The present study was aimed to assess the hypoglycaemic, hypolipidemic and antioxidant
activities of a common herb, Coccinia indica. The study was conducted in Sprague-Dawley
strain of albino rats and the chemical, alloxan was used for the experimental induction of diabetes.
Thirty two adult albino rats were divided into four groups of eight each. Group I served as
normal control and group II was made as diabetic control. Group III and IV were made diabetic
and administered orally with 200 mg/kg of ethanolic extract of C. indica leaves and 0.25 mg/kg
of glibenclamide, respectively, for 45 days. There was a significant (p<0.05) reduction in blood
glucose, serum cholesterol, triglyceride and lipid peroxides levels and elevation of reduced
glutathione and liver glycogen in C. indica treated group when compared with the diabetic
control. The results showed that the ethanolic extract of C. indica leaves possessed significant
hypoglycaemic, hypolipidemic and antioxidant effects. The ethanolic extract of C. indica leaves
was screened for the active ingredients and also for acute oral toxicity and sub acute toxicity.
No toxic effects were revealed from the toxicity studies. The results indicate the safety and
efficacy of indica in diabetes mellitus.