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Current IssueEditorial BoardOnline First ArticlesArchive

volume 44 issue 2 (june 2010) : 139 - 142

ANAESTHETIC EVALUATION OF KETAMINE/PROPOFOL IN ACEPROMAZINE- XYLAZINE PREMEDICATED HORSES*

P
P. Sankar1
B
B. Justin William
G
G. Dhanan Jaya Rao
S
S. Prathaban
R
R. Suresh Kumar
V
V. Leela
1Madras Veterinary College Vepery, Chennai-600 007, Tamil Nadu, India

  • Submitted|

  • First Online |

  • doi

Cite article:- Sankar1 P., William Justin B., Rao Jaya Dhanan G., Prathaban S., Kumar Suresh R., Leela V. (2025). ANAESTHETIC EVALUATION OF KETAMINE/PROPOFOL IN ACEPROMAZINE- XYLAZINE PREMEDICATED HORSES*. Indian Journal of Animal Research. 44(2): 139 - 142. doi: .

ABSTRACT

The study was conducted in twelve clinical cases of horses for diagnostic and surgical
procedures warranting general anaesthesia were randomly divided into two groups, group I and
group II, each consisting of six cases. Xylazine @ 0.50mg/kg and acepromazine @ 0.03mg/kg
body weight was used as pre-anaesthetic in both the groups. Ketamine @ 2.20 mg/kg body
weight and 0.50mg/kg/min was used as induction and maintenance agent in group I and Propofol
2.0 mg/kg body weight and 0.15mg/kg/min was used as induction and maintenance agent in
group II. The mean time for sedation in group I and group II were 5.16±0.30 minutes and
5.10±0.21 minutes respectively. The mean quality of sedation in group I and group II were 2.27
±0.21 minutes and 2.67 ± 0.21 minutes respectively and the mean time for induction was
1.83± 0.17 minutes and 1.17 ±0.17 minutes respectively. The induction was smooth in all
horses (100%) in group II. In group I smooth induction was observed in 83.33% and rough
induction in 16.67% of the cases. The total dose of xylazine administered including the
incremental doses in group I was 1.00 ± 0.00 mg/kg/hr where as in group II xylazine incremental
dose was not administered. The calculated dose was 6.52 ± 0.13mg/kg/hr in group I and 11.86±
0.533 mg/kg/hr in group II. The score for the quality of muscle relaxation was 2.50± 0.22 and
2.33 ±0.21 in group I and group II respectively. The score for reflex status in group I and group
II were 1.00± 0.36and 0.67±0.31 respectively. The mean time for recovery in group I and
group II were 32.00±2.87 minutes and 14.00±1.05 minutes respectively. The quality of recovery
was smooth in 66.66% of group I and 83.33% of group II. The quality of recovery was rough in
33.34% of group I and 16.67% of group II. The number of attempts for unassisted standing was
4.67± 0.21times in group I and 1.50± 0.22 times in group II. None of the animals in any groups
showed any intra and post operative complication.

