Indian Journal of Animal Research

  • Chief EditorK.M.L. Pathak

  • Print ISSN 0367-6722

  • Online ISSN 0976-0555

  • NAAS Rating 6.50

  • SJR 0.263

  • Impact Factor 0.5 (2023)

Frequency :
Monthly (January, February, March, April, May, June, July, August, September, October, November and December)
Indexing Services :
Science Citation Index Expanded, BIOSIS Preview, ISI Citation Index, Biological Abstracts, Scopus, AGRICOLA, Google Scholar, CrossRef, CAB Abstracting Journals, Chemical Abstracts, Indian Science Abstracts, EBSCO Indexing Services, Index Copernicus
Indian Journal of Animal Research, volume 55 issue 9 (september 2021) : 1085-1090

Influences of 6-furfuryloaminopurine on Peripheral T Lymphocyte Subpopulations and Apoptosis of Thymus Lymphocytes of Aging Rats

Meng-yun Li, Luo liu, Fu Zhang, Xue-min Zhu, Li-fang Si, Jian Li, Xiang Li
1College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, Henan, P. R. China. 
Cite article:- Li Meng-yun, liu Luo, Zhang Fu, Zhu Xue-min, Si Li-fang, Li Jian, Li Xiang (2021). Influences of 6-furfuryloaminopurine on Peripheral T Lymphocyte Subpopulations and Apoptosis of Thymus Lymphocytes of Aging Rats. Indian Journal of Animal Research. 55(9): 1085-1090. doi: 10.18805/IJAR.B-1279.
Background: 6-furfuryloaminopurine (KT) is the first compound to be identified as a cytokinin. Despite that there are many studies related to KT but the mechanism of KT in resisting immunosenescence remains unclear. The objective of this study is to investigate the influences of KT on the immunity of thymus in rats by detecting the apoptosis and the proliferation index (PI).
Methods: We firstly established an aging rat model by subcutaneously injecting D- galactose (D-gal, 125mg/kg•BW) in the dorsal neck of Sprague Daly rats (SD rats); then the rats were divided into KT treatment groups (three groups for different doses of KT), aging model group (without KT treatment) and young control group. The rats in KT treatment groups were treated with different-dose KT and the key indices including the changes of the number of CD3+, CD4+ and CD8+ T lymphocyte subpopulations in peripheral blood, the apoptosis of thymus lymphocytes. 
Result: KT could increase the number of the peripheral CD3+, CD4+ and CD8+ T lymphocytes of the aging rats while decreased the apoptotic rate of thymocytes and increased PI Index.
  1. Aranburu, A., Höök, N., Gerasimcik, N., Corleis, B., Ren, W., Camponeschi, A., Carlsten, H., Grimsholm, O., Mårtensson, I.L. (2018). Age associated B cells expanded in autoimmune mice are memory cells sharing H CDR3 selected repertoires. European Journal of Immunology. 48(3): 509-521.
  2. Argente M.J., Abad-Salazar, D.M, Bermejo-González, E., García, M.L., López-Palazón, A. (2019). Reference values for selected blood parameters in rabbits: Effects of age and physiological status. Indian Journal of Animal Research. DOI: 10.18805/ijar.B-1165.
  3. Boone, N., Loriod, B., Bergon, A., Sbai, O., Formisano-Treziny, C., Gabert, J., Khrestchatisky, M., Nguyen, C., Feron, F., Axelrod, F.B., Ibrahim, E.C. ( 2015). Olfactory stem cells, a new cellular model for studying molecular mechanisms underlying familial dysautonomia. PLoS One. 5(12): e15590.
  4. Chaker, D., Mouawad, C., Azar, A., Quilliot, D., Achkar, I., Fajloun, Z., Makdissy, N. (2018). Inhibition of the RhoGTPase Cdc42 by ML141 enhances hepatocyte differentiation from human adipose-derived mesenchymal stem cells via the Wnt5a/PI3K/miR-122 pathway: impact of the age of the donor. Stem Cell Research and Therapy. 9(1):167.
  5. Chason, K.D., Jaspers, I., Parker, J., Sellers, S., Brighton, L.E., Hunsucker, S.A., Armistead, P.M., Fischer, W.A. (2018). Age-associated changes in the respiratory epithelial response to influenza infection. The Journals of Gerontology: Series A. 73(12): 1643-1650.
  6. Coiffard, B., Pelardy, M., Loundou, AD., Nicolino-Brunet, C., Thomas, P.A., Papazian, L., Dignat-George, F., Reynaud-Gaubert, M. (2018). Effect of immunosuppression on target blood immune cells within 1 year after lung transplantation: Influence of age on T lymphocytes. Annals of Transplantation. 23: 11-24.
  7. Dar, A.H., Singh, S.K., Mondal, B.C., Palod. J., Kumar, A., Singh, V., Sharma, R.K., Khadda, B.S. (2018). Effect of probiotic, prebiotic and synbiotic on faecal microbial count and cell-mediated immunity in crossbred calves. Indian Journal of Animal Research. 52(10): 1452-1456.
