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Current IssueEditorial BoardOnline First ArticlesArchive

volume 45 issue 2 (june 2011) : 95 - 101

BLOOD PROGESTERONE LEVEL DURING ESTROUS CYCLE IN GAROLE EWES AND THE LUTEOLYTIC EFFECT OF OXYTOCIN ADMINISTERED ON DIFFERENT DAYS OF ESTRUS CYCLE, PREGNANCY AND DICLOFENAC SODIUM MEDIATED EXTENDED LUTEAL PHASE

D
Dipyaman Sengupta
S
Siddhartha Basu
D
Debasis Mazumdar
1West Bengal University of Animal and Fishery Science Kshudiram Bose Sarani, Kolkata-700 037, India.

  • Submitted|

  • First Online |

  • doi

Cite article:- Sengupta Dipyaman, Basu Siddhartha, Mazumdar Debasis (2025). BLOOD PROGESTERONE LEVEL DURING ESTROUS CYCLE IN GAROLE EWES AND THE LUTEOLYTIC EFFECT OF OXYTOCIN ADMINISTERED ON DIFFERENT DAYS OF ESTRUS CYCLE, PREGNANCY AND DICLOFENAC SODIUM MEDIATED EXTENDED LUTEAL PHASE. Indian Journal of Animal Research. 45(2): 95 - 101. doi: .

ABSTRACT

The effect of exogenous oxytocin injected on different days of estrus cycle and pregnancy on uterine PGF2a mediated luteal regression in Garole ewes and compared it with physiological pattern of luteal growth and regression was investigated. Three consecutive days progesterone concentration was measured after intravenous injection of oxytocin to non-mated ewes on day 5 (n=5), on day 8 (n=5), on day 13 (n=4), on day 18 to pregnant ewes (n=4) and diclofenac treated ewes (days 11 to 15) with extended luteal phase. All ewes were detected for heat twice daily by a vasectomized ram. In Garole ewes blood progesterone level starts increasing from day 3, reaches a maximum level on day 9, stays steady till day 12 and thereafter starts declining from day 13 onwards. Oxytocin injection on day 5, on day 8 and on day 18 (pregnant) had non-significant (P>0.05) effect on estrus cycle length as well as two successive day progesterone concentration compared to control unlike in ewes injected with oxytocin on day 13 and on day 18 (diclofenac treated). The results indicated that the endometrium of Garole ewes was insensitive to a luteolytic dose of oxytocin during the diestrous period but as the sensitivity was regained on day 13 of estrous, it persisted thereafter. The presence of conceptus rendered the endometrium insensitive to oxytocin during and after the time of normal luteolysis.

REFERENCES

  1. Baguma-Nibasheka, M. and Nathanielsz, P. W. (1998). J Soc Gynecol Investig, 5(6): 296-299.
  2. Bazer, F. W. (1992). Proc Soc Exp Biol Med, 199: 373-384.
  3. Fairclough, R. J. et al., (1981). Journal of Reproduction and Fertility 62: 213-219.
  4. Knigge, U. et al., (2003). Journal of Neuroendocrinology, 15(10): 940-945.
  5. Kraeling, R. R. et al., (1981). Biology of Reproduction, 25: 511-518.
  6. Lewis, P. E. and Warren, J. E. (1977). Journal of Animal Science, 46: 763-767.
  7. Mirando, M. A. et al., (1993). Biology of Reproduction, 48: 874-882.
  8. Montogomery, G. W. et al., (1992) Endocrine Reviews, 13: 309-328.
  9. Pant, H. C. et al., (1977). Journal of Endocrinology, 73(2): 247-255.
  10. Piper, L. R. et al., (1985). In: Genetics of Reproduction in sheep. (Eds. R. B. Land & D. W. Robinson), Butterworths, London, pp. 115-125.
  11. Roberts, R. M. et al., (1999). Placenta, 20: 259-264.
  12. Schrick, P. N. et al., (1993). Biology of Reproduction, 49: 1135-1140.
  13. Sheldrick, E. L. and Flint, A. P. F. (1985). Journal of Endocrinology, 106: 249-258.
  14. Spencer, T. E. and Bazer, F. W. (1996). Endocrinology, 137: 1144-1147.
  15. SPSS 7.5 copyright 1997 by SPSS Inc., USA Base 7.5 Application Guide.
  16. Turner, H. N. (1982). In: The Booroola Merino (Eds. L. R. Piper, B. M. Bindon, R. D. Nethery), CSIRO, Melbourne, pp. 1-7.
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Indian Journal of Animal Research
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    volume 45 issue 2 (june 2011) : 95 - 101

