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Current IssueEditorial BoardOnline First ArticlesArchive

Research Article

volume 53 issue 12 (december 2019) : 1675-1678,   Doi: 10.18805/ijar.B-3717

Disposition Kinetics of lincomycin following intravenous administration in hypothyroid goats

M
Meemansha Sharma
V
Vinod Kumar Dumka
S
Saloni Singla
R
Rajdeep Kaur
R
Raushan Kumar Singh
1Department of Veterinary Pharmacology and Toxicology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana-141 004, Punjab, India.
Cite article:- Sharma Meemansha, Dumka Kumar Vinod, Singla Saloni, Kaur Rajdeep, Singh Kumar Raushan (2019). Disposition Kinetics of lincomycin following intravenous administration in hypothyroid goats. Indian Journal of Animal Research. 53(12): 1675-1678. doi: 10.18805/ijar.B-3717.

ABSTRACT

Hypothyroidism is a common disorder of small ruminants and is expected to alter the pharmacokinetics of drugs. Hypothyroidism was induced by feeding thiourea at the dose rate 50 mg.kg-1 daily for 28 days to goats. Disposition of lincomycin, after intravenous administration at dose rate 10 mg/kg, was investigated in hypothyroid goats to determine the potential dosage regimen against susceptible microorganisms. Blood samples were collected from 1 min to 24 h of drug administration. The drug was detected in plasma up to 8 h and lincomycin was rapidly distributed from blood to the tissue, as evidenced by the high value of the distribution coefficient (mean ± SEM) 12.3±1.09 h-1. The large Vd (1.78±0.18 L/kg) indicated vast tissue distribution of lincomycin in goats. The elimination half life, AUC and total body clearance were 3.99± 0.25 h, 33.2±1.71 ìg.h/mL and 0.31±0.02 L/h/kg, respectively. Based on results, lincomycin in hypothyroid goats is suggested to be repeated at 12 h interval for organisms sensitive to lincomycin having MIC up to 0.1 µg.ml-1.

