Indian Journal of Animal Research

  • Chief EditorK.M.L. Pathak

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Indian Journal of Animal Research, volume 50 issue 5 (october 2016) : 769-772

Effects of the Coreopsis tinctoria extracts on anti-aging in the aging model mice

Weixin Zhang, Haiyan Hao2, Ailong Sha1*
1<p>College of Animal Science, Tarim University,&nbsp;843300, Alar, Xinjiang, P.R. China.</p>
Cite article:- Zhang Weixin, Hao2 Haiyan, Sha1* Ailong (2016). Effects of the Coreopsis tinctoria extracts on anti-agingin the aging model mice . Indian Journal of Animal Research. 50(5): 769-772. doi: 10.18805/ijar.9630.

The effects of the Coreopsis tinctoria extracts on anti-aging were observed by investigating the cerebral index and viscera indexes, the contents of hydrogen peroxide (H2O2) and malondialdehyde (MDA) in the serums, the activities of glutathione peroxidase (GSH-Px) in the brain tissues and the ones of catalase (CAT) and superoxide dismutase (SOD) in the liver tissues of the aging model mice. The aging model mice were injected subcutaneously with D-galactose in vivo and intragastric administrated with the Coreopsis tinctoria extracts at doses of low (0.5g/kg), medium (1g/ kg) and high (2g/ kg) once daily for 6 weeks. The results showed that all the cerebral index, spleen index, thymus index, liver index and kidney index of the three groups dosed of the Coreopsis tinctoria extracts increased, the activities of GSH-Px in the brain tissues and the ones of CAT and SOD in the liver tissues increased to different degree while the contents of H2O2 and MDA in the serums decreased extremely and significantly (P<0.01) compared with the aging model mice. All of these results suggested that the Coreopsis tinctoria extracts might possess anti-aging effects by improving antioxidant capacity of the mice.

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