Indian Journal of Animal Research

  • Chief EditorK.M.L. Pathak

  • Print ISSN 0367-6722

  • Online ISSN 0976-0555

  • NAAS Rating 6.50

  • SJR 0.263

  • Impact Factor 0.5 (2023)

Frequency :
Monthly (January, February, March, April, May, June, July, August, September, October, November and December)
Indexing Services :
Science Citation Index Expanded, BIOSIS Preview, ISI Citation Index, Biological Abstracts, Scopus, AGRICOLA, Google Scholar, CrossRef, CAB Abstracting Journals, Chemical Abstracts, Indian Science Abstracts, EBSCO Indexing Services, Index Copernicus
Indian Journal of Animal Research, volume 52 issue 1 (january 2018) : 79-82

Effect of peanut oil and nandrolone on serum cytokines in pubertal term rats

Erdal Tasgin, Seyfullah Haliloglu
1<p>Sports Sciences Faculty,&nbsp;Faculty of Veterinary Medicine, Selcuk University Campus, 42075, Konya, Turkey.</p>
Cite article:- Tasgin Erdal, Haliloglu Seyfullah (2017). Effect of peanut oil and nandrolone on serum cytokines in pubertal term rats . Indian Journal of Animal Research. 52(1): 79-82. doi: 10.18805/ijar.v0iOF.7819.

The purpose of this study was to determine the effect of nandrolone on cytokine levels in pubertal term female and male rats. Totally 60 pubertal term Spraque Dawley rat (30/30 female/male) were divided into 3 equal groups. Control group received no treatment. PO group received intraperitoneally peanut oil every 5 days with an intervening gap of 2 days where no treatment was given. ND group received intraperitoneally nandrolone decanoate (10 mg/kg) within peanut oil like PO group. At the end of the four weeks, blood samples were obtained. Serum cytokine levels were measured by ELISA. Peanut oil significantly (P<0.05) increased serum levels of interleukin-1â and interleukin-6 in pubertal term male rats, while nandrolone decanoate had no any effect on the cytokine levels compared to experimental groups. It may be stated that nandrolone decanoate has no excessive inducer effect on the cytokine synthesis in pubertal male and female term. 

  1. Aldridge, A.J. (2002). Role of the neutrophil in septic shock and the adult respiratory distress syndrome. Eur. J. Surg. 168: 204-214. 

  2. Andrade, T.U., Santos. M.C.S., Busato. V.C.W., Medeiros. A.R.S., Abreu. G.R., Moyses MR and Bissoli S. (2008). Higher physiological doses of nandrolone decanoate do not influence the bezolod-jarish reflex control of bradycardia. Arc. Med. Res. 39: 27-32. 

  3. Andreasen, A.S., Krabbe. K.S., Krogh-Madsen. R., Taudorf. S., Pedersen. B.K.and Moller K. (2008). Human endotoxemia as a model of systemic inflammation. Cur. Med. Chem. 15: 1697-1705.

  4. Barroso O, Mazzoni I and Rabin O. (2008). Hormone abuse in sports: the antidoping perspective. Asian J. Androl. 10: 391-402.

  5. Bathori, M., Toth. N., Hunyadi. A., Marki. A., and Zador E. (2008). Phytoecdysteroids and anabolic-androgenic steroids – structure and effects on humans. Cur. Med. Chem. 15: 75-91.

  6. Bruley-Rosset, M., Dardenne. M., and Schuurs S. (1985). Functional and quantitave changes of immune vcells of ageing NZB mice treated with nandrolone decanoate. I. Effecct on survival and autoantibody development. Clin Exp Immunol. 62: 630-638.

  7. Casavant, MJ., Blake. K., Pharmd. J.G., Yates. A., and Copley L.M. (2007). Consequences of Use of Anabolic Androgenic Steroids. Pediatr. Clin. N. Am. 54: 677-690.

