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Current IssueEditorial BoardOnline First ArticlesArchive

Research Article

volume 53 issue 12 (december 2019) : 1604-1606,   Doi: 10.18805/ijar.v0iOF.7611

Study of effects of selenium and Vitamin E on Liver physiology in Fayoumi

S
Safeer Abbas
R
Razia Iqbal
M
Muhammad Zeeshan Butt
S
Sadaf Niaz
N
Naser M. AbdEl-Salam
S
Sumbal Haleem
M
Mansour S. Alsaid
R
Riaz Ullah
1Department of Pharmacognosy (MAPPRC), College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Cite article:- Abbas Safeer, Iqbal Razia, Butt Zeeshan Muhammad, Niaz Sadaf, AbdEl-Salam M. Naser, Haleem Sumbal, Alsaid S. Mansour, Ullah Riaz (2017). Study of effects of selenium and Vitamin E on Liver physiology in Fayoumi. Indian Journal of Animal Research. 53(12): 1604-1606. doi: 10.18805/ijar.v0iOF.7611.

ABSTRACT

Vitamin E is familiar for its antioxidative properties for neutralizing oxide radicals and plays a role to keep cells safe from physiological damage and Selenium being an integral part of Glutathione peroxidase assists Vit.E and help chicks grow normal and healthy. In current study four sets of chicken were given doses of vit. E and Selenium (0, 1 ml /10L; 1 ml /7.5L; 1 ml /5L) in water. The Chicken were grouped in four sets as A,B,C and D. The experiment was continued sixty days and5ml blood samples were collected from all the groups A, B, C and D at interval of 15 days. In Fayoumi chicks a decrease was noted in the value of ALAT in all experimental sets excluding D on 3rd and 4th sampling. A significant increase (p>0.05) was observed in the amount of ASAT in all treated groups excluding group C which showed decreased (p<0.05) levels of ASAT on 2nd and 3rd sampling. The level of Alkaline Phosphatase reduced considerably in all experimental sets except group C where a slight increase (p>0.05) was observed on 2nd sampling. A considerable decrease was also observed in the amount of Bilirubin in all experimental sets except group C where an insignificant increase (p>0.05) was observed on 2nd sampling. The research suggested that vitamin E increases organism’s ability to cope infections besides hepatoprotective activity in desi layer bird Fayoumi.

