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Current IssueEditorial BoardOnline First ArticlesArchive

Research Article

volume 53 issue 8 (august 2019) : 1094-1096,   Doi: 10.18805/ijar.B-3618

Analgesic and isoflurane sparing effect of buprenorphine and butorphanol in cats anaesthetized with midazolam-ketamine-isoflurane

K
K.S. Ramakrishnan
S
S. Dharmaceelan
S
S. Senthilkumar
G
G. Vijayakumar
N
N. Rajendran
1Department of Veterinary Surgery and Radiology, Veterinary College and Research Institute, Tamil Nadu Veterinary and Animal Sciences University, Namakkal– 637 001, Tamil Nadu, India.
Cite article:- Ramakrishnan K.S., Dharmaceelan S., Senthilkumar S., Vijayakumar G., Rajendran N. (2018). Analgesic and isoflurane sparing effect of buprenorphine and butorphanol in cats anaesthetized with midazolam-ketamine-isoflurane. Indian Journal of Animal Research. 53(8): 1094-1096. doi: 10.18805/ijar.B-3618.

ABSTRACT

A clinical study was conducted in 18 female cats subjected for ovariohysterectomy to access the analgesic and isoflurane sparing effect of buprenorphine and butorphanol in cats anaesthetized with midazolam-ketamine- isoflurane. The cats were divided into three Groups. In Group I, anaesthesia was induced by midazolam (@0.3mg/kg) ketamine (11mg/kg) mixture. In Group II and Group III cats, butorphanol and buprenorphine were administered intramuscularly @ 0.4 mg/kg and 0.01 mg/kg, 15 minutes prior to induction of anaesthesia as in Group I. Anaesthesia was maintained with isoflurane. Inspired fraction of isoflurane (FiISO) and End-tidal isoflurane (ETISO) in percentage were recorded by main stream infrared spectroscopy analysis. The postoperative antinociceptive efficacy of drugs was studied by four point simple descriptive scale (SDS) scoring system. The study on end-tidal isoflurane concentration revealed both buprenorphine and butorphanol had reduced the use of isoflurane when compared to control group and among that butorphanol had a higher isoflurane sparing effect than buprenorphine. The pain score study revealed buprenorphine produced adequate postoperative analgesia when compared to butorphanol.

REFERENCES

  1. Giordano, T., Steagall, P.V., Ferreira, T.H., Minto, B.W., Lorena, S.E., Brondani,J. and Luna, S.P. (2010). Postoperative analgesic effects of intravenous, intramuscular, subcutaneous or oral transmucosal buprenorphine administered to cats undergoing ovariohysterectomy. Vet. Anaesth. Analg., 37: 357-66.
  2. Ilkiw, J.E., Pascoe,P.J. and Tripp, L.D. (2002). Effects of morphine, butorphanol, buprenorphine on the minimal alveolar concentration of isoflurane in cats. American J. Vet Res.,63: 1198-1202.
  3. Malavasi, L.M., Jensen-Waern, M., Augustsson,H. and Nyman, G. (2008). Changes in minimal alveolar concentration of isoflurane following treatment with medetomidine and tiletamine / zolazepam, epidural morphine or systemic buprenorphine in pigs. Lab. Anim., 42: 62-70.
  4. Snedecor, G.W. and Cochran, W.G. (1994). Statistical Methods, 9th edn., Oxford and IMB publishing company, Mumbai, India.
  5. Taylor, P.M., Kirby, J.J., Robinson, C., Watkins, E.A., Clarke, D.D., Ford, M.A., Church, K.E. (2010). A postoperative multi-centre clinical trial to compare buprenorphine and butorphanol for postoperative analgesia in cats. J. Feline Med. Surg., 12: 247-255.
  6. Thurmon, J.C., Tranquilli,W.J. and Benson, G.J. (1996). Lumb and Jones’ Veterinary Anaesthesia. 3rdedn., Williams and Wilkins, Baltimore, USA., pp.591-598.
  7. Tranquilli, W. J., Thurmon,J. C. and Grimm, K. A. (2007). Lumb and Jones’ Veterinary Anaesthesia and Analgesia.4thedn., Blackwell Publishers, Iowa, USA., pp.731-743.
  8. Visnugurubaran, D., Kathirvel, S., Senthilkumar, S., Balasundaram, K. AND Dharmaceelan, S. (2017) Isoflurane sparing effect of diazepam and midazolam to Xylazine- ketamine induction and isoflurane maintenance in goats. Indian J. Anim. Res., 51: 762-763
  9. Zwijinenberg, R.J., Rio, C.L.D., Pollet, R.A. and Muir, W.W. (2009). Effects of perzinfotel, butorphanol tartrate and a butorphanol-    perzinfotel combination on the minimal alveolar concentration of isoflurane in cats. American J. Vet. Res., 11: 1270-1276.
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Indian Journal of Animal Research
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    Research Article

    volume 53 issue 8 (august 2019) : 1094-1096,   Doi: 10.18805/ijar.B-3618

    Analgesic and isoflurane sparing effect of buprenorphine and butorphanol in cats anaesthetized with midazolam-ketamine-isoflurane