    BLOOD PROGESTERONE LEVEL DURING ESTROUS CYCLE IN GAROLE EWES AND THE LUTEOLYTIC EFFECT OF OXYTOCIN ADMINISTERED ON DIFFERENT DAYS OF ESTRUS CYCLE, PREGNANCY AND DICLOFENAC SODIUM MEDIATED EXTENDED LUTEAL PHASE

    D
    Dipyaman Sengupta
    S
    Siddhartha Basu
    D
    Debasis Mazumdar
    1West Bengal University of Animal and Fishery Science Kshudiram Bose Sarani, Kolkata-700 037, India.

    • Submitted|

    • First Online |

    • doi

    Cite article:- Sengupta Dipyaman, Basu Siddhartha, Mazumdar Debasis (2025). BLOOD PROGESTERONE LEVEL DURING ESTROUS CYCLE IN GAROLE EWES AND THE LUTEOLYTIC EFFECT OF OXYTOCIN ADMINISTERED ON DIFFERENT DAYS OF ESTRUS CYCLE, PREGNANCY AND DICLOFENAC SODIUM MEDIATED EXTENDED LUTEAL PHASE. Indian Journal of Animal Research. 45(2): 95 - 101. doi: .

    ABSTRACT

    The effect of exogenous oxytocin injected on different days of estrus cycle and pregnancy on uterine PGF2a mediated luteal regression in Garole ewes and compared it with physiological pattern of luteal growth and regression was investigated. Three consecutive days progesterone concentration was measured after intravenous injection of oxytocin to non-mated ewes on day 5 (n=5), on day 8 (n=5), on day 13 (n=4), on day 18 to pregnant ewes (n=4) and diclofenac treated ewes (days 11 to 15) with extended luteal phase. All ewes were detected for heat twice daily by a vasectomized ram. In Garole ewes blood progesterone level starts increasing from day 3, reaches a maximum level on day 9, stays steady till day 12 and thereafter starts declining from day 13 onwards. Oxytocin injection on day 5, on day 8 and on day 18 (pregnant) had non-significant (P>0.05) effect on estrus cycle length as well as two successive day progesterone concentration compared to control unlike in ewes injected with oxytocin on day 13 and on day 18 (diclofenac treated). The results indicated that the endometrium of Garole ewes was insensitive to a luteolytic dose of oxytocin during the diestrous period but as the sensitivity was regained on day 13 of estrous, it persisted thereafter. The presence of conceptus rendered the endometrium insensitive to oxytocin during and after the time of normal luteolysis.

    REFERENCES

    1. Baguma-Nibasheka, M. and Nathanielsz, P. W. (1998). J Soc Gynecol Investig, 5(6): 296-299.
    2. Bazer, F. W. (1992). Proc Soc Exp Biol Med, 199: 373-384.
    3. Fairclough, R. J. et al., (1981). Journal of Reproduction and Fertility 62: 213-219.
    4. Knigge, U. et al., (2003). Journal of Neuroendocrinology, 15(10): 940-945.
    5. Kraeling, R. R. et al., (1981). Biology of Reproduction, 25: 511-518.
    6. Lewis, P. E. and Warren, J. E. (1977). Journal of Animal Science, 46: 763-767.
    7. Mirando, M. A. et al., (1993). Biology of Reproduction, 48: 874-882.
    8. Montogomery, G. W. et al., (1992) Endocrine Reviews, 13: 309-328.
    9. Pant, H. C. et al., (1977). Journal of Endocrinology, 73(2): 247-255.
    10. Piper, L. R. et al., (1985). In: Genetics of Reproduction in sheep. (Eds. R. B. Land & D. W. Robinson), Butterworths, London, pp. 115-125.
    11. Roberts, R. M. et al., (1999). Placenta, 20: 259-264.
    12. Schrick, P. N. et al., (1993). Biology of Reproduction, 49: 1135-1140.
    13. Sheldrick, E. L. and Flint, A. P. F. (1985). Journal of Endocrinology, 106: 249-258.
    14. Spencer, T. E. and Bazer, F. W. (1996). Endocrinology, 137: 1144-1147.
    15. SPSS 7.5 copyright 1997 by SPSS Inc., USA Base 7.5 Application Guide.
    16. Turner, H. N. (1982). In: The Booroola Merino (Eds. L. R. Piper, B. M. Bindon, R. D. Nethery), CSIRO, Melbourne, pp. 1-7.
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