IMMUNOMODULATORY IMPACT OF METAMITRON IN BLACK BENGAL GOATS FOLLOWING REPEATED ORAL ADMINISTRATION

Article Id: ARCC167 | Page : 412-416
Citation :- IMMUNOMODULATORY IMPACT OF METAMITRON IN BLACK BENGAL GOATS FOLLOWING REPEATED ORAL ADMINISTRATION.Indian Journal Of Animal Research.2013.(47):412-416
A.K. Nayek , M. Khan, S.K. Manna1, J.R. Dash, and T.K. Mandal* drtkan48@yahoo.co.in
Address : Department of Veterinary Pharmacology and Toxicology, University of Animal and Fishery Sciences, 37, Kshudiram Bose Sarani, Kolkata- 700 037, India

Abstract

The study was conducted to evaluate immunomodulatory effect of the herbicide, Metamitron in goats .Nine Black Bengal male adult goats were divided into three  groups,  each  containing  3  animals. Control (Gr-I) group  received  carboxy methyl cellulose, while experimental control (Gr- II) group received levamisole at immunostimulating dose and experimental group (Gr-III) received Metamitron daily for 35 days. On day 36   all goats   were immunized with 5% SRBC intraperitoneally. Animals were sacrificed for conducting Haemolytic Plaque Assay on day 5 post dosing SRBC. Total serum IgG level was estimated by Sandwitch ELISA. No significant variation in serum IgG level was observed at different days against 0 day in control and experimental group. But serum IgG level was increased significantly in experimental control group. No significant variation was observed in percentage of plaque formation in control and experimental group but the value was significantly higher in experimental control group.  Results indicated that Metamitron had no effect on immunomodulation of goats during this observation period.

Keywords

Black Bengal goat Haemolytic Plaque Assay Immunomodulation Sandwitch ELISA.

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