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Current IssueEditorial BoardOnline First ArticlesArchive

volume 47 issue 1 (february 2013) : 75-78

COMPARATIVE STUDY OF In Vivo AND In Vitro EFFICACY OF CEFTRIAXONE IN GOAT MASTITIS

S
S. Sreeja*
P
P.P. Bineesh
K
K. Vijayakumar
M
M.R. Saseendranath
1Department of Veterinary Epidemiology and Preventive Medicine, College of Veterinary and Animal Sciences, Mannuthy-680 651, India

  • Submitted|

  • First Online |

  • doi

Cite article:- Sreeja* S., Bineesh P.P., Vijayakumar K., Saseendranath M.R. (2025). COMPARATIVE STUDY OF In Vivo AND In Vitro EFFICACY OF CEFTRIAXONE IN GOAT MASTITIS. Indian Journal of Animal Research. 47(1): 75-78. doi: .

ABSTRACT

Mastitis is an economically important disease of small ruminants which is prone to become gangrenous and may even endanger the life of the animal.  The antibiotic sensitivity patterns in clinical and sub clinical caprine mastitis were compared with 12 treatment results after administration of a broad spectrum antibiotic, ceftriaxone at a dose rate of 10 mg/kg for 5 days.  Staphylococcus aureus was the most common isolate.  Although S. aureus isolates showed 97% sensitivity to ceftriaxone in vitro, the in vivo results of the treatment trial was different.  Clinical cure was only 58.33 % and bacteriological cure was 50 %.

REFERENCES

  1. Abu-Samra, M.T., Elsanousi, S.M., Abdalla, M.A., Gameel, A.A., Aziz, M.A., Abbas, B., Ibrahim, K.E.E. and Idris, S.O. (1988). Studies on gangrenous mastitis in goats. Cornell Vet. 78: 281-300.
  2. Adams, H. R. (2001). Pencillins and related â-lactam antibiotics. In: Veterinary pharmacology and therapeutics (Vaden. S.L. and Reviere, J.E. eds.). Eighth edition. Iowa State University Press, Iowa. pp. 818-827.
  3. Bauer, A.W., Kirby, W.M.M., Scherris, J.C. and Truck, M. (1966). Antibiotic susceptibility testing by a standard single disc method. Am. J. Clin. Path. 45 : 493.
  4. Cowan, S.T. (1974). Cowan and Steel’s Manual for the Identification of Medical Bacteria. Third edition. Cambridge University Press, New York. p. 331.
  5. Da Silva, E.R., Siqueira, A.P., Martins, J.C.D., Ferreira, W.P.B. and Silva, N.da. (2004). Identification and in vitro antimicrobial susceptibility of Staphylococcus species isolated from goat mastitis in the northeast of Brazil. Small Rumin. Res. 55: 45-49.
  6. Da Silva, E.R., Boechat, J.U.D., Martins, J.C.D., Ferreira, W.P.B., Siqueira, A.P. and Silva, N.da. (2005). Hemolysin production by Staphylococcus aureus species isolated from mastitic goat milk in Brazilian dairy herds. Small Rumin. Res. 56:271-275.
  7. Erskine, R.J., Wilson, R.C., Tyler, J.W., McClurre, K.A., Nelson, R.S. and Spears, H.J. (1995). Ceftiofur distribution in serum and milk from clinically normal cows and cows with experimental Escherichia coli-induced mastitis. Am. J. Vet. Res. 56: 481-485.
  8. Fthenakis, G.C. (1998). Susceptibility to antibiotics of Staphylococcal isolates from cases of ovine or bovine mastitis in Greece. Small Rumin. Res. 28: 9-13.
  9. Gupta, R.K. and Gupta, S. (2005). Therapeutic efficacy of ceftriaxone and Seri-D combination against acute mastitis in bovines. Intas Polivet 6: 39-40.
  10. Gupta, V.K., Sharma, S.D. and Kumar, A. (2002). In vitro and in vivo therapeutic studies on subclinical mastitis in goats. Indian J. Anim. Sci. 72: 125-127.
  11. Hornish, R.E, and Kotarski, S.F. (2002). Cephalosporins in veterinary medicine - ceftiofur use in food animals. Curr Top Med Chem. 2 :717-731.
  12. Mavrogianni V.S, Menzies P.I, Fragkou I.A, Fthenakis G.C. (2011). Principles of mastitis treatment in sheep and goats. Vet Clin North Am Food Anim. Pract. 27 :115-20.
  13. Moroni, P., Vellere, F., Antonini, M., Pisoni, G., Ruffo, G. and Carli, S. (2004). Antibiotic susceptibility of coagulase- negative Staphylococci isolated from goats’ milk. Int. J. Antimicrob. Agents 23: 637-640.
  14. Radostitis, O.M.., Blood, D.C., Gay, C.C. and Hinchcliff, K.W. (2000). Veterinary Medicine. A Text book of the Diseases of cattle, sheep, pig, goat and horses. Ninth edition. W. B. Saunders Company Ltd, London, p.1877.
  15. Sanchez, A., Contreras, A., Jimenez, J., Luengo, C., Corrales, J.C. and Fernandez, C. (2003). Effect of freezing goat milk samples on recovery of intramammary pathogens. Vet. Microbiol. 94: 71-77.
  16. Sar, T.K, Mandal, T.K., Das, S.K., Chakraborty, A.K., Bhattacharyya, A. (2006). Pharmacokinetics of Ceftriaxone inHealthy and Mastitic Goats with Special Reference to Its InteractionWith Polyherbal Drug (Fibrosin®) Intern J Appl Res Vet Med. 4 : 142-154.
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    volume 47 issue 1 (february 2013) : 75-78

