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Current IssueEditorial BoardOnline First ArticlesArchive

volume 41 issue 4 (december 2007) : 278-281

CHANGES IN BLOOD AND TISSUE COPPER LEVELS DUE TO THEILERIA ANNULATA INFECTION IN CROSS-BRED CALVES

N
Nirmal Sangwan 1
A
A.K. Sangwan2
1Department of Veterinary Biochemistry, CCS Haryana Agricultural University, Hisar – 125004, India

  • Submitted|

  • First Online |

  • doi

Cite article:- 1 Sangwan Nirmal, Sangwan2 A.K. (2025). CHANGES IN BLOOD AND TISSUE COPPER LEVELS DUE TO THEILERIA ANNULATA INFECTION IN CROSS-BRED CALVES. Indian Journal of Animal Research. 41(4): 278-281. doi: .

ABSTRACT

During Theileria annulata infection indirect losses of essential body nutrients can be caused by
their accelerated metabolism or excretion. Also some abnormalities in the utilization and excretion
of copper in theileriosis have been reported. Therefore, to know the changes in the copper status of calves in response to Theileriosis , two groups (Gp.I – infected; Gp.II- control) of six cross-bred male calves of 4-6 months old were used. Concentrations of copper in blood, plasma and tissues were estimated on Atomic Absorption Spectrophotometer. The infected animals showed clinical symptoms like fever, anorexia, respiratory distress and recumbancy and peak parasitaemias ranged from 14 to 85 per cent and piroplasms were first seen between days 11 and 13 post-infection. With the progression of disease, haemoglobin and haematocrit decreased significantly. However, the blood copper concentrations did not exhibit changes due to Theileriosis. Also liver, spleen and heart copper concentrations were within normal range. It appears that T. annulata is not interfering with the host’s copper metabolism. Therefore, being normal copper reserves of the liver of infected animals, there seems no advantage of copper supplementation in animals suffering from T. annulata infection

KEYWORDS

    REFERENCES

    1. Beisel, W.R. (1991). In : Nutritional Biochemistry and Metabolism with Clinical Applications, 2nd edn., (M.C. Linder Ed.) , Elsevier, New York, pp., 507-542.
    2. Duncan, L. (1976). Chemical Analysis by Atomic Absorption Spectrophotoscopy, 3rd edn. Lea and Febiger, Philadelphia.
    3. Forsyth, L.M.G. et al. (1999). J. Comparative Pathol., 120: 39-57.
    4. Georgievskii, V.I. (1982). In: Studies in the Agricultural and Food Sciences. Mineral Nutrition of Animals. (Georgievskii, V.I. et al. Eds.) Butterworths, London, pp. 171-224.
    5. Gill, B.S., et al.(1997). Annales de Parasitologie, 52: 597-608.
    6. Klimov, N.M. and Polyakov, V.F. (1971). Trudy-Vsesoyuznogo-Instituta-Eksperimental-noi-Veterinarii, 39: 276-283.
    7. Kumar, R. and Malik, J.K. (1999). J. Vet. Pharmacol. Therapeutics, 22: 320-326.
    8. National Research Council, (1988). Nutrient Requirements of Dairy Cattle. Sixth edn. National Academy of Science. Washington, D.C., U.S.A.
    9. Omer, O.H. et al. (2003). Vet. Res. Communic., 27(1): 15-25.
    10. Powanda, M.C., Canonico, P.G. (1981). Infection: The Physiologic and Metabolic Responses of the Host. Elsevier/ North Holland, New York.
    11. Preston, P.M., et al. (1992). Res. Vet. Sci., 53: 230-243.
    12. Purnell, R.E. (1978). Vet. Res. Communic., 2: 3-10.
    13. Sahu, P.K., et al.(1996). Indian Vet. J., 73(9): 995-997.
    14. Smith, B. and Coup, M.R. (1973). New Zealand Vet. J., 21: 252-258.
    15. Snedecor, G.W. and Cochran, W.J.(1967). Statistical Methods. 7th edn. Oxford and IBH Publishing Co., New Delhi.
    16. Suttle, N.F. (1987). In: Copper in Animals and Man, (Howell, J.McC. and Gawthorne, J.M. Eds.). Vol. 1. CRC Press, Boca Raton, Florida, pp. 21-44.
    17. Suttle, N.F. (1994). In: Recent Advances in Animal Nutrition. Garnsworthy, P.C. and Cole, D.J.A. (eds.). Nottingham University Press, Nottingham, pp. 173-188.
    18. Underwood, E.J. and Suttle, N.F. (1999). The Mineral Nutrition of Livestock, 3rd edn, CAB International Publishing, pp. 283-342.
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    Indian Journal of Animal Research
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      volume 41 issue 4 (december 2007) : 278-281

