Indian Journal Of Animal Research

Study on the polymorphism of fibroblast growth facor receptor (FGFR1) in sheep

DOI: 10.18805/ijar.v0iOF.4551    | Article Id: B-432 | Page : 856-859
Citation :- Study on the polymorphism of fibroblast growth facorreceptor (FGFR1) in sheep .Indian Journal Of Animal Research.2017.(51):856-859

Jun Yan Bai, Xiao Ping Jia, You Bing Yang, You. Zhi. Pang  and Yu Qin Wang

junyanb@163.com
Address :

College of Animal Science and Technology, Henan University of Science and Technology, Henan, Luoyang 471003, China.

Submitted Date : 8-01-2016
Accepted Date : 12-09-2016
First Online:

Abstract

The polymorphisms of fibroblast growth factor receptor (FGFR1) were detected in large-tailed Han sheep, small-tailed Han sheep, Yuxi fat-tailed sheep and Lanzhou large-tailed sheep by PCR product sequencing technology. The results showed that FGFR1 gene had 4 mutation sites in large-tailed Han sheep, small-tailed Han sheep, Yuxi fat-tailed sheep and Lanzhou large-tailed sheep, including T558C, G342A, G417A and G420A. FGFR1 gene sequences of different species clustering showed that sheep, buffalo and Tibetan antelope clustered together firstly, suggesting that the three phylogenetic species had a close relationship.

Keywords

Clustering analysis DNA pool Fibroblast growth factor receptor Genetic diversity Sheep.

References

  1. Cai,H.F., Chen, Z., Luo, W.X., Liu, R.Y., Zhang, Y.Y. and Li, J.R. (2011). Polymorphism of fibroblast growth factor receptor 1 ( FGFR1) gene detection in goat breeds. Guizhou Animal Science and Veterinary Medicine, 35: 8-11.
  2. Chang,Y.P., Miao, C.L., Feng, L.P., Lou, G.Y. and Yu, Y.L. (1999). Changes of FGFR-1 genomic DNA in human colorectal carcinoma. Immunological Journal 15: 90-92.
  3. Cui,J.X., Du, H.L. and Zhang, X.Q. (2005). Rapidly Screening SNPs and Estmi ating Allelic Frequencies by DNA Pooling and Sequencing. Acta Genetica Sinica, 32: 372-377.
  4. Deng,C.X., Wynshaw-Boris, A., Shen, M.M., Daugherty, C., Ornitz, D.M. and Leder, P. (1994). Murine FGFR1 is required for early postim plantation growth and axial organizati0n. Genes Dev, 8: 3045-3057.
  5. Li,J.R., Ding, Y.H., Zhang, Y.L., Wang, B.R. and Liu, R.Y. (2011). Rapidly screening SNPs and estimating allelic frequencies by DNA pooling and sequencing. Animal Husbandry, Veterinary Medicine 43: 17-19.
  6. Schultz,G.A., Harvey, M.B., Watson, A.J., Arcellana-Panlilio, M.Y., Jones, K. and Wasthusin, M.E. (1996). Regulation of early embryonic development by growth factors. Growth factor gene expression in cloned bovine embryos. J.Anim.Sci.74:50-57. 
  7. Song,T.W., Cai, H.F., Luo, W.X., Liu, R.Y. and Zhang, Y.Y. (2013). Polymorphism analysis of FGFR-1 gene in Goats. Chinese Journal of Animal Science, 49:19-22.
  8. Xie, M.R., Wang, Z.J., Lin, C.Y., Lu, J.J., Zzhang, W.Y., Wang, J.X. and Wang, S.E. (2009). Distribution of FGF10, FGFR1 and FGFR2 in the mouse mviduct and uterus. Progress of Anatomical Sciences 15:257-260.
  9. Ye,Z., Zhao, H.F. and Qian, G.X. (2003). Structure and Function of Fibroblast Gro wth Factor Receptor. Acta Universitatis Medicinalis Secondae Shanghai, 23: 176-179.

Global Footprints