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Research Article

volume 52 issue 10 (october 2018) : 1416-1421,   Doi: 10.18805/ijar.B-3390

Post-ingestional effects of red chilli powder containing capsaicin in stomach of house rat, Rattus rattus: histomorphological and histoenzymic studies

R
Ramandeep Kaur
N
Neena Singla
N
Neelam Bansal
D
Devendra Pathak
1Department of Zoology, Punjab Agricultural University, Ludhiana-141004, Punjab, India
Cite article:- Kaur Ramandeep, Singla Neena, Bansal Neelam, Pathak Devendra (2017). Post-ingestional effects of red chilli powder containing capsaicin in stomach of house rat, Rattus rattus: histomorphological and histoenzymic studies. Indian Journal of Animal Research. 52(10): 1416-1421. doi: 10.18805/ijar.B-3390.

ABSTRACT

Present study reports post-ingestional effects of red chilli in stomach of house rat, Rattus rattus. Three different groups of female rats (5 per group) were fed on bait containing 1 and 2% red chilli powder and plain bait, respectively. Histomorphological study revealed cellular degeneration of gastric region, sloughing and distortion of superficial layer of epithelium and lymphocytic infiltration in the treated groups of rats. Histoenzymic study revealed an increase in AKPase and decrease in LDH, SDH, G-6-PD and GLD activities in glandular stomach of treated groups of rats. The present study revealed that the ingestion of red chilli powder causes gastric lesions and variation in the activity of alkaline phosphatase and oxidoreductases.

REFERENCES

  1. Arora, R., Gill, N.S., Chauhan, G. and Rana, A.C. (2011). An overview about versatile molecule capsaicin. Int J Pharm Sci Drug Res 3:280-86.
  2. Barka, T. and Anderson, P.G. (1963). Histochemistry: Theory, Practice and Bibliography. pp 273-316. Harper and Row Publishers Inc, New York.
  3. Buchheim, R. (1873). Fructus capsici. Proc Am Pharm Assoc 22:106. 
  4. Chukwu, L.O. (2006). Histophysiological and basal metabolic responses of albino rat, Rattus norvegicus. Am J Biotechnol 5:1279-83.
  5. Fayaz, P.P. and Ramachandran, H.D. (2014). The effect of spice principles on body composition and lipogenesis in rats. WJPPS 4(1):732-37.
  6. Gavosto, F. and Pileri A, (1958) The effect of administration of 6-mercaptopurine on nucleic acids and alkaline phosphatase of regenerating rat liver. Cancer 11:222-25.
  7. Gill, G.S. (2000). Histomorphological, histochemical and histoenzymological study on organs/systems of buffalo in experimental selenosis. MVSc Thesis, Punjab Agricultural University, Ludhiana, Punjab. 
  8. Johnson, W.J. (2007). Final report on the safety assessment of Capsicum annuum extract, Capsicum annuum fruit extract, Capsicum annuum resin, Capsicum annuum fruit powder, Capsicum frutescens fruit, Capsicum frutescens fruit extract, Capsicum frutescens resin, and capsaicin. Int J Toxicol 26(1):3-106.
  9. Luna, L.G. (1968). Manual of Histologic Staining Methods of the Armed Forces Institute of Pathology. 3rd ed. McGraw Hill Book Company, New York, USA.
  10. Pearse, A.G.E. (1972). Histochemistry: Theoretical and Applied. 3rd edn. Churchill Livingstone, London, pp. 607.
  11. Reddy, M.V.B and Sasikala, P. (2013). Capsaicin and Colour Extraction From Different Varieties Of Green And Red Chilli Peppers Of Andhra Pradesh. IJAST 2(3): 554 -72.
  12. Shrader, E. and Zeman, J. (1972). Progress in Histochemistry and Cytochemistry. In: Histochemically Demonstrable Enzymes in Organs of the Digestive System of Newborn Rat. Gustav Fisher Verlag, Stuttgart.
  13. Srinivasan, K. (2005). Role of spices beyond food flavouring: Nutraceuticals with multiple health effects. Food Rev Int 21:167-88.
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Indian Journal of Animal Research
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    Research Article

    volume 52 issue 10 (october 2018) : 1416-1421,   Doi: 10.18805/ijar.B-3390

    Post-ingestional effects of red chilli powder containing capsaicin in stomach of house rat, Rattus rattus: histomorphological and histoenzymic studies