REFERENCES

  1. Aubin, M.L. and Mama K., (2002). Compendium @ medimedia.com., 24: 411- 415.
  2. Bovil, J.G. et al , ( 1971). The Lancet., 19: 1285-1288.
  3. Brock, N. (1994). Can. Vet. J ., 35: 458-459.
  4. Figueiredo, J.P. et al (2005). Intern. J. Appl. Res. Vet. Med., 3: 249-258.
  5. Folts, J.D. et al (1975). Vet. Anaesth. Analg., 30: 193-201.
  6. Gaikwad, S.V. et al, (2006). J. Bombay Vet. Coll., 14: 121-123.
  7. Gleed, R.D, (1987). Tranquilizers and sedatives, In Principles and practice of veterinary anaesthesia Edt.
  8. Short, C.F. Edn. I., Williams and Wilkens, London, pp.16-21.
  9. Haskins, S.C. et al , (1975). Am. J. Vet. Res., 36: 1537-1542.
  10. Haskins, S.C. et al, (1985). Am. J. Vet. Res., 46: 1855-1860.
  11. Hopkins, T.J. (1972). Aust. Vet. J., 48 :109-112.
  12. Mackenzie, G and D.H. Snow, (1977). Vet. Rec., 101: 30-33.
  13. Mama, K.R., et al, (1995) Evaluation of Propofol as a General Anaesthetic For Horses. Vet. Anaesth., 24 :
  14. 188-194.
  15. Matthews, N.S. et al (1999). Vet. Sur., 28: 196-201.
  16. Muir, W.W., R.T., Skarda and W. Shgeehan, 1978. Evaluation of xylazine and ketamine hydrochloride for
  17. restraint in horses. Am. J.Vet Res., 40 : 1418-1522.
  18. Nilsfors, L. et al, (1987). Eq. Vet. J., 67: 364-367.
  19. Ott, L. and Longneker, (2001). Completely randomized block design, In An introduction to statistical
  20. method and data analysis 5th Edn. Duxbury California, pp. 855-859.
  21. Pathak, S.C.et al, (1982). Indian J. Anim Sci., 52: 319-324.
  22. Raut, S.S. et al, (2006). J. Bombay Vet. Coll., 14: 48-51.
  23. Short, C.E, (1987). Dissociative anaesthetics, In Principles and Practice of Veterinary Anaesthesia Edn.I.
  24. William and Walkins, London pp.158-162.
  25. Singh A.P..J. Singh et al, (1985) ZbI. Vet. Med. A., 32 : 54-58.
  26. Taylor, P.M. (1989). Br. J. Anaesth., 63: 702-709.
  27. Vende, S.S. et al, (2006). J. Bombay Vet. Coll., 14: 16-19.
  28. Villar, R.G. et al, (1981). J. Vet. Pharmacol. Ther., 4: 87-92.
  29. Wright, M. (1982). J. Am. Vet. Med. Assoc., 180: 1462-1471.
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    volume 44 issue 2 (june 2010) : 139 - 142

    ANAESTHETIC EVALUATION OF KETAMINE/PROPOFOL IN ACEPROMAZINE- XYLAZINE PREMEDICATED HORSES*

    P
    P. Sankar1
    B
    B. Justin William
    G
    G. Dhanan Jaya Rao
    S
    S. Prathaban
    R
    R. Suresh Kumar
    V
    V. Leela
    1Madras Veterinary College Vepery, Chennai-600 007, Tamil Nadu, India

    • Submitted|

    • First Online |

    • doi

    Cite article:- Sankar1 P., William Justin B., Rao Jaya Dhanan G., Prathaban S., Kumar Suresh R., Leela V. (2025). ANAESTHETIC EVALUATION OF KETAMINE/PROPOFOL IN ACEPROMAZINE- XYLAZINE PREMEDICATED HORSES*. Indian Journal of Animal Research. 44(2): 139 - 142. doi: .

