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Current IssueEditorial BoardOnline First ArticlesArchive

Research Article

volume 53 issue 9 (september 2019) : 1194-1198,   Doi: 10.18805/ijar.B-1122

Effects of traditional Chinese herbal medicines on blood parameters and antibody level in laying hens

C
C.H. Li
Y
Y.L. Dong
W
W.Y. Song
R
R.H. Zhang
J
J.L. Li
L
L. Wang
W
W.Y. Shi
T
T. Xu
1<div>Department of Animal Medicine,&nbsp;Hebei North<br />University, Zhangjiakou 075131, China.</div>
Cite article:- Li C.H., Dong Y.L., Song W.Y., Zhang R.H., Li J.L., Wang L., Shi W.Y., Xu T. (2019). Effects of traditional Chinese herbal medicines on blood parameters and antibody level in laying hens. Indian Journal of Animal Research. 53(9): 1194-1198. doi: 10.18805/ijar.B-1122.

ABSTRACT

A study was conducted to evaluate the effect of traditional Chinese herbal medicines (TCHM) on Hematological Parameters and immunity in chickens, Astragalus membranaceus (AM), angelicae sinensis extract (ASE) and Danggui buxue san (DBS) were used for the study of Hematological Parameters and immunity in order to provide basis for clinical reference. A total of 400 58-week-old hens were randomized into 10 groups. The added TCHM Period was 42 days. The blood index, ND and AI antibody titer were measured. The results showed that DBS significantly increased the count of White Blood Cell (WBC) (P<0.05) and Red Blood Cell (RBC) (P<0.01), the content of Hemoglobin (Hb) (P<0.01) and Packed Cell Volume (PCV) (P<0.01) in 10 mg/kg group; DBS(15 mg/kg) had significant increase on the count of WBC and RBC and the content of Hb (P<0.05);ASE (15 mg/kg) significantly increased the count of RBC and the content of Hb (P<0.05). At the same time, DBS (10 mg/kg) significantly decreased the dropping rate of blood cell at 30min (P<0.01).In addition, DBS (10 mg/kg) could improve the antibody level of ND and AI than control group (P<0.05).This indicated that DBS (10 mg/kg) had the ability on improving hemopoietic function and immunity in chickens. 

