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Current IssueEditorial BoardOnline First ArticlesArchive

Research Article

volume 51 issue 5 (october 2017) : 832-836,   Doi: 10.18805/ijar.B-3425

Ameliorating potential of Hedychium spictum on oxidative stress following chronic exposure to indoxacarb in WLH cockerels

G
Govind Kumar Choudhary
S
Satya Pal Singh
1Department of Pharmacology & Toxicology, College of Veterinary and Animal Sciences, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, 263145, India.
Cite article:- Choudhary Kumar Govind, Singh Pal Satya (2017). Ameliorating potential of Hedychium spictum on oxidative stress following chronic exposure to indoxacarb in WLH cockerels. Indian Journal of Animal Research. 51(5): 832-836. doi: 10.18805/ijar.B-3425.

ABSTRACT

Present study was designed to evaluate ameliorating potential of Hydechium spicatum on oxidative stress following chronic exposure to indoxacarb in White Leg Horn (WLH) cockerels. Chronic oxidative stress was induced in WLH cockerels. Lipid peroxidation, reduced GSH, GPx, GST, SOD and catalase levels were estimated in blood and tissues. Indoxacarb produced toxicity in the form of alteration of lipid peroxidation, reduced GSH, GPx, GST, SOD and catalase levels. Hedychium spicatum was effective in restoration of these parameters towards normal. It was concluded that Hedychium spicatum has ameliorating potential on oxidative stress following chronic exposure to indoxacarb in WLH cockerels.

