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Current IssueEditorial BoardOnline First ArticlesArchive

volume 39 issue 2 (july to december 2005) : 102 - 106

DISTRIBUTION STUDIES OF ENROFLOXACIN AND GENTAMICIN IN PLASMA AND UTERINE FLUID OF HEALTHY COWS AND COWS SUFFERING FROM ENDOMETRITIS FOLLOWING INTRAVENOUS ADMINISTRATION

A
Ankesh Kumar
M
M.H. Akhtar
C
C. Jayachandran*
1Department of Animal Reproduction, Gynaecology and Obstetrics. Bihar Veterinary College, Patna - 800 014, Bihar, India

  • Submitted|

  • First Online |

  • doi

Cite article:- Kumar Ankesh, Akhtar M.H., Jayachandran* C. (2025). DISTRIBUTION STUDIES OF ENROFLOXACIN AND GENTAMICIN IN PLASMA AND UTERINE FLUID OF HEALTHY COWS AND COWS SUFFERING FROM ENDOMETRITIS FOLLOWING INTRAVENOUS ADMINISTRATION. Indian Journal of Animal Research. 39(2): 102 - 106. doi: .

ABSTRACT

Distribution studies of enrofloxacin and gentamicin (5 mg/kg, Lv.) revealed that significant
decrease in plasma drug concentrations at most of the time intervals were noted for both the drugs while significant increase in uterine fluid levels of enrofloxacin and gentamicin were noted at all time intervals in cows with endometritis as compared to healthy animals. Further, therapeutic concentration of 0.12 Ilg/m1 in uterine fluid was maintained for a longer time (1 to > 24 h) with enrofloxacin while therapeutic concentration of 4 Ilg/ml was maintained for a shorter time (1 to 8 h) with gentamicin in cows suffering from endometritis. Hence, the study recommends the parental administration of enrofloxacin @ 5 mg!kg once daily while a dose of 5 mg/kg of gentamicin by parentral route twice ndaily for effective therapy of susceptible bacteria causing endometritis in cows.

KEYWORDS

    REFERENCES

    1. AI-Guedawy et a/. (1983). J. Vet. Pharmacol. Ther., 6: 85.
    2. Ames, T.R. eta/. (1983). Am. J. Vet. Res., 44: 1354-1357.
    3. Arret, B. et al. (1971). J. Pharma. Sci., 60: 1689-1694.
    4. Dabas. Y.P.S. and Maurya. S.N. (1"988). Indian J. Anim. Reprod., 9: 138-139.
    5. Giguere. S. etal. (1996). Am. J. Vet. Res., 57: 1025-1030.
    6. Jayachandran, C. et al. (1987). Vet. Res. Commun., 11: 353-358.
    7. Jayacharidran, C. et al. (1988). Indian J. Anim. Sci., 58: 343-346.
    8. Jayachandran, C. et a/. (1995). Indian J. Pharmacal., 27: 30-33.
    9. Kumar, A. et a/. (2004). Indian. Vet. Med. J., 28: 67-68.
    10. Nitesh Kumar (2002). M.v.Sc Thesis, Rajendra Agric. University, Pusa, Samastipur, Bihar, India.
    11. Leroy, A. et al. (1978). Antibiotic Chemother., 25: 163-180.
    12. Mevius. D.J. et a/. (1990). Vet. Q., 12: 212-220.
    13. Prescott, J. and Veilding, K.H. (1990). Canadian J. Vet. Res., 54: 194-197.
    14. Salim, M. et a/. (2000). Second Annual conference of Indian Society of Veterinary Pharmacology and Toxicology.
    15. Compendium of Abstracts (ISVP11, pp. 46.
    16. Sinha. R.N. etal. (1994). Indian. J. Anim. Reprod., 15: 29-31.
    17. Snedecor, GW. and Cochran, w.G. (1967). Statistical Method. 6th edition, Oxford and I.B.H. Publishing Co., Calcutta, India.
    18. Sood. P. et al. (1999). Indian. Vet. J., 76: 1071-1073.
    19. Wiedmann, B. and Atkinson. BA (1991). In: Antibiotics in Labaratory Medicine. 3,d ed. (Lorian, Y. ed). Williams and Wilkins, Baltimore, USA, pp. 962-1208.
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    Indian Journal of Animal Research
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      volume 39 issue 2 (july to december 2005) : 102 - 106

