Indian Journal of Animal Research

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Indian Journal of Animal Research, volume 44 issue 2 (june 2010) : 113 - 117

OXIDATIVE STRESS RESPONSE DURING SURGERY UNDER KETAMINE/PROPOFOL ANAESTHESIA IN ACEPROMAZINE-XYLAZINE PREMEDICATED HORSES

P. Sankar, B. Justin William, G. Dhanan Jaya Rao, S. Prathaban R. Suresh Kumar, V. Leela
1Department of Veterinary Surgery and Radiology Madras Veterinary College, Vepery, Chennai-600 007, Tamil Nadu, India

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Cite article:- Sankar P., William Justin B., Rao Jaya Dhanan G., Kumar Suresh R. Prathaban S., Leela V. (2024). OXIDATIVE STRESS RESPONSE DURING SURGERY UNDER KETAMINE/PROPOFOL ANAESTHESIA IN ACEPROMAZINE-XYLAZINE PREMEDICATED HORSES. Indian Journal of Animal Research. 44(2): 113 - 117. doi: .

ABSTRACT

The study was conducted in twelve clinical cases of horses undergoing diagnostic and surgical
procedures warranting general anaesthesia. The cases were randomly divided into two groups:
group I and group II each consisting of six cases. Xylazine @ 0.5mg/kg and Acepromazine @
0.03 mg/kg body weight were used as pre-anaesthetic in both the groups. Ketamine @ 2.20 mg/
kg body weight and 0.50mg/kg/min was used as induction and maintenance agent in group I and
Propofol @ 2.0 mg/kg body weight and 0.15mg/kg/min was used as induction and maintenance
agent in group II. A non significant difference in the neutrophil, lymphocyte, eosinophil, and
monocyte counts were observed in both the groups. The magnitude of blood glucose was higher
in group I compared to that of group II. A non significant reduction in total serum protein was
observed after sedation, after induction, during maintenance and after recovery in both the groups.
Group I exhibited an increase in Plasma cortisol level, when compared to that of group II

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