Indian Journal of Animal Research

  • Chief EditorK.M.L. Pathak

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Indian Journal of Animal Research, volume 50 issue 5 (october 2016) : 769-772

Effects of the Coreopsis tinctoria extracts on anti-aging in the aging model mice

Weixin Zhang, Haiyan Hao2, Ailong Sha1*
1<p>College of Animal Science, Tarim University,&nbsp;843300, Alar, Xinjiang, P.R. China.</p>
Cite article:- Zhang Weixin, Hao2 Haiyan, Sha1* Ailong (2016). Effects of the Coreopsis tinctoria extracts on anti-agingin the aging model mice . Indian Journal of Animal Research. 50(5): 769-772. doi: 10.18805/ijar.9630.

The effects of the Coreopsis tinctoria extracts on anti-aging were observed by investigating the cerebral index and viscera indexes, the contents of hydrogen peroxide (H2O2) and malondialdehyde (MDA) in the serums, the activities of glutathione peroxidase (GSH-Px) in the brain tissues and the ones of catalase (CAT) and superoxide dismutase (SOD) in the liver tissues of the aging model mice. The aging model mice were injected subcutaneously with D-galactose in vivo and intragastric administrated with the Coreopsis tinctoria extracts at doses of low (0.5g/kg), medium (1g/ kg) and high (2g/ kg) once daily for 6 weeks. The results showed that all the cerebral index, spleen index, thymus index, liver index and kidney index of the three groups dosed of the Coreopsis tinctoria extracts increased, the activities of GSH-Px in the brain tissues and the ones of CAT and SOD in the liver tissues increased to different degree while the contents of H2O2 and MDA in the serums decreased extremely and significantly (P<0.01) compared with the aging model mice. All of these results suggested that the Coreopsis tinctoria extracts might possess anti-aging effects by improving antioxidant capacity of the mice.


  1. Dias T, Bronze MR, Houghton PJ, Mota-Filipe H, Paulo A. (2010). The flavonoid-rich fraction of Coreopsis tinctoria promotes glucose tolerance regain through pancreatic function recovery in streptozotocin-induced glucose-intolerant rats. J. Ethnopharmacol. 132: 483-490.

  2. Esterbauer H, Schaur RJ, Zollner H. (1991). Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Rad Biol Med 11: 81-128.

  3. Farahmand SK, Samini F, Samini M, Samarghandian S. (2013). Safranal ameliorates antioxidant enzymes and suppresses lipid peroxidation and nitric oxide formation in aged male rat liver. Biogerontology 14: 63-71.

  4. Guo LM, Zhang WS, Li SM, Ho CT. (2015). Chemical and nutraceutical properties of Coreopsis tinctoria. J. Funct. Foods. 13: 11-20.

  5. Harman D. (1956). Ageing: a theory based on free radical and radiation chemistry. Journal of Gerontology, 11: 298–300.

  6. Harman D. (2009). Origin and evolution of the free radical theory of aging: a brief personal history, 1954–2009. Biogerontol 10: 773-781.

  7. Ji DB, Ye J, Li CL, Wang YH, Zhao J, Cai SQ. (2009). Antiaging Effect of Cordyceps sinensis Extract. Phytother. Res. 23: 116-122.

  8. Knight J. A. (2000). The biochemistry of aging. Adv Clin Chem 35: 1-62.

  9. Li N, Meng DL, Pan Y, Cui QL, Li GX, Ni H, Sun Y, Qing DG, Jia XG, Pan YN, Hou Y. (2015). Anti-neuroinflammatory and NQO1 inducing activity of natural phytochemicals from Coreopsis tinctoria. J. Funct. Foods. 17: 837-846.

  10. Li Y, Chen X, Xue J, Liu J, Chen X, Wulasihan M. (2014). Flavonoids furom Coreopsis tinctoria adjust lipid metabolism in hyperlipidemia animals by down-regulating adipose differentiation-related protein. Lipids Health Dis 13: 193-200.

  11. Liang SH, HAMulati, Pang SB, Sun YH. (2010b). Experimental study on hypertensive effects of extracts of Coreopsis basalis. Lishizhen Medicine and Materia Medica Research 21: 1619-1621.

  12. Liang SH, Pang SB, Liu XY, XU L, HAMulati, Sun YH. (2009). Laboratory study of Coreopsis extracts on reducing blood lipid in hyperlipidemia model mice. Journal of Nongken Medicine 31: 495-498.

  13. Liang SH, Pang SB, Liu XY, XU L, HAMulati, Sun YH. (2010a). Study on hypolipidemia effect of Coreopsis tinctoria extract. Chinese Journal of Experimental Traditional Medical Formulae 6: 234-235.