    R
    Ramandeep Kaur
    N
    Neena Singla
    N
    Neelam Bansal
    D
    Devendra Pathak
    1Department of Zoology, Punjab Agricultural University, Ludhiana-141004, Punjab, India
    Cite article:- Kaur Ramandeep, Singla Neena, Bansal Neelam, Pathak Devendra (2017). Post-ingestional effects of red chilli powder containing capsaicin in stomach of house rat, Rattus rattus: histomorphological and histoenzymic studies. Indian Journal of Animal Research. 52(10): 1416-1421. doi: 10.18805/ijar.B-3390.

    ABSTRACT

    Present study reports post-ingestional effects of red chilli in stomach of house rat, Rattus rattus. Three different groups of female rats (5 per group) were fed on bait containing 1 and 2% red chilli powder and plain bait, respectively. Histomorphological study revealed cellular degeneration of gastric region, sloughing and distortion of superficial layer of epithelium and lymphocytic infiltration in the treated groups of rats. Histoenzymic study revealed an increase in AKPase and decrease in LDH, SDH, G-6-PD and GLD activities in glandular stomach of treated groups of rats. The present study revealed that the ingestion of red chilli powder causes gastric lesions and variation in the activity of alkaline phosphatase and oxidoreductases.

    REFERENCES

    1. Arora, R., Gill, N.S., Chauhan, G. and Rana, A.C. (2011). An overview about versatile molecule capsaicin. Int J Pharm Sci Drug Res 3:280-86.
    2. Barka, T. and Anderson, P.G. (1963). Histochemistry: Theory, Practice and Bibliography. pp 273-316. Harper and Row Publishers Inc, New York.
    3. Buchheim, R. (1873). Fructus capsici. Proc Am Pharm Assoc 22:106. 
    4. Chukwu, L.O. (2006). Histophysiological and basal metabolic responses of albino rat, Rattus norvegicus. Am J Biotechnol 5:1279-83.
    5. Fayaz, P.P. and Ramachandran, H.D. (2014). The effect of spice principles on body composition and lipogenesis in rats. WJPPS 4(1):732-37.
    6. Gavosto, F. and Pileri A, (1958) The effect of administration of 6-mercaptopurine on nucleic acids and alkaline phosphatase of regenerating rat liver. Cancer 11:222-25.
    7. Gill, G.S. (2000). Histomorphological, histochemical and histoenzymological study on organs/systems of buffalo in experimental selenosis. MVSc Thesis, Punjab Agricultural University, Ludhiana, Punjab. 
    8. Johnson, W.J. (2007). Final report on the safety assessment of Capsicum annuum extract, Capsicum annuum fruit extract, Capsicum annuum resin, Capsicum annuum fruit powder, Capsicum frutescens fruit, Capsicum frutescens fruit extract, Capsicum frutescens resin, and capsaicin. Int J Toxicol 26(1):3-106.
    9. Luna, L.G. (1968). Manual of Histologic Staining Methods of the Armed Forces Institute of Pathology. 3rd ed. McGraw Hill Book Company, New York, USA.
    10. Pearse, A.G.E. (1972). Histochemistry: Theoretical and Applied. 3rd edn. Churchill Livingstone, London, pp. 607.
    11. Reddy, M.V.B and Sasikala, P. (2013). Capsaicin and Colour Extraction From Different Varieties Of Green And Red Chilli Peppers Of Andhra Pradesh. IJAST 2(3): 554 -72.
    12. Shrader, E. and Zeman, J. (1972). Progress in Histochemistry and Cytochemistry. In: Histochemically Demonstrable Enzymes in Organs of the Digestive System of Newborn Rat. Gustav Fisher Verlag, Stuttgart.
    13. Srinivasan, K. (2005). Role of spices beyond food flavouring: Nutraceuticals with multiple health effects. Food Rev Int 21:167-88.
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