In vivo anti-tumor efficacy of Croton oblongifolius in DMBA induced mammary tumor in rats

DOI: 10.18805/ijar.B-3301    | Article Id: B-3301 | Page : 144-147
Citation :- In vivo anti-tumor efficacy of Croton oblongifolius in DMBA induced mammary tumor in rats.Indian Journal Of Animal Research.2018.(52):144-147
Gowrav Adiga P., N.B. Shridhar, Jagadeesh S. Sanganal, Suguna Rao, N. Shilpa, V. Aparna, I.M. Santhosh, M. Tirumala and B.M. Sindhu adiga.gowrav@gmail.com
Address : Department of Veterinary Pharmacology and Toxicology, Veterinary College, Karnataka Veterinary Animal and Fisheries Sciences University, Hebbal, Bengaluru-560 024, Karnataka, India.
Submitted Date : 3-09-2016
Accepted Date : 9-11-2016

Abstract

The present study was designed to evaluate anti-tumor activity of the methanolic extract of stem bark of Croton oblongifolius in Sprague Dawley rats. The tumor was induced in rats by DMBA given orally and intramammarily and challenging with plant extract. After obtaining suitable mass of tumor, the extract was gavaged to rats @ 200, 500 and 800 mg/kg which showed reduction in mammary tumor volume in dose-dependent manner, which was supported by histopathological observations of the treatment groups. 

Keywords

Anti-tumor activity Croton oblongifolius Histopathology.

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