  14. Liu DM, Sheng JW, Qi HM, Zhang W. (2015). Anti-aging activities of polysaccharides from Athyrium multidentatum (Doll.) Ching. Journal of Chemical and Pharmaceutical Research 7: 386-389.

  15. Liu GS, Zhang ZS, Yang B, He W. (2012). Resveratrol attenuates oxidative damage and ameliorates cognitive impairment in the brain of senescence-accelerated mice. Life Sci 91: 872-877.

  16. Lü J M, Lin P H, Yao Q, Chen C. (2010). Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems. J. Cell. Mol. Med. 14: 840-860.

  17. Mao XM, Han X., Lu W., Luo X, Wang Y, Jin CL, Li LL. (2014). Effect of the ethyl acetate extract from Coreopsis tinctoria nutt. on fasting blood levels and blood lipids in diabetes mice. Pharmacology and Clinics of Chinese Materia Medica 30: 78-82.

  18. Ming T, Sun YH, Hu MY, HAMulati, Pang SB, Liu XY,Zhang LL,Jin HT. (2012). Experimental study on anti-hypertension and in vivo antioxidant function of Coreopsis extract. Chinese Journal of Experimental Traditional Medical Formulae 18: 249-252.

  19. Okada Y, Okita M, Murai Y, Okano Y, Nomura M. (2014). Isolation and identification of flavonoids from Coreopsis lanceolata L. petals. Nat Prod Res 28: 201-204.

  20. Sun YH, Zhao J, Jin HT, Cao Y, Ming T, Zhang LL, Hu MY, Hamlati H, Pang SB, Ma XP. (2013). Vasorelaxant effects of the extracts and some flavonoids from the buds of Coreopsis tinctoria. Pharm. Biol. 51: 1158-1164.

  21. Urso M. L. and Clarkson P. M. (2003). Oxidative stress, exercise, and antioxidant supplementation. Toxicology 189: 41-54.

  22. Wang W, Chen W, Yang Y, Liu T, Yang H, Xin Z. (2015). New Phenolic Compounds from Coreopsis tinctoria Nutt. and Their Antioxidant and Angiotensin I Converting Enzyme Inhibitory Activities. J. Agric. Food Chem. 63: 200-207.

  23. Yang Q., Sun YH., Zhang L., Xu L, Hu MY, Liu XY, Shi FY, Gu ZY. (2014). Antihypertensive effects of extract from flower buds of Coreopsis tinctoria on spontaneously hypertensive rats. Chinese Herbal Medicines 6: 103–109.

  24. Yao DC, Shi WB, Gou YL, Zhou X, Yee Aw T, Zhou Y, Liu Z. (2005). Fatty acid-mediated intracellular iron translocation: a synergistic mechanism of oxidative injury. Free Radical Bio Med 39: 1385-1398.

  25. Yao XC, Gu CZ, Tian LP, Wang X, Tang H. (2016). Comparative study on the antioxidant activities of extracts of Coreopsis tinctoria flowering tops from Kunlun Mountains, Xinjiang, north-western China. Nat Prod Res 30: 429-432.

  26. Yu LJ, Wuliji A, Bao SY, Gong GH. (2015). Anti-Aging and Enhanced Physique Activities Research of Astragalus Mongolicus Water Extract in Mice. Clin Exp Pharmacol 5: 1-4.

  27. Za¢laru C., Crisan C. C., Ca¢linescu I., Moldovan Z, Þârcomnicu I. (2014). Polyphenols in Coreopsis tinctoria Nutt. fruits and the plant extracts antioxidant capacity evaluation. Cent Eur J Chem 12: 858–867.

  28. Zhang SP, LI LL, Ablise M. (2011a). Effects of extracts from Coreopsis tinctoria flowers of Xinjiang Kunlun mountain on á-glucosidase activity. Chinese Journal of Experimental Traditional Medical Formulae 17: 166–169.

  29. Zhang SP, LI LL, Ablise M, Wang LF, Jing ZJ, Mao XM. (2011b). Inhibition of extracts of Coreopsis tinctoria flowers from Kunlun mountain on á-glucosidase. Progress in Modern Biomedicine 11: 1055–1058.

  30. Zhang Y, Shi S, Zhao M, Chai X, Tu P. (2013). Coreosides A”D, C14-polyacetylene glycosides from the capitula of Coreopsis tinctoria and its anti-inflammatory activity against COX-2. Fitoterapia 87: 93-97.

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