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Research Article

volume 53 issue 5 (may 2019) : 599-603,   Doi: 10.18805/ijar.B-3569

Age-specific peripheral anti-müllerian hormone concentrations in goats (capra hircus)

A
Avijit Haldar
S
Sachinandan De
V
Vinay Singh
M
Mrinmoy Datta
P
Prasenjit Pal
B
Bukkaraya S. Prakash
1ICAR Research Complex for North Eastern Hill Region, Tripura Centre, Agartala, P.O.- Lembucherra- 799 210, West Tripura, India.
Cite article:- Haldar Avijit, De Sachinandan, Singh Vinay, Datta Mrinmoy, Pal Prasenjit, Prakash S. Bukkaraya (2018). Age-specific peripheral anti-müllerian hormone concentrations in goats(capra hircus). Indian Journal of Animal Research. 53(5): 599-603. doi: 10.18805/ijar.B-3569.

ABSTRACT

Anti- Mullerian hormone (AMH) appears to be the best biochemical-endocrine marker in assessing the age-related decline of the ovarian follicular reserve. There is inadequate information on age-related changes in peripheral AMH concentrations in goats (Capra hircus). The present study thus aimed (i) to investigate the responsiveness of the ovary to gonadotrophin releasing hormone (GnRH) challenge to release plasma AMH into circulation in view of addressing the question whether ovarian secretion of AMH would be affected by gonadotrophic status in goats and (ii) to determine plasma AMH concentrations at different ages in goats (n= 82) using enzyme immune-assay technique. Data on hormonal concentrations in GnRH-treated animals as well as in different ages of animals were analyzed by nonparametric one-way repeated measure ANOVA and one-way ANOVA, respectively. There was no change (P>0.05) of plasma AMH concentrations after GnRH challenge in experimental goats. Plasma AMH concentrations changed significantly (P<0.05) between the mean rank of the related groups over the time (age) in goats. Plasma AMH concentration at 3 months of age was 0.36 ± 0.04 ng/ ml and thereafter it started increasing and reached ³ 2 ng/ ml between 3 and 4 years of age and then showed a progressive decline from 5 years of age and reached at 0.30 ± 0.07 ng/ ml at 10 years of age. A cubic model was found to be the best fitted model that delineated the change of plasma AMH level with age. Hence, the present study indicated that peripheral AMH concentration could be a useful management tool for the selection of goats in breeding programmes.

