Chief Editor:

M. R. Saseendranath

Kerala Veterinary and Animal Science University, Mannuthy, Thrissur, INDIA

Frequency:Monthly

Indexing:

Science Citation Index Expanded, BIOSIS Preview, ISI Citation Index, Biological Abstracts, Scopus, ...

STUDIES ON THE GENOTOXIC EFFECTS OF SUCRALOSE IN LABORATORY MICE

Ashwani Sharma, Sunil Panwar, A.K. Singh, K.K. Jakhar*

Affiliations

¹National Dairy Research Institute, Karnal - 132 001 Haryana, India

Submitted|
First Online |
doi

Cite article:- Sharma Ashwani, Panwar Sunil, Singh A.K., Jakhar* K.K. (2025). STUDIES ON THE GENOTOXIC EFFECTS OF SUCRALOSE IN LABORATORY MICE. Indian Journal of Animal Research. 41(1): 1 - 8. doi: .

ABSTRACT

Forty female (Swiss albino) mice were divided into 4 groups of ten animals each. Mice of
groups I, II and III were fed sucralose 500, 1000 and 1500 ppm, respectively in feed. Group IV
was fed sucralose free diet. Five animals were sacrificed from each group on 30th and 60th day
of study and metaphase spreads prepared for evaluation of mitotic index and chromosomal
aberrations. Liver and kidney samples of mice were also collected on 30th and 60th day of
experiment for histopathological study. Among the chromosomal aberrations observed, polyploidy
and monosomy were most common. The differences in mitotic indices and chromosomal
aberrations between the 4 groups at different intervals were found to be statistically nonsignificant.
Histopathological changes were observed in the liver and kidney of all treated groups.
It is concluded from the present study that sucralose consumption up to 1500 ppm for two
months did not produce any genotoxicity but it is hepatotoxic and nephrotoxic. However, its
effect at higher doses and longer duration needs to be studies.

KEYWORDS

REFERENCES

Carlberg, F.W. (1985). Fd. Chem. Toxic, 23(4/5): 499-506.
Ford, C.E. and Hamerton, J.L. (1956). Stain Technol., 31(6): 247-251.
Henkel, J. (1999). FDA Consum., 33(6): 12-16.
John, B.A. et al. (2000). Fd. Chem. Toxic, 38(2): S107-110.
Luna, L.G. (1968). Histologic Staining Methods. 3rd edn. McGraw Hill Book Company, New York.
Minot, C.S. (1968). A Study on Cytomorphosis. Putman’s Sons, New York.
Mukhopodhyay, M. et al. (2000). Fd. Chem. Toxic, 38: 75-77.
Roberts, A. et al. (2000). Fd. Chem. Toxic, 38(2): S31-41.
Sasaki, Y.F. and Tsuda (2002). Mutation Res., 519(1-2): 103-109.

Disclaimer :

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Copyright :

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.