REFERENCES

  1. Brucato, M., S.F. Sundlof, J.U Bell and G.T. Edds, (1986). Aflatoxin B1 toxicosis in dairy calves pretreated with selenium-vitamin E. Am. J. Vet. Res., 47:179-183
  2. Daniel, S.P and Marshall, M. K. (1999). Evaluation of the liver: laboratory tests.Schiff’s diseases of the liver, 8th edn. USA; JB Lippincott publications.205-239. 
  3. Durak, I., Guven, T., Birey, M., Ozturk, H. S., Kurtipek, O. And Yel,M. (1996). Halothane hepatotoxicity and hepatic free radical metabolism inguienapigs:The effects of vitamin E. Can. J. Anaesth.,43:741-748.
  4. Erf, G. F., Bottje, W. G., Bersi, T. K., Hedrick, M. D. and Frits, C. A.(1998). Effects of dietary vitamin E on the immune system in broilers: Alteredproportions    of CD4 T cells in the thymus and spleen. poult. sci. 77:529-537. EUDirective (2004): 70/524/EEC.
  5. Harvey, R. B., Kubena, L. F. andElissalde, M. (1994). Influence of vitamin E    on aflatoxicosis in growing swine. Am. J. Vet. Res.,55:572-577. 
  6. Hoekstra W.G. (1975). Biochemical function of selenium and its relation to vitaminE. Feed.Proc., 34:2083–2089
  7. Marsh, J. A., Combs, JR G.F., Whotacre, M. E. andDietert, R. R. (1986).Effect of Selenium and Vitamin E dietary deficiencies on chick lymphoid organ development. Proc. Soc. Exp. Biol. Med., 182: 425-436.
  8. Mitra, A., Kulkarni, A. P., Ravikumar, V. C. and Bourcier, D. R. (1991).Effect of ascorbic acid esters on hepatic glutathione levels in mice treated with hepatotoxic dose of acetaminophen. J. Biochem. Toxicol.,6:93-100.
  9. Mills, G. C. (1975). Hemoglobin metabolism I. Glutathione peroxidase, an erythrocyte enzyme which protect hemoglobin from oxidative damage. The Journal of Biological Chemistry,229:189–197
  10. Nazroglu, M. (1999). Protective role of intraperitoneally administered vitamin E and Selenium in rats anesthetized with enflurane. Biol. Trace Elem. Res.,69:199-209.
  11. Netke, S. P., Roomi, M. V., Tsao, C. and NieedzwieckiI, A. (1997). Ascorbic acid protects guinea pigs from acute aflatoxin toxicity. Toxicol. Appl.Pharmacol.,143:429-435. 
  12. Olmez, D. and A. Z. Karakilck, (2004). Protective role of S-carotene dietarysupplementation on activities of functional liver enzymes and some biochemicalparameters in experimental hepatotoxicity of rats. J. Nutr. Biochem., (In press). 
  13. Parola, M., Leonarduzzi, G. F., Biasi, E., Albano, M. E., Biocca, G., Richter, G., Marckwardt, E., Henning, A. and Steinbach, G. (1986).Vitamin E requirements of laying hens. Archivfür Tierernährung36: 1133-1143.
  14. Rehana S.K. (2011). Effects of Vitamin E and selenium on immunity, egg production and LFT in laying hens (Hy-Line W98)..M.Sc. Thesis Departmnt of Zoology, University of Gujrat, Punjab, Pakistan. pp.22-25
  15. Rotruck J. T., Pope A. L., Ganther H. E., Swanson A. B. and HafmanD. G. (1973).Selenium: Biochemical role as a component of glutathione peroxidase. Poult.Sci.,179:588-590. 
  16. Salwa, S., Siam, Mansour, K.M.,EL-Anwar,E.M.M. and EL-Warith, A.A. (2005). Laying hen performance, hatchability, immune and selenium supplementation under hot condition. Egypt. Poult. Sci.24(1):483-496 
  17. Sies, H., Stahl, W. andSundquist, A.R. (1992). Antioxidant functions of vitamins. Vitamin E and C, S-Carotene and other carotenoids. Ann. N. Y. Acad. Sci.,669: 7-20. 
  18. Tengerdy, R. P. and Brown, J. C. (1977). Effect of vitamins E and A on humoralimmunity and phagocytosis in E. coli infected chickens. Poultry Sci.,56:957–963.
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Indian Journal of Animal Research
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    Research Article

    volume 53 issue 12 (december 2019) : 1604-1606,   Doi: 10.18805/ijar.v0iOF.7611

    Study of effects of selenium and Vitamin E on Liver physiology in Fayoumi

    S
    Safeer Abbas
    R
    Razia Iqbal
    M
    Muhammad Zeeshan Butt
    S
    Sadaf Niaz
    N
    Naser M. AbdEl-Salam
    S
    Sumbal Haleem
    M
    Mansour S. Alsaid
    R
    Riaz Ullah
    1Department of Pharmacognosy (MAPPRC),&nbsp;College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
    Cite article:- Abbas Safeer, Iqbal Razia, Butt Zeeshan Muhammad, Niaz Sadaf, AbdEl-Salam M. Naser, Haleem Sumbal, Alsaid S. Mansour, Ullah Riaz (2017). Study of effects of selenium and Vitamin E on Liver physiology in Fayoumi. Indian Journal of Animal Research. 53(12): 1604-1606. doi: 10.18805/ijar.v0iOF.7611.

    ABSTRACT

    Vitamin E is familiar for its antioxidative properties for neutralizing oxide radicals and plays a role to keep cells safe from physiological damage and Selenium being an integral part of Glutathione peroxidase assists Vit.E and help chicks grow normal and healthy. In current study four sets of chicken were given doses of vit. E and Selenium (0, 1 ml /10L; 1 ml /7.5L; 1 ml /5L) in water. The Chicken were grouped in four sets as A,B,C and D. The experiment was continued sixty days and5ml blood samples were collected from all the groups A, B, C and D at interval of 15 days. In Fayoumi chicks a decrease was noted in the value of ALAT in all experimental sets excluding D on 3rd and 4th sampling. A significant increase (p>0.05) was observed in the amount of ASAT in all treated groups excluding group C which showed decreased (p<0.05) levels of ASAT on 2nd and 3rd sampling. The level of Alkaline Phosphatase reduced considerably in all experimental sets except group C where a slight increase (p>0.05) was observed on 2nd sampling. A considerable decrease was also observed in the amount of Bilirubin in all experimental sets except group C where an insignificant increase (p>0.05) was observed on 2nd sampling. The research suggested that vitamin E increases organism’s ability to cope infections besides hepatoprotective activity in desi layer bird Fayoumi.