  8. Dotson, J.L., and Brown R.T. (2007). The history of the development of anabolic-androgenic steroids. Pediatr Clin. N. Am. 54: 761-769.

  9. Hartgens, F., and Kuipers H. (2004). Effects of androgenic-anabolic steroids in athletes. Sports Med. 34: 513-554.

  10. Ho, E.N., Leung. D.K.K., Leung. G.N., Wan. T.S., Wong. H.N., Xu. X., and Yeung J.H. (2007). Metabolic studies of mesterolone in horses. Anal. Chim. Acta. 596: 149-155. 

  11. Hughes, T.K., Fulep. E., Juelich. T., Smith. E.M., and Stanton G.J. (1995). Modulation of immune responses by anabolic androgenic steroids. Int. J. Immunopharmacol. 17: 857-853. 

  12. Hughes, T.K., Rady. P.L., and Smith E.M. (1998). Potential for the of anabolic steroid abuse in the immune and neuroendocrine axis. J. Neuroimmunol. 83: 163-167.

  13. Jean-Baptiste, E. (2007). Cellular mechanisms in sepsis. J. Intens. Care Med. 22: 63-72.

  14. Kerr, J.M., and Congeni J.A.(2007). Anabolic-androgenic steroids: use and abuse in pediatric patients. Pediatr. Clin. N. Am. 54: 771-785.

  15. Marshall-Gradisnik, S., Green. R., Brenu. E.W., and Weatherby R.P. (2009). Anabolic androgenic steroids effects on the immune system: A review. Cent. Eur. J. Biol. 4: 19-33. 

  16. Moneret-Vautrin, D.A., Rance. F., Kanny. G., Olsewski. A., Gueant. J.L., Dutau G., and Guerin L. (1998). Food allergy to peanuts in France—evaluation of 142 observations. Clin. Exp. Allergy. 28:1113-1119.

  17. Morisset, M.,. Moneret-Vautrin. D.A, Kanny. G., Guénard. L., Beaudouin. E., Flabbée. J., and Hatahet R. (2003). Thresholds of clinical reactivity to milk, egg, peanut and sesame in immunoglobulin E-dependent allergies: evaluation by double-blind or single-blind placebo-controlled oral challenges. Clin. Exp. Allergy. 33: 1046-1051.

  18. Netea, M.G., van der Meer. J.W.M., Deuren. M. van., and Kullberg B.J. (2003). Proinflammatory cytokines and sepsis syndrome: not enough, or too much of a good thing? Trends Immunol. 24: 254-258. 

  19. Saitoh, T., Morimoto. K., Kumagai. T., Tsuboi. I., Aikawa. S., and Horie T. (1999). Comparison of erythropoietic response to androgen in young and old senescense accelerated mice. Mech. Ageing Dev. 109: 125-139. 

  20. Sjoqvist, F., Garle. M., and Rane A. (2008). Use of doping agents, particularly anabolic steroids, in sports and society. Lancet. 371: 1872-1882. 

  21. Thompson, R.W., McClung. J.M., Baltgalvis K.A., Davis J.M., and Carson J.A.(2006). Modulation of overload-induced inflammation by aging and anabolic steroid administration. Exp. Gerontol. 41: 1136-1148.

  22. Van de Vosse, E., and Agtmael M.A. van. (2007). Targets of anticytokine therapy and the risk of infections in humans and mice. Curr. Opin. Rheumatol. 19: 626-35.

  23. Wu, W.M., Lin. B.F., Su. Y.C., Suen. J.L., and Chiang B.L. (2000). Tamoxifen decreases renal inflammation and alleviates disease severity in autoimmune NZB/W F1 Mice. Scand. J. Immunol. 52: 393-400. 

  24. Yamaguchi, M., and Weitzmann M.N. (2009). The estrogen 17beta-estradiol and phytoestrogen genistein mediate differential effects on osteoblastic NF-KappaB activity. Int. J. Mol. Med. 23: 297-301. 

Editorial Board

View all (0)