REFERENCES

  1. Chen, X.P., Chen, J.H., Zhang, P., Du, J.Z. (2006). Angelica stimulates proliferation of murine bone marrow mononuclear cells by the MAPK pathway. Blood. Cell. Mol. Dis. 36:402-405. 
  2. Gao, Q.T., Cheung, J.K.H., Li, J. (2007). A Chinese herbal decoction, Danggui Buxue Tang, activates extracellular signalregulated kinase in cultured T-lymphocytes. Febs. Lett. 581:5087-5093. 
  3. Hatano, R., Takano, F., Fushiya, S. (2004). Water-soluble extracts from Angelica acutiloba Kitagawa enhance hematopoiesis by activating immature erythroid cells in mice with 5-fluorouracil-induced anemia. Exp. Hematol. 32:918-924. 
  4. Hong, Y. (2001).The effect of angelica polysaccharide on the cell immune function of radiated mice. Med. J. Wuhan. Univ. 22:27-28. 
  5. Jinous, Asgarpanah and Fereshteh, R. (2012). Chemistry, pharmacology and medicinal properties of Peganum harmala L. AFR J pharm pharmaco. 6(22): 1573-1580.
  6. Kale, V.R., Bhattacharya, T.K., Wankhede1, S.M., Patil, C.S. and Share, A.A. (2016). Effect of supplementation of Withania somnifera (Ashwagandha) root powder as feed additive on performance and blood biochemicals of broilers. Indian Journal of Animal Research. 50(1): 53-56. DOI: 10. 18805/ijar.6706. 
  7. Liang, Y., Lu, X.H., Chen, R.Q. (1999). Research progress of blood-deficient syndrome in traditional Chinese Medicine. Chin. J. Inf. TCM. 6:16-18.
  8. Li, L., Xu, C.L., Ji, C., Ma, Q., Hao, K., Jin, Z.Y., Li, K. (2006). Effects of a dried Bacillus subtilis culture on egg quality. Poult. Sci. 85:364–368.
  9. Liu, P.J., Hsieh, W.T., Huang, S.H., Liao, H.F, Chiang, B.H. (2010). Hematopoietic effect of water soluble polysaccharides from Angelica sinensis on mice with acute blood loss. Exp. Hematol. 38:437-445. 
  10. Mak, D.H., Chiu, P.Y., Dong, T.T., Tsim, K.W., Ko, K.M. (2006). Dang-Gui Buxue Tang produces a more potent cardioprotective effect than its component herb extracts and enhances glutathione status in rat heart mitochondria and erythrocytes. Phytother. Res. 20: 561-567.
  11. Naif, O. Al-Harbi., Saleh, A., Bahashwan, Ahmed, A., Fayed, Mohamed, A., Ramadan. (2013). Pharmacological activities evaluation of some new pyrazolo-pyrimidino-pyridazine derivatives. AFR J Pharm Pharmaco. 7: 517-523.
  12. Shang, P., Qian, A.R., Yang, T.H., Jia, M., Mei, Q.B., Cho, C.H., Zhao, W.M., Chen, Z.N. (2003). Experimental study of anti-tumor effects of polysaccharides from Angelica sinensis. World. J. Gastroenterol. 9: 1963-1967. 
  13. Shao, B.M., Xu, W., Dai, H., Tu, P.F., Li, Z.J. (2004). A study on the immune receptors for polysaccharides from the roots of Astragalus membranaceus, a Chinese medicinal herb. Biochem. Bioph. Res. Co. 320: 1103-1111.
  14. Sheoran, N., Maan, S., Kumar, A., Kanisht, B., Chaudhary, D., Sihag, S., Kumar, V. and Maan, N.S. (2018). Probiotic and prebiotic supplementation improving the production performance and immune characteristics of laying hens. Indian Journal of Animal Research. 52(10): 1433-1439. DOI: 10. 18805/ijar.B-3394. 
  15. Teng, J.L. (1994). Qi supply mechanism of Tangkuei blood-supplementing. Pharmacol. Clin. Chin. Mate. Medi. 5:42. 
  16. Tin, M., Cho, C.H., Chan, K., James, A.E., Ko, J. (2007). Astragalus saponins induce growth inhibition and apoptosis in human colon cancer cells and tumor xenograft. Carcinogenesis. 28: 1347-1355.
  17. Tsai, N.M., Lin, S.Z., Lee, C.C., Chen, S.P., Su, H.C., Chang, W.L., Harn, H.J. (2005). The antitumor effects of Angelica sinensis on malignant brain tumors in vitro and in vivo. Clin. Cancer. Res. 11: 3475-3484. 
  18. WHO (2002). Manual on Animal influenza diagnosis and surveillance. WHO/CDS/CSR/NCS. 5:15-62.
  19. Xia, X.Y., Peng, R.X. (1999). Effect of chinese angelica tuber (Angelica Sinensis) ethanol sediments on mice spleen and thymus lymphocytes proliferation in vitro. Chin. Tradit. Herb. Dreys. 33:112-115. 
  20. Yang, Q., Populo, S.M., Zhang, J., Yang, G., Kodama, H. (2002). Effect of Angelica sinensis on the proliferation of human bone cells. Clin. Chim. Acta. 324:89-97. 
  21. Zheng, K.Y.Z., Choi, R.C.Y., Xie, H.Q.H. (2010). The expression of erythropoietin triggered by Danggui Buxue Tang, a Chinese herbal decoction prepared from Radix Astragali and Radix Angelicae Sinensis, is mediated by the hypoxia-inducible factor in cultured HEK293T cells. J. Ethnopharmacol. 132:259-267. 
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Indian Journal of Animal Research
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    Research Article

    volume 53 issue 9 (september 2019) : 1194-1198,   Doi: 10.18805/ijar.B-1122

    Effects of traditional Chinese herbal medicines on blood parameters and antibody level in laying hens

