Chief EditorYashpal Singh Malik
Print ISSN 0303-3821
Online ISSN 0976-4631
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A Case Report of Mammary Carcinoma in Royal Bengal Tiger
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First Online 11-04-2023|
Methods: Detailed necropsy examination of Royal Bengal Tiger revealed the subcutaneous massive lesion in the lower abdominal region. Representative tissue samples were collected in 10% formalin for histopathology examination.
Result: Histopathological examination revealed small clusters of neoplastic epithelial cells. Micropapillae lacking fibrovascular cores extending into clear spaces. Cells exhibit moderate anisokaryosis and anisocytosis and variable numbers of mitoses with proliferation of fibrous connective tissue. Microscopic examination of lungs revealed the congestion, edema with focal proliferative neoplastic epithelial cells arranged in small clusters were scattered in the alveolar walls and spaces, indicative of metastasis. These histological features were suggestive of Mammary carcinoma with micropapillary pattern.
MATERIALS AND METHODS
RESULTS AND DISCUSSION
The lesion is white to yellow-coloured, firm and poorly demarcated from the surrounding mammary tissue (Fig 2).
In lung, diffuse consolidated areas observed throughout the lobes (Fig 3) Microscopic examination of the section revealed neoplastic cells arranged in small clusters, micropapillae lacking fibrovascular cores extending into clear spaces.
Cells exhibit moderate anisokaryosis and anisocytosis and variable numbers of mitoses with proliferation of fibrous connective tissue. The epithelium lining the papillae consisted of cuboidal to columnar cells round to ovoid hyper chromatic nuclei, increased nuclear–cytoplasmic ratio (Fig 4, 5).
In the lung, focal proliferative neoplastic epithelial cells arranged in clusters were scattered in the alveolar walls and spaces (Fig 6, 7).
Intra-alveolar and interstitial edema with congestion were evident. Riccardo Finotello et al., 2011 described histological features of Mammary Carcinoma metastasized to lungs, liver and Spleen in a 14-yr-old female tiger. Munson and A. Moresco, 2007 described, the morphologic patterns of mammary cancer of domestic and zoo cats are similar to breast cancer in women. Seixas et al., 2007 described the micropapillary invasive pattern, a distinct histologic pattern in 16 female cat tumors were associated with clinicopathologic features of high biologic aggressiveness and low survival rates. In present case micropapillary invasive pattern of mammary carcinoma metastasised to lungs caused the death of the tiger.
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