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volume 47 issue 6 (december 2013) : 465-471

EFFECT OF FASTING AND RE-FEEDING WITH DIFFERENT FAT SUPPLEMENTS ON HEPATIC LIPIDOSIS IN MINK

L
Lei Sha andYong-Ping Xu*1
1Department of Bioscience and Biotechnology, Dalian University of Technology, No.2 Linggong Road, Dalian, Liaoning 116 024, China

  • Submitted|

  • First Online |

  • doi

Cite article:- Xu*1 andYong-Ping Sha Lei (2025). EFFECT OF FASTING AND RE-FEEDING WITH DIFFERENT FAT SUPPLEMENTS ON HEPATIC LIPIDOSIS IN MINK. Indian Journal of Animal Research. 47(6): 465-471. doi: .

ABSTRACT

Fatty liver syndrome is a metabolic disorder that occurs in mink (Mustela vison). The aim of this study was to compare the effects of dietary fat sources (chicken oil, fish oil and soybean oil) on the recovery fatty liver syndrome in female mink in response to short term fasting for 5 days and subsequent re-feeding for 7-28 days. Food deprivation resulted in the rapid mobilization of body fat, causing an elevated hepatosomatic index and increased liver lipid content. Re-feeding resulted in a more pronounced recovery of liver health in the mink fed the fish oil diet than chicken oil or soybean oil diet. The fish oil diet was found to be useful to relieve the severity of hepatic lipidosis in mink.

REFERENCES

  1. Bjornvad C.R., Elnif J., and Sangild P.T. (2004). Short-term fasting induces intrahepatic lipid accumulation and decreases intestinal mass without reduced brush-border enzyme activity in mink (Mustela vison) small intestine. J Comp Physiol B, 174: 625-632.
  2. Brown J.H., and Lasiewski R.C. (1972). Metabolism of weasels: the cost of being long and thin. Ecology, 53: 939-943.
  3. Caughey G.E., Mantzioris E., Gibson R.A., Cleland L.G., and James M.J. (1996). The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil. Am J Clin Nutr, 63: 116-122.
  4. Clausen T.N., and Sandbol P. (2004). Correlation between liver fat and dry matter in mink (Mustela vison). Poster Presentation g! International Scientific Congress in Fur Animal Production, Den Bosch, The Netherlands, September 15-18, Scientifur, 28: 168-169.
  5. Clausen T.N., and Sandbol P. (2005). Fasting of mink kits fed different feed rations and its effect on liver fat content, plasma metabolites and enzymes. Proceedings of the Nordic Association of Agricultural Scientists (NJF) Seminar, Sweden: 5.
  6. Clausen T.N., and Sandbøl P. (2006). Fasting of male mink after mating influence on liver fat and blood ketone content. Proceedings of the Nordic Association of Agricultural Scientists (NJF) Seminar, Iceland: 4.
  7. Damgaard B.M., Clausen T.N., and Henriksen P. (1994). Effect of protein and fat content in feed on plasma alanine- aminotransferase and hepatic fatty infiltration in mink. Zentralbl Veterinarmed A, 41: 620-629.
  8. “Dick M.F. (2010)”. Fatty Liver Syndrome in Mink - Causes and Metabolic Consequences. M.Sc. Thesis. Dalhousie University, Halifax and Nova Scotia Agricultural College, Truro, Nova Scotia. 157p.
  9. Folch J., Lees M., and Sloane Stanley G.H. (1957). A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem, 226: 497-509.
  10. Hunter D.B., and Barker I.K. (1996). Digestive system of mink. In: Hunter B, Lemieux N (Eds) Mink…biology, health and disease University of Guelph Graphic and Print Services, Guelph.
  11. Kakela R., Pölönen I., Miettinen M., and Asikainen K. (2001). Effects of different fat supplements on growth and hepatic lipids and fatty acids in male mink. Acta Agric Scand Sect A, Animal Sci, 51: 217-223.
  12. Mayes P.A. (1990). Oxidation of fatty acids: ketogenesis. In: Murray, RK, Granner, DK, Mayes, PA, Rodwell, VW (Eds), Harper’s Biochemistry, 22nd ed Appleton & Lange.
  13. Mustonen A.M., Puukka M., Pyykonen T., and Nieminen P. (2005a). Adaptations to fasting in the American mink (Mustela vison): nitrogen metabolism. J Comp Physiol, 175: 357-363.
  14. Mustonen A.M., Pyykonen T., Paakkonen T., Ryokkynen A., Asikainen J., Aho J., Mononen J., and Nieminen P. (2005b). Adaptations to fasting in the American mink (Mustela vison): carbohydrate and lipid metabolism. Comp Biochem Physiol A Mol Integr Physiol, 140: 195-202.
  15. Mustonen A.M., Puukka M., Saarela S., Paakkonen T., Aho J., and Nieminen P. (2006). Adaptations to fasting in a terrestrial mustelid, the sable (Martes zibellina). Comp Biochem Physiol A Mol Integr Physiol, 144: 444-450.
  16. Nieminen P., Mustonen A.M., Karja V., Asikainen J., and Rouvinen-Watt K. (2009). Fatty acid composition and development of hepatic lipidosis during food deprivation—mustelids as a potential animal model for liver steatosis. Exp Biol Med, 234: 278-286.
  17. Olfert ED C.B. and McWilliam AA (eds). (1993). Canadian Council on Animal Care. The care and use of experimental animals.
  18. Rouvinen-Watt K., Mustonen A.M., Conway R., Pal C., Harris L., Saarela S., Strandberg U., and Nieminen P. (2010). Rapid development of fasting-induced hepatic lipidosis in the American mink (Neovison vison): effects of food deprivation and re-alimentation on body fat depots, tissue fatty acid profiles, hematology and endocrinology. Lipids, 45: 111-128.
  19. Rouvinen-Watt K., White M.B., and Campbell R. (2005). Mink Feeds and Feeding, applied feeding guide and mink feed ingredient database. CD-ROM. Ontario Ministry of Agriculture and Food through the Agricultural Research Institute of Ontario and the Nova Scotia Agricultural College.
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    volume 47 issue 6 (december 2013) : 465-471

