Indian Journal of Animal Research

  • Chief EditorK.M.L. Pathak

  • Print ISSN 0367-6722

  • Online ISSN 0976-0555

  • NAAS Rating 6.50

  • SJR 0.263

  • Impact Factor 0.4 (2024)

Frequency :
Monthly (January, February, March, April, May, June, July, August, September, October, November and December)
Indexing Services :
Science Citation Index Expanded, BIOSIS Preview, ISI Citation Index, Biological Abstracts, Scopus, AGRICOLA, Google Scholar, CrossRef, CAB Abstracting Journals, Chemical Abstracts, Indian Science Abstracts, EBSCO Indexing Services, Index Copernicus
Indian Journal of Animal Research, volume 54 issue 2 (february 2020) : 160-162

Influence of hepcidin on iron homeostasis during last trimester of gestation in Bos indicus (cattle)

K. Rajamanickam, M. Sameer Ali, V. Leela
1Department of Veterinary Physiology, Madras Veterinary College, TANUVAS, Chennai-600 007, Tamil Nadu, India.
Cite article:- Rajamanickam K., Ali Sameer M., Leela V. (2019). Influence of hepcidin on iron homeostasis during last trimester of gestation in Bos indicus (cattle). Indian Journal of Animal Research. 54(2): 160-162. doi: 10.18805/ijar.B-3743.
Hepcidin is an important hormone regulating the systemic iron bio-availability. Blood samples were collected from thirty pregnant cattle during their last trimester of pregnancy to assess the relation of hepcidin to iron homeostasis. Serum hepcidin level was quantified using ELISA and serum iron, transferrin iron binding capacity and unsaturated iron binding capacity were estimated by colorimetric method. Correlation between hepcidin and other iron related parameters was assessed. Dependency of serum iron level on hepcidin was also determined by regression method. It was revealed that hepcidin was negatively correlated to serum iron and transferrin iron binding capacity (p< 0.001) and also hepcidin has highest predictive value on serum iron level and transferrin iron binding capacity (p< 0.001). It can be concluded that during pregnancy increase in hepcidin reduces the maternal serum iron and also it is a biomarker for iron bioavailability to the developing fetus.
  1. Blackburn, S.T. (2003). Maternal, Fetal & Neonatal Physiology: A Clinical Perspective. 2nd ed. Saunders,USA.
  2. Cogswell, M.E., Parvanta, I., Ickes, L., Yip, R and Brittenham, G.M. (2003). Iron supplementation during pregnancy, anemia, and birth weight: A randomized controlled trial. Am. J. Clin. Nutr.78: 773– 781.
  3. De Domenico, I., Lo, E., Ward, D.M and Kaplan, J. (2009). Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2. Proc. Natl. Acad. Sci. USA.106: 3800 - 3805.
  4. Djokovic, R.D., Kurcubic,V.S and Ilic,Z.Z. (2014). Blood serum levels of macro – and micronutrients in transition and full lactation cows. Bulg. J. Agric. Sci. 20: 715 – 720.
  5. Ganz, T and Nemeth, E. (2006). Iron imports. IV. Hepcidin and regulation of body iron metabolism. Am. J. Physiol.290:G199-G203. 
  6. Greer, J.P. (2009). Wintrobe’s Clinical Hematology. 12th ed.Lippincott Williams& Wilkins,Philadelphia, USA. 
  7. Harris, E.D. (1992). New insights into placental iron transport. Nutr. Rev.50: 329 –331.
  8. Hilton, K.B and Lambert, L.A. (2008). Molecular evaluation and characterization of hepcidin 367 gene products in vertebrates. Gene.415:40- 48.
  9. Kaneko, J.J., Harvey, J.W and Bruss, M.L. (1997).Clinical Biochemistry of Domestic animals. Academic Press, New York.
  10. Khangembam, V.C and Kumar, A. (2011). Buffalo hepcidin: characterization of cDNA and study of antimicrobial property. Vet. Res. Commun.35:79-87.
  11. Millard, K.N., Frazer, D.M., Wilkins, S.J and Anderson, G.J. (2004). Changes in the expression of intestinal iron transport and hepatic regulatory molecules explain the enhanced iron absorption associated with pregnancy in the rat. Gut53: 655 – 660.
  12. Nemeth, E and Ganz, T. (2006). Regulation of iron metabolism by hepcidin. Annu. Rev.Nutr.26: 323 – 342.
  13. Nicolas, G., Bennoun, M., Porteu, A., Mativet, S., Beaumont,C., Grandchamp, B., Mario, S., Michele, S., Axel, K and Sophie, V. (2002). Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc. Natl. Acad. Sci. USA.99: 4596–601.
  14. Pantopoulos, K., Porwal, S.K., Tartakoff, A and Devireddy, L. (2012). Mechanisms of mammalian iron homeostasis. Biochemistry.51: 5705 - 5724.
  15. Rajamanickam, K., Leela, V., Loganathasamy, K., Bhaskaran Ravi Latha and Balagangatharathilagar, M. (2017). Hepcidin: Discovery to Destiny. International Journal of Chemical Studies5(6): 1725-1733
  16. Roperto, S., Russo, V., Urraro, C., Cutarelli, A., Perillo, A., De Falco, F and Roperto, F. (2017). Expression of hepcidin and ferroportin in full term placenta of pregnant cows.Theriogenology103: 90 - 97.
  17. Scott, D.E. (1972). Anemia in pregnancy. Obstet. Gynecol. Annu.1: 219 – 244.
  18. Snedecor, G.W and Cochran,W.G. (1994).Statistsical Methods. 8th ed. Iowa State University Press,USA.

Editorial Board

View all (0)