      DISTRIBUTION STUDIES OF ENROFLOXACIN AND GENTAMICIN IN PLASMA AND UTERINE FLUID OF HEALTHY COWS AND COWS SUFFERING FROM ENDOMETRITIS FOLLOWING INTRAVENOUS ADMINISTRATION

      A
      Ankesh Kumar
      M
      M.H. Akhtar
      C
      C. Jayachandran*
      1Department of Animal Reproduction, Gynaecology and Obstetrics. Bihar Veterinary College, Patna - 800 014, Bihar, India

      • Submitted|

      • First Online |

      • doi

      Cite article:- Kumar Ankesh, Akhtar M.H., Jayachandran* C. (2025). DISTRIBUTION STUDIES OF ENROFLOXACIN AND GENTAMICIN IN PLASMA AND UTERINE FLUID OF HEALTHY COWS AND COWS SUFFERING FROM ENDOMETRITIS FOLLOWING INTRAVENOUS ADMINISTRATION. Indian Journal of Animal Research. 39(2): 102 - 106. doi: .

      ABSTRACT

      Distribution studies of enrofloxacin and gentamicin (5 mg/kg, Lv.) revealed that significant
      decrease in plasma drug concentrations at most of the time intervals were noted for both the drugs while significant increase in uterine fluid levels of enrofloxacin and gentamicin were noted at all time intervals in cows with endometritis as compared to healthy animals. Further, therapeutic concentration of 0.12 Ilg/m1 in uterine fluid was maintained for a longer time (1 to > 24 h) with enrofloxacin while therapeutic concentration of 4 Ilg/ml was maintained for a shorter time (1 to 8 h) with gentamicin in cows suffering from endometritis. Hence, the study recommends the parental administration of enrofloxacin @ 5 mg!kg once daily while a dose of 5 mg/kg of gentamicin by parentral route twice ndaily for effective therapy of susceptible bacteria causing endometritis in cows.

      KEYWORDS

        REFERENCES

        1. AI-Guedawy et a/. (1983). J. Vet. Pharmacol. Ther., 6: 85.
        2. Ames, T.R. eta/. (1983). Am. J. Vet. Res., 44: 1354-1357.
        3. Arret, B. et al. (1971). J. Pharma. Sci., 60: 1689-1694.
        4. Dabas. Y.P.S. and Maurya. S.N. (1"988). Indian J. Anim. Reprod., 9: 138-139.
        5. Giguere. S. etal. (1996). Am. J. Vet. Res., 57: 1025-1030.
        6. Jayachandran, C. et al. (1987). Vet. Res. Commun., 11: 353-358.
        7. Jayacharidran, C. et al. (1988). Indian J. Anim. Sci., 58: 343-346.
        8. Jayachandran, C. et a/. (1995). Indian J. Pharmacal., 27: 30-33.
        9. Kumar, A. et a/. (2004). Indian. Vet. Med. J., 28: 67-68.
        10. Nitesh Kumar (2002). M.v.Sc Thesis, Rajendra Agric. University, Pusa, Samastipur, Bihar, India.
        11. Leroy, A. et al. (1978). Antibiotic Chemother., 25: 163-180.
        12. Mevius. D.J. et a/. (1990). Vet. Q., 12: 212-220.
        13. Prescott, J. and Veilding, K.H. (1990). Canadian J. Vet. Res., 54: 194-197.
        14. Salim, M. et a/. (2000). Second Annual conference of Indian Society of Veterinary Pharmacology and Toxicology.
        15. Compendium of Abstracts (ISVP11, pp. 46.
        16. Sinha. R.N. etal. (1994). Indian. J. Anim. Reprod., 15: 29-31.
        17. Snedecor, GW. and Cochran, w.G. (1967). Statistical Method. 6th edition, Oxford and I.B.H. Publishing Co., Calcutta, India.
        18. Sood. P. et al. (1999). Indian. Vet. J., 76: 1071-1073.
        19. Wiedmann, B. and Atkinson. BA (1991). In: Antibiotics in Labaratory Medicine. 3,d ed. (Lorian, Y. ed). Williams and Wilkins, Baltimore, USA, pp. 962-1208.
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