REFERENCES

  1. Amanvermez, R., Tosun, M. (2016). An update on ovarian aging and ovarian reserve tests. International Journal of Fertility and Sterility, 9: 411-415.
  2. Christiansen, S.C., Eilertsen, T.B., Vanky, E., Carlsen, S.M. (2016). Does AMH Reflect follicle number similarly in women with and without PCOS? PLoS One, 11: e0146739. doi: 10.1371/journal.pone.0146739. eCollection 2016.
  3. de Vet, A., Laven, J.S., de Jong, F.H., Themmen, A.P.N., Fauser, B.C. (2002). Antimullerian hormone serum levels: a putative marker for ovarian aging. Fertility and Sterility, 77: 357–362.
  4. Du, X., Ding, T., Zhang, H., Zhang, C., Ma, W., Zhong, Y., Qu, W., Zheng, J., Liu, Y., et al (2016). Age-Specific normal reference range for serum anti-müllerian hormone in healthy chinese han women: A nationwide population-based study. Reproduction Science, 23: 1019-1027.
  5. Elgindy, E.A., EI-Haieg, D.O., EI-Sebaey, A. (2007). Anti-Müllerian hormone: correlation of early follicular, ovulatory and midluteal levels with ovarian response and cycle outcome in intracytoplasmic sperm injection patients. Fertility and Sterility, 89: 1670-1676.
  6. Fanchin, R., Schonauer, L.M., Righini, C., Guibourdenche, J., Frydman, R., Taieb, J. (2003). Serum anti-mullerian hormone is more strongly related to ovarian follicular status than serum inhibin B, estradiol, FSH and LH on day 3. Human Reproduction, 18: 323–327.
  7. Grynnerup, A.G., Lindhard, A., Sorensen, S. (2012). The role of anti-Müllerian hormone in female fertility and infertility – an overview. Acta Obstetricia et Gynecologica Scandinavica, 91: 1252-1260.
  8. Haldar, A., Pal, S.K., Chakraborty, S., Hazorika, M., Pan, S., Majumdar, D., Biswas, C.K., Patra, A., Mirmahmoudi, R., Prakash, B.S. (2013). Endocrine markers for identifying prolificacy potential and predicting fetal number in goats. Animal Reproduction Science, 140: 54-61.
  9. Haldar, A., Paul, R., Pan, S., Mitra, A., Biswas, C., Majumdar, D., Ghosh, S., et al (2009). Validation of a simple, sensitive enzyme immunoassay (EIA) for the determination of caprine plasma LH. Small Ruminant Research, 84: 22-27.
  10. Hollinshead, F.K., Walker, C., Hanlon, D.W. (2017). Determination of the normal reference interval for anti-Müllerian hormone (AMH) in bitches and use of AMH as a potential predictor of litter size. Reproduction in Domestic Animal, 52 Suppl 2: 35-40.
  11. Jimenez-Krassel, F., Scheetz, D.M., Neuder, L.M., Ireland, J.L., Pursley, J.R., et al (2015). Concentration of anti-Müllerian hormone in dairy heifers is positively associated with productive herd life. Journal of Dairy Science, 98: 3036-3045. 
  12. Jirge, P.R. (2011). Ovarian reserve tests. Journal of Human Reproduction Science, 4: 108-113.
  13. Kevenaar, M.E., Meerasahib, M.F., Kramer, P., Van de Lang-Born, B.M.N., De Jong, F.H., et al (2006). Serum AMH levels reflect the size of the primordial follicle pool in mice. Endocrinology, 147: 3228–3234.
  14. La Marca, A., Giulini, S., Orvieto, R., De Leo, V., Volpe, A. (2005). Anti- Mullerian hormone concentrations in maternal serum during pregnancy. Human Reproduction, 20: 1569–1572.
  15. Lahoz, B., Alabart, J.L., Cocero, M.J., Monniaux, D., Echegoyen, E., Sánchez, P., Folch, J. (2014). Anti-Müllerian hormone concentration in sheep and its dependence of age and independence of BMP15 genotype: an endocrine predictor to select the best donors for embryo biotechnologies. Theriogenology, 81: 347-357. 
  16. Liang, A., Salzano, A., D’Esposito, M., Comin, A., Montillo, M., Yang, L., Campanile, G., Gasparrini, B. (2016). Anti-Mullerian hormone (AMH) concentration in follicular fluid and mRNA expression of AMH receptor type II and LH receptor in granulosa cells as predictive markers of good buffalo (Bubalus bubalis) donors. Theriogenology, 86: 963-970. 
  17. Monniaux, D., Baril, G., Laine, A.L., Jarrier, P., Poulin, N., Cognié, J., Fabre, S. (2011). Anti-Mullerian hormone as a predictive endocrine marker for embryo production in the goat. Reproduction, 142: 845-854. 
  18. Pfeiffer, K.E., Jury, L.J., Larson, J.E. (2014). Determination of anti-Müllerian hormone at estrus during a synchronized and a natural bovine estrous cycle. Domestic Animal Endocrinology, 46: 58-64. 
  19. Poomthavorn, P., Khlairit, P., Mahachoklertwattana, P. (2009). Subcutaneous gonadotropin-releasing hormone agonist (triptorelin) test for di-agnosing precocious puberty. Hormone Research, 72: 114-119. 
  20. Prakash, B.S., Paul, V., Anandlaxmi, N. (2002). Development and validation of a simple, sensitive, second antibody format enzyme immunoassay for LH determination in plasma. Journal of Immunological Method, 270: 281–290.
  21. Rico, C., Médigue, C., Fabre, S., Jarrier, P., Bontoux, M., Clément, F., Monniaux, D. (2011). Regulation of anti-müllerian hormone production in the cow: A multiscale study at endocrine, ovarian, follicular and granulosa cell levels. Biology of Reproduction, 84: 560–571.
  22. SAS, 9.3. (2012). Foundation for Microsoft Windows, SAS Institute Inc., Cary, NC.
  23. Van Rooij, I.A., Broekmans, F.J., Te Velde, E.R., Fause,r B.C., Bancsi, L.F., De Jong, F.H., Themmen, A.P.N. (2002). Serum anti-    Mullerian hormone levels: a novel measure of ovarian reserve. Human Reproduction, 17: 3065–3071.
  24. Visser, J.A., Schippe,r I., Laven, J.S.E., Themmen, A.P.N. (2012). Anti-Müllerian hormone: an ovarian reserve marker in primary ovarian insufficiency. Nature Reviews Endocrinology, 8: 331–341. 
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Indian Journal of Animal Research
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    Research Article

    volume 53 issue 5 (may 2019) : 599-603,   Doi: 10.18805/ijar.B-3569

    Age-specific peripheral anti-müllerian hormone concentrations in goats (capra hircus)