    REFERENCES

    1. Brucato, M., S.F. Sundlof, J.U Bell and G.T. Edds, (1986). Aflatoxin B1 toxicosis in dairy calves pretreated with selenium-vitamin E. Am. J. Vet. Res., 47:179-183
    2. Daniel, S.P and Marshall, M. K. (1999). Evaluation of the liver: laboratory tests.Schiff’s diseases of the liver, 8th edn. USA; JB Lippincott publications.205-239. 
    3. Durak, I., Guven, T., Birey, M., Ozturk, H. S., Kurtipek, O. And Yel,M. (1996). Halothane hepatotoxicity and hepatic free radical metabolism inguienapigs:The effects of vitamin E. Can. J. Anaesth.,43:741-748.
    4. Erf, G. F., Bottje, W. G., Bersi, T. K., Hedrick, M. D. and Frits, C. A.(1998). Effects of dietary vitamin E on the immune system in broilers: Alteredproportions    of CD4 T cells in the thymus and spleen. poult. sci. 77:529-537. EUDirective (2004): 70/524/EEC.
    5. Harvey, R. B., Kubena, L. F. andElissalde, M. (1994). Influence of vitamin E    on aflatoxicosis in growing swine. Am. J. Vet. Res.,55:572-577. 
    6. Hoekstra W.G. (1975). Biochemical function of selenium and its relation to vitaminE. Feed.Proc., 34:2083–2089
    7. Marsh, J. A., Combs, JR G.F., Whotacre, M. E. andDietert, R. R. (1986).Effect of Selenium and Vitamin E dietary deficiencies on chick lymphoid organ development. Proc. Soc. Exp. Biol. Med., 182: 425-436.
    8. Mitra, A., Kulkarni, A. P., Ravikumar, V. C. and Bourcier, D. R. (1991).Effect of ascorbic acid esters on hepatic glutathione levels in mice treated with hepatotoxic dose of acetaminophen. J. Biochem. Toxicol.,6:93-100.
    9. Mills, G. C. (1975). Hemoglobin metabolism I. Glutathione peroxidase, an erythrocyte enzyme which protect hemoglobin from oxidative damage. The Journal of Biological Chemistry,229:189–197
    10. Nazroglu, M. (1999). Protective role of intraperitoneally administered vitamin E and Selenium in rats anesthetized with enflurane. Biol. Trace Elem. Res.,69:199-209.
    11. Netke, S. P., Roomi, M. V., Tsao, C. and NieedzwieckiI, A. (1997). Ascorbic acid protects guinea pigs from acute aflatoxin toxicity. Toxicol. Appl.Pharmacol.,143:429-435. 
    12. Olmez, D. and A. Z. Karakilck, (2004). Protective role of S-carotene dietarysupplementation on activities of functional liver enzymes and some biochemicalparameters in experimental hepatotoxicity of rats. J. Nutr. Biochem., (In press). 
    13. Parola, M., Leonarduzzi, G. F., Biasi, E., Albano, M. E., Biocca, G., Richter, G., Marckwardt, E., Henning, A. and Steinbach, G. (1986).Vitamin E requirements of laying hens. Archivfür Tierernährung36: 1133-1143.
    14. Rehana S.K. (2011). Effects of Vitamin E and selenium on immunity, egg production and LFT in laying hens (Hy-Line W98)..M.Sc. Thesis Departmnt of Zoology, University of Gujrat, Punjab, Pakistan. pp.22-25
    15. Rotruck J. T., Pope A. L., Ganther H. E., Swanson A. B. and HafmanD. G. (1973).Selenium: Biochemical role as a component of glutathione peroxidase. Poult.Sci.,179:588-590. 
    16. Salwa, S., Siam, Mansour, K.M.,EL-Anwar,E.M.M. and EL-Warith, A.A. (2005). Laying hen performance, hatchability, immune and selenium supplementation under hot condition. Egypt. Poult. Sci.24(1):483-496 
    17. Sies, H., Stahl, W. andSundquist, A.R. (1992). Antioxidant functions of vitamins. Vitamin E and C, S-Carotene and other carotenoids. Ann. N. Y. Acad. Sci.,669: 7-20. 
    18. Tengerdy, R. P. and Brown, J. C. (1977). Effect of vitamins E and A on humoralimmunity and phagocytosis in E. coli infected chickens. Poultry Sci.,56:957–963.
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