REFERENCES

  1. Aebi, H. (1983). Catalase in method of Enzymatic Analysis (ed. H. U. Bergmeyer), 3rd ed. : Verlag Chemie, Weinheim 273-286.
  2. Choudhary, G. K. and Singh, S. P. (2016). Ameliorative efficacy of Hedychium spicatum root powder in indoxacarb intoxicated WLH cockerels. J. Vet. Parmacol. & Toxicol. 15 (2): 61-64.
  3. Choudhary, G. K. and Singh, S. P. (2017). Cytotoxic potential of rhizome extracts of Hedychium spicatum L. in HepG2 cell line using MTT, Indian J of An Scs; 87 (3): 313–315.
  4. Eaton, D. L. and Bammler, T. K. (1999). Concise review of the glutathione S- transferases and their significance to toxicology. Toxicol. Sci. 49 (2): 156-164.
  5. Frame, S. R. (1997). Oncogenicity study with DPX-JW062-106 (50% DPX-KN128, 50% DPX-KN127) eighteen-month feeding study in mice. Unpublished report No. HLR 799-96 from DuPont Haskell Laboratory, Newark, Delaware, USA. Submitted to WHO by E.I. du Pont de Nemours and Company, Wilmington, Delaware, USA. 
  6. Habig, W. H., Pabst, M. J. and Jakoby, W. B. (1974). Glutathione S- transferases: the first enzymatic step in mercapturic acid formation. J. Biol. Chem. 249: 7130-7139.
  7. Hafeman, D. G., Sunde, R. A. and Hoekstra, W. G. (1974). Effect of Dietry Selenium on Erythrocyte and Liver GPx in the Rat. J. Nutrition. pp. 580-587.
  8. Halliwell B and Cross C E. 1994. Review Oxygen-derived species: their relation to human disease and environmental stress. Environ Health Perspect. 102 Suppl 10:5-12.
  9. Kajaria D., Tripathi J. S., Tiwari, S. K., Pandey, B. L. (2013). In-vitro evaluation of immunomodulatory effect of polyherbal compound – Bharangyadi. Journal of Drug Delivery & Therapeutics, 3 (1): 36-39. 
  10. Kalender, Y., Kaya, S., Durak, D., Uzun, F. G. and Demir, F. (2012). Protective effects of catechin and quercetin on antixoidant status, lipid peroxidation and testis-histoarchitecture induced by chlorpyrifos in male rats. Environ Toxicol Pharmacol 33(2):141-8.
  11. Khalid, R. (2007). Studies on free radicals, antioxidants, and co-factors. Clin Interv Aging. 2(2): 219–236.
  12. Lapied, B., Grolleau, F. and Sattelle, D. B. (2001). Indoxacarb, an oxadiazine insecticide, blocks insect neuronal sodium channels, British Journal of Pharmacology 132: 587"595.
  13. Marklund, S. and Marklund, G. (1974). Involvement of the superoxide anion rsdical in the autooxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur. J. Biochem. 47: 469-474.
  14. Mehta, A., Verma, R. S. and Srivastava, N. (2009). Chlorpyrifos induced alterations in the levels of hydrogen peroxide, nitrate and nitrite in rat brain and liver. Pestic Biochem Physiol. 94(2-3):55-59.
  15. Mertens, J. J.W. M. (1997). Subchronic oral toxicity: 90-day study with DPX-JW062-106 (50% DPX-KN128, 50% DPX-KN127) feeding study in dogs. Unpublished report No. HLO 494-95, RV3 from WIL Research Laboratories, Inc., Ashland, Ohio, USA. Submitted to WHO by E.I. du Pont de Nemours and Company, Wilmington, Delaware, USA.
  16. Mudaraddi, T. Y. and Kaliwal, B. B. (2009). Indoxacarb induces testes oxidative stress in Swiss Albino Mice. Inter Jour of Biotech. Res (IJBR), 1: 40-48.
  17. Mudaraddi, T. Y., Potadar, R. R. and Kaliwal, B. B. (2012). Indoxacarb induces liver oxidative stress in Swiss Albino Mice, Eur J of Experi Bio, 2 (1): 180-186.
  18. Oakley, A. (2001). Glutathione transferases: a structural perspective. Drug Metab. Rev., 43 (2): 138-151. 
  19. Prins, H. K. and Loos, J. A. (1969). Glutathione, In: Biochemical Methods in Red Cell Genetics.Yunis, J.J. ed. New York, Academic Press. pp.115-137.
  20. Puri, A., Srivastava, A., Bhardwaj, A., Tondon, J. S. and Saxena K. C. (2013). Immunostimulant activity of certain plants used in Indian
  21. traditional medicine Journal of Medicinal Plants Research. 7 (44): 3242-3246.
  22. Rehman, S.U. (1984). Lead induced regional lipid peroxidation in brain. Toxicol. Lett., 21: 333-337.
  23. Singh, K. L. and Bagh, G.C. (2013). Phytochemical Analysis And Determination Of Total Phenolics Content In Water Extracts Of Three Species of Hedychium. Inter Journal of Pharm. Tech. Research, CODEN (USA), 5 (4): 1516-1521.
  24. Snedecor, G. W. and Cochran, W. G. (1994). Statistical methods, 9th edition. Iowa State University Press, Ame. 
  25. Sravani, T. and Paarakh, P. M. (2012). Antioxidant property of Hedychium spicatum Buch.-Ham. rhizomes, Ind. J. of Natural Product and Resources, 3 (3): 354-358.
  26. Stoh, S. J. and Bagchi, D. (1995). Oxidative mechanisms in the toxicity of metal ions. Free Radic. Biol. Med. 18: 321-336.
  27. Thapliyal, S., Juya, V. and Bhandari, A. (2014). Pharmacognostic Screening of Hedychium spicatum Rhizomes, Inter J of Pharmaceutical and Chem Scis, 3 (4): 483-488.
  28. Thapliyal, S., Juyal, V. and Bhandari, A. (2014). Hepatoprotective and Antioxidant Activity of Methanol Extract of Hedychium spicatum against CCl4-Induced Liver Injury in Rats. Res J of Pharmaceutical, Biol. and Chem. Sci., 5 (2): 1428.
  29. Watts, Meriel. (2013). Chlorpyrifos. Pesticide Action Network Asia and the Pacific, p: 1-67.
  30. Yan, S, and Asmah, R. (2010). Comparison of total phenolic contents and antioxidant activities of turmeric leaf, pandan leaf and torch ginger flower. Int Food Res. J. 17: 417–423. 
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Indian Journal of Animal Research
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    Research Article

    volume 51 issue 5 (october 2017) : 832-836,   Doi: 10.18805/ijar.B-3425

    Ameliorating potential of Hedychium spictum on oxidative stress following chronic exposure to indoxacarb in WLH cockerels

