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Current IssueEditorial BoardOnline First ArticlesArchive

volume 44 issue 2 (june 2010) : 113 - 117

OXIDATIVE STRESS RESPONSE DURING SURGERY UNDER KETAMINE/PROPOFOL ANAESTHESIA IN ACEPROMAZINE-XYLAZINE PREMEDICATED HORSES

P
P. Sankar
B
B. Justin William
G
G. Dhanan Jaya Rao
S
S. Prathaban R. Suresh Kumar
V
V. Leela
1Department of Veterinary Surgery and Radiology Madras Veterinary College, Vepery, Chennai-600 007, Tamil Nadu, India

  • Submitted|

  • First Online |

  • doi

Cite article:- Sankar P., William Justin B., Rao Jaya Dhanan G., Kumar Suresh R. Prathaban S., Leela V. (2025). OXIDATIVE STRESS RESPONSE DURING SURGERY UNDER KETAMINE/PROPOFOL ANAESTHESIA IN ACEPROMAZINE-XYLAZINE PREMEDICATED HORSES. Indian Journal of Animal Research. 44(2): 113 - 117. doi: .

ABSTRACT

The study was conducted in twelve clinical cases of horses undergoing diagnostic and surgical
procedures warranting general anaesthesia. The cases were randomly divided into two groups:
group I and group II each consisting of six cases. Xylazine @ 0.5mg/kg and Acepromazine @
0.03 mg/kg body weight were used as pre-anaesthetic in both the groups. Ketamine @ 2.20 mg/
kg body weight and 0.50mg/kg/min was used as induction and maintenance agent in group I and
Propofol @ 2.0 mg/kg body weight and 0.15mg/kg/min was used as induction and maintenance
agent in group II. A non significant difference in the neutrophil, lymphocyte, eosinophil, and
monocyte counts were observed in both the groups. The magnitude of blood glucose was higher
in group I compared to that of group II. A non significant reduction in total serum protein was
observed after sedation, after induction, during maintenance and after recovery in both the groups.
Group I exhibited an increase in Plasma cortisol level, when compared to that of group II

REFERENCES

  1. Alva, N, et al., (2006). Nitric oxide., 15: 64-69.
  2. Aubin, M.L. and K. Mama, (2002). Compendium @ medimedia.com., 24: 411- 415.
  3. Basu, S, et al., (2001). Resuscitation., 50: 341-348.
  4. Brasil, L.J, et al., (2006). Toxicology., 227: 53-61.
  5. Clarke, R.S. et.al., (1970). Br. J. Anaesth., 42: 295-299.
  6. Davis, C.A. (1990). Equine Vet. J ., 22.304-305.
  7. Delogu, G, et al ., (2004). J. Clinical Anaesth., 16: 189-194.
  8. Montane, J, et al. , (2003). J. Wildlife disease. 39: 375-386.
  9. Ozer, A.B and D. Kaman, (2007). Firat Medical J., 12: 93-96.
  10. Peter, C.E, et al., (2001). Anaesthesiol., 94: 313-321.
  11. Ruffoli, R, et al., (2006). Andrologia., 38 :159-165.
  12. Runzer, T.M, et al ., (2002). Anesth. Analg., 94: 89-93.
  13. Sagara, Y. et al., (1999). J. Neurochem., 73: 2524-2530.
  14. Steffey, E.P et al ., (1977). Am. J. Vet. Res. , 38: 379-382.
  15. Taylor, P.M. (1989). Br. J. Anaesth., 63: 702-709.
  16. Taylor, P.M. and S.B. Watkins, (1992). J. Vet. Anaesth., 19: 13-17.
  17. Traynor, C. and G.M. Hall, (1981). Br. J. Anaesth., 53: 153-160.
  18. Wong, C.H et al., (2006). Food and chemical toxicol. 44: 1399 -1407.
  19. Wagner, A.E, (1991). In: Equine anaesthesia, Monitoring and emergency therapy (Muir, W.W. and J.A.E.
  20. Hubbel, Edt), Mosby year book, St. Louis, pp.105-113.
  21. Wagner, A.E. ., (1991). Am. J. Vet. Res., 52: 651-657.
  22. Wolfensberger, R.B. et al., (1996). Am. J. Vet. Res., 57: 1472-1477
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Indian Journal of Animal Research
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    volume 44 issue 2 (june 2010) : 113 - 117