    EFFECT OF FASTING AND RE-FEEDING WITH DIFFERENT FAT SUPPLEMENTS ON HEPATIC LIPIDOSIS IN MINK

    L
    Lei Sha andYong-Ping Xu*1
    1Department of Bioscience and Biotechnology, Dalian University of Technology, No.2 Linggong Road, Dalian, Liaoning 116 024, China

    • Submitted|

    • First Online |

    • doi

    Cite article:- Xu*1 andYong-Ping Sha Lei (2025). EFFECT OF FASTING AND RE-FEEDING WITH DIFFERENT FAT SUPPLEMENTS ON HEPATIC LIPIDOSIS IN MINK. Indian Journal of Animal Research. 47(6): 465-471. doi: .

    ABSTRACT

    Fatty liver syndrome is a metabolic disorder that occurs in mink (Mustela vison). The aim of this study was to compare the effects of dietary fat sources (chicken oil, fish oil and soybean oil) on the recovery fatty liver syndrome in female mink in response to short term fasting for 5 days and subsequent re-feeding for 7-28 days. Food deprivation resulted in the rapid mobilization of body fat, causing an elevated hepatosomatic index and increased liver lipid content. Re-feeding resulted in a more pronounced recovery of liver health in the mink fed the fish oil diet than chicken oil or soybean oil diet. The fish oil diet was found to be useful to relieve the severity of hepatic lipidosis in mink.