    A
    Avijit Haldar
    S
    Sachinandan De
    V
    Vinay Singh
    M
    Mrinmoy Datta
    P
    Prasenjit Pal
    B
    Bukkaraya S. Prakash
    1ICAR Research Complex for North Eastern Hill Region, Tripura Centre, Agartala, P.O.- Lembucherra- 799 210, West Tripura, India.
    Cite article:- Haldar Avijit, De Sachinandan, Singh Vinay, Datta Mrinmoy, Pal Prasenjit, Prakash S. Bukkaraya (2018). Age-specific peripheral anti-m&uuml;llerian hormone concentrations in goats(capra hircus). Indian Journal of Animal Research. 53(5): 599-603. doi: 10.18805/ijar.B-3569.

    ABSTRACT

    Anti- Mullerian hormone (AMH) appears to be the best biochemical-endocrine marker in assessing the age-related decline of the ovarian follicular reserve. There is inadequate information on age-related changes in peripheral AMH concentrations in goats (Capra hircus). The present study thus aimed (i) to investigate the responsiveness of the ovary to gonadotrophin releasing hormone (GnRH) challenge to release plasma AMH into circulation in view of addressing the question whether ovarian secretion of AMH would be affected by gonadotrophic status in goats and (ii) to determine plasma AMH concentrations at different ages in goats (n= 82) using enzyme immune-assay technique. Data on hormonal concentrations in GnRH-treated animals as well as in different ages of animals were analyzed by nonparametric one-way repeated measure ANOVA and one-way ANOVA, respectively. There was no change (P>0.05) of plasma AMH concentrations after GnRH challenge in experimental goats. Plasma AMH concentrations changed significantly (P<0.05) between the mean rank of the related groups over the time (age) in goats. Plasma AMH concentration at 3 months of age was 0.36 ± 0.04 ng/ ml and thereafter it started increasing and reached ³ 2 ng/ ml between 3 and 4 years of age and then showed a progressive decline from 5 years of age and reached at 0.30 ± 0.07 ng/ ml at 10 years of age. A cubic model was found to be the best fitted model that delineated the change of plasma AMH level with age. Hence, the present study indicated that peripheral AMH concentration could be a useful management tool for the selection of goats in breeding programmes.