    C
    C.H. Li
    Y
    Y.L. Dong
    W
    W.Y. Song
    R
    R.H. Zhang
    J
    J.L. Li
    L
    L. Wang
    W
    W.Y. Shi
    T
    T. Xu
    1<div>Department of Animal Medicine,&nbsp;Hebei North<br />University, Zhangjiakou 075131, China.</div>
    Cite article:- Li C.H., Dong Y.L., Song W.Y., Zhang R.H., Li J.L., Wang L., Shi W.Y., Xu T. (2019). Effects of traditional Chinese herbal medicines on blood parameters and antibody level in laying hens. Indian Journal of Animal Research. 53(9): 1194-1198. doi: 10.18805/ijar.B-1122.

    ABSTRACT

    A study was conducted to evaluate the effect of traditional Chinese herbal medicines (TCHM) on Hematological Parameters and immunity in chickens, Astragalus membranaceus (AM), angelicae sinensis extract (ASE) and Danggui buxue san (DBS) were used for the study of Hematological Parameters and immunity in order to provide basis for clinical reference. A total of 400 58-week-old hens were randomized into 10 groups. The added TCHM Period was 42 days. The blood index, ND and AI antibody titer were measured. The results showed that DBS significantly increased the count of White Blood Cell (WBC) (P<0.05) and Red Blood Cell (RBC) (P<0.01), the content of Hemoglobin (Hb) (P<0.01) and Packed Cell Volume (PCV) (P<0.01) in 10 mg/kg group; DBS(15 mg/kg) had significant increase on the count of WBC and RBC and the content of Hb (P<0.05);ASE (15 mg/kg) significantly increased the count of RBC and the content of Hb (P<0.05). At the same time, DBS (10 mg/kg) significantly decreased the dropping rate of blood cell at 30min (P<0.01).In addition, DBS (10 mg/kg) could improve the antibody level of ND and AI than control group (P<0.05).This indicated that DBS (10 mg/kg) had the ability on improving hemopoietic function and immunity in chickens. 