    REFERENCES

    1. Bjornvad C.R., Elnif J., and Sangild P.T. (2004). Short-term fasting induces intrahepatic lipid accumulation and decreases intestinal mass without reduced brush-border enzyme activity in mink (Mustela vison) small intestine. J Comp Physiol B, 174: 625-632.
    2. Brown J.H., and Lasiewski R.C. (1972). Metabolism of weasels: the cost of being long and thin. Ecology, 53: 939-943.
    3. Caughey G.E., Mantzioris E., Gibson R.A., Cleland L.G., and James M.J. (1996). The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil. Am J Clin Nutr, 63: 116-122.
    4. Clausen T.N., and Sandbol P. (2004). Correlation between liver fat and dry matter in mink (Mustela vison). Poster Presentation g! International Scientific Congress in Fur Animal Production, Den Bosch, The Netherlands, September 15-18, Scientifur, 28: 168-169.
    5. Clausen T.N., and Sandbol P. (2005). Fasting of mink kits fed different feed rations and its effect on liver fat content, plasma metabolites and enzymes. Proceedings of the Nordic Association of Agricultural Scientists (NJF) Seminar, Sweden: 5.
    6. Clausen T.N., and Sandbøl P. (2006). Fasting of male mink after mating influence on liver fat and blood ketone content. Proceedings of the Nordic Association of Agricultural Scientists (NJF) Seminar, Iceland: 4.
    7. Damgaard B.M., Clausen T.N., and Henriksen P. (1994). Effect of protein and fat content in feed on plasma alanine- aminotransferase and hepatic fatty infiltration in mink. Zentralbl Veterinarmed A, 41: 620-629.
    8. “Dick M.F. (2010)”. Fatty Liver Syndrome in Mink - Causes and Metabolic Consequences. M.Sc. Thesis. Dalhousie University, Halifax and Nova Scotia Agricultural College, Truro, Nova Scotia. 157p.
    9. Folch J., Lees M., and Sloane Stanley G.H. (1957). A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem, 226: 497-509.
    10. Hunter D.B., and Barker I.K. (1996). Digestive system of mink. In: Hunter B, Lemieux N (Eds) Mink…biology, health and disease University of Guelph Graphic and Print Services, Guelph.
    11. Kakela R., Pölönen I., Miettinen M., and Asikainen K. (2001). Effects of different fat supplements on growth and hepatic lipids and fatty acids in male mink. Acta Agric Scand Sect A, Animal Sci, 51: 217-223.
    12. Mayes P.A. (1990). Oxidation of fatty acids: ketogenesis. In: Murray, RK, Granner, DK, Mayes, PA, Rodwell, VW (Eds), Harper’s Biochemistry, 22nd ed Appleton & Lange.
    13. Mustonen A.M., Puukka M., Pyykonen T., and Nieminen P. (2005a). Adaptations to fasting in the American mink (Mustela vison): nitrogen metabolism. J Comp Physiol, 175: 357-363.
    14. Mustonen A.M., Pyykonen T., Paakkonen T., Ryokkynen A., Asikainen J., Aho J., Mononen J., and Nieminen P. (2005b). Adaptations to fasting in the American mink (Mustela vison): carbohydrate and lipid metabolism. Comp Biochem Physiol A Mol Integr Physiol, 140: 195-202.
    15. Mustonen A.M., Puukka M., Saarela S., Paakkonen T., Aho J., and Nieminen P. (2006). Adaptations to fasting in a terrestrial mustelid, the sable (Martes zibellina). Comp Biochem Physiol A Mol Integr Physiol, 144: 444-450.
    16. Nieminen P., Mustonen A.M., Karja V., Asikainen J., and Rouvinen-Watt K. (2009). Fatty acid composition and development of hepatic lipidosis during food deprivation—mustelids as a potential animal model for liver steatosis. Exp Biol Med, 234: 278-286.
    17. Olfert ED C.B. and McWilliam AA (eds). (1993). Canadian Council on Animal Care. The care and use of experimental animals.
    18. Rouvinen-Watt K., Mustonen A.M., Conway R., Pal C., Harris L., Saarela S., Strandberg U., and Nieminen P. (2010). Rapid development of fasting-induced hepatic lipidosis in the American mink (Neovison vison): effects of food deprivation and re-alimentation on body fat depots, tissue fatty acid profiles, hematology and endocrinology. Lipids, 45: 111-128.
    19. Rouvinen-Watt K., White M.B., and Campbell R. (2005). Mink Feeds and Feeding, applied feeding guide and mink feed ingredient database. CD-ROM. Ontario Ministry of Agriculture and Food through the Agricultural Research Institute of Ontario and the Nova Scotia Agricultural College.
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