    REFERENCES

    1. Amanvermez, R., Tosun, M. (2016). An update on ovarian aging and ovarian reserve tests. International Journal of Fertility and Sterility, 9: 411-415.
    2. Christiansen, S.C., Eilertsen, T.B., Vanky, E., Carlsen, S.M. (2016). Does AMH Reflect follicle number similarly in women with and without PCOS? PLoS One, 11: e0146739. doi: 10.1371/journal.pone.0146739. eCollection 2016.
    3. de Vet, A., Laven, J.S., de Jong, F.H., Themmen, A.P.N., Fauser, B.C. (2002). Antimullerian hormone serum levels: a putative marker for ovarian aging. Fertility and Sterility, 77: 357–362.
    4. Du, X., Ding, T., Zhang, H., Zhang, C., Ma, W., Zhong, Y., Qu, W., Zheng, J., Liu, Y., et al (2016). Age-Specific normal reference range for serum anti-müllerian hormone in healthy chinese han women: A nationwide population-based study. Reproduction Science, 23: 1019-1027.
    5. Elgindy, E.A., EI-Haieg, D.O., EI-Sebaey, A. (2007). Anti-Müllerian hormone: correlation of early follicular, ovulatory and midluteal levels with ovarian response and cycle outcome in intracytoplasmic sperm injection patients. Fertility and Sterility, 89: 1670-1676.
    6. Fanchin, R., Schonauer, L.M., Righini, C., Guibourdenche, J., Frydman, R., Taieb, J. (2003). Serum anti-mullerian hormone is more strongly related to ovarian follicular status than serum inhibin B, estradiol, FSH and LH on day 3. Human Reproduction, 18: 323–327.
    7. Grynnerup, A.G., Lindhard, A., Sorensen, S. (2012). The role of anti-Müllerian hormone in female fertility and infertility – an overview. Acta Obstetricia et Gynecologica Scandinavica, 91: 1252-1260.
    8. Haldar, A., Pal, S.K., Chakraborty, S., Hazorika, M., Pan, S., Majumdar, D., Biswas, C.K., Patra, A., Mirmahmoudi, R., Prakash, B.S. (2013). Endocrine markers for identifying prolificacy potential and predicting fetal number in goats. Animal Reproduction Science, 140: 54-61.
    9. Haldar, A., Paul, R., Pan, S., Mitra, A., Biswas, C., Majumdar, D., Ghosh, S., et al (2009). Validation of a simple, sensitive enzyme immunoassay (EIA) for the determination of caprine plasma LH. Small Ruminant Research, 84: 22-27.
    10. Hollinshead, F.K., Walker, C., Hanlon, D.W. (2017). Determination of the normal reference interval for anti-Müllerian hormone (AMH) in bitches and use of AMH as a potential predictor of litter size. Reproduction in Domestic Animal, 52 Suppl 2: 35-40.
    11. Jimenez-Krassel, F., Scheetz, D.M., Neuder, L.M., Ireland, J.L., Pursley, J.R., et al (2015). Concentration of anti-Müllerian hormone in dairy heifers is positively associated with productive herd life. Journal of Dairy Science, 98: 3036-3045. 
    12. Jirge, P.R. (2011). Ovarian reserve tests. Journal of Human Reproduction Science, 4: 108-113.
    13. Kevenaar, M.E., Meerasahib, M.F., Kramer, P., Van de Lang-Born, B.M.N., De Jong, F.H., et al (2006). Serum AMH levels reflect the size of the primordial follicle pool in mice. Endocrinology, 147: 3228–3234.
    14. La Marca, A., Giulini, S., Orvieto, R., De Leo, V., Volpe, A. (2005). Anti- Mullerian hormone concentrations in maternal serum during pregnancy. Human Reproduction, 20: 1569–1572.
    15. Lahoz, B., Alabart, J.L., Cocero, M.J., Monniaux, D., Echegoyen, E., Sánchez, P., Folch, J. (2014). Anti-Müllerian hormone concentration in sheep and its dependence of age and independence of BMP15 genotype: an endocrine predictor to select the best donors for embryo biotechnologies. Theriogenology, 81: 347-357. 
    16. Liang, A., Salzano, A., D’Esposito, M., Comin, A., Montillo, M., Yang, L., Campanile, G., Gasparrini, B. (2016). Anti-Mullerian hormone (AMH) concentration in follicular fluid and mRNA expression of AMH receptor type II and LH receptor in granulosa cells as predictive markers of good buffalo (Bubalus bubalis) donors. Theriogenology, 86: 963-970. 
    17. Monniaux, D., Baril, G., Laine, A.L., Jarrier, P., Poulin, N., Cognié, J., Fabre, S. (2011). Anti-Mullerian hormone as a predictive endocrine marker for embryo production in the goat. Reproduction, 142: 845-854. 
    18. Pfeiffer, K.E., Jury, L.J., Larson, J.E. (2014). Determination of anti-Müllerian hormone at estrus during a synchronized and a natural bovine estrous cycle. Domestic Animal Endocrinology, 46: 58-64. 
    19. Poomthavorn, P., Khlairit, P., Mahachoklertwattana, P. (2009). Subcutaneous gonadotropin-releasing hormone agonist (triptorelin) test for di-agnosing precocious puberty. Hormone Research, 72: 114-119. 
    20. Prakash, B.S., Paul, V., Anandlaxmi, N. (2002). Development and validation of a simple, sensitive, second antibody format enzyme immunoassay for LH determination in plasma. Journal of Immunological Method, 270: 281–290.
    21. Rico, C., Médigue, C., Fabre, S., Jarrier, P., Bontoux, M., Clément, F., Monniaux, D. (2011). Regulation of anti-müllerian hormone production in the cow: A multiscale study at endocrine, ovarian, follicular and granulosa cell levels. Biology of Reproduction, 84: 560–571.
    22. SAS, 9.3. (2012). Foundation for Microsoft Windows, SAS Institute Inc., Cary, NC.
    23. Van Rooij, I.A., Broekmans, F.J., Te Velde, E.R., Fause,r B.C., Bancsi, L.F., De Jong, F.H., Themmen, A.P.N. (2002). Serum anti-    Mullerian hormone levels: a novel measure of ovarian reserve. Human Reproduction, 17: 3065–3071.
    24. Visser, J.A., Schippe,r I., Laven, J.S.E., Themmen, A.P.N. (2012). Anti-Müllerian hormone: an ovarian reserve marker in primary ovarian insufficiency. Nature Reviews Endocrinology, 8: 331–341. 
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