    REFERENCES

    1. Chen, X.P., Chen, J.H., Zhang, P., Du, J.Z. (2006). Angelica stimulates proliferation of murine bone marrow mononuclear cells by the MAPK pathway. Blood. Cell. Mol. Dis. 36:402-405. 
    2. Gao, Q.T., Cheung, J.K.H., Li, J. (2007). A Chinese herbal decoction, Danggui Buxue Tang, activates extracellular signalregulated kinase in cultured T-lymphocytes. Febs. Lett. 581:5087-5093. 
    3. Hatano, R., Takano, F., Fushiya, S. (2004). Water-soluble extracts from Angelica acutiloba Kitagawa enhance hematopoiesis by activating immature erythroid cells in mice with 5-fluorouracil-induced anemia. Exp. Hematol. 32:918-924. 
    4. Hong, Y. (2001).The effect of angelica polysaccharide on the cell immune function of radiated mice. Med. J. Wuhan. Univ. 22:27-28. 
    5. Jinous, Asgarpanah and Fereshteh, R. (2012). Chemistry, pharmacology and medicinal properties of Peganum harmala L. AFR J pharm pharmaco. 6(22): 1573-1580.
    6. Kale, V.R., Bhattacharya, T.K., Wankhede1, S.M., Patil, C.S. and Share, A.A. (2016). Effect of supplementation of Withania somnifera (Ashwagandha) root powder as feed additive on performance and blood biochemicals of broilers. Indian Journal of Animal Research. 50(1): 53-56. DOI: 10. 18805/ijar.6706. 
    7. Liang, Y., Lu, X.H., Chen, R.Q. (1999). Research progress of blood-deficient syndrome in traditional Chinese Medicine. Chin. J. Inf. TCM. 6:16-18.
    8. Li, L., Xu, C.L., Ji, C., Ma, Q., Hao, K., Jin, Z.Y., Li, K. (2006). Effects of a dried Bacillus subtilis culture on egg quality. Poult. Sci. 85:364–368.
    9. Liu, P.J., Hsieh, W.T., Huang, S.H., Liao, H.F, Chiang, B.H. (2010). Hematopoietic effect of water soluble polysaccharides from Angelica sinensis on mice with acute blood loss. Exp. Hematol. 38:437-445. 
    10. Mak, D.H., Chiu, P.Y., Dong, T.T., Tsim, K.W., Ko, K.M. (2006). Dang-Gui Buxue Tang produces a more potent cardioprotective effect than its component herb extracts and enhances glutathione status in rat heart mitochondria and erythrocytes. Phytother. Res. 20: 561-567.
    11. Naif, O. Al-Harbi., Saleh, A., Bahashwan, Ahmed, A., Fayed, Mohamed, A., Ramadan. (2013). Pharmacological activities evaluation of some new pyrazolo-pyrimidino-pyridazine derivatives. AFR J Pharm Pharmaco. 7: 517-523.
    12. Shang, P., Qian, A.R., Yang, T.H., Jia, M., Mei, Q.B., Cho, C.H., Zhao, W.M., Chen, Z.N. (2003). Experimental study of anti-tumor effects of polysaccharides from Angelica sinensis. World. J. Gastroenterol. 9: 1963-1967. 
    13. Shao, B.M., Xu, W., Dai, H., Tu, P.F., Li, Z.J. (2004). A study on the immune receptors for polysaccharides from the roots of Astragalus membranaceus, a Chinese medicinal herb. Biochem. Bioph. Res. Co. 320: 1103-1111.
    14. Sheoran, N., Maan, S., Kumar, A., Kanisht, B., Chaudhary, D., Sihag, S., Kumar, V. and Maan, N.S. (2018). Probiotic and prebiotic supplementation improving the production performance and immune characteristics of laying hens. Indian Journal of Animal Research. 52(10): 1433-1439. DOI: 10. 18805/ijar.B-3394. 
    15. Teng, J.L. (1994). Qi supply mechanism of Tangkuei blood-supplementing. Pharmacol. Clin. Chin. Mate. Medi. 5:42. 
    16. Tin, M., Cho, C.H., Chan, K., James, A.E., Ko, J. (2007). Astragalus saponins induce growth inhibition and apoptosis in human colon cancer cells and tumor xenograft. Carcinogenesis. 28: 1347-1355.
    17. Tsai, N.M., Lin, S.Z., Lee, C.C., Chen, S.P., Su, H.C., Chang, W.L., Harn, H.J. (2005). The antitumor effects of Angelica sinensis on malignant brain tumors in vitro and in vivo. Clin. Cancer. Res. 11: 3475-3484. 
    18. WHO (2002). Manual on Animal influenza diagnosis and surveillance. WHO/CDS/CSR/NCS. 5:15-62.
    19. Xia, X.Y., Peng, R.X. (1999). Effect of chinese angelica tuber (Angelica Sinensis) ethanol sediments on mice spleen and thymus lymphocytes proliferation in vitro. Chin. Tradit. Herb. Dreys. 33:112-115. 
    20. Yang, Q., Populo, S.M., Zhang, J., Yang, G., Kodama, H. (2002). Effect of Angelica sinensis on the proliferation of human bone cells. Clin. Chim. Acta. 324:89-97. 
    21. Zheng, K.Y.Z., Choi, R.C.Y., Xie, H.Q.H. (2010). The expression of erythropoietin triggered by Danggui Buxue Tang, a Chinese herbal decoction prepared from Radix Astragali and Radix Angelicae Sinensis, is mediated by the hypoxia-inducible factor in cultured HEK293T cells. J. Ethnopharmacol. 132:259-267. 
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