    ABSTRACT

    The study was conducted in twelve clinical cases of horses for diagnostic and surgical
    procedures warranting general anaesthesia were randomly divided into two groups, group I and
    group II, each consisting of six cases. Xylazine @ 0.50mg/kg and acepromazine @ 0.03mg/kg
    body weight was used as pre-anaesthetic in both the groups. Ketamine @ 2.20 mg/kg body
    weight and 0.50mg/kg/min was used as induction and maintenance agent in group I and Propofol
    2.0 mg/kg body weight and 0.15mg/kg/min was used as induction and maintenance agent in
    group II. The mean time for sedation in group I and group II were 5.16±0.30 minutes and
    5.10±0.21 minutes respectively. The mean quality of sedation in group I and group II were 2.27
    ±0.21 minutes and 2.67 ± 0.21 minutes respectively and the mean time for induction was
    1.83± 0.17 minutes and 1.17 ±0.17 minutes respectively. The induction was smooth in all
    horses (100%) in group II. In group I smooth induction was observed in 83.33% and rough
    induction in 16.67% of the cases. The total dose of xylazine administered including the
    incremental doses in group I was 1.00 ± 0.00 mg/kg/hr where as in group II xylazine incremental
    dose was not administered. The calculated dose was 6.52 ± 0.13mg/kg/hr in group I and 11.86±
    0.533 mg/kg/hr in group II. The score for the quality of muscle relaxation was 2.50± 0.22 and
    2.33 ±0.21 in group I and group II respectively. The score for reflex status in group I and group
    II were 1.00± 0.36and 0.67±0.31 respectively. The mean time for recovery in group I and
    group II were 32.00±2.87 minutes and 14.00±1.05 minutes respectively. The quality of recovery
    was smooth in 66.66% of group I and 83.33% of group II. The quality of recovery was rough in
    33.34% of group I and 16.67% of group II. The number of attempts for unassisted standing was
    4.67± 0.21times in group I and 1.50± 0.22 times in group II. None of the animals in any groups
    showed any intra and post operative complication.

    REFERENCES

    1. Aubin, M.L. and Mama K., (2002). Compendium @ medimedia.com., 24: 411- 415.
    2. Bovil, J.G. et al , ( 1971). The Lancet., 19: 1285-1288.
    3. Brock, N. (1994). Can. Vet. J ., 35: 458-459.
    4. Figueiredo, J.P. et al (2005). Intern. J. Appl. Res. Vet. Med., 3: 249-258.
    5. Folts, J.D. et al (1975). Vet. Anaesth. Analg., 30: 193-201.
    6. Gaikwad, S.V. et al, (2006). J. Bombay Vet. Coll., 14: 121-123.
    7. Gleed, R.D, (1987). Tranquilizers and sedatives, In Principles and practice of veterinary anaesthesia Edt.
    8. Short, C.F. Edn. I., Williams and Wilkens, London, pp.16-21.
    9. Haskins, S.C. et al , (1975). Am. J. Vet. Res., 36: 1537-1542.
    10. Haskins, S.C. et al, (1985). Am. J. Vet. Res., 46: 1855-1860.
    11. Hopkins, T.J. (1972). Aust. Vet. J., 48 :109-112.
    12. Mackenzie, G and D.H. Snow, (1977). Vet. Rec., 101: 30-33.
    13. Mama, K.R., et al, (1995) Evaluation of Propofol as a General Anaesthetic For Horses. Vet. Anaesth., 24 :
    14. 188-194.
    15. Matthews, N.S. et al (1999). Vet. Sur., 28: 196-201.
    16. Muir, W.W., R.T., Skarda and W. Shgeehan, 1978. Evaluation of xylazine and ketamine hydrochloride for
    17. restraint in horses. Am. J.Vet Res., 40 : 1418-1522.
    18. Nilsfors, L. et al, (1987). Eq. Vet. J., 67: 364-367.
    19. Ott, L. and Longneker, (2001). Completely randomized block design, In An introduction to statistical
    20. method and data analysis 5th Edn. Duxbury California, pp. 855-859.
    21. Pathak, S.C.et al, (1982). Indian J. Anim Sci., 52: 319-324.
    22. Raut, S.S. et al, (2006). J. Bombay Vet. Coll., 14: 48-51.
    23. Short, C.E, (1987). Dissociative anaesthetics, In Principles and Practice of Veterinary Anaesthesia Edn.I.
    24. William and Walkins, London pp.158-162.
    25. Singh A.P..J. Singh et al, (1985) ZbI. Vet. Med. A., 32 : 54-58.
    26. Taylor, P.M. (1989). Br. J. Anaesth., 63: 702-709.
    27. Vende, S.S. et al, (2006). J. Bombay Vet. Coll., 14: 16-19.
    28. Villar, R.G. et al, (1981). J. Vet. Pharmacol. Ther., 4: 87-92.
    29. Wright, M. (1982). J. Am. Vet. Med. Assoc., 180: 1462-1471.
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