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volume 43 issue 2 (june 2009) : 103-106

EVALUATION OF IMMUNOMODULATORY POTENTIAL' OF EMBLICA OFFICINALIS FRUIT PULP EXTRACT IN MICE

R
R. S. Suja
A
A. M. C. Nair
S
S. Sujith
J
J. Preethy
A
A. K. Deepa
1College of Veterinary and Animal Sciences (K.A.U.), Mannuthy, 680651, India.

  • Submitted|

  • First Online |

  • doi

Cite article:- Suja S. R., Nair C. M. A., Sujith S., Preethy J., Deepa K. A. (2025). EVALUATION OF IMMUNOMODULATORY POTENTIAL' OF EMBLICA OFFICINALIS FRUIT PULP EXTRACT IN MICE. Indian Journal of Animal Research. 43(2): 103-106. doi: .

ABSTRACT

Aqueous extract of dried Emblica officinalis Gaertn. (Amla) fruit pulp powder was evaluated for
immunomodulatory effect on male Swiss Albino mice. The mice were divided into three groups.
The first group received vehicle alone to serve as control. The second and third groups received
the extract orally at 100 and 200 mg! kg body weight dose levels respectively per day for a period
of 19 days. There was significant dose dependent increase in haemagglutination antibody titre,
sheep red blood cells induced delayed type of hypersensitivity reaction, macrophage migration
index, respiratory burst activity of the peritoneal macrophages, total leukocyte count, percentage
lymphocyte distribution, serum globulin and relative lymphoid organ weight in Emblica treated
mice indicating its ability to stimulate humoral as well as cell mediated immunity along with
macrophage phagocyte.

REFERENCES

  1. Benencia, E eta!. (1996). Phyother. Res., 10: 37-40.
  2. Doumas, B.T. (1971). Clin. Chern. Acta., 31: 87-88.
  3. Elizabeth, M.W. (2002). Major Herbs of Ayurveda. Churchill Livingstone, NewYork
  4. ,,::.
  5. 106 INDIAN JOURNAL OF ANIMAL RESEARCH
  6. Gomall, AG. etaI. (1949). J. BioI. Chem., 77: 751-752.
  7. Harborne, J.8. (1991). Phytochemical Methods-Guide to Modern Techniques of Plant Analysis. 2nd Edn., Chapman
  8. and Hall, India.
  9. Jayathirtha, M.G. and Mishra, S.H. (2004). Phytomed.,l1: 361-365.
  10. Kaneko, J.J. et aI. (1997). In: Clinical Biochemistry of Domestic Animals, 5th Edn., Academic Press, U.S.A.
  11. Kapil, A and Sharma, S. (1997). J. EthnopharmacoI., 58: 89-91.
  12. Nores, M.M. etaI. (1997). J. EthnopharmacoI., 55: 99.
  13. Puri, A et aI. (1994). J. EthnopharmacoI., 42: 31-35.
  14. Sairam, M. et aI. (1997). J. EthnopharmacoI., 55: 133-137.
  15. Saraf, M.N. et al. (1989). J. Ethnopharmacol., 25: 159-162.
  16. Saxena"K.C. et aI. (1991). IrnmunoI. Invest., 20: 431-436.
  17. Snedecor, G.w. and Cochran, D.G. (1976). Statististical Methods. 8th Edn., Academic Press, USA
  18. Thakur, C.P. et al. (1988). Int J CardioI .,21:167-170.
  19. Zhang, Y,]. et a/. (2000). J. Nat. Prod., 63:1507-1509.
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    volume 43 issue 2 (june 2009) : 103-106

    EVALUATION OF IMMUNOMODULATORY POTENTIAL' OF EMBLICA OFFICINALIS FRUIT PULP EXTRACT IN MICE

    R
    R. S. Suja
    A
    A. M. C. Nair
    S
    S. Sujith
    J
    J. Preethy
    A
    A. K. Deepa
    1College of Veterinary and Animal Sciences (K.A.U.), Mannuthy, 680651, India.

    • Submitted|

    • First Online |

    • doi

    Cite article:- Suja S. R., Nair C. M. A., Sujith S., Preethy J., Deepa K. A. (2025). EVALUATION OF IMMUNOMODULATORY POTENTIAL' OF EMBLICA OFFICINALIS FRUIT PULP EXTRACT IN MICE. Indian Journal of Animal Research. 43(2): 103-106. doi: .

    ABSTRACT

    Aqueous extract of dried Emblica officinalis Gaertn. (Amla) fruit pulp powder was evaluated for
    immunomodulatory effect on male Swiss Albino mice. The mice were divided into three groups.
    The first group received vehicle alone to serve as control. The second and third groups received
    the extract orally at 100 and 200 mg! kg body weight dose levels respectively per day for a period
    of 19 days. There was significant dose dependent increase in haemagglutination antibody titre,
    sheep red blood cells induced delayed type of hypersensitivity reaction, macrophage migration
    index, respiratory burst activity of the peritoneal macrophages, total leukocyte count, percentage
    lymphocyte distribution, serum globulin and relative lymphoid organ weight in Emblica treated
    mice indicating its ability to stimulate humoral as well as cell mediated immunity along with
    macrophage phagocyte.

    REFERENCES

    1. Benencia, E eta!. (1996). Phyother. Res., 10: 37-40.
    2. Doumas, B.T. (1971). Clin. Chern. Acta., 31: 87-88.
    3. Elizabeth, M.W. (2002). Major Herbs of Ayurveda. Churchill Livingstone, NewYork
    4. ,,::.
    5. 106 INDIAN JOURNAL OF ANIMAL RESEARCH
    6. Gomall, AG. etaI. (1949). J. BioI. Chem., 77: 751-752.
    7. Harborne, J.8. (1991). Phytochemical Methods-Guide to Modern Techniques of Plant Analysis. 2nd Edn., Chapman
    8. and Hall, India.
    9. Jayathirtha, M.G. and Mishra, S.H. (2004). Phytomed.,l1: 361-365.
    10. Kaneko, J.J. et aI. (1997). In: Clinical Biochemistry of Domestic Animals, 5th Edn., Academic Press, U.S.A.
    11. Kapil, A and Sharma, S. (1997). J. EthnopharmacoI., 58: 89-91.
    12. Nores, M.M. etaI. (1997). J. EthnopharmacoI., 55: 99.
    13. Puri, A et aI. (1994). J. EthnopharmacoI., 42: 31-35.
    14. Sairam, M. et aI. (1997). J. EthnopharmacoI., 55: 133-137.
    15. Saraf, M.N. et al. (1989). J. Ethnopharmacol., 25: 159-162.
    16. Saxena"K.C. et aI. (1991). IrnmunoI. Invest., 20: 431-436.
    17. Snedecor, G.w. and Cochran, D.G. (1976). Statististical Methods. 8th Edn., Academic Press, USA
    18. Thakur, C.P. et al. (1988). Int J CardioI .,21:167-170.
    19. Zhang, Y,]. et a/. (2000). J. Nat. Prod., 63:1507-1509.
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