    K
    K.S. Ramakrishnan
    S
    S. Dharmaceelan
    S
    S. Senthilkumar
    G
    G. Vijayakumar
    N
    N. Rajendran
    1Department of Veterinary Surgery and Radiology, Veterinary College and Research Institute, Tamil Nadu Veterinary and Animal Sciences University, Namakkal– 637 001, Tamil Nadu, India.
    Cite article:- Ramakrishnan K.S., Dharmaceelan S., Senthilkumar S., Vijayakumar G., Rajendran N. (2018). Analgesic and isoflurane sparing effect of buprenorphine and butorphanol in cats anaesthetized with midazolam-ketamine-isoflurane. Indian Journal of Animal Research. 53(8): 1094-1096. doi: 10.18805/ijar.B-3618.

    ABSTRACT

    A clinical study was conducted in 18 female cats subjected for ovariohysterectomy to access the analgesic and isoflurane sparing effect of buprenorphine and butorphanol in cats anaesthetized with midazolam-ketamine- isoflurane. The cats were divided into three Groups. In Group I, anaesthesia was induced by midazolam (@0.3mg/kg) ketamine (11mg/kg) mixture. In Group II and Group III cats, butorphanol and buprenorphine were administered intramuscularly @ 0.4 mg/kg and 0.01 mg/kg, 15 minutes prior to induction of anaesthesia as in Group I. Anaesthesia was maintained with isoflurane. Inspired fraction of isoflurane (FiISO) and End-tidal isoflurane (ETISO) in percentage were recorded by main stream infrared spectroscopy analysis. The postoperative antinociceptive efficacy of drugs was studied by four point simple descriptive scale (SDS) scoring system. The study on end-tidal isoflurane concentration revealed both buprenorphine and butorphanol had reduced the use of isoflurane when compared to control group and among that butorphanol had a higher isoflurane sparing effect than buprenorphine. The pain score study revealed buprenorphine produced adequate postoperative analgesia when compared to butorphanol.

    REFERENCES

    1. Giordano, T., Steagall, P.V., Ferreira, T.H., Minto, B.W., Lorena, S.E., Brondani,J. and Luna, S.P. (2010). Postoperative analgesic effects of intravenous, intramuscular, subcutaneous or oral transmucosal buprenorphine administered to cats undergoing ovariohysterectomy. Vet. Anaesth. Analg., 37: 357-66.
    2. Ilkiw, J.E., Pascoe,P.J. and Tripp, L.D. (2002). Effects of morphine, butorphanol, buprenorphine on the minimal alveolar concentration of isoflurane in cats. American J. Vet Res.,63: 1198-1202.
    3. Malavasi, L.M., Jensen-Waern, M., Augustsson,H. and Nyman, G. (2008). Changes in minimal alveolar concentration of isoflurane following treatment with medetomidine and tiletamine / zolazepam, epidural morphine or systemic buprenorphine in pigs. Lab. Anim., 42: 62-70.
    4. Snedecor, G.W. and Cochran, W.G. (1994). Statistical Methods, 9th edn., Oxford and IMB publishing company, Mumbai, India.
    5. Taylor, P.M., Kirby, J.J., Robinson, C., Watkins, E.A., Clarke, D.D., Ford, M.A., Church, K.E. (2010). A postoperative multi-centre clinical trial to compare buprenorphine and butorphanol for postoperative analgesia in cats. J. Feline Med. Surg., 12: 247-255.
    6. Thurmon, J.C., Tranquilli,W.J. and Benson, G.J. (1996). Lumb and Jones’ Veterinary Anaesthesia. 3rdedn., Williams and Wilkins, Baltimore, USA., pp.591-598.
    7. Tranquilli, W. J., Thurmon,J. C. and Grimm, K. A. (2007). Lumb and Jones’ Veterinary Anaesthesia and Analgesia.4thedn., Blackwell Publishers, Iowa, USA., pp.731-743.
    8. Visnugurubaran, D., Kathirvel, S., Senthilkumar, S., Balasundaram, K. AND Dharmaceelan, S. (2017) Isoflurane sparing effect of diazepam and midazolam to Xylazine- ketamine induction and isoflurane maintenance in goats. Indian J. Anim. Res., 51: 762-763
    9. Zwijinenberg, R.J., Rio, C.L.D., Pollet, R.A. and Muir, W.W. (2009). Effects of perzinfotel, butorphanol tartrate and a butorphanol-    perzinfotel combination on the minimal alveolar concentration of isoflurane in cats. American J. Vet. Res., 11: 1270-1276.
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