volume 38 issue 2 (july to december 2004) : 107 - 111
PHARMACOKINETICS, DISTRIBUTIONAND DOSAGE REGIMEN OF CEFUROXIME IN LACfATING GOATS AFTER INTRAVENOUS ADMINISTRATION·
1Bihar Veterinary College, Patna - 800 014, India
Published In
Indian Journal of Animal Research
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volume 38 issue 2 (july to december 2004) : 107 - 111
PHARMACOKINETICS, DISTRIBUTIONAND DOSAGE REGIMEN OF CEFUROXIME IN LACfATING GOATS AFTER INTRAVENOUS ADMINISTRATION·
1Bihar Veterinary College, Patna - 800 014, India
ABSTRACT
Pharmacokinetic study of cefuroxime, a second generation cephalosporin was conducted in six lactating goats after i.v. administration (20 mg/kg). The therapeutic concentration (≥1.0 μg/ml) was maintained from 2.5 min to 1 h, 30 to 45 min and 2.5 min to 12 h in plasma, milk and urine, respectively. Distribution half life (t½ α) of 0.58±0.09 h and elimination half life (t½ β) of 3.35±0.09 h were obtained for cefuroxime in goats. A high Vdarea of 5.88±0.48 L/kg denotes greater distribution of the drug in different body fluids and tissues. This fact is supported by higher approximate tissue to plasma concentration ratio (T ≈ P) ratio of 4.80±1.84 and also higher drug concentrations obtained in milk. Total body clearance (ClB) value of 20.23±1.39 ml/kg/min was obtained in goats in the present study. For treating mild to moderate systemic infections (Cp∞ min = 0.5 μg/ml), the required loading (D*) and maintenance (Do) doses calculated as 15 and 12 mg/kg at the dosage interval (γ) of 8 h while for treating severe systemic infections (Cp∞ min =1.0 μg/ml), D* and Do of 20 and 14 mg/kg at the dosage interval (γ), respectively are calculated following i.v. administration
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In this Article
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Published In
Indian Journal of Animal Research