Effects of eugenia jambolana extract against streptozotocin induced acute liver damage in rats

DOI: 10.5958/0976-0555.2015.00017.5    | Article Id: B-2690 | Page : 81-85
Citation :- Effects of eugenia jambolana extract against streptozotocin induced acute liver damage in rats.Indian Journal Of Animal Research.2015.(49):81-85
B. Dhanush Krishna*, Suguna Rao, M.L. Satyanarayana and S.M. Byregowda dhanushkb@gmail.com
Address : Department of Veterinary Pathology, KVAFSU, Bangalore-560 024, India.

Abstract

The aim of the study was to compare the effects of Eugenia jambolana (EJ) extract and glibenclamide on streptozotocin (STZ) induced hepatotoxicity in rats.  Wistar rats were divided into four groups: untreated control (UC), untreated diabetic (UD), EJ (200 mg/kg) treated diabetic (ED) and glibenclamide (0.6 mg/kg) treated diabetic (GD) orally for 45 days. There was various evidence of hepatotoxicity, including significant increase (Phen compared to GD rats.

Keywords

Eugenia jambolana Hepatotoxicity Liver Serum transaminases Streptozotocin.

References

  1. Babu, P. S. and Prince, P. S. M. (2004). Antihyperglycaemic and antioxidant effect of hyponidd, an ayurvedic herbomineral formulation in streptozotocin-induced diabetic rats. J. Pharm. Pharmaco., 56: 1435–1442.
  2. Bhuiyan, M.A., Mia, M.Y. and Rashid, M.A. (1996). Antibacterial principles of the seeds of Eugenia jambolana. Bangladesh J. Bot., 25: 239–241.
  3. Can, A., Akev, N., Ozsoy, N., Bolkent, S., Arda, B.P., Yanardag, R., and Okyar, A. (2004). Effect of aloe vera leaf gel and pulp extracts on the liver in type-II diabetic rat models. Biol. Pharm. Bull., 27: 694-8.
  4. Chakraborty, D., Mahapatra, P.K. and Chaudhuri, A.K.N. (1985). A neuropsycho-pharmacological study of Syzigium cumini. Planta Medica, 2: 139–143.
  5. Chaudhuri, A.K.N., Pal, S., Gomes, A. and Bhattacharya, S. (1990). Anti- inflammatory and related actions of Syzigium cumini seed extract. Phytother. Res., 4:5–10
  6. Chopra, R.N., Chopra, I.C., Handa, K.L. and Kapur, L.D. (1958). Indigenous Drugs of India, 2nd Ed. Dhar and Sons, Calcutta, pp 686–689.
  7. Indira, G. and Mohan, R. (1993). Jamun fruits, National Institute of Nutrition, ICMR, Hyderabad, pp 34–37.
  8. Karan, M., Vasisht, K., Handa, S.S. (1999). Antihepatotoxic activity of Swertia chirata on carbon tetrachloride-induced hepatotoxicity in rats. Phytother. Res., 13:24–30.
  9. Kumar, V., Abbas, A.K., Fausto, N. and Aster, J. (2009). Robbins and Cotran Pathologic Basis of Disease, 8th Ed. Elsevier, pp 878-880.
  10. Kusumoto, I.T., Nakabayashi, T., Kida, H., Miyashiro, H., Hattori, H., Namba, T. and Shimotohno, K., (1995). Screening of various plant extracts used in Ayurvedic medicine for inhibitory effects on human immunodeficiency virus type I (HIV-I) protease. Phytother. Res., 12: 488–493.
  11. Luna, L. G. (1968). Manual of Histologic Staining Methods of the Armed Forces Institute of Pathology, 3rd Ed. McGraw Hill Book, Co., London.
  12. Ravi, K., Ramchandran, B. and Subramanian, S. (2004). Effect of Eugenia jambolana seed kernel on antioxidant defence system in streptozotocin induced diabetes in rats. Life Sci. 75: 2717–2731.
  13. Rupasinghe, H. P., Jackson, C. J., Poysa, V., Diberado, C., Bewely, J. D. and Jenkinson, J. (2003). Soyasapogenol A and B distribution in Soybena in relation to seed physiology, genetic variability and growing location. J. Agri. and Food Chem., 51(20): 5888–5894.
  14. Sakamoto, K., Yonoki, Y., Fujioka, T., Matsumura, M., Mitsuta, Y., Sano, M., Saito, M., Nakahara, T. and Ishii K. (2006). Disappearance of glibenclamide-induced hypoglycemia in Wistar-Kyoto rats. Biol. Pharm. Bull. 29 (3): 574-6.
  15. Singer, A.J., Carracio, T.R. and Mofenson, H.C. (1995). The temporal profile of increased transaminase levels in patients with acetaminophen-induced liver dysfunction. Ann. Emerg. Med., 26:49-53.
  16. Tietz, N. W. (1982). Fundamentals of Clinical Chemistry, 2nd Ed. W B Saunders Co., Philadelphia.

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