    G
    Govind Kumar Choudhary
    S
    Satya Pal Singh
    1Department of Pharmacology & Toxicology, College of Veterinary and Animal Sciences, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, 263145, India.
    Cite article:- Choudhary Kumar Govind, Singh Pal Satya (2017). Ameliorating potential of Hedychium spictum on oxidative stress following chronic exposure to indoxacarb in WLH cockerels. Indian Journal of Animal Research. 51(5): 832-836. doi: 10.18805/ijar.B-3425.

    ABSTRACT

    Present study was designed to evaluate ameliorating potential of Hydechium spicatum on oxidative stress following chronic exposure to indoxacarb in White Leg Horn (WLH) cockerels. Chronic oxidative stress was induced in WLH cockerels. Lipid peroxidation, reduced GSH, GPx, GST, SOD and catalase levels were estimated in blood and tissues. Indoxacarb produced toxicity in the form of alteration of lipid peroxidation, reduced GSH, GPx, GST, SOD and catalase levels. Hedychium spicatum was effective in restoration of these parameters towards normal. It was concluded that Hedychium spicatum has ameliorating potential on oxidative stress following chronic exposure to indoxacarb in WLH cockerels.

    REFERENCES

    1. Aebi, H. (1983). Catalase in method of Enzymatic Analysis (ed. H. U. Bergmeyer), 3rd ed. : Verlag Chemie, Weinheim 273-286.
    2. Choudhary, G. K. and Singh, S. P. (2016). Ameliorative efficacy of Hedychium spicatum root powder in indoxacarb intoxicated WLH cockerels. J. Vet. Parmacol. & Toxicol. 15 (2): 61-64.
    3. Choudhary, G. K. and Singh, S. P. (2017). Cytotoxic potential of rhizome extracts of Hedychium spicatum L. in HepG2 cell line using MTT, Indian J of An Scs; 87 (3): 313–315.
    4. Eaton, D. L. and Bammler, T. K. (1999). Concise review of the glutathione S- transferases and their significance to toxicology. Toxicol. Sci. 49 (2): 156-164.
    5. Frame, S. R. (1997). Oncogenicity study with DPX-JW062-106 (50% DPX-KN128, 50% DPX-KN127) eighteen-month feeding study in mice. Unpublished report No. HLR 799-96 from DuPont Haskell Laboratory, Newark, Delaware, USA. Submitted to WHO by E.I. du Pont de Nemours and Company, Wilmington, Delaware, USA. 
    6. Habig, W. H., Pabst, M. J. and Jakoby, W. B. (1974). Glutathione S- transferases: the first enzymatic step in mercapturic acid formation. J. Biol. Chem. 249: 7130-7139.
    7. Hafeman, D. G., Sunde, R. A. and Hoekstra, W. G. (1974). Effect of Dietry Selenium on Erythrocyte and Liver GPx in the Rat. J. Nutrition. pp. 580-587.
    8. Halliwell B and Cross C E. 1994. Review Oxygen-derived species: their relation to human disease and environmental stress. Environ Health Perspect. 102 Suppl 10:5-12.
    9. Kajaria D., Tripathi J. S., Tiwari, S. K., Pandey, B. L. (2013). In-vitro evaluation of immunomodulatory effect of polyherbal compound – Bharangyadi. Journal of Drug Delivery & Therapeutics, 3 (1): 36-39. 
    10. Kalender, Y., Kaya, S., Durak, D., Uzun, F. G. and Demir, F. (2012). Protective effects of catechin and quercetin on antixoidant status, lipid peroxidation and testis-histoarchitecture induced by chlorpyrifos in male rats. Environ Toxicol Pharmacol 33(2):141-8.
    11. Khalid, R. (2007). Studies on free radicals, antioxidants, and co-factors. Clin Interv Aging. 2(2): 219–236.
