
Haigang Wu, Jinni Liu, Gugangke Xu, Zhaowei Ye, Jicheng Liu and Benchi Yi jinniliu@126.com
Address : Laboratory of Veterinary Pharmacology and Toxicology, College of Animal Science and Veterinary Medicine, Xinyang Agriculture and Forestry University, Xinyang 464 000, PR China.
Submitted Date : 17-05-2017
Accepted Date : 2-03-2018

Abstract

We evaluated the pharmacokinetics of cefquinome sulfate (CEF) liposomes in eight healthy goats following intramuscular administration at 4 mg/kg. The average particle diameter of CEF liposomes prepared by the ethanol injection method was 335nm with a CEF entrapment efficiency of 69.56%. The elimination half-life (t1/2b) of CEF liposomes was 33.04h compared with 16.21 h for CEF injected without carrier (p<0.05). The area under the concentration curve (AUC) for CEF liposomes was approximately three-times greater than for CEF alone (P<0.05). The time-point of maximum plasma concentration of the drug (Tp) and the maximum plasma concentration (Cmax) were 4.38 h and 1.99 ìg/mL for CEF liposomes, compared with 1.86 h and 3.55 ìg/mL for CEF without carrier, respectively. 

Keywords

Cefquinome sulfate Ethanol injection method Goats Liposome Pharmacokinetics.

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