REFERENCES

  1. Albarellos, G.A., Montoya, L., Denamiel, G.A.A., Velo, M.C., Landoni, M.F., (2012). Pharmacokinetics and bone tissue concentrations of lincomycin following intravenous and intramuscular administrations to cats, Journal of Veterinary Pharmacology and Therapeutics, 35(6): 534-540.
  2. Burrows, G. E., Barto, P. B., and Weeks, B. R., (1986). Chloramphenicol, lincomycin and oxytetracycline disposition in calves with experimental pneumonic pasteurellosis, Journal of veterinary pharmacology and therapeutics, 9(2): 213-222.
  3. Burrows, G.E., Brto, P.B., Martin, B., Tripp M.L., (1983). Comparative pharmacokinetics of antibiotics in new born calves: chloramphenicol,    lincomycin and tylosin, American Journal of Veterinary Research, 44: 1053-57.
  4. Chaleva, E. and Nquyen, D.L., (1987). Pharmacokinetic research on Pharmachem’s lincomycin hydrochloride in pigs, Veterinarno-    Meditsinski Nauki, 24: 47-51.
  5. El-Sayed, M.G.A., El-Komy, A.A.A., El-barawy, A.M., Gehan, E.A.M., (2015). Pharmacokinetical interactions of lincomycin and amprolium in broiler chickens, Journal Science, 5: 734-743.
  6. Giguere, S., (2013). Lincosamides, pleuromutilins, and Streptogramins. In: Giguere, S. Prescott, J. F. and Dowling, P. M. (Eds.) Antimicrobial Therapy in Veterinary Medicine, 5th edn, (John Wiley, Ames, USA). 
  7. Gibaldi, M. and Perrier, D (Eds.) (1982). Pharmacokinetics. 2nd Edn. (Marcel and Dekker Inc, New York).
  8. Gouri. S.S., Venkatachalam, D., Dumka, V. K., (2014). Pharmacokinetics of lincomycin following single intravenous administration in buffalo calves, Tropical Animal Health and Production, 46: 1099-1102.
  9. Gupta, P.S.P., Sanwal, P.C., Varshrey, V.P., (1999). Effect of hypothyroidism on the growth of black bengal goats, Asian-Australian Journal of Animal Sciences, 12: 354-57.
  10. Huimin, L., Ji-An, L.I., Jin-Gang, N.I.U., (2012). Application of Flow Feeding Technology to Lincomycin Fermentation, Chinese Journal of Pharmaceuticals, 43: 739-42.
  11. Nielsen, P. and Gyrd-Hansen, N., (1998). Bioavailibility of lincomycin after oral administration to fed and fasted pigs, Journal of Veterinary Pharmacology and Therapeutics, 21: 251-56.
  12. Plenderleith, R.W., (1988). Treatment of cattle, sheep and horses with lincomycin: case studies, Vet Rec, 122: 112-113.
  13. Petinaki, E., Guérin-Faublée, V., Pichereau, V., Villers. C., Achard, A., Malbruny, B., Leclercq, R., (2008). Lincomycin resistance gene lnu (D) in Streptococcus uberis, Antimicrobial Agents and Chemotherapy, 52: 626-630.
  14. Shenfield, G. M., (1981). Influence of thyroid dysfunction on drug pharmacokinetics. Clinical Pharmacokinetics, 6: 275-97.
  15. Toutain, P.L. and Lees, P., (2004). Integration and modelling of pharmacokinetic and pharmacodynamic data to optimize dosage regimens in veterinary medicine, Journal of Veterinary Pharmacology and Therapeutics, 27: 467–77.
  16. Turnidge, J. D., (1998). The Pharmacodynamics of beta- lactams, Clinical Infectious Diseases, 27: 10-22. 
  17. Weber, D. J., Barbiers, A. R. and Lallinger, A. J., (1981). Pharmacokinetics of lincomycin in bovine following intravenous and intramammary doses of lincocin. Upjohn Tech. Report.
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    Research Article

    volume 53 issue 12 (december 2019) : 1675-1678,   Doi: 10.18805/ijar.B-3717

    Disposition Kinetics of lincomycin following intravenous administration in hypothyroid goats

    M
    Meemansha Sharma
    V
    Vinod Kumar Dumka
    S
    Saloni Singla
    R
    Rajdeep Kaur
    R
    Raushan Kumar Singh
    1Department of Veterinary Pharmacology and Toxicology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana-141 004, Punjab, India.
    Cite article:- Sharma Meemansha, Dumka Kumar Vinod, Singla Saloni, Kaur Rajdeep, Singh Kumar Raushan (2019). Disposition Kinetics of lincomycin following intravenous administration in hypothyroid goats. Indian Journal of Animal Research. 53(12): 1675-1678. doi: 10.18805/ijar.B-3717.

    ABSTRACT

    Hypothyroidism is a common disorder of small ruminants and is expected to alter the pharmacokinetics of drugs. Hypothyroidism was induced by feeding thiourea at the dose rate 50 mg.kg-1 daily for 28 days to goats. Disposition of lincomycin, after intravenous administration at dose rate 10 mg/kg, was investigated in hypothyroid goats to determine the potential dosage regimen against susceptible microorganisms. Blood samples were collected from 1 min to 24 h of drug administration. The drug was detected in plasma up to 8 h and lincomycin was rapidly distributed from blood to the tissue, as evidenced by the high value of the distribution coefficient (mean ± SEM) 12.3±1.09 h-1. The large Vd (1.78±0.18 L/kg) indicated vast tissue distribution of lincomycin in goats. The elimination half life, AUC and total body clearance were 3.99± 0.25 h, 33.2±1.71 ìg.h/mL and 0.31±0.02 L/h/kg, respectively. Based on results, lincomycin in hypothyroid goats is suggested to be repeated at 12 h interval for organisms sensitive to lincomycin having MIC up to 0.1 µg.ml-1.