      CHANGES IN BLOOD AND TISSUE COPPER LEVELS DUE TO THEILERIA ANNULATA INFECTION IN CROSS-BRED CALVES

      N
      Nirmal Sangwan 1
      A
      A.K. Sangwan2
      1Department of Veterinary Biochemistry, CCS Haryana Agricultural University, Hisar – 125004, India

      • Submitted|

      • First Online |

      • doi

      Cite article:- 1 Sangwan Nirmal, Sangwan2 A.K. (2025). CHANGES IN BLOOD AND TISSUE COPPER LEVELS DUE TO THEILERIA ANNULATA INFECTION IN CROSS-BRED CALVES. Indian Journal of Animal Research. 41(4): 278-281. doi: .

      ABSTRACT

      During Theileria annulata infection indirect losses of essential body nutrients can be caused by
      their accelerated metabolism or excretion. Also some abnormalities in the utilization and excretion
      of copper in theileriosis have been reported. Therefore, to know the changes in the copper status of calves in response to Theileriosis , two groups (Gp.I – infected; Gp.II- control) of six cross-bred male calves of 4-6 months old were used. Concentrations of copper in blood, plasma and tissues were estimated on Atomic Absorption Spectrophotometer. The infected animals showed clinical symptoms like fever, anorexia, respiratory distress and recumbancy and peak parasitaemias ranged from 14 to 85 per cent and piroplasms were first seen between days 11 and 13 post-infection. With the progression of disease, haemoglobin and haematocrit decreased significantly. However, the blood copper concentrations did not exhibit changes due to Theileriosis. Also liver, spleen and heart copper concentrations were within normal range. It appears that T. annulata is not interfering with the host’s copper metabolism. Therefore, being normal copper reserves of the liver of infected animals, there seems no advantage of copper supplementation in animals suffering from T. annulata infection

      KEYWORDS

        REFERENCES

        1. Beisel, W.R. (1991). In : Nutritional Biochemistry and Metabolism with Clinical Applications, 2nd edn., (M.C. Linder Ed.) , Elsevier, New York, pp., 507-542.
        2. Duncan, L. (1976). Chemical Analysis by Atomic Absorption Spectrophotoscopy, 3rd edn. Lea and Febiger, Philadelphia.
        3. Forsyth, L.M.G. et al. (1999). J. Comparative Pathol., 120: 39-57.
        4. Georgievskii, V.I. (1982). In: Studies in the Agricultural and Food Sciences. Mineral Nutrition of Animals. (Georgievskii, V.I. et al. Eds.) Butterworths, London, pp. 171-224.
        5. Gill, B.S., et al.(1997). Annales de Parasitologie, 52: 597-608.
        6. Klimov, N.M. and Polyakov, V.F. (1971). Trudy-Vsesoyuznogo-Instituta-Eksperimental-noi-Veterinarii, 39: 276-283.
        7. Kumar, R. and Malik, J.K. (1999). J. Vet. Pharmacol. Therapeutics, 22: 320-326.
        8. National Research Council, (1988). Nutrient Requirements of Dairy Cattle. Sixth edn. National Academy of Science. Washington, D.C., U.S.A.
        9. Omer, O.H. et al. (2003). Vet. Res. Communic., 27(1): 15-25.
        10. Powanda, M.C., Canonico, P.G. (1981). Infection: The Physiologic and Metabolic Responses of the Host. Elsevier/ North Holland, New York.
        11. Preston, P.M., et al. (1992). Res. Vet. Sci., 53: 230-243.
        12. Purnell, R.E. (1978). Vet. Res. Communic., 2: 3-10.
        13. Sahu, P.K., et al.(1996). Indian Vet. J., 73(9): 995-997.
        14. Smith, B. and Coup, M.R. (1973). New Zealand Vet. J., 21: 252-258.
        15. Snedecor, G.W. and Cochran, W.J.(1967). Statistical Methods. 7th edn. Oxford and IBH Publishing Co., New Delhi.
        16. Suttle, N.F. (1987). In: Copper in Animals and Man, (Howell, J.McC. and Gawthorne, J.M. Eds.). Vol. 1. CRC Press, Boca Raton, Florida, pp. 21-44.
        17. Suttle, N.F. (1994). In: Recent Advances in Animal Nutrition. Garnsworthy, P.C. and Cole, D.J.A. (eds.). Nottingham University Press, Nottingham, pp. 173-188.
        18. Underwood, E.J. and Suttle, N.F. (1999). The Mineral Nutrition of Livestock, 3rd edn, CAB International Publishing, pp. 283-342.
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