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Indian Journal of Animal Research

  • Chief EditorM. R. Saseendranath

  • Print ISSN 0367-6722

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Research Article

Indian Journal of Animal Research, volume 52 issue 1 (january 2018) : 144-147

In vivo anti-tumor efficacy of Croton oblongifolius in DMBA induced mammary tumor in rats

Gowrav Adiga P., N.B. Shridhar, Jagadeesh S. Sanganal, Suguna Rao, N. Shilpa, V. Aparna, I.M. Santhosh, M. Tirumala, B.M. Sindhu
1Department of Veterinary Pharmacology and Toxicology, Veterinary College, Karnataka Veterinary Animal and Fisheries Sciences University, Hebbal, Bengaluru-560 024, Karnataka, India.
Cite article:- P. Adiga Gowrav, Shridhar N.B., Sanganal S. Jagadeesh, Rao Suguna, Shilpa N., Aparna V., Santhosh I.M., Tirumala M., Sindhu B.M. (2017). In vivo anti-tumor efficacy of Croton oblongifolius in DMBA induced mammary tumor in rats. Indian Journal of Animal Research. 52(1): 144-147. doi: 10.18805/ijar.B-3301.

ABSTRACT

The present study was designed to evaluate anti-tumor activity of the methanolic extract of stem bark of Croton oblongifolius in Sprague Dawley rats. The tumor was induced in rats by DMBA given orally and intramammarily and challenging with plant extract. After obtaining suitable mass of tumor, the extract was gavaged to rats @ 200, 500 and 800 mg/kg which showed reduction in mammary tumor volume in dose-dependent manner, which was supported by histopathological observations of the treatment groups. 

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