    12. Lapied, B., Grolleau, F. and Sattelle, D. B. (2001). Indoxacarb, an oxadiazine insecticide, blocks insect neuronal sodium channels, British Journal of Pharmacology 132: 587"595.
    13. Marklund, S. and Marklund, G. (1974). Involvement of the superoxide anion rsdical in the autooxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur. J. Biochem. 47: 469-474.
    14. Mehta, A., Verma, R. S. and Srivastava, N. (2009). Chlorpyrifos induced alterations in the levels of hydrogen peroxide, nitrate and nitrite in rat brain and liver. Pestic Biochem Physiol. 94(2-3):55-59.
    15. Mertens, J. J.W. M. (1997). Subchronic oral toxicity: 90-day study with DPX-JW062-106 (50% DPX-KN128, 50% DPX-KN127) feeding study in dogs. Unpublished report No. HLO 494-95, RV3 from WIL Research Laboratories, Inc., Ashland, Ohio, USA. Submitted to WHO by E.I. du Pont de Nemours and Company, Wilmington, Delaware, USA.
    16. Mudaraddi, T. Y. and Kaliwal, B. B. (2009). Indoxacarb induces testes oxidative stress in Swiss Albino Mice. Inter Jour of Biotech. Res (IJBR), 1: 40-48.
    17. Mudaraddi, T. Y., Potadar, R. R. and Kaliwal, B. B. (2012). Indoxacarb induces liver oxidative stress in Swiss Albino Mice, Eur J of Experi Bio, 2 (1): 180-186.
    18. Oakley, A. (2001). Glutathione transferases: a structural perspective. Drug Metab. Rev., 43 (2): 138-151. 
    19. Prins, H. K. and Loos, J. A. (1969). Glutathione, In: Biochemical Methods in Red Cell Genetics.Yunis, J.J. ed. New York, Academic Press. pp.115-137.
    20. Puri, A., Srivastava, A., Bhardwaj, A., Tondon, J. S. and Saxena K. C. (2013). Immunostimulant activity of certain plants used in Indian
    21. traditional medicine Journal of Medicinal Plants Research. 7 (44): 3242-3246.
    22. Rehman, S.U. (1984). Lead induced regional lipid peroxidation in brain. Toxicol. Lett., 21: 333-337.
    23. Singh, K. L. and Bagh, G.C. (2013). Phytochemical Analysis And Determination Of Total Phenolics Content In Water Extracts Of Three Species of Hedychium. Inter Journal of Pharm. Tech. Research, CODEN (USA), 5 (4): 1516-1521.
    24. Snedecor, G. W. and Cochran, W. G. (1994). Statistical methods, 9th edition. Iowa State University Press, Ame. 
    25. Sravani, T. and Paarakh, P. M. (2012). Antioxidant property of Hedychium spicatum Buch.-Ham. rhizomes, Ind. J. of Natural Product and Resources, 3 (3): 354-358.
    26. Stoh, S. J. and Bagchi, D. (1995). Oxidative mechanisms in the toxicity of metal ions. Free Radic. Biol. Med. 18: 321-336.
    27. Thapliyal, S., Juya, V. and Bhandari, A. (2014). Pharmacognostic Screening of Hedychium spicatum Rhizomes, Inter J of Pharmaceutical and Chem Scis, 3 (4): 483-488.
    28. Thapliyal, S., Juyal, V. and Bhandari, A. (2014). Hepatoprotective and Antioxidant Activity of Methanol Extract of Hedychium spicatum against CCl4-Induced Liver Injury in Rats. Res J of Pharmaceutical, Biol. and Chem. Sci., 5 (2): 1428.
    29. Watts, Meriel. (2013). Chlorpyrifos. Pesticide Action Network Asia and the Pacific, p: 1-67.
    30. Yan, S, and Asmah, R. (2010). Comparison of total phenolic contents and antioxidant activities of turmeric leaf, pandan leaf and torch ginger flower. Int Food Res. J. 17: 417–423. 
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