  8. Gamal, B., Ghada, A.E.R., Hany, E.G., Mohamed, E.A.F. (2020). Exposure to radioactive rocks from the Egyptian eastern desert attenuates the efficiency of the immune organs and induces apoptosis of blood lymphocytes in rat model. Environmental Science and Pollution Research. 27: 8684-8695.
  9. Ilienko, I.M., Lyaskivska, O.V., Belayev, O.A., Pleskach, O.Y., Shinkarenko, V.I., Bazyka, D.A. (2017). Impact of chronic blood viral infection on lymphocyte telomere length in Chornobyl clean-up workers in a remote period after radiation exposure. Probl Radiac Med. Radiobiol. 22: 372-381.
  10. Juhyun, Oh, Angela Magnuson, Christophe Benoist, Mikael J. Pittet, Ralph Weissleder. (2018). Age-related tumor growth in mice is related to integrin á 4 in CD8+ T cells. The Journal of Clinical Investigation. 3(21): e122961.
  11. Li, M.Y., Ouyang, W.Q., Li, J., Si, L.F., Li, X., Guo, J.J. and Li, H.F. (2016). Effects of kinetin on thymus and immune function of aging rats. Pakistan Veterinary Journal. 36(3): 356-362.
  12. Lopes, A.B., Lopes, L.B., da Silveira Antunes, R.N., Fukasawa, J.T., de Aguiar Cavaretto, D., Calamita, Z. (2018). Effects of immunosenescence on the lower expression of surface molecules in neutrophils and lymphocytes. Current Aging Science. 11(2): 118-125.
  13. Pevzner, I.B., Pavlenko, TA, Popkov, V.A. andrianova, N.V., Zorova, L.D., Brezgunova, A.A., Zorov, S.D., Yankauskas, S.S., Silachev, D.N., Zorov, D.B., Plotnikov, E.Y. (2018). comparative study of the severity of renal damage in newborn and adult rats under conditions of ischemia/reperfusion and endotoxin administration. Bulletin of Experimental Biology and Medicine. 165(2): 189-194.
  14. Radhika, G., Subriya, S.K. Manjari, K.D., Parthiban, M.N. Pazhanivel, N., Vijayarani, K. (2020). Immunomodulatory potential of microencapsulated multispecies probiotic consortium in newcastle disease virus vaccinated chicken. Indian Journal of Animal Research. 54(2): 216-221.
  15. Sanderson, S.L, Simon, A.K. (2017). In aged primary T cells, mitochondrial stress contributes to telomere attrition measured by a novel imaging flow cytometry assay. Aging Cell. 16(6): 1234-1243.
  16. Sezcan Mumusoglu, Volkan Turan, Hasan Uckan, Aysegul uzer, Lale Karakoc Sokmensuer, Gurkan Bozdag. (2018). The impact of a long-acting oral Sphingosine-1- Phosphate analogue on ovarian aging in a rat model. Reproductive Sciences. 25(9): 1330-1335.
  17. Sindan, N., Bhandari, A., Zhao, Y., Lu, X., Lv J. (2018). Expression and localization of nuclear factor erythroid 2-related factor 2 in the ovarian tissues of mice at different ages. Experimental and Therapeutic Medicine. 16(4): 3546-3552.
  18. Thornfeldt, C.R., Rizer, R.L. (2016). Superior efficacy of an herbal-based cosmeceutical compared with common prescription and cosmetic anti-aging therapies. Journal of Drugs in Dermatology. 15(2): 218-223.
  19. Wanitphakdeedecha, R., Meeprathom, W., Manuskiatti W. (2015). Efficacy and safety of 0.1% kinetin cream in the treatment of photoaging skin. Indian Journal of Dermatology Venereology and Liprology. 81(5): 547. 
  20. Wei, Y.P., Liu, D., Zheng, Y., Li, H.L., Hao, C.S., Ouyang, W.Q. (2017). Protective effects of kinetin against aluminum chloride and D-galactose induced cognitive impairment and oxidative damage in mouse. Brain Research Bulletin. 134: 262-272.
  21. Wei Y.P., Liu, D., Zheng, Y., Hao, C.S., Li, H.L., Ouyang, W.Q. (2018). Neuroprotective effects of kinetin against glutamate- induced oxidative cytotoxicity in HT22 cells: Involvement of Nrf2 and Heme Oxygenase-1. Neurotoxicity Research. 33: 725-737.
  22. Withers, S.S., Moore, P.F., Chang, H., Choi, J.W., McSorley, S.J., Kent, M.S., Monjazeb, A.M., Canter, R.J., Murphy, W.J., Sparger, E.E., Rebhun, R.B. (2018). Multi-color flow cytometry for evaluating age-related changes in memory lymphocyte subsets in dogs. Developmental and Comparative Immunology. 87: 64-74.
  23. Xie, J., Zhang, J., Wu, H., Tang, X., Liu, J., Cheng, G., Li, P. (2017). The influences of age on T lymphocyte subsets in C57BL/6 mice. Saudi Journal of Biological Sciences. 24(1): 108-113.
  24. Zhou, Y.C., Chen L.L., Xu, H.B., Sun, Q., Zhang, Q., Cai, H.F., Jiang, H. (2018). Aging related prognosis analysis of definitive radiotherapy for very elderly esophageal cancer. Cancer Medicine. 7(5): 1837-1844.

Editorial Board

View all (0)