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Current IssueEditorial BoardOnline First ArticlesArchive

volume 35 issue 2 (july to december 2001) : 112 - 115

BIOCHEMICAL CHANGES FOLLOWING ULNAR SEGMENTAL DEFECT REPAIR WITH FIBRILLAR COLLAGEN - HYDROXYAPATITE, AND POROUS HYDROXYAPATITE IMPLANTS IN CANINES·

T
T Madhava Rao\ G.V. Lakshmipathi2
T
T.P. SastrY
O
O. Ramakrishna4
1Department of Surgery and Radiology College of Veterinary Science, Tirupati - 517 502, India

  • Submitted|

  • First Online |

  • doi

Cite article:- Lakshmipathi2 G.V. Rao\ Madhava T, SastrY T.P., Ramakrishna4 O. (2025). BIOCHEMICAL CHANGES FOLLOWING ULNAR SEGMENTAL DEFECT REPAIR WITH FIBRILLAR COLLAGEN - HYDROXYAPATITE, AND POROUS HYDROXYAPATITE IMPLANTS IN CANINES·. Indian Journal of Animal Research. 35(2): 112 - 115. doi: .

ABSTRACT

In 24 clinically healthy adult mongrel dogs divided into 4 groups of 6 animals each, a transverse middle third diaphyseal segmental defect of 1. 2 cm was created in the ulma. The healing of the gap was evaluated biochemically following repair with autogenous cancellous bone (Group-II), fibrillar collagen-hydroxyapatite composite (Group-III), porous hydroxyapatite (Group-IV). The gap was unfilled in control group (Group-I). The changes in serum calcium, phosphorus and alkaline phosphatase levels were compared with clinical and radiological findings and it is concluded that the fibrillar collagen-hydroxyapatite composite implants can be used as a suitable alternative to the use of autogenous cancellous bone in repair of segmental bone loss defects or non-union fractures.

KEYWORDS

    REFERENCES

    1. Baker, RW.R (1955). Biochem. J. 59:566.
    2. Ganesh, T.N. and Mohammed, M.S.D.M. (1993). Indian J. Vet. Surg. 14:48.
    3. Heilman, B. and Pallan, M. (1973). Beitr. Klin. Chir. 220:649-653 (Abstr. Cal. Tiss, 6: 579, 1974).
    4. Holmes, RE. etal. (1986). J. Bone JointSurg. 68-A: 904-911.
    5. Kind, P. R N. and King, E.J. (1954). J. Clin. Path. 7: 322.
    6. Lane, J.M. and Sandhu, H.S. (1987). Orlho. Clin. Norlh. America 18: 213-225.
    7. Laurnc;n, E.L and Kelly, P.J. (1969). J. Bone Joint Surg. 51-A: 1298-1308.
    8. Lemaire, RG. (1966). J. Bone Joint Surg. 48-A: 1156-1170.
    9. Oonishi, H. (1991) Biomaterials 12: 171-178.
    10. Pandey, S.K. and Udapa, KN. (1981). Indian Vet. J. 58:37-41. .
    11. Sahkhar, KB. et al. (1998). Indian J. Vet.Surg. 19:29-30.
    12. Saikia J. (1983). Ph. D. Thesis, Haryana Agril. Univ. Hisar, India.
    13. Sh:nesen, M.G. (1971). In: Clinical Biochemistry of Domestic Animals. VoLl, edn.2 (Keneko, J.J. and Cornelius, C.E. eds), Academic Press Inc. New York, pp.313-375.
    14. Singh et al. (1976). Indian Vet. J. 53: 862-865.
    15. Singh, A.P. and Nigam, J.M. (1976). HAUJ. Res. 6: 196-200.
    16. Snedecor, G.W and Cochran, WG. (1967). Statistical Methods 6th edn. The IOWA State University Press, Ames, IOWA, U.S.A. pp:93-94.
    17. Soleman, F.A. and Hassan, S.v.S. (1964). Nature 204: 693-694.
    18. Takaoka, K et al. (1998). Clin. Orthopaedics 234: 250-254
    19. Tanabe, Y. and Wilcox, F.H. (1960). Proc. Sec. Exptl. BioI. 103: 68-70.
    20. Taussky, H.H. and Shorr, E. (1953). J. Biol.Chem. 202: 675-685. Cited in Clin. Methods Manual Spectronic 20: • Bausch and Lamb Inc., U.S.A.pp. 271-277.
    21. Whittick, WG. (1974). Canine Orthopaedics Lea and Febiger, Philadelphia, pp 73
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    Indian Journal of Animal Research
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      volume 35 issue 2 (july to december 2001) : 112 - 115

