Indian Journal of Animal Research

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Research Article

Indian Journal of Animal Research, volume 54 issue 1 (january 2020) : 36-40

Association of single nucleotide polymorphisms in IFNGR1 and IFNGR2 genes with bovine tuberculosis 

Ashish Bhaladhare, Anuj Chauhan, Arvind Sonwane, Amit Kumar, Pushpendra Kumar, Subodh Kumar, Sushil Kumar, Manjit Panigrahi, Bharat Bhushan
1Division of Animal Genetics, Indian Veterinary Research Institute, Izatnagar, Bareilly-243 122, Uttar Pradesh, India.
Cite article:- Bhaladhare Ashish, Chauhan Anuj, Sonwane Arvind, Kumar Amit, Kumar Pushpendra, Kumar Subodh, Kumar Sushil, Panigrahi Manjit, Bhushan Bharat (2019). Association of single nucleotide polymorphisms in IFNGR1 and IFNGR2 genes with bovine tuberculosis. Indian Journal of Animal Research. 54(1): 36-40. doi: 10.18805/ijar.B-3733.

ABSTRACT

Interferon Gamma Receptor (IFNGR) genes play an important role in the immune response against mycobacteria by regulating the proinflammatory cytokine Interferon Gamma (IFNG) alongwith subsequent mycobactericidal milieu and are potential strong candidates for investigating genetic basis of disease resistance. Present investigation was aimed at exploring the association of one SNP in IFNGR1 gene and two SNPs in IFNGR2 gene with susceptibility/resistance against bovine tuberculosis infection in cattle. All the three SNPs under investigation (rs109049057, rs109579937 and rs110689128) revealed polymorphism. SNP loci rs109049057 was found to be significantly (P < 0.01) associated with susceptibility to bovine tuberculosis in cattle in our case control population. The SNP was non-synonymous, suggesting its functional role in the immune response against bovine tuberculosis.  

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