    COMPARATIVE STUDY OF In Vivo AND In Vitro EFFICACY OF CEFTRIAXONE IN GOAT MASTITIS

    S
    S. Sreeja*
    P
    P.P. Bineesh
    K
    K. Vijayakumar
    M
    M.R. Saseendranath
    1Department of Veterinary Epidemiology and Preventive Medicine, College of Veterinary and Animal Sciences, Mannuthy-680 651, India

    • Submitted|

    • First Online |

    • doi

    Cite article:- Sreeja* S., Bineesh P.P., Vijayakumar K., Saseendranath M.R. (2025). COMPARATIVE STUDY OF In Vivo AND In Vitro EFFICACY OF CEFTRIAXONE IN GOAT MASTITIS. Indian Journal of Animal Research. 47(1): 75-78. doi: .

    ABSTRACT

    Mastitis is an economically important disease of small ruminants which is prone to become gangrenous and may even endanger the life of the animal.  The antibiotic sensitivity patterns in clinical and sub clinical caprine mastitis were compared with 12 treatment results after administration of a broad spectrum antibiotic, ceftriaxone at a dose rate of 10 mg/kg for 5 days.  Staphylococcus aureus was the most common isolate.  Although S. aureus isolates showed 97% sensitivity to ceftriaxone in vitro, the in vivo results of the treatment trial was different.  Clinical cure was only 58.33 % and bacteriological cure was 50 %.

    REFERENCES

    1. Abu-Samra, M.T., Elsanousi, S.M., Abdalla, M.A., Gameel, A.A., Aziz, M.A., Abbas, B., Ibrahim, K.E.E. and Idris, S.O. (1988). Studies on gangrenous mastitis in goats. Cornell Vet. 78: 281-300.
    2. Adams, H. R. (2001). Pencillins and related â-lactam antibiotics. In: Veterinary pharmacology and therapeutics (Vaden. S.L. and Reviere, J.E. eds.). Eighth edition. Iowa State University Press, Iowa. pp. 818-827.
    3. Bauer, A.W., Kirby, W.M.M., Scherris, J.C. and Truck, M. (1966). Antibiotic susceptibility testing by a standard single disc method. Am. J. Clin. Path. 45 : 493.
    4. Cowan, S.T. (1974). Cowan and Steel’s Manual for the Identification of Medical Bacteria. Third edition. Cambridge University Press, New York. p. 331.
    5. Da Silva, E.R., Siqueira, A.P., Martins, J.C.D., Ferreira, W.P.B. and Silva, N.da. (2004). Identification and in vitro antimicrobial susceptibility of Staphylococcus species isolated from goat mastitis in the northeast of Brazil. Small Rumin. Res. 55: 45-49.
    6. Da Silva, E.R., Boechat, J.U.D., Martins, J.C.D., Ferreira, W.P.B., Siqueira, A.P. and Silva, N.da. (2005). Hemolysin production by Staphylococcus aureus species isolated from mastitic goat milk in Brazilian dairy herds. Small Rumin. Res. 56:271-275.
    7. Erskine, R.J., Wilson, R.C., Tyler, J.W., McClurre, K.A., Nelson, R.S. and Spears, H.J. (1995). Ceftiofur distribution in serum and milk from clinically normal cows and cows with experimental Escherichia coli-induced mastitis. Am. J. Vet. Res. 56: 481-485.
    8. Fthenakis, G.C. (1998). Susceptibility to antibiotics of Staphylococcal isolates from cases of ovine or bovine mastitis in Greece. Small Rumin. Res. 28: 9-13.
    9. Gupta, R.K. and Gupta, S. (2005). Therapeutic efficacy of ceftriaxone and Seri-D combination against acute mastitis in bovines. Intas Polivet 6: 39-40.
    10. Gupta, V.K., Sharma, S.D. and Kumar, A. (2002). In vitro and in vivo therapeutic studies on subclinical mastitis in goats. Indian J. Anim. Sci. 72: 125-127.
    11. Hornish, R.E, and Kotarski, S.F. (2002). Cephalosporins in veterinary medicine - ceftiofur use in food animals. Curr Top Med Chem. 2 :717-731.
    12. Mavrogianni V.S, Menzies P.I, Fragkou I.A, Fthenakis G.C. (2011). Principles of mastitis treatment in sheep and goats. Vet Clin North Am Food Anim. Pract. 27 :115-20.
    13. Moroni, P., Vellere, F., Antonini, M., Pisoni, G., Ruffo, G. and Carli, S. (2004). Antibiotic susceptibility of coagulase- negative Staphylococci isolated from goats’ milk. Int. J. Antimicrob. Agents 23: 637-640.
    14. Radostitis, O.M.., Blood, D.C., Gay, C.C. and Hinchcliff, K.W. (2000). Veterinary Medicine. A Text book of the Diseases of cattle, sheep, pig, goat and horses. Ninth edition. W. B. Saunders Company Ltd, London, p.1877.
    15. Sanchez, A., Contreras, A., Jimenez, J., Luengo, C., Corrales, J.C. and Fernandez, C. (2003). Effect of freezing goat milk samples on recovery of intramammary pathogens. Vet. Microbiol. 94: 71-77.
    16. Sar, T.K, Mandal, T.K., Das, S.K., Chakraborty, A.K., Bhattacharyya, A. (2006). Pharmacokinetics of Ceftriaxone inHealthy and Mastitic Goats with Special Reference to Its InteractionWith Polyherbal Drug (Fibrosin®) Intern J Appl Res Vet Med. 4 : 142-154.
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