    OXIDATIVE STRESS RESPONSE DURING SURGERY UNDER KETAMINE/PROPOFOL ANAESTHESIA IN ACEPROMAZINE-XYLAZINE PREMEDICATED HORSES

    P
    P. Sankar
    B
    B. Justin William
    G
    G. Dhanan Jaya Rao
    S
    S. Prathaban R. Suresh Kumar
    V
    V. Leela
    1Department of Veterinary Surgery and Radiology Madras Veterinary College, Vepery, Chennai-600 007, Tamil Nadu, India

    • Submitted|

    • First Online |

    • doi

    Cite article:- Sankar P., William Justin B., Rao Jaya Dhanan G., Kumar Suresh R. Prathaban S., Leela V. (2025). OXIDATIVE STRESS RESPONSE DURING SURGERY UNDER KETAMINE/PROPOFOL ANAESTHESIA IN ACEPROMAZINE-XYLAZINE PREMEDICATED HORSES. Indian Journal of Animal Research. 44(2): 113 - 117. doi: .

    ABSTRACT

    The study was conducted in twelve clinical cases of horses undergoing diagnostic and surgical
    procedures warranting general anaesthesia. The cases were randomly divided into two groups:
    group I and group II each consisting of six cases. Xylazine @ 0.5mg/kg and Acepromazine @
    0.03 mg/kg body weight were used as pre-anaesthetic in both the groups. Ketamine @ 2.20 mg/
    kg body weight and 0.50mg/kg/min was used as induction and maintenance agent in group I and
    Propofol @ 2.0 mg/kg body weight and 0.15mg/kg/min was used as induction and maintenance
    agent in group II. A non significant difference in the neutrophil, lymphocyte, eosinophil, and
    monocyte counts were observed in both the groups. The magnitude of blood glucose was higher
    in group I compared to that of group II. A non significant reduction in total serum protein was
    observed after sedation, after induction, during maintenance and after recovery in both the groups.
    Group I exhibited an increase in Plasma cortisol level, when compared to that of group II

    REFERENCES

    1. Alva, N, et al., (2006). Nitric oxide., 15: 64-69.
    2. Aubin, M.L. and K. Mama, (2002). Compendium @ medimedia.com., 24: 411- 415.
    3. Basu, S, et al., (2001). Resuscitation., 50: 341-348.
    4. Brasil, L.J, et al., (2006). Toxicology., 227: 53-61.
    5. Clarke, R.S. et.al., (1970). Br. J. Anaesth., 42: 295-299.
    6. Davis, C.A. (1990). Equine Vet. J ., 22.304-305.
    7. Delogu, G, et al ., (2004). J. Clinical Anaesth., 16: 189-194.
    8. Montane, J, et al. , (2003). J. Wildlife disease. 39: 375-386.
    9. Ozer, A.B and D. Kaman, (2007). Firat Medical J., 12: 93-96.
    10. Peter, C.E, et al., (2001). Anaesthesiol., 94: 313-321.
    11. Ruffoli, R, et al., (2006). Andrologia., 38 :159-165.
    12. Runzer, T.M, et al ., (2002). Anesth. Analg., 94: 89-93.
    13. Sagara, Y. et al., (1999). J. Neurochem., 73: 2524-2530.
    14. Steffey, E.P et al ., (1977). Am. J. Vet. Res. , 38: 379-382.
    15. Taylor, P.M. (1989). Br. J. Anaesth., 63: 702-709.
    16. Taylor, P.M. and S.B. Watkins, (1992). J. Vet. Anaesth., 19: 13-17.
    17. Traynor, C. and G.M. Hall, (1981). Br. J. Anaesth., 53: 153-160.
    18. Wong, C.H et al., (2006). Food and chemical toxicol. 44: 1399 -1407.
    19. Wagner, A.E, (1991). In: Equine anaesthesia, Monitoring and emergency therapy (Muir, W.W. and J.A.E.
    20. Hubbel, Edt), Mosby year book, St. Louis, pp.105-113.
    21. Wagner, A.E. ., (1991). Am. J. Vet. Res., 52: 651-657.
    22. Wolfensberger, R.B. et al., (1996). Am. J. Vet. Res., 57: 1472-1477
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      Indian Journal of Animal Research

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