      BIOCHEMICAL CHANGES FOLLOWING ULNAR SEGMENTAL DEFECT REPAIR WITH FIBRILLAR COLLAGEN - HYDROXYAPATITE, AND POROUS HYDROXYAPATITE IMPLANTS IN CANINES·

      T
      T Madhava Rao\ G.V. Lakshmipathi2
      T
      T.P. SastrY
      O
      O. Ramakrishna4
      1Department of Surgery and Radiology College of Veterinary Science, Tirupati - 517 502, India

      • Submitted|

      • First Online |

      • doi

      Cite article:- Lakshmipathi2 G.V. Rao\ Madhava T, SastrY T.P., Ramakrishna4 O. (2025). BIOCHEMICAL CHANGES FOLLOWING ULNAR SEGMENTAL DEFECT REPAIR WITH FIBRILLAR COLLAGEN - HYDROXYAPATITE, AND POROUS HYDROXYAPATITE IMPLANTS IN CANINES·. Indian Journal of Animal Research. 35(2): 112 - 115. doi: .

      ABSTRACT

      In 24 clinically healthy adult mongrel dogs divided into 4 groups of 6 animals each, a transverse middle third diaphyseal segmental defect of 1. 2 cm was created in the ulma. The healing of the gap was evaluated biochemically following repair with autogenous cancellous bone (Group-II), fibrillar collagen-hydroxyapatite composite (Group-III), porous hydroxyapatite (Group-IV). The gap was unfilled in control group (Group-I). The changes in serum calcium, phosphorus and alkaline phosphatase levels were compared with clinical and radiological findings and it is concluded that the fibrillar collagen-hydroxyapatite composite implants can be used as a suitable alternative to the use of autogenous cancellous bone in repair of segmental bone loss defects or non-union fractures.

      KEYWORDS

        REFERENCES

        1. Baker, RW.R (1955). Biochem. J. 59:566.
        2. Ganesh, T.N. and Mohammed, M.S.D.M. (1993). Indian J. Vet. Surg. 14:48.
        3. Heilman, B. and Pallan, M. (1973). Beitr. Klin. Chir. 220:649-653 (Abstr. Cal. Tiss, 6: 579, 1974).
        4. Holmes, RE. etal. (1986). J. Bone JointSurg. 68-A: 904-911.
        5. Kind, P. R N. and King, E.J. (1954). J. Clin. Path. 7: 322.
        6. Lane, J.M. and Sandhu, H.S. (1987). Orlho. Clin. Norlh. America 18: 213-225.
        7. Laurnc;n, E.L and Kelly, P.J. (1969). J. Bone Joint Surg. 51-A: 1298-1308.
        8. Lemaire, RG. (1966). J. Bone Joint Surg. 48-A: 1156-1170.
        9. Oonishi, H. (1991) Biomaterials 12: 171-178.
        10. Pandey, S.K. and Udapa, KN. (1981). Indian Vet. J. 58:37-41. .
        11. Sahkhar, KB. et al. (1998). Indian J. Vet.Surg. 19:29-30.
        12. Saikia J. (1983). Ph. D. Thesis, Haryana Agril. Univ. Hisar, India.
        13. Sh:nesen, M.G. (1971). In: Clinical Biochemistry of Domestic Animals. VoLl, edn.2 (Keneko, J.J. and Cornelius, C.E. eds), Academic Press Inc. New York, pp.313-375.
        14. Singh et al. (1976). Indian Vet. J. 53: 862-865.
        15. Singh, A.P. and Nigam, J.M. (1976). HAUJ. Res. 6: 196-200.
        16. Snedecor, G.W and Cochran, WG. (1967). Statistical Methods 6th edn. The IOWA State University Press, Ames, IOWA, U.S.A. pp:93-94.
        17. Soleman, F.A. and Hassan, S.v.S. (1964). Nature 204: 693-694.
        18. Takaoka, K et al. (1998). Clin. Orthopaedics 234: 250-254
        19. Tanabe, Y. and Wilcox, F.H. (1960). Proc. Sec. Exptl. BioI. 103: 68-70.
        20. Taussky, H.H. and Shorr, E. (1953). J. Biol.Chem. 202: 675-685. Cited in Clin. Methods Manual Spectronic 20: • Bausch and Lamb Inc., U.S.A.pp. 271-277.
        21. Whittick, WG. (1974). Canine Orthopaedics Lea and Febiger, Philadelphia, pp 73
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