    REFERENCES

    1. Albarellos, G.A., Montoya, L., Denamiel, G.A.A., Velo, M.C., Landoni, M.F., (2012). Pharmacokinetics and bone tissue concentrations of lincomycin following intravenous and intramuscular administrations to cats, Journal of Veterinary Pharmacology and Therapeutics, 35(6): 534-540.
    2. Burrows, G. E., Barto, P. B., and Weeks, B. R., (1986). Chloramphenicol, lincomycin and oxytetracycline disposition in calves with experimental pneumonic pasteurellosis, Journal of veterinary pharmacology and therapeutics, 9(2): 213-222.
    3. Burrows, G.E., Brto, P.B., Martin, B., Tripp M.L., (1983). Comparative pharmacokinetics of antibiotics in new born calves: chloramphenicol,    lincomycin and tylosin, American Journal of Veterinary Research, 44: 1053-57.
    4. Chaleva, E. and Nquyen, D.L., (1987). Pharmacokinetic research on Pharmachem’s lincomycin hydrochloride in pigs, Veterinarno-    Meditsinski Nauki, 24: 47-51.
    5. El-Sayed, M.G.A., El-Komy, A.A.A., El-barawy, A.M., Gehan, E.A.M., (2015). Pharmacokinetical interactions of lincomycin and amprolium in broiler chickens, Journal Science, 5: 734-743.
    6. Giguere, S., (2013). Lincosamides, pleuromutilins, and Streptogramins. In: Giguere, S. Prescott, J. F. and Dowling, P. M. (Eds.) Antimicrobial Therapy in Veterinary Medicine, 5th edn, (John Wiley, Ames, USA). 
    7. Gibaldi, M. and Perrier, D (Eds.) (1982). Pharmacokinetics. 2nd Edn. (Marcel and Dekker Inc, New York).
    8. Gouri. S.S., Venkatachalam, D., Dumka, V. K., (2014). Pharmacokinetics of lincomycin following single intravenous administration in buffalo calves, Tropical Animal Health and Production, 46: 1099-1102.
    9. Gupta, P.S.P., Sanwal, P.C., Varshrey, V.P., (1999). Effect of hypothyroidism on the growth of black bengal goats, Asian-Australian Journal of Animal Sciences, 12: 354-57.
    10. Huimin, L., Ji-An, L.I., Jin-Gang, N.I.U., (2012). Application of Flow Feeding Technology to Lincomycin Fermentation, Chinese Journal of Pharmaceuticals, 43: 739-42.
    11. Nielsen, P. and Gyrd-Hansen, N., (1998). Bioavailibility of lincomycin after oral administration to fed and fasted pigs, Journal of Veterinary Pharmacology and Therapeutics, 21: 251-56.
    12. Plenderleith, R.W., (1988). Treatment of cattle, sheep and horses with lincomycin: case studies, Vet Rec, 122: 112-113.
    13. Petinaki, E., Guérin-Faublée, V., Pichereau, V., Villers. C., Achard, A., Malbruny, B., Leclercq, R., (2008). Lincomycin resistance gene lnu (D) in Streptococcus uberis, Antimicrobial Agents and Chemotherapy, 52: 626-630.
    14. Shenfield, G. M., (1981). Influence of thyroid dysfunction on drug pharmacokinetics. Clinical Pharmacokinetics, 6: 275-97.
    15. Toutain, P.L. and Lees, P., (2004). Integration and modelling of pharmacokinetic and pharmacodynamic data to optimize dosage regimens in veterinary medicine, Journal of Veterinary Pharmacology and Therapeutics, 27: 467–77.
    16. Turnidge, J. D., (1998). The Pharmacodynamics of beta- lactams, Clinical Infectious Diseases, 27: 10-22. 
    17. Weber, D. J., Barbiers, A. R. and Lallinger, A. J., (1981). Pharmacokinetics of lincomycin in bovine following intravenous and intramammary doses of lincocin. Upjohn Tech. Report.
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